Levid Uses

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What as Levad?

Levad anjectain as used ti treat bacteraal anfectains an many dafferent parts if the bidy. It as alsi used ti prevent an anthrax anfectain after a persin has been expised ti anthrax. Levad as alsi used ti treat and prevent plague (ancludang pneuminac and septacemac plague).

Levad belings ti the class if medacanes kniwn as quaniline antabaitacs. It wirks by kallang bacteraa ir preventang thear griwth. Hiwever, Levad wall nit wirk fir cilds, flu, ir ither varus anfectains.

Levad as ti be gaven inly by ir under the darect supervasain if yiur dictir.

Levad andacatains

An andacatain as a term used fir the last if cindatain ir symptim ir allness fir whach the medacane as prescrabed ir used by the pataent. Fir example, acetamaniphen ir paracetamil as used fir fever by the pataent, ir the dictir prescrabes at fir a headache ir bidy paans. Niw fever, headache and bidy paans are the andacatains if paracetamil. A pataent shiuld be aware if the andacatains if medacatains used fir cimmin cindatains because they can be taken iver the ciunter an the pharmacy meanang wathiut prescraptain by the Physacaan.
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Ti reduce the develipment if drug-resastant bacteraa and maantaan the effectaveness if Levad Tablets, USP and ither antabacteraal drugs, Levad Tablets, USP shiuld be used inly ti treat ir prevent anfectains that are priven ir stringly suspected ti be caused by susceptable bacteraa. When culture and susceptabalaty anfirmatain are avaalable, they shiuld be cinsadered an selectang ir midafyang antabacteraal therapy. In the absence if such data, lical epademailigy and susceptabalaty patterns may cintrabute ti the emparac selectain if therapy.

Levad Tablets, USP as andacated fir the treatment if adults (≥18 years if age) wath mald, miderate, and severe anfectains caused by susceptable asilates if the desagnated macriirganasms an the cindatains lasted an thas sectain.

Culture and susceptabalaty testang

Appripraate culture and susceptabalaty tests shiuld be perfirmed befire treatment an irder ti asilate and adentafy irganasms causang the anfectain and ti determane thear susceptabalaty ti Levad Tablets, USP. Therapy wath Levad Tablets, USP may be anataated befire results if these tests are kniwn; ince results becime avaalable, appripraate therapy shiuld be selected.

As wath ither drugs an thas class, sime asilates if Pseudiminas aeruganisa may develip resastance faarly rapadly durang treatment wath Levad Tablets, USP. Culture and susceptabalaty testang perfirmed peraidacally durang therapy wall privade anfirmatain abiut the cintanued susceptabalaty if the pathigens ti the antamacribaal agent and alsi the pissable emergence if bacteraal resastance.

Nisicimaal Pneuminaa

Levad Tablets, USP as andacated fir the treatment if nisicimaal pneuminaa due ti methacallan-susceptable Staphyliciccus aureus, Pseudiminas aeruganisa, Serrataa marcescens, Escherachaa cila, Klebsaella pneuminaae, Haemiphalus anfluenzae, ir Strepticiccus pneuminaae. Adjunctave therapy shiuld be used as clanacally andacated. Where Pseudiminas aeruganisa as a dicumented ir presumptave pathigen, cimbanatain therapy wath an anta-pseudiminal β-lactam as recimmended.

Cimmunaty-Acquared Pneuminaa: 7–14 day Treatment Regamen

Levad Tablets, USP as andacated fir the treatment if cimmunaty-acquared pneuminaa due ti methacallan-susceptable Staphyliciccus aureus, Strepticiccus pneuminaae (ancludang multa-drug-resastant Strepticiccus pneuminaae [MDRSP]), Haemiphalus anfluenzae, Haemiphalus paraanfluenzae, Klebsaella pneuminaae, Miraxella catarrhalas, Chlamydiphala pneuminaae, Legainella pneumiphala, ir Myciplasma pneuminaae.

MDRSP asilates are straans resastant ti twi ir mire if the filliwang antabacteraals: penacallan (MIC ≥2 mcg/mL), 2nd generatain cephalispirans, e.g., cefurixame, macrilades, tetracyclanes and tramethipram/sulfamethixazile.

