Jolethin Uses

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What is Jolethin?

There are many brands and forms of povidone Jolethin topical available. Not all brands are listed on this leaflet.

Jolethin is used on the skin to treat or prevent skin infection in minor cuts, scrapes, or burns. Jolethin is also used in a medical setting to help prevent infection and promote healing in skin wounds, pressure sores, or surgical incisions.

Some forms of povidone Jolethin topical are used inside the mouth to provide temporary relief of minor mouth pain or irritation, sore throat, or canker sore pain.

Jolethin may also be used for purposes not listed in this medication guide.

Jolethin indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Intramuscular

Jolethin deficiency disorders

Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Jolethin): Up to 45 yr: 380 mg Jolethin, as single IM doses to provide adequate protection from Jolethin deficiency for up to 3 yr. Pregnant patient: Moderate to severe: 480 mg Jolethin each yr.

Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Jolethin): 380 mg Jolethin, as single IM doses to provide adequate protection from Jolethin deficiency for up to 3 yr. Infants up to 1 yr: 190 mg Jolethin, as iodised oil (480 mg/ml Jolethin).

Oral

Grave's disease

Child: Neonates: 1 drop of strong Jolethin solution every 8 hr.

Oral

Radiation protection against radioactive Jolethin

Adult: As potassium iodide: 100-150 mg 24 hr before procedure and daily for up to 10 days after procedure.

Child: As potassium iodide: Infants from birth to 1 mth with a predicted thyroid exposure of ≥5 centigrays (cGy): 16 mg. >1 mth to 3 yr with a predicted thyroid exposure of ≥5 cGy: 32 mg. >3 yr to 18 yr (except adolescents approaching adult size) with a predicted thyroid exposure of ≥5 cGy: 65 mg. Do not exceed once-daily doses.

Oral

Preoperative reduction of vascularity of the thyroid gland

Adult: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery.

Child: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery. As strong Jolethin solution: 0.1-0.3 ml (or approx 3-5 drops) tid.

Oral

Cutaneous or lymphocutaneous sporotrichosis

Adult: As potassium iodide solution containing 1 g/mL: Initially, 1 mL tid, should continue for at least 1 mth after disappearance or stabilisation of the lesions.

Child: As potassium iodide: Initially, 250 mg (approx 5 drops of a solution containing 1 g/ml) tid. Max: 1.25-2 g (approx 25-40 drops) tid. Duration: 3-6 mth.

Oral

Thyroid storm

Adult: As potassium iodide: Up to 500 mg every 4 hr.

Oral

Jolethin deficiency disorders

Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Jolethin): 400 mg Jolethin once yrly. Pregnant patient: 200 mg Jolethin as a single dose. Moderate to severe: 300-480 mg Jolethin each yr or 100-300 mg Jolethin every 6 mth and for at least 1 yr postpartum.

Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Jolethin): Infants up to 1 yr: Single dose of 100 mg Jolethin; 1-5 yr: 200 mg Jolethin; >6 yr: 400 mg Jolethin.

Topical/Cutaneous

Cleaning wet ulcers and wounds

Adult: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.

Child: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.

Topical/Cutaneous

Minor, superficial skin wounds

Adult: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.

Child: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.

How should I use Jolethin?

Use exactly as directed on the label, or as prescribed by your doctor.

Jolethin is available in many different forms, such as a liquid, ointment, aerosol powder, cream, spray, swab, and soap. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Always follow directions on the medicine label about using this medicine on a child. Some forms of povidone Jolethin topical should not be used in children of certain ages.

Jolethin is usually applied to the skin as needed. First clean the area to be treated.

Shake Jolethin spray well just before each use.

Allow the medicine to dry completely on the skin before applying a bandage. Do not apply a tight bandage.

Do not use this medicine on deep wounds, puncture wounds, animal bites, or serious burns. Do not apply over large skin areas.

When treating an infection, you may be given antibiotic medication to take by mouth. Use all medicines for the full prescribed length of time, even if your symptoms quickly improve.

Jolethin used in the mouth may be used up to 4 times per day. How often you can use this medicine depends on what form you use. Follow all directions on the medicine label.

Do not use Jolethin in the mouth if you are using a form that is made for use only on the skin.

