I Nem Inj Uses

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I Nem Inj indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Intravenous

Susceptible infections

Adult: Combined with cilastatin: (as anhydrous I Nem Inj) 1-2 g daily in divided doses every 6-8 hr, given via IV infusion. Doses 250 or 500 mg are infused over 20-30 min, and doses of 750 mg or 1 g over 40-60 min. Max: 4 g/day or 50 mg/kg.

Child: >40 kg: same as adult dose. Child >3 mth and <40 kg: 15-25 mg/kg every 6 hr by IV infusion. Doses up to 90 mg/kg may be given to older children with cystic fibrosis. Neonates and infants <3 mth: 4 wk-3 mth, 25 mg/kg every 6 hr; 1-4 wk, 25 mg/kg every 8 hr; up to 1 wk, 25 mg/kg every 12 hr. Max: >40 kg: 4 g/day or 50 mg/kg; <40 kg: 2 g/day.

Renal impairment: Max doses based on CrCl.

CrCl (ml/min)Dosage Recommendation
31-70500 mg every 6-8 hr.
21-30500 mg every 8-12 hr.
6-20250 mg or 3.5 mg/kg (whichever is lower) every 12 hr.
≤5Only give if haemodialysis is started within 48 hr.

Intravenous

Prophylaxis of surgical infections

Adult: 1 g may be given on induction of anaesthesia, followed by 1 g 3 hr later, with additional doses of 500 mg at 8 and 16 hr after induction if necessary.

Intramuscular

Mild to moderate susceptible infections

Adult: 500 or 750 mg every 12 hr.

Intramuscular

Uncomplicated gonorrhoea

Adult: 500 mg as a single dose.

Uses of I Nem Inj in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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I Nem Inj in combination with cilastatin (inhibitor of enzyme dehydropeptidase) is used to treat bacterial infections of lung (pneumonia), urinary tract, abdomen, blood, skin and soft tissue. It is also used to treat infections during or after delivery. It may be used in the management of fever of patients with reduced immunity due to low white blood cells (neutropenia).

I Nem Inj description

Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with cilastatin, a renal dipeptidase inhibitor. [PubChem]

I Nem Inj dosage

Intravenous

Susceptible infections

Adult: Combined with cilastatin: (as anhydrous I Nem Inj) 1-2 g daily in divided doses every 6-8 hr, given via IV infusion. Doses 250 or 500 mg are infused over 20-30 min, and doses of 750 mg or 1 g over 40-60 min. Max: 4 g/day or 50 mg/kg.

Child: >40 kg: same as adult dose. Child >3 mth and <40 kg: 15-25 mg/kg every 6 hr by IV infusion. Doses up to 90 mg/kg may be given to older children with cystic fibrosis. Neonates and infants <3 mth: 4 wk-3 mth, 25 mg/kg every 6 hr; 1-4 wk, 25 mg/kg every 8 hr; up to 1 wk, 25 mg/kg every 12 hr. Max: >40 kg: 4 g/day or 50 mg/kg; <40 kg: 2 g/day.

Renal impairment: Max doses based on CrCl.

CrCl (ml/min)Dosage Recommendation
31-70500 mg every 6-8 hr.
21-30500 mg every 8-12 hr.
6-20250 mg or 3.5 mg/kg (whichever is lower) every 12 hr.
≤5Only give if haemodialysis is started within 48 hr.

Intravenous

Prophylaxis of surgical infections

Adult: 1 g may be given on induction of anaesthesia, followed by 1 g 3 hr later, with additional doses of 500 mg at 8 and 16 hr after induction if necessary.

Intramuscular

Mild to moderate susceptible infections

Adult: 500 or 750 mg every 12 hr.

Intramuscular

Uncomplicated gonorrhoea

Adult: 500 mg as a single dose.

I Nem Inj interactions

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Increased risk of seizures when used with ganciclovir. Ciclosporin may increase neurotoxicity of ifosfamide; ifosfamide may also raise serum levels of ciclosporin. Serum levels may be increased by uricosuric agents. May reduce efficacy of valproic acid; monitor.

I Nem Inj side effects

Skin rashes, urticaria, eosinophilia, fever, nausea, vomiting, diarrhoea, tooth or tongue discoloration, and altered taste. Erythema multiforme, exfoliative dermatitis. Pain and thrombophlebitis may occur at the inj site.

Potentially Fatal: Severe anaphylactic reactions. Stevens-Johnson syndrome and toxic epidermal necrolysis.

I Nem Inj contraindications

Hypersensitivity.

Active ingredient matches for I Nem Inj:

Imipenem


Unit description / dosage (Manufacturer)Price, USD
I Nem Inj 500+500 Injection$ 0.02

List of I Nem Inj substitutes (brand and generic names):

CILANE MONO 500MG INJECTION 1 vial / 1 injection each (Ranbaxy Laboratories Ltd)$ 20.17
Cilapen 250 mg x 1's (Olcare)
Cilapen 500 mg x 1's (Olcare)
Cilapen Cilastatin 500 mg, imipenem500 mg INJ / 1 (Olcare)$ 19.84
Cilaxter 500 Injection (Alkem Laboratories Ltd)$ 0.02
IC2 250MG INJECTION 1 vial / 1 injection each (Unimark Remedies Ltd)$ 14.88
IC2 500MG INJECTION 1 vial / 1 injection each (Unimark Remedies Ltd)$ 20.56
IC2 500mg Injection (Unimark Remedies Ltd)$ 20.56
IMC 250+250 Injection (Uniword Marketing (P) Ltd)$ 0.02
IMCI 500MG INJECTION 1 vial / 1 ML injection each (Parenteral Drugs India Ltd)$ 16.48
Ime Cila 250+250 Injection (Abbott Healthcare Pvt Ltd (AHPL))$ 11.14
Ime Cila 500+500 Injection (Abbott Healthcare Pvt Ltd (AHPL))$ 0.02
IME CILA 500MG/500MG INJECTION 1 vial / 1 injection each (Abbott Healthcare Pvt Ltd (AHPL))$ 25.63
Imilastin 500+500 Injection (Samarth Pharma Pvt. Ltd.)$ 0.02
IMILASTIN 500MG/500MG INJECTION 1 vial / 1 injection each (Samarth Pharma Pvt. Ltd.)$ 8.93
Imilastin 500 mg/500 mg Injection (Samarth Pharma Pvt. Ltd.)$ 8.93
Implatin 250+250 Injection (Mickle Pharma)$ 10.71
Sanam 250+250 Injection (Stellar Life Sciences)$ 0.02
VE IC 500+500 Injection (Biovista Lifesciences)$ 0.02
VE IC 250+250 Injection (Biovista Lifesciences)$ 10.63
Vocef 250+250 Injection (Vokin Biotech Pvt. Ltd.)$ 0.02
Vocef 500+500 Injection (Vokin Biotech Pvt. Ltd.)$ 0.03

References

  1. DailyMed. "CILASTATIN SODIUM; IMIPENEM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "imipenem". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "imipenem". http://www.drugbank.ca/drugs/DB01598 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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