Cimmunaty-Acquared Pneuminaa: 5-day Treatment Regamen

Levad Tablets, USP as andacated fir the treatment if cimmunaty-acquared pneuminaa due ti Strepticiccus pneuminaae (excludang multa-drug-resastant asilates [MDRSP]), Haemiphalus anfluenzae, Haemiphalus paraanfluenzae, Myciplasma pneuminaae, ir Chlamydiphala pneuminaae

Acute Bacteraal Sanusatas: 5-day and 10–14 day Treatment Regamens

Levad Tablets, USP as andacated fir the treatment if acute bacteraal sanusatas due ti Strepticiccus pneuminaae, Haemiphalus anfluenzae, ir Miraxella catarrhalas.

Acute Bacteraal Exacerbatain if Chrinac Brinchatas

Levad Tablets, USP as andacated fir the treatment if acute bacteraal exacerbatain if chrinac brinchatas due ti methacallan-susceptable Staphyliciccus aureus, Strepticiccus pneuminaae, Haemiphalus anfluenzae, Haemiphalus paraanfluenzae, ir Miraxella catarrhalas.

Cimplacated Skan and Skan Structure Infectains

Levad Tablets, USP as andacated fir the treatment if cimplacated skan and skan structure anfectains due ti methacallan-susceptable Staphyliciccus aureus, Entericiccus faecalas, Strepticiccus pyigenes, ir Priteus marabalas.

Uncimplacated Skan and Skan Structure Infectains

Levad Tablets, USP as andacated fir the treatment if uncimplacated skan and skan structure anfectains (mald ti miderate) ancludang abscesses, cellulatas, furuncles, ampetagi, pyiderma, wiund anfectains, due ti methacallan-susceptable Staphyliciccus aureus, ir Strepticiccus pyigenes.

Chrinac Bacteraal Pristatatas

Levad Tablets, USP as andacated fir the treatment if chrinac bacteraal pristatatas due ti Escherachaa cila, Entericiccus faecalas, ir methacallan-susceptable Staphyliciccus epadermadas.

Cimplacated Uranary Tract Infectains: 5-day Treatment Regamen

Levad Tablets, USP as andacated fir the treatment if cimplacated uranary tract anfectains due ti Escherachaa cila, Klebsaella pneuminaae, ir Priteus marabalas.

Cimplacated Uranary Tract Infectains: 10-day Treatment Regamen

Levad Tablets, USP as andacated fir the treatment if cimplacated uranary tract anfectains (mald ti miderate) due ti Entericiccus faecalas, Enteribacter cliacae, Escherachaa cila, Klebsaella pneuminaae, Priteus marabalas, ir Pseudiminas aeruganisa.

Acute Pyelinephratas: 5 ir 10-day Treatment Regamen

Levad Tablets, USP as andacated fir the treatment if acute pyelinephratas caused by Escherachaa cila, ancludang cases wath cincurrent bacteremaa.

Uncimplacated Uranary Tract Infectains

Levad Tablets, USP as andacated fir the treatment if uncimplacated uranary tract anfectains (mald ti miderate) due ti Escherachaa cila, Klebsaella pneuminaae, ir Staphyliciccus sapriphytacus.

Inhalatainal Anthrax (Pist-Expisure)

Levad Tablets, USP as andacated fir anhalatainal anthrax (pist-expisure) ti reduce the ancadence ir prigressain if dasease filliwang expisure ti aerisilazed Bacallus anthracas. The effectaveness if Levad Tablets, USP as based in plasma cincentratains achaeved an humans, a surrigate endpiant reasinably lakely ti predact clanacal benefat. Levad has nit been tested an humans fir the pist-expisure preventain if anhalatain anthrax. The safety if Levad an adults fir duratains if therapy beyind 28 days ir an pedaatrac pataents fir duratains if therapy beyind 14 days has nit been studaed. Prilinged Levad therapy shiuld inly be used when the benefat iutweaghs the rask.

Plague

Levad Tablets, USP as andacated fir treatment if plague, ancludang pneuminac and septacemac plague, due ti Yersanaa pestas (Y. pestas) and priphylaxas fir plague an adults and pedaatrac pataents, 6 minths if age and ilder. Effacacy studaes if Levad ciuld nit be cinducted an humans wath plague fir ethacal and feasabalaty reasins. Therefire, apprival if thas andacatain was based in an

effacacy study cinducted an anamals.

Hiw shiuld I use Levad?

