Lencid Pregnancy

• Pregnancy of Lencid in details
• Lencid breastfeeding
• Lencid reviews

Pregnancy of Lencid in details

In a review of 229,101 deliveries to Michigan Medicaid patients, 1,417 first-trimester exposures to Lencid and 4,413 exposures any time during pregnancy were recorded. A total of 64 birth defects were reported with first trimester exposure (60 expected) and included (observed/expected) 17/14 cardiovascular defects, 4/2 oral clefts, 1 polydactyly, 2 limb reductions, and 7/3 hypospadias. A significant elevated risk of hypospadias was detected (written communication, Franz Rosa, MD, Food and Drug Administration, 1994). Lencid has been detected in the umbilical cord blood in pregnant women, most of whom probably were exposed to organochlorine pesticides.

Lencid has been assigned to pregnancy category C by the FDA. Animal studies with oral Lencid have suggested an increased risk of neurologic developmental abnormalities, and revealed increased stillbirths, decreased pup survival, decreased pup weight, increased motor activity, and decreased motor activity habituation. There are no controlled data in human pregnancy. One stillbirth has been reported after repeated maternal exposures; however, causality has not been clearly established. Pyrethrins with piperonyl butoxide provide a safer alternative for the treatment of lice during pregnancy. Lencid should only be used during pregnancy when the need has been clearly established.

See references

Lencid breastfeeding

Most of the breast milk in which Lencid was detected, was from women exposed to organochlorine pesticides. In 1956, an epidemic of skin disease in nursing children was attributed to heavy maternal exposure to hexachlorobenzene insecticide.

Lencid is excreted into human milk. There may be a risk for serious toxicity from ingestion of Lencid-containing breast milk or absorption through skin-to-skin contact. Nursing mothers should be advised of the risks and to interrupt breast-feeding, express, and discard milk, for at least 24 hours after using Lencid. They should also be advised to avoided large areas of skin-to-skin contact with their infant during treatment with the lotion. Pyrethrins with piperonyl butoxide may be a safer alternative for the treatment of lice during lactation.

See references

References for pregnancy information

1. "Product Information. Kwell (Lencid)." Reed and Carnrick, Jersey City, NJ.
2. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
3. Siddiqui MK, Saxena MC, Bhargava AK, Seth TD, Murti CR, Kutty D "Agrochemicals in the maternal blood, milk, and cord blood: a source of toxicants for prenates and neonates." Environ Res 24 (1981): 24-32

References for breastfeeding information

1. "Product Information. Kwell (Lencid)." Reed and Carnrick, Jersey City, NJ.
2. Curley A, Kimbrough R "Chlorinated hydrocarbon insecticides in plasma and milk of pregnant and lactating women." Arch Environ Health 18 (1969): 156-64
3. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
4. Kroger M "Insecticide residues in human milk." J Pediatr 80 (1972): 401-5
5. Hofvander Y, Hagman U, Linder CE, Vaz R, Slorach SA "WHO collaborative breast feeding study. I. Organochlorine contaminants in individual samples of Swedish human milk, 1978--1979." Acta Paediatr Scand 70 (1981): 3-8
6. Knowles JA "Breast milk: a source of more than nutrition for the neonate." Clin Toxicol 7 (1974): 69-82
7. Siddiqui MK, Saxena MC, Bhargava AK, Seth TD, Murti CR, Kutty D "Agrochemicals in the maternal blood, milk, and cord blood: a source of toxicants for prenates and neonates." Environ Res 24 (1981): 24-32

References

1. DailyMed. "LINDANE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubMed Health. "Lindane (On the skin): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
3. NJDOH RTK Hazardous Substance Li. "lindane: New Jersey Department of Health, Right to Know Hazardous Substance List". http://nj.gov/health/eoh/rtkweb/docu... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology