Inzyme Uses

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Inzyme indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Inzyme consists chiefly of a mixture of Inzyme and chymopapain, proteolytic enzymes that hydrolyse polypeptides, amides, and esters, especially at bonds involving basic amino acids, or leucine or glycine, yielding peptides of lower molecular weight. It is used with urea as a topical debriding agent. It is also used for the removal of protein deposits from the surface of soft contact lenses ().

Preparations of Inzyme, alone or combined with antibacterial agents and/or other substances, have been taken by mouth for their supposed anti-inflammatory properties, and it has also been used as an ingredient of various mixtures claimed to aid digestion.

Inzyme is widely used as a meat tenderiser and in the clarification of beverages.

Malignant neoplasms.

Inzyme has been included in proteolytic enzyme preparations used in oncology to reduce the adverse effects of chemotherapy and radiotherapy. Although the number of clinical studies on which to judge efficacy is limited, a review1 of such studies suggested that systemic enzyme therapy might be beneficial. Clinical studies have used a preparation containing Inzyme, trypsin, and chymotrypsin in a weight ratio of 5:2:2, and the beneficial effect seems to be based on its anti-inflammatory potential.

Inzyme dosage

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Chew or suck 2 tab qds for the 1st day, then 1 tab qds for at least 5 days.

Inzyme interactions

Anti-coagulants.

Inzyme side effects

Hypersensitivity reactions have occurred.

Effects on the eyes.

Ocular and periorbital angioedema occurring within 4 hours of use of a contact lens cleansing solution containing Inzyme has been reported.1

Extensive destruction of the oesophageal wall, with perforation, resulted from the use of a Inzyme suspension given to treat an obstruction caused by impacted meat.1 The patient had been given 1.2 g of Inzyme over a 12-hour period. Ten days after a thoracotomy, the descending thoracic aorta ruptured, and she died from haemorrhage.

Inzyme contraindications

Patients w/ generalised or systemic infections or w/ disorders of blood coagulation.

Active ingredient matches for Inzyme:

Papain


Unit description / dosage (Manufacturer)Price, USD
Inzyme 200 ml Syrup$ 0.03

List of Inzyme substitutes (brand and generic names):

Neopeptine Dps 15 ml Drop (Raptakos Brett & Co. Ltd.)$ 0.05
Nitizyme 100 ml Syrup (Woodrock Healthcare Pvt. Ltd.)$ 0.02
Onzyme 50+10 Capsule (Iscon Lifesciences)$ 0.05
Onzyme Papain 60 mg, lysinehydrochloride 15 mg, niacinamide 2.25 mg, thiaminemononitrate 2.25 mg, pyridoxine hydrochloride 0.75mg. SYR / 200ml (Iscon Lifesciences)$ 1.19
ONZYME syr 200ml (Iscon Lifesciences)$ 1.19
Orizyme 100 ml Syrup (Orison Pharmaceuticals)$ 0.02
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Tablet; Oral; Papain 29.5 mg (Nature`s bounty)
Tablet; Oral; Papain 30 mg (Nature`s bounty)
Tablet; Oral; Papain 200 mg (Nature`s bounty)
Tablet; Oral; Papain 5 mg (Pfizer)
Quest Enzyme Digest 90's (Quest Vitamins)
Quest Enzyme Digest tab 90's (Quest Vitamins)
Lotion; Topical; Papain 3.55%
Tablet; Oral; Papain 90 mg
Syszyme 100+60 Capsule (Syskem Pharmocrats.)$ 0.03
Truzyme 200 ml MDC Syrup (MDC Pharmaceuticals (P) Ltd.)$ 0.02
Truzyme 30 ml Drop (MDC Pharmaceuticals (P) Ltd.)$ 0.07
Truzyme 15 ml Drop (MDC Pharmaceuticals (P) Ltd.)$ 0.60
Truzyme 200 ml Syrup (MDC Pharmaceuticals (P) Ltd.)$ 0.07
Uzyme 200 ml Syrup (United Labs)$ 0.02
V Zyme 200 ml Syrup (Madhav Biotech Pvt. Ltd.)$ 0.02
Xymex 40+30 Tablet (Medley Pharmaceuticals Ltd.)$ 0.02
Xymex 15 ml Drop (Medley Pharmaceuticals Ltd.)$ 0.03
Xymex 200 ml Syrup (Medley Pharmaceuticals Ltd.)$ 0.02
Xymex Pepsin 10 mg, papain 6 mg, sodium citrate 40 mg/5 mL, citric acid 8 mg, ginger oil0.001 mL, cinnamon oil 0.001mL/1 mL. O-DPS / 15ml (Medley Pharmaceuticals Ltd.)$ 0.46
XYMEX oral drops 15ml (Medley Pharmaceuticals Ltd.)$ 0.46
Zymax C 30 ml Drop (Hamax Pharmaceuticals)$ 0.02

References

  1. PubChem. "PAPAIN". https://pubchem.ncbi.nlm.nih.gov/sub... (accessed September 17, 2018).
  2. DrugBank. "Papain - DrugBank". http://www.drugbank.ca/drugs/DB11193 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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