What is Indalix?
Indalix belongs to the group of medicines known as diuretics. It is commonly used to treat high blood pressure (hypertension).
High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.
Indalix is also used to help reduce the amount of water in the body by increasing the flow of urine.
Indalix is available only with your doctor's prescription.
Indalix indications
Indalix (Indalix) is indicated for the treatment of hypertension, alone or in combination with other antihypertensive drugs.
Indalix (Indalix) is also indicated for the treatment of salt and fluid retention associated with congestive heart failure.
Usage in Pregnancy
The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard.
Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia.
Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy. Indalix is indicated in pregnancy when edema is due to pathologic causes, just as it is in the absence of pregnancy (however, see PRECAUTIONS below). Dependent edema in pregnancy, resulting from restriction of venous return by the expanded uterus, is properly treated through elevation of the lower extremities and use of support hose; use of diuretics to lower intravascular volume in this case is illogical and unnecessary. There is hypervolemia during normal pregnancy which is not harmful to either the fetus or the mother (in the absence of cardiovascular disease), but which is associated with edema, including generalized edema in the majority of pregnant women. If this edema produces discomfort, increased recumbency will often provide relief. In rare instances, this edema may cause extreme discomfort which is not relieved by rest. In these cases, a short course of diuretics may provide relief and may be appropriate.
How should I use Indalix?
Use Indalix as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Indalix by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Indalix may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
- If you miss a dose of Indalix and you are taking 1 dose daily, take the missed dose if you remember the same day. Skip the missed dose if you do not remember until the next day. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Indalix.
Uses of Indalix in details
Use: Labeled Indications
Heart failure: Treatment of edema in heart failure
Hypertension: Management of mild to moderate hypertension
Guideline recommendations: The 2017 Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults recommends if monotherapy is warranted, in the absence of comorbidities (eg, cerebrovascular disease, chronic kidney disease, diabetes, heart failure, ischemic heart disease, etc), that thiazide-like diuretics or dihydropyridine calcium channel blockers may be preferred options due to improved cardiovascular endpoints (eg, prevention of heart failure and stroke). ACE inhibitors and ARBs are also acceptable for monotherapy. Combination therapy may be required to achieve blood pressure goals and is initially preferred in patients at high risk (stage 2 hypertension or atherosclerotic cardiovascular disease [ASCVD] risk ≥10%) (ACC/AHA [Whelton 2017]).
Off Label Uses
Calcium nephrolithiasis
Data from a prospective, randomized, study supports the use of Indalix for the prevention of recurrent calcium nephrolithiasis. Additional trials may be necessary to further define the role of Indalix in the treatment of this condition.
Based on the American Urologic Association (AUA) guidelines for the medical management of kidney stones, Indalix is effective and recommended for the prevention of recurrent calcium stones in patients with high or relatively high urine calcium concentrations.
Indalix description
Indalix also contains the following excipients: Tablet: Lactose monohydrate 124.5 mg, anhydrous colloidal silica, hypromellose, magnesium stearate, povidone. Film-coating: Glycerol, hypromellose, macrogol 6000, magnesium stearate, titanium dioxide.
Indalix dosage
Indalix Dosage
Generic name: Indalix
Dosage form: Tablets
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Hypertension
The adult starting Indalix dose for hypertension is 1.25 mg as a single daily dose taken in the morning. If the response to 1.25 mg is not satisfactory after four weeks, the daily dose may be increased to 2.5 mg taken once daily. If the response to 2.5 mg is not satisfactory after four weeks, the daily dose may be increased to 5.0 mg taken once daily, but adding another antihypertensive should be considered.
Edema of Congestive Heart Failure
The adult starting Indalix dose for edema of congestive heart failure is 2.5 mg as a single daily dose taken in the morning. If the response to 2.5 mg is not satisfactory after one week, the daily dose may be increased to 5.0 mg taken once daily.
If the antihypertensive response to Indalix is insufficient, Indalix may be combined with other antihypertensive drugs, with careful monitoring of blood pressure. It is recommended that the usual dose of other agents be reduced by 50% during initial combination therapy. As the blood pressure response becomes evident, further dosage adjustments may be necessary.
In general, doses of 5.0 mg and larger have not appeared to provide additional effects on blood pressure or heart failure, but are associated with a greater degree of hypokalemia. There is minimal clinical trial experience in patients with doses greater than 5.0 mg once a day.
More about Indalix (Indalix)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- 0 Reviews - Add your own review/rating
Consumer resources
- Indalix
- Indalix (Advanced Reading)
Professional resources
- Indalix (AHFS Monograph)
- Indalix (FDA)
Related treatment guides
- Edema
- High Blood Pressure
Indalix interactions
See also:
What other drugs will affect Indalix?
Other Antihypertensives
Indalix (Indalix) may add to or potentiate the action of other antihypertensive drugs. In limited controlled trials that compared the effect of Indalix combined with other antihypertensive drugs with the effect of the other drugs administered alone, there was no notable change in the nature or frequency of adverse reactions associated with the combined therapy.
Lithium
Post-Sympathectomy Patient
The antihypertensive effect of the drug may be enhanced in the post-sympathectomized patient.
Norepinephrine
Indalix, like the thiazides, may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use.
Indalix side effects
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What are the possible side effects of Indalix?
Applies to Indalix: oral tablet
In addition to its needed effects, some unwanted effects may be caused by Indalix (the active ingredient contained in Indalix). In the event that any of these side effects do occur, they may require medical attention.
