Inogest Uses

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What is Inogest?

Progestins are hormones. They are used by both men and women for different purposes.

Progestins are prescribed for several reasons:

Progestins may also be used for other conditions as determined by your doctor.

Depending on how much and which Inogest you use or take, a Inogest can have different effects. For instance, high doses of Inogest are necessary for some women to continue a pregnancy while other progestins in low doses can prevent a pregnancy from occurring. Other effects include causing weight gain, increasing body temperature, developing the milk-producing glands for breast-feeding, and relaxing the uterus to maintain a pregnancy.

Progestins can help other hormones work properly. Progestins may help to prevent anemia (low iron in blood), too much menstrual blood loss, and cancer of the uterus.

Progestins are available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, progestins are used in certain patients with the following medical conditions:

Inogest indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Disorders related to a Inogest deficit.

By oral route (vaginal route is recommended as an alternative if oral route is not suitable): Menstrual irregularities due to ovulation disorders or anovulation, premenstrual disorders, breast pain or benign breast disorders (mastopathies), bleeding (due to fibroma), therapy of the menopause (adjunctive use with estrogen in postmenopausal women for prevention of endometrial hyperplasia), menace of preterm delivery and can be used up to 36 week of pregnancy, threatened miscarriage or prevention of habitual miscarriage due to luteal phase deficiency up to the 12th week of pregnancy, treatment of subfertility or primary or secondary infertility related to Inogest insufficiency in particular in In Vitro fertilization (IVF) cycles and/or oocyte donation.

For all other Inogest indications, the vaginal route represents an alternative to the oral route, in case of adverse events due to Inogest (somnolence, dizzinesss).

How should I use Inogest?

Use Inogest oil as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Inogest oil.

Uses of Inogest in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Oral: Prevention of endometrial hyperplasia in nonhysterectomized, postmenopausal women who are receiving conjugated estrogens; treatment of secondary amenorrhea

IM: Treatment of amenorrhea or abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer

Intravaginal gel: Part of assisted reproductive technology (ART) for infertile women with Inogest deficiency; treatment of secondary amenorrhea

Vaginal insert: To support embryo implantation and early pregnancy by supplementation of corpus luteal function as part of ART for infertile women

Off Label Uses

Reduce the risk of recurrent spontaneous preterm birth

Based on the American College of Obstetricians and Gynecologists (ACOG) practice bulletin for the prediction and prevention of preterm birth, vaginal Inogest is an effective and recommended treatment option to reduce the risk of recurrent spontaneous preterm birth in appropriately selected women (ie, singleton pregnancy and prior spontaneous preterm singleton birth). Therapy may begin at 16 to 24 weeks (regardless of cervical length) or sooner (ie, <24 weeks) in women who have a cervix <20 mm. Use is not recommended as an intervention for women with multiple gestations.

Inogest description

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The major progestational steroid that is secreted primarily by the corpus luteum and the placenta. Inogest acts on the uterus, the mammary glands and the brain. It is required in embryo implantation; pregnancy maintenance, and the development of mammary tissue for milk production. Inogest, converted from pregnenolone, also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids.

Inogest dosage

Inogest Dosage

Generic name: Inogest 100mg

Dosage form: capsule

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Prevention of Endometrial Hyperplasia

Inogest Capsules should be given as a single daily dose at bedtime, 200 mg orally for 12 days sequentially per 28-day cycle, to a postmenopausal woman with a uterus who is receiving daily conjugated estrogens tablets.

Treatment of Secondary Amenorrhea

Inogest Capsules may be given as a single daily dose of 400 mg at bedtime for 10 days.

Some women may experience difficulty swallowing Inogest Capsules. For these women, Inogest Capsules should be taken with a glass of water while in the standing position.

More about Inogest (Inogest)

Consumer resources

Professional resources

Related treatment guides

Inogest interactions

See also:
What other drugs will affect Inogest?

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Drugs known to induce the hepatic cytochrome-P450-3A4 system [e.g. rifampicin, carbamazepine or St. John's wort (Hypericum perforatum)-containing herbal products] may increase the elimination rate and thereby decrease the bioavailability of Inogest. In contrast ketoconazole and other inhibitors of cytochrome P450-3A4 may decrease elimination rate and thereby increase the bioavailability of Inogest.

The effect of concomitant vaginal products on the exposure of Inogest from Inogest has not been assessed. However, Inogest is not recommended for use with other vaginal products (such as antifungal products) as this may alter Inogest release and absorption from the vaginal tablet.

Inogest side effects

See also:
What are the possible side effects of Inogest?

Clinical Studies Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

The safety data reflect exposure to Inogest in 808 infertile women (74.9% White, 10.3% Hispanic, 5.4% Black, 5% Asian, and 4.6% Other) in a single Assisted Reproductive Technology 10 week clinical study conducted in the U.S. Inogest was studied at doses of 100 mg twice daily and 100 mg three times daily. The adverse reactions that occurred at a rate greater than or equal to 2% in either Inogest group are summarized in Table 1.