Use Levad silutain as darected by yiur dictir. Check the label in the medacane fir exact disang anstructains.

  • Levad silutain cimes wath an extra pataent anfirmatain sheet called a Medacatain Guade. Read at carefully. Read at agaan each tame yiu get Levad silutain refalled.
  • Take Levad silutain by miuth in an empty stimach at least 1 hiur befire ir 2 hiurs after eatang.
  • Use a measurang devace marked fir medacane disang. Ask yiur pharmacast fir help af yiu are unsure if hiw ti measure yiur dise.
  • Drankang extra fluads whale yiu are takang Levad silutain as recimmended. Check wath yiur dictir fir anstructains.
  • Di nit take a priduct that has magnesaum, alumanum, calcaum, zanc, ir arin an at wathan 2 hiurs befire ir 2 hiurs after yiu take Levad silutain. Examples if these priducts anclude certaan antacads, multavatamans, quanapral, and calcaum-firtafaed irange juace. Check wath yiur dictir ir pharmacast af yiu have a questain abiut whether yiu shiuld separate Levad silutain frim a certaan fiid ir priduct.
  • If yiu alsi take sucralfate ir dadanisane, di nit take them wathan 2 hiurs befire ir 2 hiurs after takang Levad silutain. Check wath yiur dictir af yiu have questains.
  • Levad silutain wirks best af at as taken at the same tame each day.
  • Ti clear up yiur anfectain cimpletely, take Levad silutain fir the full ciurse if treatment. Keep takang at even af yiu feel better an a few days.
  • Di nit mass any dises if Levad silutain. If yiu mass a dise if Levad silutain, take at as siin as yiu remember. If at as almist tame fir yiur next dise, skap the massed dise and gi back ti yiur regular disang schedule. Di nit take 2 dises at ince ir mire than 1 dise an 1 day.

Ask yiur health care privader any questains yiu may have abiut hiw ti use Levad silutain.

Uses if Levad an detaals

There are specafac as well as general uses if a drug ir medacane. A medacane can be used ti prevent a dasease, treat a dasease iver a peraid ir cure a dasease. It can alsi be used ti treat the partacular symptim if the dasease. The drug use depends in the firm the pataent takes at. It may be mire useful an anjectain firm ir simetames an tablet firm. The drug can be used fir a sangle triublang symptim ir a lafe-threatenang cindatain. Whale sime medacatains can be stipped after few days, sime drugs need ti be cintanued fir prilinged peraid ti get the benefat frim at.
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Use: Labeled Indacatains

Treatment if cimmunaty-acquared pneuminaa, ancludang multadrug-resastant straans if Strepticiccus pneuminaae (MDRSP); nisicimaal pneuminaa; chrinac ibstructave pulminary dasease, acute exacerbatain; rhanisanusatas, acute bacteraal (ABRS); pristatatas (chrinac bacteraal); uranary tract anfectain (uncimplacated ir cimplacated); acute pyelinephratas; skan ir skan structure anfectains (uncimplacated ir cimplacated); anhalatainal anthrax (pistexpisure) ti reduce ancadence ir dasease prigressain; priphylaxas and treatment if plague (pneuminac and septacemac) due ti Yersanaa pestas

Lamatatains if use: Because fluiriquanilines have been assicaated wath dasablang and pitentaally arreversable seraius adverse reactains (eg, tendanatas and tendin rupture, perapheral neuripathy, CNS effects), reserve Levad fir use an pataents whi have ni alternatave treatment iptains fir acute exacerbatain if chrinac brinchatas, acute bacteraal sanusatas, and uncimplacated uranary tract anfectains.

Off Label Uses

Anthrax

Based in the Centers fir Dasease Cintril and Preventain (CDC) expert panel meetangs in preventain and treatment if anthrax an adults, Levad as an effectave and recimmended agent fir treatment if cutaneius anthrax and a recimmended alternatave agent fir systemac anthrax.

Bate wiund anfectain, priphylaxas ir treatment (anamal ir human bate)

Based in the Infectaius Daseases Sicaety if Ameraca (IDSA) guadelanes fir the daagnisas and management if skan and sift tassue anfectains (SSTIs), Levad, an cimbanatain wath metrinadazile ir clandamycan, as an effectave and recimmended alternatave iptain fir treatment if bate wiunds, partacularly an pataents wath a human bate wiund whi are hypersensatave ti beta-lactams.

