Legalon Uses

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How do you administer this medicine?

Legalon indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Pernicious anemia, both uncomplicated and accompanied by nervous system involvement.

Dietary deficiency of Vitamin B12, occurring in strict vegetarians and in their breast-fed infants. (Isolated vitamin B12 deficiency is very rare).

Malabsorption of vitamin B12, resulting from structural or functional damage to the stomach, where intrinsic factor is secreted or to the ileum, where intrinsic factor facilitates vitamin B12 absorption. These conditions include tropical sprue, and nontropical sprue (idiopathic steatorrhea, gluten-induced enteropathy). Folate deficiency in these patients is usually more severe than vitamin B12 deficiency.

Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy). Total gastrectomy always produces vitamin B12 deficiency.

Structural lesions leading to vitamin B12 deficiency include regional ileitis, ileal resections, malignancies, etc.

Competition for Vitamin B12 by intestinal parasites or bacteria.

The fish tapeworm (Diphyilobothrium latum) absorbs huge quantities of vitamin B12 and infested patients often have associated gastric atrophy. The blind-loop syndrome may produce deficiency of Vitamin B12 or folate.

Inadequate utilization of vitamin B12. This may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia.

For the Schilling Test.

Uses of Legalon in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Legalon is a liver protectant and antioxidant. Treatment with Legalon has shown slightly improved liver function, and showed improvement in patients with type 2 diabetes and diabetic nephropathy (kidney disease).

Legalon description

Each 70-mg capsule contains Silibinin 70 mg (calculated as Legalon) in dried extract of Legalon fruits 86.5-93.3 mg while the 140-mg capsule contains Silibinin 140 mg (calculated as Legalon) in dried extract of Legalon fruits 173-186.6 mg.

Legalon dosage

Unless otherwise directed by the physician: Adults and Children >12 years: Usual Dose: Initially, 1 cap 3 times daily.

Maintenance Dose: 1 cap 2 times daily.

Administration: Legalon should be taken whole with some liquid before meals.

The physician should decide on the length of treatment.

Legalon interactions

Fish lipid oil prevents blood clotting too quickly, therefore patients who are treated with anticoagulants must consult their doctor before taking Legalon.

Legalon side effects

Body as a Whole: Enlarged abdomen, asthenia, body odor, chest pain, chills, suicide, fever, generalized edema, fungal infection, malaise, neck pain, neoplasm, rheumatoid arthritis, and sudden death.

Cardiovascular System: Arrhythmia, bypass surgery, cardiac arrest, hyperlipemia, hypertension, migraine, myocardial infarct, myocardial ischemia, occlusion, peripheral vascular disorder, syncope, and tachycardia.

Digestive System: Anorexia, constipation, dry mouth, dysphagia, colitis, fecal incontinence, gastritis, gastroenteritis, gastrointestinal disorder, increased appetite, intestinal obstruction, melena, pancreatitis, tenesmus, and vomiting.

Hematologic-Lymphatic System: Lymphadenopathy.

Infections and Infestations: Viral infection.

Metabolic and Nutritional Disorders: Edema, hyperglycemia, increased ALT, and increased AST.

Musculoskeletal System: Arthralgia, arthritis, myalgia, pathological fracture, and tendon disorder.

Nervous System: Central nervous system neoplasia, depression, dizziness, emotional lability, facial paralysis, insomnia, vasodilatation, and vertigo.

Respiratory System: Asthma, bronchitis, increased cough, dyspnea, epistaxis, laryngitis, pharyngitis, pneumonia, rhinitis, and sinusitis.

Skin: Alopecia, eczema, pruritus, and sweating.

Special Senses: Cataract.

Urogenital System: Cervix disorder, endometrial carcinoma, epididymitis, and impotence.

Legalon contraindications

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Hypersensitivity to Legalon fruits and/or other plants of the compositae, or to any of the excipients of Legalon.

Active ingredient matches for Legalon:

Silibinin in Bahrain, Brazil, Bulgaria, China, Colombia, Georgia, Germany, Hungary, Italy, Luxembourg, Malta, Mexico, Oman, Philippines, Poland, Portugal, Romania, Slovakia, South Africa, South Korea, Spain, Thailand, Venezuela.

140 mg in dried extr of milk thistle fruits 865-933 mg/173-1866 mg/Silymarin 70 in Philippines.

Disodium Silibinin Dihemisuccinate

Milk thistle in Portugal.

