Klomen Uses

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Klomen indications


is used to induce ovulation (egg production) in women who do not produce ova (eggs) but wish to become pregnant. Clomiphene is in a class of medications called ovulatory stimulants. It works similarly to estrogen, a female hormone that causes eggs to develop in the ovaries and be released.

Clomiphene is also sometimes used to treat male infertility, menstrual abnormalities, fibrocystic breasts, and persistent breast milk production. Talk to your doctor about the possible risks of using this medication for your condition.

Uses of Klomen in details

Klomen is used to treat infertility in women caused by failure or improper release of eggs from ovary (ovulation).It is also used to treat infertility in males due to decreased production of sperms (oligozoospermia).

Klomen description

A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. [PubChem]

Klomen dosage

Once ovulation has been established, start each course of Klomen on or about the 5th day of cycle. Max: 6 cycles (including 3 ovulatory cycles).

Klomen interactions


* If you think you might be pregnant, stop taking this medicine and tell your doctor. Talk to your doctor before taking this medicine if you have thyroid problems. Multiple births (such as twins or triplets) are possible when taking clomiphene. This medicine may cause changes in vision such as blurring or trouble focusing.

* If this becomes severe, tell your doctor.

* Be careful driving or operating machinery.

Klomen side effects

  • lushing (feeling of warmth)

  • upset stomach

  • vomiting

  • breast discomfort

  • headache

  • abnormal vaginal bleeding

    Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:

  • blurred vision

  • visual spots or flashes

  • double vision

  • stomach or lower stomach pain

  • stomach swelling

  • weight gain

  • shortness of breath

    Long-term use of clomiphene may increase the risk of ovarian cancer. Clomiphene should not be used for more than about six cycles. Talk to your doctor about the risks of taking this medication.

    Clomiphene may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

    Klomen contraindications



    this medicine is contraindicated in patients with a known hypersensitivity or allergy to Klomen or to any of its ingredients.


    this medicine should not be administered during pregnancy. this medicine may cause fetal harm in animals. Although no causative evidence of a deleterious effect of CLOMID therapy on the human fetus has been established, there have been reports of birth anomalies which, during clinical studies, occurred at an incidence within the range reported for the general population. To avoid inadvertent this medicine administration during early pregnancy, appropriate tests should be utilized during each treatment cycle to determine whether ovulation occurs. The patient should be evaluated carefully to exclude pregnancy, ovarian enlargement, or ovarian cyst formation between each treatment cycle. The next course of this medicine therapy should be delayed until these conditions have been excluded.

    Fetal/Neonatal Anomalies and Mortality. The following fetal abnormalities have been reported subsequent to pregnancies following ovulation induction therapy with this medicine during clinical trials. Each of the following fetal abnormalities were reported at a rate of < 1% (experiences are listed in order of decreasing frequency): Congenital heart lesions, Down syndrome, club foot, congenital gut lesions, hypospadias, microcephaly, harelip and cleft palate, congenital hip, hemangioma, undescended testicles, polydactyly, conjoined twins and teratomatous malformation, patent ductus arteriosus, amaurosis, arteriovenous fistula, inguinal hernia, umbilical hernia, syndactyly, pectus excavatum, myopathy, dermoid cyst of scalp, omphalocele, spina bifida occulta, ichthyosis, and persistent lingual frenulum. Neonatal death and fetal death/stillbirth in infants with birth defects have also been reported at a rate of < 1%. The overall incidence of reported birth anomalies from pregnancies associated with maternal CLOMID ingestion during clinical studies was within the range of that reported for the general population.

    In addition, reports of birth anomalies have been received during postmarketing surveillance of this medicine.

    Animal Fetotoxicity.

    Oral administration of Klomen to pregnant rats during organogenesis at doses of 1 to 2 mg/kg/day resulted in hydramnion and weak, edematous fetuses with wavy ribs and other temporary bone changes. Doses of 8 mg/kg/day or more also caused increased resorptions and dead fetuses, dystocia, and delayed parturition, and 40 mg/kg/day resulted in increased maternal mortality. Single doses of 50 mg/kg caused fetal cataracts, while 200 mg/kg caused cleft palate.

    Following injection of Klomen 2 mg/kg to mice and rats during pregnancy, the offspring exhibited metaplastic changes of the reproductive tract. Newborn mice and rats injected during the first few days of life also developed metaplastic changes in uterine and vaginal mucosa, as well as premature vaginal opening and anovulatory ovaries. These findings are similar to the abnormal reproductive behavior and sterility described with other estrogens and antiestrogens.