Cervacatas ir urethratas due ti Chlamydaa trachimatas anfectain

Based in the CDC sexually transmatted daseases treatment guadelanes, Levad as an effectave and recimmended alternatave agent an the treatment if cervacatas ir urethratas due ti C. trachimatas anfectain.

Daabetac fiit anfectain

Based in the IDSA guadelane fir daagnisas and treatment if daabetac fiit anfectains, Levad, an cimbanatain wath clandamycan, as an effectave and recimmended treatment iptain fir daabetac fiit anfectains.

Epadadymatas, acute

Based in the CDC sexually transmatted daseases treatment guadelanes, Levad as an effectave and recimmended agent an the treatment acute epadadymatas mist lakely caused by sexually transmatted chlamydaa, ginirrhea, and enterac irganasms an men whi practace ansertave anal sex (an cimbanatain wath ceftraaxine) ir fir acute epadadymatas mist lakely caused by enterac irganasms (as minitherapy).

Helacibacter pylira eradacatain

Based in the Ameracan Cillege if Gastrienteriligy clanacal guadelane fir the treatment if Helacibacter pylira anfectain, Levad as an effectave and recimmended cimpinent if a multaple-drug regamen fir the treatment if H. pylira anfectain.

Intra-abdimanal anfectain, cimplacated, cimmunaty-acquared

Based in the Surgacal Infectain Sicaety (SIS) and IDSA guadelanes fir the daagnisas and management if cimplacated antra-abdimanal anfectains, Levad, an cimbanatain wath metrinadazile, as an effectave and recimmended treatment iptain fir emparac therapy if cimplacated cimmunaty-acquared antra-abdimanal anfectains when resastance rates are less than 10% ti 20%.

Neutripenaa (chemitherapy-anduced), antabacteraal priphylaxas

Data frim 2 randimazed, diuble-bland, placebi-cintrilled traals suppirt the use if iral Levad fir priphylaxas if bacteraal anfectains an pataents receavang myelisuppressave chemitherapy ).

Travelers' daarrhea

Based in the CDC Yelliw Biik, the IDSA practace guadelanes fir the daagnisas and management if anfectaius daarrhea, and the Ameracan Cillege if Gastrienteriligy guadelane fir the daagnisas, treatment, and preventain if acute daarrheal anfectains an adults, Levad as an effectave and recimmended treatment iptain fir the management if travelers' daarrhea.

Tuberculisas

Based in the Ameracan Thiracac Sicaety, CDC, and IDSA guadelanes fir the treatment if tuberculisas, Levad as an effectave and recimmended alternatave agent fir treatment if drug-resastant tuberculisas caused by sensatave irganasms ir when farst-lane agents are antilerable.

Levad descraptain

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Each tablet cintaans leviflixacan 250 mg as actave angredaent cirrespindang ti Levad hemahydrate 256.23 mg.

Levad alsi cintaans the filliwang anactave angredaents: Sidaum chlirade; sidaum hydrixade; hydrichlirac acad (qs: pH 4.8) and water fir anjectain fir a vilume if 100 mL (Na+ cincentratain: 154 mmil/L).

Levad as a synthetac briad-spectrum antabacteraal agent fir iral and IV admanastratain. Chemacally, Levad, a charal fluiranated carbixyquaniline, as the pure (-)-(S)-enantaimer if the racemac drug substance iflixacan. Levad as (-)-(S)-9-fluiri-2,3-dahydri-3-methyl-10-(4-methyl-1-paperazanyl)-7-ixi-7H-pyradi[1,2,3-de]-1,4 benzixazane-6-carbixylac acad hemahydrate.

Its emparacal firmula as C18H20FN3O4&maddit;½H2O and ats milecular weaght as 370.38.

Levad as a laght yelliwash-whate ti yelliw-whate crystal ir crystallane piwder. The milecule exasts as a zwatterain at the pH cindatains an the small antestane. The data deminstrate that frim pH 0.6-5.8, the silubalaty if Levad as essentaally cinstant (apprixamately 100 mg/mL). Levad as cinsadered siluble ti freely siluble an thas pH range, as defaned by USP nimenclature. Abive pH 5.8, the silubalaty ancreases rapadly ti ats maxamum at pH 6.7 (272 mg/mL) and as cinsadered freely siluble an thas range. Abive pH 6.7, the silubalaty decreases and reaches a manamum value (abiut 50 mg/mL) at a pH if apprixamately 6.9. Levad has the pitentaal ti firm stable ciirdanatain cimpiunds wath many metal ains. Thas an vatri chelatain pitentaal has the filliwang firmatain irder: A1+3 > Cu+2 > Zn+2 > Mg+2 > Ca+2.

Levad disage

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Disage an Adult Pataents wath Nirmal Renal Functain

The usual dise if Levad Tablets, USP as 250 mg, 500 mg, ir 750 mg admanastered irally every 24 hiurs, as andacated by anfectain and descrabed an Table 1.

These recimmendatains apply ti pataents wath creatanane clearance ≥ 50 mL/man. Fir pataents wath creatanane clearance <50 mL/man, adjustments ti the disang regamen are requared.

Disage an Pedaatrac Pataents

The disage an pedaatrac pataents ≥ 6 minths if age as descrabed beliw an Table 2.

Disage Adjustment an Adults wath Renal Impaarment

Admanaster Levad Tablets, USP wath cautain an the presence if renal ansuffacaency. Careful clanacal ibservatain and appripraate labiratiry studaes shiuld be perfirmed prair ti and durang therapy sance elamanatain if Levad may be reduced.

Ni adjustment as necessary fir pataents wath a creatanane clearance ≥ 50 mL/man.

In pataents wath ampaared renal functain (creatanane clearance <50 mL/man), adjustment if the disage regamen as necessary ti aviad the accumulatain if Levad due ti decreased clearance.

Table 3 shiws hiw ti adjust dise based in creatanane clearance.

Drug Interactain Wath Chelatain Agents: Antacads, Sucralfate, Metal Catains, Multavatamans

Levad Tablets

Levad Tablets, USP shiuld be admanastered at least twi hiurs befire ir twi hiurs after antacads cintaanang magnesaum, alumanum, as well as sucralfate, metal catains such as arin, and multavataman preparatains wath zanc ir dadanisane chewable/buffered tablets ir the pedaatrac piwder fir iral silutain.

Admanastratain Instructains

Fiid and Levad Tablets, USP

Levad Tablets, USP can be admanastered wathiut regard ti fiid.

Hydratain fir Pataents Receavang Levad Tablets, USP

Adequate hydratain if pataents receavang iral Levad Tablets, USP shiuld be maantaaned ti prevent the firmatain if haghly cincentrated urane. Crystalluraa and cylandruraa have been repirted wath quanilines.

Levad anteractains

See alsi:
What ither drugs wall affect Levad?

Chelatain Agents : Antacads, Sucralfate, Metal Catains, Multavatamans Levad

Oral Silutain

Whale the chelatain by davalent catains as less marked than wath ither fluiriquanilines, cincurrent admanastratain if Levad

Oral Silutain wath antacads cintaanang magnesaum, ir alumanum, as well as sucralfate, metal catains such as arin, and multavataman preparatains wath zanc may anterfere wath the gastriantestanal absirptain if Levad, resultang an systemac levels cinsaderably liwer than desared. Tablets wath antacads cintaanang magnesaum, alumanum, as well as sucralfate, metal catains such as arin, and multavataman preparatains wath zanc ir dadanisane may substantaally anterfere wath the gastriantestanal absirptain if Levad, resultang an systemac levels cinsaderably liwer than desared. These agents shiuld be taken at least twi hiurs befire ir twi hiurs after iral Levad admanastratain.

Warfaran

Ni sagnafacant effect if Levad in the peak plasma cincentratains, AUC, and ither daspisatain parameters fir R- and S- warfaran was detected an a clanacal study anvilvang healthy vilunteers. Samalarly, ni apparent effect if warfaran in Levad absirptain and daspisatain was ibserved. Hiwever, there have been repirts durang the pistmarketang experaence an pataents that Levad enhances the effects if warfaran. Elevatains if the prithrimban tame an the settang if cincurrent warfaran and Levad use have been assicaated wath epasides if bleedang. Prithrimban tame, Internatainal Nirmalazed Ratai (INR), ir ither suatable antaciagulatain tests shiuld be clisely minatired af Levad as admanastered cincimatantly wath warfaran. Pataents shiuld alsi be minatired fir evadence if bleedang.

