Levofloxacin 1.5.% Amel Actions

Is this medication very expensive?
sponsored

Actions of Levofloxacin 1.5.% Amel in details

The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
sponsored

Pharmacology: Mechanism of Action: The main mechanism of action of Levofloxacin 1.5.% Amel is the inhibition of DNA gyrase. It is 2-fold stronger than that of ofloxacin. There is not much difference between the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The activity of Levofloxacin 1.5.% Amel is bactericidal. In the observation of bacterial morphology, bacteriolysis can be seen in the concentration around MIC.

Pharmacokinetics: Absorption:

Orally administered Levofloxacin 1.5.% Amel is rapidly and almost completely absorbed with peak plasma concentrations being obtained within 1 hr. The absolute bioavailability is approximately 100%. Food has little effect on the absorption of Levofloxacin 1.5.% Amel.

Distribution in Plasma: Approximately 30-40% of Levofloxacin 1.5.% Amel is bound to serum protein. Multiple dosing with Levofloxacin 1.5.% Amel 500 mg once daily showed neglible accumulation. There is modest but predictable accumulation of Levofloxacin 1.5.% Amel after doses of 500 mg twice daily. Steady state is achieved within 3 days.

Penetration into Tissues and Body Fluids: Penetration into Bronchial Mucosa, Epithelial Lining Fluid (ELF): Maximum Levofloxacin 1.5.% Amel concentrations in bronchial mucosa and ELF were 8.3 mcg/mL and 10.8 mcg/mL, respectively. These were reached approximately 1 hr after administration.

Penetration into Lung Tissue: Maximum Levofloxacin 1.5.% Amel concentrations in lung tissues were approximately 11.3 mcg/mL and were reached between 4-6 hrs after administration.

Metabolism: Levofloxacin 1.5.% Amel is metabolised to a very small extent, the metabolites being desmethyl-Levofloxacin 1.5.% Amel and Levofloxacin 1.5.% Amel N-oxide. These metabolites account for <5% of the dose excretion in urine. Levofloxacin 1.5.% Amel is stereochemically stable and does not undergo chiral inversion.

Elimination: Following oral and IV administration, Levofloxacin 1.5.% Amel is eliminated relatively slowly from the plasma (half-life: 6-8 hrs). Excretion is primarily by the renal route (>85% of the administered dose).

Microbiology: Levofloxacin 1.5.% Amel is a broad-spectrum antibacterial agent against gram-positive and gram-negative bacteria including anaerobes. Levofloxacin 1.5.% Amel has shown strong antibacterial activities against Staphylococcus spp, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus hemolyticus, Enterobacter spp, Escherichia coli, Klebsiella spp, Serratia spp, Enterococcus spp, Proteus spp and other glucose nonfermentative gram-negative rods, Pseudomonas aeruginosa, Haemophilus influenzae and Neisseria gonorrhoeae. Morever, Levofloxacin 1.5.% Amel has shown antibacterial activity against Chlamydia trachomatis. Levofloxacin 1.5.% Amel has an excellent protective and treatment effects in mice.

How should I take Levofloxacin 1.5.% Amel?

Take Levofloxacin 1.5.% Amel only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Levofloxacin 1.5.% Amel comes with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Levofloxacin 1.5.% Amel oral liquid should be taken 1 hour before or 2 hours after eating. You may measure your dose with a marked measuring spoon, oral syringe, or medicine cup.

Levofloxacin 1.5.% Amel tablets may be taken with meals or on an empty stomach.

Levofloxacin 1.5.% Amel is best taken with a full glass (8 ounces) of water. Several additional glasses of water should be taken every day, unless otherwise directed by your doctor. Drinking extra water will help to prevent some unwanted effects of Levofloxacin 1.5.% Amel.

Levofloxacin 1.5.% Amel works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times, day and night. For example, if you are to take one dose a day, try to take it at the same time each day.

