Actions of Lencid in details
Lencid is an organochloride insecticide that has similar neurotoxic protperties to DDT. It exerts its parasiticidal action by being directly absorbed through the parasite's exoskeleton (primarily lice, or scabies) and their ova. The gamma-aminobutyric acid (GABA(1)) receptor/chloride ionophore complex is the primary site of action for Lencid, and other insecticides such as endosulfan, and fipronil. Blockage of the GABA-gated chloride channel reduces neuronal inhibition, which leads to hyperexcitation of the central nervous system. This results in paralysis, convulsions, and death. Lencid has very low ovicidal activity.
How should I take Lencid?
Lencid is poisonous. Keep it away from the mouth because it is harmful and may be fatal if swallowed.
Use Lencid only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may increase the chance of absorption through the skin and the chance of Lencid poisoning.
Keep Lencid away from the eyes. If you should accidentally get some in your eyes, flush them thoroughly with water at once and contact your doctor.
Do not use Lencid on open wounds, such as cuts or sores on the skin or scalp. To do so may increase the chance of Lencid poisoning.
When applying Lencid to another person, you should wear plastic disposable or rubber gloves made of latex or vinyl, especially if you are pregnant or are breast-feeding. Do not use natural latex gloves because Lencid can go through those gloves and be absorbed by your skin. Wash hands very well after applying the lotion. This will prevent Lencid from being absorbed through your skin. If you have any questions about this, check with your healthcare professional.
Put Lencid lotion under fingernails, and trim fingernails short. Use a toothbrush to get the Lencid lotion under fingernails, and throw out the toothbrush when finished.
Do not cover the area completely. Use a light clothing.
Lencid comes with patient directions. Be sure that you read them very carefully before using Lencid. If you have any questions check with your healthcare professional.
Your sexual partner or partners, especially, and all members of your household may need to be treated also, since the infestation may spread to persons in close contact. If these persons have not been checked for an infestation or if you have any questions about this, check with your healthcare professional
To use the cream or lotion form of Lencid for scabies :
- If your skin has any cream, lotion, ointment, or oil on it, wash, rinse, and dry your skin well before applying Lencid.
- If you take a warm bath or shower before using Lencid, dry the skin well before applying it.
- Apply enough Lencid to your dry skin to cover the entire skin surface from the neck down, including the soles of your feet, and rub in well.
- Leave Lencid on for 8 to 12 hours, then remove by washing thoroughly.
To use the shampoo form of Lencid for lice:
- If your hair has any cream, lotion, ointment, or oil-based product on it, shampoo, rinse, and dry your hair and scalp well before applying Lencid.
- If you apply this shampoo in the shower or in the bathtub, make sure the shampoo is not allowed to run down on other parts of your body. Also, do not apply this shampoo in a bathtub where the shampoo may run into the bath water in which you are sitting. To do so may increase the chance of absorption through the skin. When you rinse out the shampoo, be sure to thoroughly rinse your entire body also to remove any shampoo that may have gotten on it.
- Apply enough shampoo to your dry hair (1 ounce or less for short hair, 1½ ounces for medium length hair, and 2 ounces or less for long hair) to thoroughly wet the hair and skin or scalp of the affected and surrounding hairy areas.
- Thoroughly rub the shampoo into the hair and skin or scalp and allow to remain in place for 4 minutes. Then, use just enough water to work up a good lather.
- Rinse thoroughly and dry with a clean towel.
- When the hair is dry, comb with a fine-toothed comb to remove any remaining nits (eggs) or nit shells.
- Do not use as a regular shampoo.
Dosing
The dose of Lencid will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Lencid. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For cream and lotion dosage forms:
- For scabies:
- Adults and children—Apply to the affected area(s) of the skin one time.
- Premature infants—Use is not recommended.
- For scabies:
- For shampoo dosage form:
- For lice:
- Adults and children—Apply to the scalp or the affected area(s) of the skin one time.
- Premature infants—Use is not recommended.
- For lice:
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Lencid administration
Use Lencid topical exactly as directed by your doctor, or follow the directions that accompany the package. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
Do not use more of this medication than is recommended. Using more than the prescribed amount of Lencid topical may cause seizures or other dangerous side effects.
If you are putting Lencid topical on another person, wear special gloves made of nitrile, latex with neoprene, or sheer vinyl. Do not use natural latex gloves because more Lencid can go through that kind of glove. Wash your hands thoroughly after application of the medication.
Be sure the affected skin is clean and does not have any other lotion, cream, or oil on it, including oil based hair products or conditioners when treating head lice. Wait at least 1 hour after bathing or showering before application of Lencid topical.