Severity: Moderate
If any of the following side effects occur while taking Indalix, check with your doctor or nurse as soon as possible:
Signs and symptoms of an imbalance of water or potassium in the body
- Dryness of mouth
- increased thirst
- irregular heartbeat
- mood or mental changes
- muscle cramps or pain
- nausea or vomiting
- unusual tiredness or weakness
- weak pulse
- Skin rash, itching, or hives
Minor Side Effects
Some of the side effects that can occur with Indalix may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Less common or rare:
- Diarrhea
- dizziness or lightheadedness, especially when getting up from a lying or sitting position
- headache
- loss of appetite
- trouble in sleeping
- stomach upset
Indalix contraindications
See also:
What is the most important information I should know about Indalix?
Hypersensitivity to Indalix or any component of the formulation or sulfonamide-derived drugs; anuria
Note: Although the FDA approved product labeling states this medication is contraindicated with other sulfonamide-containing drug classes, the scientific basis of this statement has been challenged. See “Warnings/Precautions” for more detail.
Canadian labeling: Additional contraindications (not in US labeling): Severe renal failure (CrCl <30 mL/minute); hepatic encephalopathy; severe hepatic impairment; hypokalemia; concomitant use with antiarrhythmic agents causing torsade de pointes; pregnancy; breast-feeding; hereditary problems of galactose intolerance, glucose-galactose malabsorption, or Lapp lactase deficiency
Active ingredient matches for Indalix:
Indapamide in Malaysia.
| Unit description / dosage (Manufacturer) | Price, USD |
| Indalix 2.5 mg x 500's | |
| Indalix 2.5 mg x 1000's | |
List of Indalix substitutes (brand and generic names): | |
| Indahexal (Australia) | |
| Tablet; Oral; Indapamide Hemihydrate 2.5 mg (Hexal) | |
| Indalix Quality Pharm (Hong Kong) | |
| Indalix Quality Pharm 2.5 mg x 1, 000's | $ 380.00 |
| Indamax (Estonia) | |
| Indamid SR (Croatia (Hrvatska)) | |
| Indamide (Egypt) | |
| Indamide SR (Taiwan) | |
| Indamide SR 1.5 mg | |
| Indamol (Italy) | |
| Indamol 500 mg Tablet (Indamed Pharmaceuticals Pvt. Ltd) | $ 0.01 |
| Indamol 650 mg Tablet (Indamed Pharmaceuticals Pvt. Ltd) | $ 0.02 |
| Indanorm (Bahrain) | |
| Indap (Bosnia & Herzegowina, Czech Republic, Georgia, Poland, Slovakia, Taiwan) | |
| Capsule; Oral; Indapamide Hemihydrate 2.5 mg (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | |
| Indapamid 1.5mg - 30 Tablets (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 18.80 |
| Indap 2, 5mg - 30 Capsule (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 15.60 |
| Indapamid 1, 5mg - 30 Tablets (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 10.40 |
| Indapamid 2, 5mg - 20 Capsule (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 8.40 |
| Indapamid 2, 5mg - 30 Tablets (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 15.60 |
| Indapamid 2.5mg - 30 Tablets (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 14.60 |
| Indapamid LHP 2.5mg - 30 Tablets (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 10.40 |
| Indap 1.5 mg (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | |
| 2.5 mg x 10's (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 0.64 |
| 1.5 mg x 100's (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 0.75 |
| Indap 2.5 mg Tablet (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 0.06 |
| Indap 2.5mg TAB / 10 (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 0.64 |
| Indap 1.5mg SR-TAB / 100 (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 0.75 |
| INDAP 1.5 MG TABLET SR 1 strip / 10 tablet srs each (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 0.89 |
| INDAP 2.5 MG TABLET 1 strip / 10 tablets each (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 0.67 |
| INDAP tab 2.5 mg x 10's (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 0.64 |
| INDAP SR tab 1.5 mg x 10's (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 0.75 |
| Indap 1.5mg Tablet SR (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 0.09 |
| Indap 2.5mg Tablet (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 0.07 |
| Indap SR | |
| Indap SR 1.5 mg Tablet (Mano (Orchid Chemicals & Pharmaceuticals Ltd.)) | $ 0.09 |
| Indapa (Bangladesh, Myanmar) | |
| Indapa SR (Vietnam) | |
| Indapa SR 1.5 mg x 3 Blister x 10 Tablet | |
| Indapa-SR (Bangladesh) | |
| Indapafon (Georgia) | |
| Indapagamma (Bulgaria, Hungary, Lithuania, Poland) | |
| Indapagamma 1.5 mg retard (Hungary) | |
| Indapamid (Georgia, Romania, Russian Federation, Serbia) | |
| Tablet, Film-Coated; Oral; Indapamide 2.5 mg (Labormed pharma) | |
| Tablet, Prolonged Release; Oral; Indapamide 1.5 mg (Labormed pharma) | |
| Tablet, Controlled Release; Oral; Indapamide 1.5 mg (Labormed pharma) | |
| Capsule; Oral; Indapamide 2.5 mg (Labormed pharma) | |
| Capsule; Oral; Indapamide (Labormed pharma) | |
| Indapamid 1APharma (Slovenia) | |
See 703 substitutes for Indalix | |
References
- DailyMed. "INDAPAMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "indapamide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "indapamide". http://www.drugbank.ca/drugs/DB00808 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Indalix are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Indalix. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
