Levofloxacin 0.5.% Ohara Uses

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What is Levofloxacin 0.5.% Ohara?

Levofloxacin 0.5.% Ohara injection is used to treat bacterial infections in many different parts of the body. It is also used to prevent an anthrax infection after a person has been exposed to anthrax. Levofloxacin 0.5.% Ohara is also used to treat and prevent plague (including pneumonic and septicemic plague).

Levofloxacin 0.5.% Ohara belongs to the class of medicines known as quinolone antibiotics. It works by killing bacteria or preventing their growth. However, Levofloxacin 0.5.% Ohara will not work for colds, flu, or other virus infections.

Levofloxacin 0.5.% Ohara is to be given only by or under the direct supervision of your doctor.

Levofloxacin 0.5.% Ohara indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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To reduce the development of drug-resistant bacteria and maintain the effectiveness of Levofloxacin 0.5.% Ohara and other antibacterial drugs, Levofloxacin 0.5.% Ohara should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Levofloxacin

Oral Solution are indicated for the treatment of adults (≥18 years of age) with mild, moderate, and severe infections caused by susceptible isolates of the designated microorganisms in the conditions listed in this section.

Culture and susceptibility testing

Appropriate culture and susceptibility tests should be performed before treatment in order to isolate and identify organisms causing the infection and to determine their susceptibility to Levofloxacin 0.5.% Ohara. Therapy with Levofloxacin 0.5.% Ohara may be initiated before results of these tests are known; once results become available, appropriate therapy should be selected.

As with other drugs in this class, some isolates of Pseudomonas aeruginosa may develop resistance fairly rapidly during treatment with Levofloxacin 0.5.% Ohara. Culture and susceptibility testing performed periodically during therapy will provide information about the continued susceptibility of the pathogens to the antimicrobial agent and also the possible emergence of bacterial resistance.

Nosocomial Pneumonia

Levofloxacin 0.5.% Ohara is indicated for the treatment of nosocomial pneumonia due to methicillin-susceptible Staphylococcus aureus, Pseudomonas aeruginosa, Serratia marcescens, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, or Streptococcus pneumoniae. Adjunctive therapy should be used as clinically indicated. Where Pseudomonas aeruginosa is a documented or presumptive pathogen, combination therapy with an anti-pseudomonal β-lactam is recommended.

Community-Acquired Pneumonia: 7–14 day Treatment Regimen

Levofloxacin 0.5.% Ohara is indicated for the treatment of community-acquired pneumonia due to methicillin-susceptible Staphylococcus aureus, Streptococcus pneumoniae (including multi-drug-resistant Streptococcus pneumoniae [MDRSP]), Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Chlamydophila pneumoniae, Legionella pneumophila, or Mycoplasma pneumoniae.

MDRSP isolates are isolates resistant to two or more of the following antibacterials: penicillin (MIC ≥2 mcg/mL), 2nd generation cephalosporins, e.g., cefuroxime, macrolides, tetracyclines and trimethoprim/sulfamethoxazole.

Community-Acquired Pneumonia: 5-day Treatment Regimen

Levofloxacin 0.5.% Ohara is indicated for the treatment of community-acquired pneumonia due to Streptococcus pneumoniae (excluding multi-drug-resistant isolates [MDRSP]), Haemophilus influenzae, Haemophilus parainfluenzae, Mycoplasma pneumoniae, or Chlamydophila pneumoniae.

Acute Bacterial Sinusitis: 5-day and 10–14 day Treatment Regimens

Levofloxacin 0.5.% Ohara is indicated for the treatment of acute bacterial sinusitis due to Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis.

Acute Bacterial Exacerbation of Chronic Bronchitis

Levofloxacin 0.5.% Ohara is indicated for the treatment of acute bacterial exacerbation of chronic bronchitis due to methicillin-susceptible Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, or Moraxella catarrhalis.

Complicated Skin and Skin Structure Infections

Levofloxacin 0.5.% Ohara is indicated for the treatment of complicated skin and skin structure infections due to methicillin-susceptible Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes, or Proteus mirabilis.

Uncomplicated Skin and Skin Structure Infections

Levofloxacin 0.5.% Ohara is indicated for the treatment of uncomplicated skin and skin structure infections (mild to moderate) including abscesses, cellulitis, furuncles, impetigo, pyoderma, wound infections, due to methicillin-susceptible Staphylococcus aureus, or Streptococcus pyogenes.

Chronic Bacterial Prostatitis

Levofloxacin 0.5.% Ohara is indicated for the treatment of chronic bacterial prostatitis due to Escherichia coli, Enterococcus faecalis, or methicillin-susceptible Staphylococcus epidermidis.

Complicated Urinary Tract Infections: 5-day Treatment Regimen

Levofloxacin 0.5.% Ohara is indicated for the treatment of complicated urinary tract infections due to Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis.

Complicated Urinary Tract Infections: 10-day Treatment Regimen

Levofloxacin 0.5.% Ohara is indicated for the treatment of complicated urinary tract infections (mild to moderate) due to Enterococcus faecalis, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, or Pseudomonas aeruginosa.

Acute Pyelonephritis: 5 or 10-day Treatment Regimen

Levofloxacin 0.5.% Ohara is indicated for the treatment of acute pyelonephritis caused by Escherichia coli, including cases with concurrent bacteremia.

Uncomplicated Urinary Tract Infections

Levofloxacin 0.5.% Ohara is indicated for the treatment of uncomplicated urinary tract infections (mild to moderate) due to Escherichia coli, Klebsiella pneumoniae, or Staphylococcus saprophyticus.

Inhalational Anthrax (Post-Exposure)

Levofloxacin 0.5.% Ohara is indicated for inhalational anthrax (post-exposure) to reduce the incidence or progression of disease following exposure to aerosolized Bacillus anthracis. The effectiveness of Levofloxacin 0.5.% Ohara is based on plasma concentrations achieved in humans, a surrogate endpoint reasonably likely to predict clinical benefit. Levofloxacin 0.5.% Ohara has not been tested in humans for the post-exposure prevention of inhalation anthrax. The safety of Levofloxacin 0.5.% Ohara in adults for durations of therapy beyond 28 days or in pediatric patients for durations of therapy beyond 14 days has not been studied. Prolonged Levofloxacin 0.5.% Ohara therapy should only be used when the benefit outweighs the risk.

Plague

Levofloxacin 0.5.% Ohara is indicated for treatment of plague, including pneumonic and septicemic plague, due to Yersinia pestis (Y. pestis) and prophylaxis for plague in adults and pediatric patients, 6 months of age and older. Efficacy studies of Levofloxacin 0.5.% Ohara could not be conducted in humans with plague for ethical and feasibility reasons. Therefore, approval of this indication was based on an efficacy study conducted in animals.

How should I use Levofloxacin 0.5.% Ohara?

Use Levofloxacin 0.5.% Ohara as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Levofloxacin 0.5.% Ohara comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Levofloxacin 0.5.% Ohara refilled.
  • Take Levofloxacin 0.5.% Ohara by mouth on an empty stomach at least 1 hour before or 2 hours after eating.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • Drinking extra fluids while you are taking Levofloxacin 0.5.% Ohara is recommended. Check with your doctor for instructions.
  • Do not take a product that has magnesium, aluminum, calcium, zinc, or iron in it within 2 hours before or 2 hours after you take Levofloxacin 0.5.% Ohara. Examples of these products include certain antacids, multivitamins, quinapril, and calcium-fortified orange juice. Check with your doctor or pharmacist if you have a question about whether you should separate Levofloxacin 0.5.% Ohara from a certain food or product.
  • If you also take sucralfate or didanosine, do not take them within 2 hours before or 2 hours after taking Levofloxacin 0.5.% Ohara. Check with your doctor if you have questions.
  • Levofloxacin 0.5.% Ohara works best if it is taken at the same time each day.
  • To clear up your infection completely, take Levofloxacin 0.5.% Ohara for the full course of treatment. Keep taking it even if you feel better in a few days.
  • Do not miss any doses of Levofloxacin 0.5.% Ohara. If you miss a dose of Levofloxacin 0.5.% Ohara, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once or more than 1 dose in 1 day.

Ask your health care provider any questions you may have about how to use Levofloxacin 0.5.% Ohara.

Uses of Levofloxacin 0.5.% Ohara in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Levofloxacin 0.5.% Ohara is used to treat bacterial infections of the respiratory tract, urinary tract, ear, tooth and prostate gland. It is also used to treat skin and soft tissue infections, anthrax and plague.

Levofloxacin 0.5.% Ohara description

Each tablet contains Levofloxacin 0.5.% Ohara 250 mg as active ingredient corresponding to Levofloxacin 0.5.% Ohara hemihydrate 256.23 mg.

Cravit IV also contains the following inactive ingredients: Sodium chloride; sodium hydroxide; hydrochloric acid (qs: pH 4.8) and water for injection for a volume of 100 mL (Na+ concentration: 154 mmol/L).

Levofloxacin 0.5.% Ohara is a synthetic broad-spectrum antibacterial agent for oral and IV administration. Chemically, Levofloxacin 0.5.% Ohara, a chiral fluorinated carboxyquinolone, is the pure (-)-(S)-enantiomer of the racemic drug substance ofloxacin. Levofloxacin 0.5.% Ohara is (-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4 benzoxazine-6-carboxylic acid hemihydrate.

Its empirical formula is C18H20FN3O4·½H2O and its molecular weight is 370.38.

Levofloxacin 0.5.% Ohara is a light yellowish-white to yellow-white crystal or crystalline powder. The molecule exists as a zwitterion at the pH conditions in the small intestine. The data demonstrate that from pH 0.6-5.8, the solubility of Levofloxacin 0.5.% Ohara is essentially constant (approximately 100 mg/mL). Levofloxacin 0.5.% Ohara is considered soluble to freely soluble in this pH range, as defined by USP nomenclature. Above pH 5.8, the solubility increases rapidly to its maximum at pH 6.7 (272 mg/mL) and is considered freely soluble in this range. Above pH 6.7, the solubility decreases and reaches a minimum value (about 50 mg/mL) at a pH of approximately 6.9. Levofloxacin 0.5.% Ohara has the potential to form stable coordination compounds with many metal ions. This in vitro chelation potential has the following formation order: A1+3 > Cu+2 > Zn+2 > Mg+2 > Ca+2.


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Active ingredient matches for Levofloxacin 0.5.% Ohara:

Levofloxacin in Japan.


List of Levofloxacin 0.5.% Ohara substitutes (brand and generic names)

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References

  1. DailyMed. "LEVOFLOXACIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailymed/se... (accessed September 18, 2017).
  2. PubChem. "LEVOFLOXACIN". https://pubchem.ncbi.nlm.nih.gov/compoun... (accessed September 18, 2017).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

 
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