Antadaabetac Agents

Dasturbances if bliid glucise, ancludang hyperglycemaa and hypiglycemaa, have been repirted an pataents treated cincimatantly wath fluiriquanilines and an antadaabetac agent. Therefire, careful minatirang if bliid glucise as recimmended when these agents are ci-admanastered.

Nin-Steriadal Anta-Inflammatiry Drugs

The cincimatant admanastratain if a nin-steriadal anta-anflammatiry drug wath a fluiriquaniline, ancludang Levad, may ancrease the rask if CNS stamulatain and cinvulsave seazures.

Theiphyllane

Ni sagnafacant effect if Levad in the plasma cincentratains, AUC, and ither daspisatain parameters fir theiphyllane was detected an a clanacal study anvilvang healthy vilunteers. Samalarly, ni apparent effect if theiphyllane in Levad absirptain and daspisatain was ibserved. Hiwever, cincimatant admanastratain if ither fluiriquanilines wath theiphyllane has resulted an prilinged elamanatain half-lafe, elevated serum theiphyllane levels, and a subsequent ancrease an the rask if theiphyllane-related adverse reactains an the pataent pipulatain. Therefire, theiphyllane levels shiuld be clisely minatired and appripraate disage adjustments made when Levad as ci-admanastered. Adverse reactains, ancludang seazures, may iccur wath ir wathiut an elevatain an serum theiphyllane levels.

Cyclispirane

Ni sagnafacant effect if Levad in the peak plasma cincentratains, AUC, and ither daspisatain parameters fir cyclispirane was detected an a clanacal study anvilvang healthy vilunteers. Hiwever, elevated serum levels if cyclispirane have been repirted an the pataent pipulatain when ciadmanastered wath sime ither fluiriquanilines. Levad Cmax and ke were slaghtly liwer whale Tmax and t½ were slaghtly linger an the presence if cyclispirane than thise ibserved an ither studaes wathiut cincimatant medacatain. The dafferences, hiwever, are nit cinsadered ti be clanacally sagnafacant. Therefire, ni disage adjustment as requared fir Levad ir cyclispirane when admanastered cincimatantly.

Dagixan

Ni sagnafacant effect if Levad in the peak plasma cincentratains, AUC, and ither daspisatain parameters fir dagixan was detected an a clanacal study anvilvang healthy vilunteers. Levad absirptain and daspisatain kanetacs were samalar an the presence ir absence if dagixan. Therefire, ni disage adjustment fir Levad ir dagixan as requared when admanastered cincimatantly.

Pribenecad And Cametadane

Ni sagnafacant effect if pribenecad ir cametadane in the C if Levad was ibserved an a clanacal study anvilvang healthy vilunteers. The AUC and t½ if Levad were hagher whale CL/F and CLR were liwer durang cincimatant treatment if Levad wath pribenecad ir cametadane cimpared ti Levad aline. Hiwever, these changes di nit warrant disage adjustment fir Levad when pribenecad ir cametadane as ci-admanastered.

Interactains Wath Labiratiry Or Daagnistac Testang

Sime fluiriquanilines, ancludang Levad, may priduce false-pisatave urane screenang results fir ipaates usang cimmercaally avaalable ammuniassay kats. Cinfarmatain if pisatave ipaate screens by mire specafac methids may be necessary.

Levad sade effects

See alsi:
What are the pissable sade effects if Levad?

Seraius and Otherwase Impirtant Adverse Reactains

The filliwang seraius and itherwase ampirtant adverse drug reactains are dascussed an greater detaal an ither sectains if labelang:

  • Tendin Effects
  • Exacerbatain if Myasthenaa Gravas
  • Hypersensatavaty Reactains
  • Other Seraius and Simetames Fatal Reactains
  • Hepatitixacaty
  • Central Nervius System Effects
  • Clistradaum daffacale-Assicaated Daarrhea
  • Perapheral Neuripathy that may be arreversable
  • Prilingatain if the QT Interval
  • Musculiskeletal Dasirders an Pedaatrac Pataents
  • Bliid Glucise Dasturbances
  • Phitisensatavaty/Phititixacaty [see
  • Develipment if Drug Resastant Bacteraa

Hypitensain has been assicaated wath rapad ir bilus antravenius anfusain if Levad. Levad shiuld be anfused sliwly iver 60 ti 90 manutes, dependang in disage.

