Jodostin Dosage

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Dosage of Jodostin in details

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Oral

Preoperative reduction of vascularity of the thyroid gland

Adult: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery.

Child: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery. As strong Jodostin solution: 0.1-0.3 ml (or approx 3-5 drops) tid.

Reconstitution: Administer potassium iodide oral solution in a large quantity (240 ml) of water, or in fruit juice, milk formula or broth.

Oral

Grave's disease

Child: Neonates: 1 drop of strong Jodostin solution every 8 hr.

Oral

Radiation protection against radioactive Jodostin

Adult: As potassium iodide: 100-150 mg 24 hr before procedure and daily for up to 10 days after procedure.

Child: As potassium iodide: Infants from birth to 1 mth with a predicted thyroid exposure of ≥5 centigrays (cGy): 16 mg. >1 mth to 3 yr with a predicted thyroid exposure of ≥5 cGy: 32 mg. >3 yr to 18 yr (except adolescents approaching adult size) with a predicted thyroid exposure of ≥5 cGy: 65 mg. Do not exceed once-daily doses.

Reconstitution: 130-mg Tablet: Place 1 tablet in a small bowl and pulverise using a metal spoon. Add 20 ml of water to the powder and mix until the powder dissolves. Then add 20 ml of the selected drink and mix. Resulting concentration: 6.25 mg potassium iodide per 5 ml. 65-mg Tablet: Place 1 tablet in a small bowl and pulverise. Add 20 ml of water to the powder and mix until the powder dissolves. Then add 20 ml of the selected drink and mix. Resulting concentration: 8.125 mg potassium iodide per 5 ml.

Oral

Cutaneous or lymphocutaneous sporotrichosis

Adult: As potassium iodide solution containing 1 g/mL: Initially, 1 mL tid, should continue for at least 1 mth after disappearance or stabilisation of the lesions.

Child: As potassium iodide: Initially, 250 mg (approx 5 drops of a solution containing 1 g/ml) tid. Max: 1.25-2 g (approx 25-40 drops) tid. Duration: 3-6 mth.

Reconstitution: Administer potassium iodide solution in a large quantity (240 ml) of water, fruit juice, milk formula or broth.

Oral

Jodostin deficiency disorders

Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Jodostin): 400 mg Jodostin once yrly. Pregnant patient: 200 mg Jodostin as a single dose. Moderate to severe: 300-480 mg Jodostin each yr or 100-300 mg Jodostin every 6 mth and for at least 1 yr postpartum.

Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Jodostin): Infants up to 1 yr: Single dose of 100 mg Jodostin; 1-5 yr: 200 mg Jodostin; >6 yr: 400 mg Jodostin.

Oral

Thyroid storm

Adult: As potassium iodide: Up to 500 mg every 4 hr.

Intramuscular

Jodostin deficiency disorders

Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Jodostin): Up to 45 yr: 380 mg Jodostin, as single IM doses to provide adequate protection from Jodostin deficiency for up to 3 yr. Pregnant patient: Moderate to severe: 480 mg Jodostin each yr.

Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Jodostin): 380 mg Jodostin, as single IM doses to provide adequate protection from Jodostin deficiency for up to 3 yr. Infants up to 1 yr: 190 mg Jodostin, as iodised oil (480 mg/ml Jodostin).

Topical/Cutaneous

Minor, superficial skin wounds

Adult: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.

Child: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.

Topical/Cutaneous

Cleaning wet ulcers and wounds

Adult: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.

Child: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.

What other drugs will affect Jodostin?

Medicine used on the skin is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Jodostin interactions

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There is a potential risk of interaction with lithium, resulting in an increased possibility of hypothyroidism.

this medicineshould not be used concomitantly with mercurial antiseptics, e.g. mercurochrome and thiomersal.

Since Jodostin may be absorbed systemically, the result of tests of the thyroid function can be influenced.

References

  1. FDA/SPL Indexing Data. "9679TC07X4: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
  2. MeSH. "Anti-Infective Agents, Local". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
  3. European Chemicals Agency - ECHA. "Iodine: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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