Karzine FC Pregnancy

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Pregnancy of Karzine FC in details

Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.

Karzine FC has not been formally assigned to a pregnancy category by the FDA. The drug has been frequently used in all stages of pregnancy for treatment of nausea and vomiting. Studies of a possible teratogenic effect have been conflicting. Use during labor is occasionally associated with hypotension which can be dangerous to both mother and fetus. There are no controlled data in human pregnancy. Neonates exposed to antipsychotic drugs during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms following delivery. There have been reports of agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress and feeding disorder in these neonates. These complications have varied in severity; while in some cases symptoms have been self-limited, in other cases neonates have required intensive care unit support and prolonged hospitalization. Karzine FC should probably be avoided during labor. It should otherwise be given during pregnancy only when benefit outweighs risk.

See references

Karzine FC breastfeeding

When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!

Karzine FC is excreted into human milk in small amounts. The American Academy of Pediatrics describes Karzine FC as a drug "whose effect on nursing infants is unknown but may be of concern". The Academy also notes drowsiness and lethargy in the infant and galactorrhea in the adult as reasons for concern.

See references

References for pregnancy information

  1. Heinonen O, Slone D, Shapiro S; Kaufman DW ed. "Birth Defects and Drugs in Pregnancy." Littleton, MA: Publishing Sciences Group, Inc. (1977): 297
  2. Rumeau-Rouquette C, Goujard J, Huel G "Posible teratogenic effect of phenothiazines in human beings." Teratology 15 (1977): 57-64
  3. O'Connor M, Johnson GH, James DI "Intrauterine effect of phenothiazines." Med J Aust 1 (1981): 416-7
  4. Ananth J "Congenital malformations with psychopharmacologic agents." Compr Psychiatry 16 (1975): 437-45

References for breastfeeding information

  1. Committee on Drugs, 1992 to 1993 "The transfer of drugs and other chemicals into human milk." Pediatrics 93 (1994): 137-50
  2. Wiles DH, Orr MW, Kolakowska T "Karzine FC levels in plasma and milk of nursing mothers." Br J Clin Pharmacol 5 (1978): 272-3
  3. Ohkubo T, Shimoyama R, Sugawara K "Determination of Karzine FC in human breast milk and serum by high-performance liquid chromatography." J Chromatogr 614 (1993): 328-32
  4. Kuller JA, Katz VL, Mcmahon MJ, Wells SR, Bashford RA "Pharmacologic treatment of psychiatric disease in pregnancy and lactation: fetal and neonatal effects." Obstet Gynecol 87 (1996): 789-94
  5. Roberts RJ, Blumer JL, Gorman RL, et al "American Academy of Pediatrics Committee on Drugs: Transfer of drugs and other chemicals into human milk." Pediatrics 84 (1989): 924-36



  1. DailyMed. "CHLORPROMAZINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubMed Health. "Chlorpromazine (Into the rectum): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
  3. Human Metabolome Database (HMDB). "Chlorpromazine: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).


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