If you need to take Levofloxacin 1.5.% Amel for anthrax infection or plague, your doctor will want you to begin taking it as soon as possible after you are exposed to anthrax or bacteria causing the plague.

If you are taking aluminum or magnesium-containing antacids, iron supplements, multivitamins, didanosine (Videx®), sucralfate (Carafate®), or zinc, do not take them at the same time that you take Levofloxacin 1.5.% Amel. It is best to take these medicines at least 2 hours before or 2 hours after taking Levofloxacin 1.5.% Amel. These medicines may keep Levofloxacin 1.5.% Amel from working properly.

Keep using Levofloxacin 1.5.% Amel for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

Dosing

The dose of Levofloxacin 1.5.% Amel will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Levofloxacin 1.5.% Amel. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Missed Dose

If you miss a dose of Levofloxacin 1.5.% Amel, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Levofloxacin 1.5.% Amel administration

Administration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.
sponsored

Oral: Tablets may be administered without regard to meals.

Oral solution should be administered at least 1 hour before or 2 hours after meals. Maintain adequate hydration of patient to prevent crystalluria. Administer at least 2 hours before or 2 hours after antacids containing magnesium or aluminum, sucralfate, metal cations (eg, iron), multivitamin preparations with zinc, or didanosine chewable/buffered tablets or the pediatric powder for solution.

IV: Infuse 250 to 500 mg IV solution over 60 minutes; infuse 750 mg IV solution over 90 minutes. Too rapid of infusion can lead to hypotension. Avoid administration through an intravenous line with a solution containing multivalent cations (eg, magnesium, calcium). Maintain adequate hydration of patient to prevent crystalluria or cylindruria.

Levofloxacin 1.5.% Amel pharmacology

Pharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.

Mechanism of Action

Levofloxacin 1.5.% Amel is a member of the fluoroquinolone class of antibacterial agents.

Pharmacokinetics

The mean ± SD pharmacokinetic parameters of Levofloxacin 1.5.% Amel determined under single and steady-state conditions following oral tablet, oral solution, or intravenous (IV) doses of Levofloxacin 1.5.% Amel are summarized in Table 8.

ND = not determined

Absorption

Levofloxacin 1.5.% Amel is rapidly and essentially completely absorbed after oral administration. Peak plasma concentrations are usually attained one to two hours after oral dosing. The absolute bioavailability of Levofloxacin 1.5.% Amel from a 500 mg tablet and a 750 mg tablet of Levofloxacin 1.5.% Amel are both approximately 99%, demonstrating complete oral absorption of Levofloxacin 1.5.% Amel. Following a single intravenous dose of Levofloxacin 1.5.% Amel to healthy volunteers, the mean ± SD peak plasma concentration attained was 6.2 ± 1.0 mcg/mL after a 500 mg dose infused over 60 minutes and 11.5 ± 4.0 mcg/mL after a 750 mg dose infused over 90 minutes. Levofloxacin 1.5.% Amel

Oral Solution and Tablet formulations are bioequivalent.

Levofloxacin 1.5.% Amel pharmacokinetics are linear and predictable after single and multiple oral or IV dosing regimens. Steady-state conditions are reached within 48 hours following a 500 mg or 750 mg once-daily dosage regimen. The mean ± SD peak and trough plasma concentrations attained following multiple once-daily oral dosage regimens were approximately 5.7 ± 1.4 and 0.5 ± 0.2 mcg/mL after the 500 mg doses, and 8.6 ± 1.9 and 1.1 ± 0.4 mcg/mL after the 750 mg doses, respectively. The mean ± SD peak and trough plasma concentrations attained following multiple once-daily IV regimens were approximately 6.4 ± 0.8 and 0.6 ± 0.2 mcg/mL after the 500 mg doses, and 12.1 ± 4.1 and 1.3 ± 0.71 mcg/mL after the 750 mg doses, respectively.