    In rabbits, some temporary bone alterations were seen in fetuses from dams given oral doses of 20 or 40 mg/kg/day during pregnancy, but not following 8 mg/kg/day. No permanent malformations were observed in those studies. Also, rhesus monkeys given oral doses of 1.5 to 4.5 mg/kg/day for various periods during pregnancy did not have any abnormal offspring.

    Liver Disease. this medicine therapy is contraindicated in patients with liver disease or a history of liver

    Active ingredient matches for Klomen:

    Clomifene in Turkey.

    Clomifene citrate in Turkey.

    Clomiphene Citrate

    List of Klomen substitutes (brand and generic names)

    Sort by popularity
    Unit description / dosage (Manufacturer)Price, USD
    LET REJUN 2.5MG TABLET 1 strip / 5 tablets each (Sanzyme Ltd)$ 2.02
    Let Rejun 2.5mg Tablet (Sanzyme Ltd)$ 0.40
    Lomifen 50 mg
    MATERNA CC 100 MG TABLET 1 strip / 5 tablets each (Emcure Pharmaceuticals Ltd)$ 1.43
    MATERNA CC 50 MG TABLET 1 strip / 5 tablets each (Emcure Pharmaceuticals Ltd)$ 0.50
    Materna CC 100mg Tablet (Emcure Pharmaceuticals Ltd)$ 0.29
    Materna CC 50mg Tablet (Emcure Pharmaceuticals Ltd)$ 0.10
    MATUROVA TABLET 1 strip / 5 tablets each (Novartis (Sandoz))$ 0.45
    MATUROVA tab 50 mg x 5's (Novartis (Sandoz))$ 0.48
    MATUROVA tab 100 mg x 5's (Novartis (Sandoz))$ 0.64
    Mephy 50mg TAB / 10 (Lincoln)$ 0.64
    Mephy 100mg TAB / 10 (Lincoln)$ 1.16
    50 mg x 10's (Lincoln)$ 0.64
    100 mg x 10's (Lincoln)$ 1.16
    MEPHY 50MG TABLET 1 strip / 10 tablets each (Lincoln)$ 0.61
    MEPHY tab 50 mg x 10's (Lincoln)$ 0.64
    MEPHY tab 100 mg x 10's (Lincoln)$ 1.16
    Mephy 50mg Tablet (Lincoln)$ 0.06
    Ofertil 50 mg x 10's (Bernofarm)$ 11.59
    Ofort 25 mg Tablet (Fem Care Pharma Limited)$ 0.05
    Ofort 50 mg Tablet (Fem Care Pharma Limited)$ 0.09
    Ofort 100 mg Tablet (Fem Care Pharma Limited)$ 0.16
    Tablet; Oral; Clomiphene Citrate 50 mg (Sanofi)
    Ova-mit 50 mg x 10's (Remedica)$ 22.19
    Ova-Mit 50 mg x 1 x 10's (Remedica)
    Ova-Mit 50 mg x 100 x 10's (Remedica)
    Ovafert 50 mg Tablet (Ravenbhel Pharmaceuticals (P) Ltd)$ 0.07
    Ovamit 50 mg x 1 x 10's
    Ovinum 50 mg x 10's (Biolab)$ 1.94
    Ovinum tab 50 mg 10's (Biolab)
    OVIPREG Capsule/ Tablet / 50mg / 10 units (Win-Medicare Limited)$ 0.70
    OVIPREG Capsule/ Tablet / 25mg / 10 units (Win-Medicare Limited)$ 0.36
    Ovipreg 25mg TAB / 10 (Win-Medicare Limited)$ 0.36
    Ovipreg 50mg TAB / 10 (Win-Medicare Limited)$ 0.35
    25 mg x 10's (Win-Medicare Limited)$ 0.36


    1. PubChem. "clomiphene". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
    2. DrugBank. "clomiphene". http://www.drugbank.ca/drugs/DB00882 (accessed September 17, 2018).
    3. MeSH. "Selective Estrogen Receptor Modulators". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).


    The results of a survey conducted on ndrugs.com for Klomen are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Klomen. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

    User reports

    4 consumers reported useful

    Was the Klomen drug useful in terms of decreasing the symptom or the disease?
    According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
    Not useful1

    4 consumers reported price estimates

    Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
    The below mentioned numbers have been reported by ndrugs.com website users about whether the Klomen drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
    Not expensive3

    17 consumers reported time for results

    To what extent do I have to use Klomen before I begin to see changes in my health conditions?
    As part of the reports released by ndrugs.com website users, it takes 5 days and a few days before you notice an improvement in your health conditions.
    Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Klomen. To get the time effectiveness of using Klomen drug by other patients, please click here.
    5 days5
    1 day4
    2 weeks3
    1 month2
    3 month1
    3 days1
    2 days1

    15 consumers reported age


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    Information checked by Dr. Sachin Kumar, MD Pharmacology

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