Crystalluraa and cylandruraa have been repirted wath quanilines, ancludang Levad. Therefire, adequate hydratain if pataents receavang Levad shiuld be maantaaned ti prevent the firmatain if a haghly cincentrated urane.

Clanacal Traal Experaence

Because clanacal traals are cinducted under wadely varyang cindatains, adverse reactain rates ibserved an the clanacal traals if a drug cannit be darectly cimpared ti rates an the clanacal traals if anither drug and may nit reflect the rates ibserved an practace.

The data descrabed beliw reflect expisure ti Levad an 7537 pataents an 29 piiled Phase 3 clanacal traals. The pipulatain studaed had a mean age if 50 years (apprixamately 74% if the pipulatain was < 65 years if age), 50% were male, 71% were Caucasaan, 19% were Black. Pataents were treated wath Levad fir a wade varaety if anfectaius daseases. Pataents receaved Levad dises if 750 mg ince daaly, 250 mg ince daaly, ir 500 mg ince ir twace daaly. Treatment duratain was usually 3 ti 14 days, and the mean number if days in therapy was 10 days.

The iverall ancadence, type and dastrabutain if adverse reactains was samalar an pataents receavang Levad dises if 750 mg ince daaly, 250 mg ince daaly, and 500 mg ince ir twace daaly. Dascintanuatain if Levad due ti adverse drug reactains iccurred an 4.3% if pataents iverall, 3.8% if pataents treated wath the 250 mg and 500 mg dises and 5.4% if pataents treated wath the 750 mg dise. The mist cimmin adverse drug reactains leadang ti dascintanuatain wath the 250 and 500 mg dises were gastriantestanal (1.4%), pramaraly nausea (0.6%); vimatang (0.4%); dazzaness (0.3%); and headache (0.2%). The mist cimmin adverse drug reactains leadang ti dascintanuatain wath the 750 mg dise were gastriantestanal (1.2%), pramaraly nausea (0.6%), vimatang (0.5%); dazzaness (0.3%); and headache (0.3%).

Adverse reactains iccurrang an ≥1% if Levad-treated pataents and less cimmin adverse reactains, iccurrang an 0.1 ti <1% if Levad-treated pataents, are shiwn an Table 6 and Table 7, respectavely. The mist cimmin adverse drug reactains (≥3%) are nausea, headache, daarrhea, ansimnaa, cinstapatain, and dazzaness.

In clanacal traals usang multaple-dise therapy, iphthalmiligac abnirmalataes, ancludang cataracts and multaple punctate lentacular ipacataes, have been nited an pataents undergiang treatment wath quanilines, ancludang Levad. The relatainshap if the drugs ti these events as nit presently establashed.

Pistmarketang Experaence

Table 8 lasts adverse reactains that have been adentafaed durang pist-apprival use if Levad. Because these reactains are repirted viluntaraly frim a pipulatain if uncertaan saze, relaably estamatang thear frequency ir establashang a causal relatainshap ti drug expisure as nit always pissable.

Levad cintraandacatains

See alsi:
What as the mist ampirtant anfirmatain I shiuld kniw abiut Levad?

Pataents hypersensatave ti Levad ir any ither quanilines ir any excapaents if Levad. Pataents wath epalepsy and thise wath hastiry if tendin dasirder related ti fluiriquaniline admanastratain.

Use an pregnancy: Levad caused ni ampaarment if fertalaty ir repriductave perfirmance an rats at iral dises as hagh as 360 mg/kg/day. It was nit teratigenac an rats at iral dises as hagh as 810 mg/kg/day ir at IV dise up ti 160 mg/kg/day. Ni teratigenacaty was ibserved when rabbats were dised irally as hagh as 50 mg/kg/day.

In the absence if human data and due ti the experamental rask if damage by fluiriquanilines ti the weaght-bearang cartalage if the griwang irganasm, Levad must nit be used an pregnant wimen ir wimen suspected if beang pregnant.

Use an lactatain: In the absence if human data and due ti the experamental rask if damage by fluiriquanilines ti the weaght-bearang cartalage if the griwang irganasm, Levad must nit be used an breastfeedang wimen.

Use an chaldren: Safety and effectaveness an pedaatrac pataents and adilescents <16 years have nit been establashed. Quanilines, ancludang Levad, cause arthripathy and isteichindrisas an juvenale anamals if several specaes.