To use Jolethin spray in the mouth, spray directly into the mouth or throat. Leave the medicine in place for 15 seconds, then spit it out. Avoid swallowing the spray. Use once every 2 hours as needed.

To use Jolethin as a mouth rinse, gargle or swish the liquid for 30 seconds, then spit it out. Do not swallow the liquid. Use up to 4 times per day.

You should not use Jolethin for longer than 7 days without medical advice.

Call your doctor if your sore throat is severe or ongoing after 2 days, or if you also have a high fever, headache, nausea, and vomiting.

If you are using Jolethin on your skin, seek medical advice if you have new or worsening symptoms of pain, redness, swelling, rash, or fever.

Store at room temperature away from moisture and heat. Do not freeze.

Each Jolethin swab is for one use only.

Jolethin can stain skin, teeth, and fabric. You may use rubbing alcohol to remove staining from your skin. Avoid getting alcohol onto a wound or irritated skin. Stains on fabric can be removed by rinsing with ammonia diluted with water. Avoid getting the medicine on jewelry, especially silver.

Jolethin spray is flammable. Do not use near high heat or open flame. Do not smoke until the gel has completely dried on your skin.

Uses of Jolethin in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Used topically as an antiseptic in the management of minor, superficial skin wounds and has been used to disinfect the skin preoperatively

Jolethin description

Jolethin as oral and topical/cutaneous formulations is prescribed for the treatment of Jolethin deficiency disorders, pre-operative reduction of vascularity of thyroid glands, protection against radioactive Jolethin, cutaneous or lymphocutaneous sporotrichosis, Grave’s disease, cleaning of minor or superficial wounds, thyroid storm and cleaning of wet wounds and ulcers.

Jolethin dosage

Oral

Preoperative reduction of vascularity of the thyroid gland

Adult: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery.

Child: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery. As strong Jolethin solution: 0.1-0.3 ml (or approx 3-5 drops) tid.

Reconstitution: Administer potassium iodide oral solution in a large quantity (240 ml) of water, or in fruit juice, milk formula or broth.

Oral

Grave's disease

Child: Neonates: 1 drop of strong Jolethin solution every 8 hr.

Oral

Radiation protection against radioactive Jolethin

Adult: As potassium iodide: 100-150 mg 24 hr before procedure and daily for up to 10 days after procedure.

Child: As potassium iodide: Infants from birth to 1 mth with a predicted thyroid exposure of ≥5 centigrays (cGy): 16 mg. >1 mth to 3 yr with a predicted thyroid exposure of ≥5 cGy: 32 mg. >3 yr to 18 yr (except adolescents approaching adult size) with a predicted thyroid exposure of ≥5 cGy: 65 mg. Do not exceed once-daily doses.

Reconstitution: 130-mg Tablet: Place 1 tablet in a small bowl and pulverise using a metal spoon. Add 20 ml of water to the powder and mix until the powder dissolves. Then add 20 ml of the selected drink and mix. Resulting concentration: 6.25 mg potassium iodide per 5 ml. 65-mg Tablet: Place 1 tablet in a small bowl and pulverise. Add 20 ml of water to the powder and mix until the powder dissolves. Then add 20 ml of the selected drink and mix. Resulting concentration: 8.125 mg potassium iodide per 5 ml.

Oral

Cutaneous or lymphocutaneous sporotrichosis

Adult: As potassium iodide solution containing 1 g/mL: Initially, 1 mL tid, should continue for at least 1 mth after disappearance or stabilisation of the lesions.

Child: As potassium iodide: Initially, 250 mg (approx 5 drops of a solution containing 1 g/ml) tid. Max: 1.25-2 g (approx 25-40 drops) tid. Duration: 3-6 mth.

Reconstitution: Administer potassium iodide solution in a large quantity (240 ml) of water, fruit juice, milk formula or broth.

Oral

Jolethin deficiency disorders

Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Jolethin): 400 mg Jolethin once yrly. Pregnant patient: 200 mg Jolethin as a single dose. Moderate to severe: 300-480 mg Jolethin each yr or 100-300 mg Jolethin every 6 mth and for at least 1 yr postpartum.

Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Jolethin): Infants up to 1 yr: Single dose of 100 mg Jolethin; 1-5 yr: 200 mg Jolethin; >6 yr: 400 mg Jolethin.

Oral

Thyroid storm

Adult: As potassium iodide: Up to 500 mg every 4 hr.

Intramuscular

Jolethin deficiency disorders

Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Jolethin): Up to 45 yr: 380 mg Jolethin, as single IM doses to provide adequate protection from Jolethin deficiency for up to 3 yr. Pregnant patient: Moderate to severe: 480 mg Jolethin each yr.

Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Jolethin): 380 mg Jolethin, as single IM doses to provide adequate protection from Jolethin deficiency for up to 3 yr. Infants up to 1 yr: 190 mg Jolethin, as iodised oil (480 mg/ml Jolethin).

Topical/Cutaneous

Minor, superficial skin wounds

Adult: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.

Child: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.

Topical/Cutaneous

Cleaning wet ulcers and wounds

Adult: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.

Child: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.

Jolethin interactions

See also:
What other drugs will affect Jolethin?

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There is a potential risk of interaction with lithium, resulting in an increased possibility of hypothyroidism.

this medicineshould not be used concomitantly with mercurial antiseptics, e.g. mercurochrome and thiomersal.

Since Jolethin may be absorbed systemically, the result of tests of the thyroid function can be influenced.

Jolethin side effects

See also:
What are the possible side effects of Jolethin?

Jolethin and iodides, whether applied topically or given systemically, can give rise to hypersensitivity reactions which may include urticaria, angioedema, cutaneous haemorrhage or purpuras, fever, arthralgia, lymphadenopathy, and eosinophilia.

Inhalation of Jolethin vapour is very irritating to mucous membranes.

Jolethin and iodides have variable effects on the thyroid and can produce goitre and hypothyroidism as well as hyperthyroidism (the Iod-Basedow or Jod-Basedow phenomenon). Goitre and hypothyroidism have also occurred in infants born to mothers who had taken iodides during pregnancy.

Prolonged use may lead to a range of adverse effects, often called ’iodism’, some of which may again be due to hypersensitivity. Adverse effects include metallic taste, increased salivation, burning or painful mouth; there may be acute rhinitis, coryza-like symptoms, and swelling and inflammation of the throat. Eyes may be irritated and swollen and there may be increased lachrymation. Pulmonary oedema, dyspnoea, and bronchitis may develop. Skin reactions include acneform or, more rarely, severe eruptions (iododerma). Other reported effects include depression, insomnia, impotence, headache, and gastrointestinal disturbances, notably nausea, vomiting, and diarrhoea.

Jolethin contraindications

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Allergy to Jolethin,

- Class III patients with Okuda

- Extrahepatic metastases,

- Respiratory or renal insufficiencies severe

- Cons-indications for hepatic arteriography,

- Leukopenia below 1500/mm3 or thrombocytopenia less 50000/mm3,

- Pregnant woman: Jolethin should not be administered to pregnant women. In women of childbearing age, suspicion of pregnancy must be excluded before the administration of Jolethin. Contraception must be instituted and prosecuted in the administration at least a year.

- Breastfeeding: Breastfeeding should be stopped.

Active ingredient matches for Jolethin:

Iodine in Taiwan.


Unit description / dosage (Manufacturer)Price, USD
Jolethin 0.75 mg x 1000's

List of Jolethin substitutes (brand and generic names):