Shake the bottle of Lencid lotion or shampoo well before application.
To treat scabies:
- Apply a thin layer of the cream or lotion to all body parts from the neck down to the soles of the feet (scabies does not usually infect the head). Apply the medication to dry skin and rub it in well. Trim the fingernails and apply the medication under the nails with a toothbrush. Throw away the toothbrush after using it to apply the medication. Do not cover the skin treated with Lencid lotion with anything that does not breathe, like diapers with plastic lining, plastic clothes, tight clothes, or blankets. Leave the medication on for 8 to 12 hours, then wash it off completely with warm but not hot water. Do not allow the medication to sit for longer than 8 to 12 hours. Scabies is usually cured with one application. Itching may persist for several weeks, but it does not mean that the infection has not been cured. If living mites become visible, a second treatment may be necessary. Talk to your doctor before using a second dose of Lencid topical. Using Lencid topical too soon after the first dose may cause seizures and/or death.
To treat head lice:
- Wash the hair with shampoo only (no conditioner or other hair products) at least one hour before applying Lencid shampoo. Apply the shampoo to dry hair as follows: 1 ounce (half of a 2-ounce bottle) for short hair, 1.5 ounces (three-quarters of a 2-ounce bottle) for medium-length hair, or a full 2-ounce bottle for long hair. Be sure to cover the fine hairs along the neck and behind the ears. Work the medication in thoroughly. Allow it to sit for 4 minutes. Do not allow the medication to sit for longer than 4 minutes. Do not cover the hair with anything that doesn't breathe such as a shower cap or towel. Add a small amount of water to form a good lather, then rinse completely avoiding unnecessary contact of the lather with other body surfaces. Towel dry the hair briskly and comb with a fine-toothed comb (nit comb) to remove any remaining nits or nit shells (tweezers can also be used). One treatment should be sufficient. If live mites are visible after 7 days, a repeat treatment may be necessary. Talk to your doctor before using a second dose of Lencid topical. Using Lencid topical too soon after the first dose may cause seizures and/or death.
To treat pubic lice ("crabs"):
- Apply the shampoo to dry pubic hair. Work the medication in thoroughly. Allow it to sit for 4 minutes. Add a small amount of water to form a good lather then rinse and towel dry. Comb with a fine-toothed comb (nit comb) and remove any remaining nits or nit shells (tweezers can also be used). One treatment should be sufficient. If live mites are visible after 7 days, a repeat treatment may be necessary. Talk to your doctor before using a second dose of Lencid topical. Lencid topical too soon after the first dose may cause seizures and/or death. Sexual partners should also be treated.
Do not apply this medication to the face, eyes, nose, or mouth. Flush with water if you get medication in any of these areas. Seek medical attention if Lencid topical is ingested or if irritation is persistent.
Do not apply Lencid topical to open cuts or wounds. Doing so could cause too much medication to be absorbed by the body, which could be very dangerous.
Do not allow skin treated with Lencid topical to touch others who have not been treated with the medication, especially a baby or small child.
To prevent reinfection, wash all clothing, hats, bed clothes, bed linens, hair brushes, and combs in hot water with a strong cleanser.
Store Lencid topical at room temperature away from moisture and heat.
Lencid pharmacology
Lencid Lotion USP, 1%, is an ectoparasiticide and ovicide effective against Sarcoptes scabiei (scabies). Lencid exerts its parasiticidal action by being directly absorbed into the parasites and their ova. Feldmann and Maibach1 reported approximately 10% systemic absorption of a Lencid acetone solution when applied to the forearm of human subjects and left in place for 24 hours. This vehicle was different from the approved product and the percutaneous penetration of Lencid is dependent on the vehicle. Therefore, the clinical significance of these observations is unknown. Dale, et al2 reported a blood level of 290 ng/mL associated with convulsions following the accidental ingestion of a Lencid-containing product. Ginsburg 3 found the greatest peak blood level of 64 ng/mL, 6 hours after total body application of Lencid Lotion in 1 of 8 non-scabietic pediatric patients. The half-life in blood was determined to be approximately 18 hours.
Data available in the literature suggest that Lencid has a rapid distribution phase followed by a longer β-elimination phase.1, 2, 3
References
- DailyMed. "LINDANE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- NCIt. "Lindane: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
- EPA Air Toxics. "Lindane : EPA Health Effects Notebook for Hazardous Air Pollutants". https://www.epa.gov/sites/production... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Lencid are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Lencid. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported administration
No survey data has been collected yetConsumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