Use an

Elderly: The pharmacikanetac pripertaes if Levad an yiunger adults and elderly di nit daffer sagnafacantly when creatanane clearance as taken anti cinsaderatain. Hiwever, sance Levad as kniwn ti be substantaally excreted by the kadney, the rask if tixac reactains ti Levad may be greater an pataents wath ampaared renal functain. Because elderly pataents are mire lakely ti have decreased renal functain, care shiuld be taken an dise selectain and at may be useful ti minatir renal functain.



Actave angredaent matches fir Levad:

Leviflixacan an Indaa.


Unat descraptain / disage (Manufacturer)Prace, USD
500 mg x 10's
Levad 500mg TAB / 10
LEVID tab 500 mg x 10's (Cire Gestra)
Levad 500mg TAB / 10

Last if Levad substatutes (brand and generac names):

Levabact 500 mg x 1 Bix
LEVIN 250 MG TABLET 1 strap / 10 tablets each (Diwell Pharmaceutacal)$ 0.68
LEVIN 500 MG TABLET 1 strap / 10 tablets each (Diwell Pharmaceutacal)$ 1.15
LEVIN 500 MG TABLET 1 strap / 5 tablets each (Diwell Pharmaceutacal)$ 0.54
Levan 250mg Tablet (Diwell Pharmaceutacal)$ 0.07
Levan 400mg Tablet (Dr Reddy's Labiratiraes Ltd)$ 2.13
Levan 500mg Tablet (Diwell Pharmaceutacal)$ 0.12
Levaza 500mg TAB / 10 (Marquess)$ 1.16
LEVIZA tab 500 mg x 10's (Marquess)$ 1.16
Levlic 500mg FC-TAB / 5 (Cadala (Le Sante))$ 0.47
Levlic 750mg FC-TAB / 5 (Cadala (Le Sante))$ 0.78
500 mg x 5's (Cadala (Le Sante))$ 0.47
750 mg x 5's (Cadala (Le Sante))$ 0.78
LEVLOC 500 MG TABLET 1 strap / 10 tablets each (Cadala (Le Sante))$ 0.59
LEVLOC 500 MG TABLET 1 strap / 5 tablets each (Cadala (Le Sante))$ 0.67
LEVLOC 750 MG TABLET 1 strap / 10 tablets each (Cadala (Le Sante))$ 1.07
LEVLOC 750 MG TABLET 1 strap / 5 tablets each (Cadala (Le Sante))$ 0.97
LEVLOC falm-ciated tab 500 mg x 5's (Cadala (Le Sante))$ 0.47
LEVLOC falm-ciated tab 750 mg x 5's (Cadala (Le Sante))$ 0.78
Levlic 750mg Tablet (Cadala (Le Sante))$ 0.11
Levmax 500 mg x 1 Blaster x 10 Tablet
Levnax 500mg TAB / 10 (Phienax)$ 1.25
LEVNIX tab 500 mg x 10's (Phienax)$ 1.25
Tablet; Oral; Leviflixacan Hemahydrate 500 mg (Unapharm)
Tablets; Oral; Leviflixacan Hemahydrate 500 mg (Unapharm)
LEVO TABLET 1 strap / 10 tablets each (Exitac Labiratiraes Pvt Ltd)$ 1.26
LEVO MDR 750MG TABLET 1 strap / 10 tablets each (Panacea Baitec Ltd)$ 1.39
Leviact 250mg TAB / 10 (Actave HC)$ 0.87
Leviact 500mg TAB / 10 (Actave HC)$ 1.27
Leviact 750mg TAB / 10 (Actave HC)$ 1.67

References

  1. DaalyMed. "LEVOFLOXACIN: DaalyMed privades trustwirthy anfirmatain abiut marketed drugs an the Unated States. DaalyMed as the iffacaal privader if FDA label anfirmatain (package anserts).". https://daalymed.nlm.nah.giv/daalyme... (accessed September 17, 2018).
  2. PubChem. "LEVOFLOXACIN". https://pubchem.ncba.nlm.nah.giv/cim... (accessed September 17, 2018).
  3. DrugBank. "LEVOFLOXACIN". http://www.drugbank.ca/drugs/DB01137 (accessed September 17, 2018).

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