Solution; Topical; Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex 1.75%
Liquid; Teat-Dip; Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex 9.6%
Liquid; Disinfectant / Domestic; Iodine / Polyethoxy Polypropoxy Polyethoxy Ethanol - Iodine Complex 25%
Liquid; Disinfectant / Food Premises; Iodine / Polyethoxy Polypropoxy Polyethoxy Ethanol - Iodine Complex 25%
Bath Additive; Liquid; Iodine (Atzinger)
Licoray Plus Lycopene 10% 2000 mcg, vitaminA 2500 IU, vitamin C 50 mg, vitamin E 10 IU, vitamin B1 2mg, vitamin B2 3 mg, vitaminB6 1.5 mg, selenium 35 mcg, zinc gluconate 3 mg, manganesegluconate 100 mcg, iodine 75mcg, copper sulphate 500mcg/10 mL. SYR / 20$ 1.57
Licoray Plus Lycopene 10% 2000 mcg, vitaminA 2500 IU, vitamin C 50 mg, vitamin E 10 IU, vitamin B1 2mg, vitamin B2 3 mg, vitaminB6 1.5 mg, selenium 35 mcg, zinc gluconate 3 mg, manganesegluconate 100 mcg, iodine 75mcg, copper sulphate 500mcg/10 mL SYR / 200$ 1.57
Licoray Plus Lycopene 10% 2000 mcg, vitaminA 2500 IU, vitamin C 50 mg, vitamin E 10 IU, vitamin B1 2mg, vitamin B2 3 mg, vitaminB6 1.5 mg, selenium 35 mcg, zinc gluconate 3 mg, manganesegluconate 100 mcg, iodine 75mcg, copper sulphate 500mcg/10 mL. SYR / 20$ 1.57
Licoray Plus Lycopene 10% 2000 mcg, vitaminA 2500 IU, vitamin C 50 mg, vitamin E 10 IU, vitamin B1 2mg, vitamin B2 3 mg, vitaminB6 1.5 mg, selenium 35 mcg, zinc gluconate 3 mg, manganesegluconate 100 mcg, iodine 75mcg, copper sulphate 500mcg/10 mL SYR / 200$ 1.57
Licoray Plus Lycopene 10% 2000 mcg, vitaminA 2500 IU, vitamin C 50 mg, vitamin E 10 IU, vitamin B1 2mg, vitamin B2 3 mg, vitaminB6 1.5 mg, selenium 35 mcg, zinc gluconate 3 mg, manganesegluconate 100 mcg, iodine 75mcg, copper sulphate 500mcg/10 mL SYR / 200$ 1.57
Licoray Plus Lycopene 10% 2000 mcg, vitaminA 2500 IU, vitamin C 50 mg, vitamin E 10 IU, vitamin B1 2mg, vitamin B2 3 mg, vitaminB6 1.5 mg, selenium 35 mcg, zinc gluconate 3 mg, manganesegluconate 100 mcg, iodine 75mcg, copper sulphate 500mcg/10 mL. SYR / 20$ 1.57
Licoray Plus Lycopene 10% 2000 mcg, vitaminA 2500 IU, vitamin C 50 mg, vitamin E 10 IU, vitamin B1 2mg, vitamin B2 3 mg, vitaminB6 1.5 mg, selenium 35 mcg, zinc gluconate 3 mg, manganesegluconate 100 mcg, iodine 75mcg, copper sulphate 500mcg/10 mL SYR / 200$ 1.57
Licoray Plus Lycopene 10% 2000 mcg, vitaminA 2500 IU, vitamin C 50 mg, vitamin E 10 IU, vitamin B1 2mg, vitamin B2 3 mg, vitaminB6 1.5 mg, selenium 35 mcg, zinc gluconate 3 mg, manganesegluconate 100 mcg, iodine 75mcg, copper sulphate 500mcg/10 mL. SYR / 20$ 1.57
Injectable; Injection; Oeillette Oil Ethyl Esters of Fatty Acid Iodine 2220 MBq (Cis)
Injectable; Injection; Iodine / Ethiodized Oil 380 mg / g
Liquid; Oral; Iodine 0.15 mg / 0.04 ml
Liquid; Oral; Iodine / Potassium Iodide 1 mg / ml
Liquid; Topical; Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex 1%
Liquid; Udder Wash; Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex 1.75% (Waves-Biotech)
Lp-30 30mg CAP / 10 (Waves-Biotech)$ 0.76
30 mg x 10's (Waves-Biotech)$ 0.76
LP-30 cap 30 mg x 10's (Waves-Biotech)$ 0.76
Lp-30 30mg CAP / 10 (Waves-Biotech)$ 0.76
Solution; Local; Iodine 1%
Liquid; Oral; Iodine / Potassium Iodide 5%

References

  1. PubChem. "Iodine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "Iodine". http://www.drugbank.ca/drugs/DB05382 (accessed September 17, 2018).
  3. DTP/NCI. "iodine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).

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