Silymarin in Venezuela.


Unit description / dosage (Manufacturer)Price, USD
Capsule; Oral; Silymarin 70 mg
Capsule; Oral; Silymarin 140 mg
Tablet, Film-Coated; Oral; Silymarin 70 mg
Legalon 140 140 mg x 4 x 10's
Legalon 70 70 mg x 10 x 10's
Legalon 140 mg x 60's
Legalon 70 mg x 80's
Legalon 140 mg
Legalon 70 mg x 20's
Legalon 70 mg x 100's$ 10.86
Legalon 140 mg x 20's
Legalon 140 mg x 100's$ 13.33
Legalon 70 mg x 3 Blister x 10 Tablet
Legalon 70 mg x 6 Blister x 10 Tablet
Legalon 70 mg x 10 Blister x 10 Tablet
Legalon cap 140 mg 20's (Madaus)$ 13.33
Legalon cap 70 mg 20's (Madaus)$ 11.63

List of Legalon substitutes (brand and generic names):

Capsule; Oral; Silymarin 140 mg (Rottapharm)
Tablet, Film-Coated; Oral; Silymarin 140 mg (Rottapharm)
Legalon Forte cap 100's (Rottapharm)
Capsule; Oral; Milk Thistle 140 mg
Capsule; Oral; Milk Thistle 70 mg
Injectable; Injection; Disodium Silibinin Dihemisuccinate 350 mg (Madaus)
Levalon 70mg TAB / 10 (Micro B & B)$ 0.72
Levalon 140mg TAB / 6 (Micro B & B)$ 0.61
70 mg x 10's (Micro B & B)$ 0.72
140 mg x 6's (Micro B & B)$ 0.61
LEVALON 150 MG TABLET 1 strip / 10 tablets each (Micro B & B)$ 1.50
LEVALON 300 MG TABLET 1 strip / 10 tablets each (Micro B & B)$ 2.87
LEVALON tab 70 mg x 10's (Micro B & B)$ 0.72
LEVALON tab 140 mg x 6's (Micro B & B)$ 0.61
Levalon 300mg Tablet (Micro B & B)$ 0.29
Leveron 70 mg x 25 x 10's (Vesco Pharma)
Leveron tab 140 mg 10 x 10's (Vesco Pharma)
Leveron tab 70 mg 25 x 10's (Vesco Pharma)
Leveron tab 70 mg 3 x 10's (Vesco Pharma)
LEVERON tab 250 mg x 10's (Vesco Pharma)$ 1.03
LEVERON tab 500 mg x 10's (Vesco Pharma)$ 1.90
LEVERON tab 750 mg x 10's (Vesco Pharma)$ 2.52
Limarin 70mg CAP / 10 (Serum Institute)$ 0.74
Limarin 140mg CAP / 10 (Serum Institute)$ 1.02
Limarin 35mg/5mL SUSP / 100ml (Serum Institute)$ 1.09
70 mg x 10's (Serum Institute)$ 0.74
140 mg x 10's (Serum Institute)$ 1.02
35 mg x 5 mL x 100ml (Serum Institute)$ 1.09
LIMARIN - 140 CAPSULE 1 strip / 10 capsules each (Serum Institute)$ 1.41
LIMARIN - 70 CAPSULE 1 strip / 10 capsules each (Serum Institute)$ 1.02
LIMARIN cap 70 mg x 10's (Serum Institute)$ 0.93
LIMARIN cap 140 mg x 10's (Serum Institute)$ 1.29

References

  1. PubChem. "silibinin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "Silibinin A". http://www.drugbank.ca/drugs/DB09298 (accessed September 17, 2018).
  3. DTP/NCI. "NSC651520: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Legalon are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Legalon. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


Consumer reported price estimates

No survey data has been collected yet


2 consumers reported time for results

To what extent do I have to use Legalon before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 1 week and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Legalon. To get the time effectiveness of using Legalon drug by other patients, please click here.
Users%
1 week1
50.0%
1 month1
50.0%


7 consumers reported age

Users%
30-455
71.4%
46-602
28.6%


Consumer reviews

Goodnews U04 Apr 2020 15:27
I was recommended to take Legalex after my rheumatoid text , so should i take this legalon and how should i use it? Before or after meal, pls this sickness has been in my system for more than 10years , pls. Help me with more information cos there is no good hospital in my area, Thank you, From Goodnews


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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