Table 1: Number and Frequency of Reported Adverse Reactions in Women Treated with Inogest in an Assisted Reproductive Technology Study

Body System Preferred Term Inogest 100 mg twice daily (N=404) Inogest 100 mg three times daily (N=404)
Gastrointestinal Disorders
Abdominal pain 50 (12%) 50 (12%)
Nausea 32 (8%) 29 (7%)
Abdominal distension 18(4%) 17(4%)
Constipation 9(2%) 14 (3%)
Vomiting 13(3%) 9(2%)
General Disorders and Administration Site Conditions
Fatigue 7(2%) 12 (3%)
Infections and Infestations
Urinary tract infection 9(2%) 4 (1%)
Injury, Poisoning and Procedural Complications
Post-ooctye retrieval pain 115(28%) 102 (25%)
Nervous System Disorders
Headache 15(4%) 13(3%)
Reproductive System and Breast Disorders
Ovarian hyperstimulation syndrome 30 (7%) 27 (7%)
Uterine spasm 15(4%) 11 (3%)
Vaginal bleeding 13(3%) 14 (3%)

Other less common reported adverse reactions included vaginal irritation, itching, burning, discomfort, urticaria, and peripheral edema.

Expected Adverse Reaction Profile Seen with Inogest

Inogest is also expected to have adverse reactions similar to other drugs containing Inogest that may include breast tenderness, bloating, mood swings, irritability, and drowsiness.

Inogest contraindications

See also:
What is the most important information I should know about Inogest?

Do not use Inogest vaginal without your doctor's consent if you are pregnant, unless you are using the medication as part of your fertility treatment. Tell your doctor if you become pregnant during treatment. If you are not being treated for infertility, use an effective form of birth control while you are using this medication.

Some forms of this medication may contain plant-based oils. Do not use Inogest vaginal without telling your doctor if you have any type of food allergy.

Using Inogest vaginal can increase your risk of blood clots, stroke, heart attack, or breast cancer.

You should not use this medication if you have: a history of stroke or blood clot, circulation problems, severe liver disease, a hormone-related cancer such as breast or uterine cancer, abnormal vaginal bleeding, or if you have recently had a tubal pregnancy or an incomplete abortion.

Inogest vaginal is sometimes given for only 6 to 12 days at a time. When used as part of fertility treatment, Inogest vaginal may be given for up to 12 weeks into a pregnancy. Following your dosing schedule is very important for this medication to be effective. Try not to miss any doses.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Inogest vaginal can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.



Active ingredient matches for Inogest:

Progesterone


Unit description / dosage (Manufacturer)Price, USD
Inogest 100 mg Capsule$ 0.14
Inogest 200 mg Capsule$ 0.27

List of Inogest substitutes (brand and generic names):

Inj Voranin 50 mg Injection (Ind-Swift Limited)$ 0.59
ISOGEST inj 100 mg x 1 mL x 1ml (Innovative)$ 1.26
ISOGEST inj 200 mg x 2 mL x 2ml (Innovative)$ 2.14
ISOGEST softgel 100 mg x 10's (Innovative)$ 2.46
ISOGEST softgel 200 mg x 10's (Innovative)$ 4.52
K Preg 200 mg Capsule (Kavya Healthcare)$ 0.31
K Preg 100 mg Capsule (Kavya Healthcare)$ 0.17
KEPTACT cap 200 mg x 10's (Biophar)$ 3.80
Kreate 100 mg Capsule (Vintage Labs Pvt. Ltd.)$ 0.14
Kreate 200 mg Capsule (Vintage Labs Pvt. Ltd.)$ 0.28
KREATE 100 MG CAPSULE 1 strip / 10 capsules each (Vintage Labs Pvt. Ltd.)$ 1.44
KREATE 200 MG CAPSULE 1 strip / 10 capsules each (Vintage Labs Pvt. Ltd.)$ 3.97
Kreate 100mg Capsule (Vintage Labs Pvt. Ltd.)$ 0.14
Kreate 200mg Capsule (Vintage Labs Pvt. Ltd.)$ 0.40
100 mg x 10's (Lexus)
200 mg x 10's (Lexus)
Lextone 100mg SG-CAP / 10 (Lexus)
Lextone 200mg SG-CAP / 10 (Lexus)
LEXTONE soft-gelatin cap 100 mg x 10's (Lexus)
LEXTONE soft-gelatin cap 200 mg x 10's (Lexus)
Lextone 100mg SG-CAP / 10 (Lexus)
Lextone 200mg SG-CAP / 10 (Lexus)
LGP 100mg CAP / 10 (Little Greave)$ 1.98
LGP 200mg CAP / 10 (Little Greave)$ 2.84
100 mg x 10's (Little Greave)$ 1.98
200 mg x 10's (Little Greave)$ 2.84
LGP cap 100 mg x 10's (Little Greave)$ 2.38
LGP cap 200 mg x 10's (Little Greave)$ 3.97
LUPIGEST 100 MG CAPSULE 1 strip / 10 capsules each (Lupin Ltd)$ 1.94
LUPIGEST 100MG INJECTION 1 vial / 2 ML injection each (Lupin Ltd)$ 1.40
LUPIGEST 200 MG CAPSULE 1 strip / 10 capsules each (Lupin Ltd)$ 3.57

References

  1. DailyMed. "PROGESTERONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "progesterone". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "progesterone". http://www.drugbank.ca/drugs/DB00396 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Inogest are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Inogest. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


Consumer reported price estimates

No survey data has been collected yet


1 consumer reported time for results

To what extent do I have to use Inogest before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 3 month and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Inogest. To get the time effectiveness of using Inogest drug by other patients, please click here.
Users%
3 month1
100.0%


1 consumer reported age

Users%
30-451
100.0%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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