Oral administration of a 500 mg dose of Levofloxacin 1.5.% Amel with food prolongs the time to peak concentration by approximately 1 hour and decreases the peak concentration by approximately 14% following tablet and approximately 25% following oral solution administration. Therefore, Levofloxacin 1.5.% Amel Tablets can be administered without regard to food. It is recommended that Levofloxacin 1.5.% Amel

Oral Solution be taken 1 hour before or 2 hours after eating.

The plasma concentration profile of Levofloxacin 1.5.% Amel after IV administration is similar and comparable in extent of exposure (AUC) to that observed for Levofloxacin 1.5.% Amel Tablets when equal doses (mg/mg) are administered. Therefore, the oral and IV routes of administration can be considered interchangeable.

Figure 2: Mean Levofloxacin 1.5.% Amel Plasma Concentration vs. Time Profile: 750 mg

Figure 3: Mean Levofloxacin 1.5.% Amel Plasma Concentration vs. Time Profile: 500 mg

Distribution

The mean volume of distribution of Levofloxacin 1.5.% Amel generally ranges from 74 to 112 L after single and multiple 500 mg or 750 mg doses, indicating widespread distribution into body tissues. Levofloxacin 1.5.% Amel reaches its peak levels in skin tissues and in blister fluid of healthy subjects at approximately 3 hours after dosing. The skin tissue biopsy to plasma AUC ratio is approximately 2 and the blister fluid to plasma AUC ratio is approximately 1 following multiple once-daily oral administration of 750 mg and 500 mg doses of Levofloxacin 1.5.% Amel respectively, to healthy subjects. Levofloxacin 1.5.% Amel also penetrates well into lung tissues. Lung tissue concentrations were generally 2- to 5-fold higher than plasma concentrations and ranged from approximately 2.4 to 11.3 mcg/g over a 24-hour period after a single 500 mg oral dose.

In vitro, over a clinically relevant range (1 to 10 mcg/mL) of serum/plasma Levofloxacin 1.5.% Amel concentrations, Levofloxacin 1.5.% Amel is approximately 24 to 38% bound to serum proteins across all species studied, as determined by the equilibrium dialysis method. Levofloxacin 1.5.% Amel is mainly bound to serum albumin in humans. Levofloxacin 1.5.% Amel binding to serum proteins is independent of the drug concentration.

Metabolism

Levofloxacin 1.5.% Amel is stereochemically stable in plasma and urine and does not invert metabolically to its enantiomer, D-ofloxacin. Levofloxacin 1.5.% Amel undergoes limited metabolism in humans and is primarily excreted as unchanged drug in the urine. Following oral administration, approximately 87% of an administered dose was recovered as unchanged drug in urine within 48 hours, whereas less than 4% of the dose was recovered in feces in 72 hours. Less than 5% of an administered dose was recovered in the urine as the desmethyl and N-oxide metabolites, the only metabolites identified in humans. These metabolites have little relevant pharmacological activity.

Excretion

Levofloxacin 1.5.% Amel is excreted largely as unchanged drug in the urine. The mean terminal plasma elimination half-life of Levofloxacin 1.5.% Amel ranges from approximately 6 to 8 hours following single or multiple doses of Levofloxacin 1.5.% Amel given orally or intravenously. The mean apparent total body clearance and renal clearance range from approximately 144 to 226 mL/min and 96 to 142 mL/min, respectively. Renal clearance in excess of the glomerular filtration rate suggests that tubular secretion of Levofloxacin 1.5.% Amel occurs in addition to its glomerular filtration. Concomitant administration of either cimetidine or probenecid results in approximately 24% and 35% reduction in the Levofloxacin 1.5.% Amel renal clearance, respectively, indicating that secretion of Levofloxacin 1.5.% Amel occurs in the renal proximal tubule. No Levofloxacin 1.5.% Amel crystals were found in any of the urine samples freshly collected from subjects receiving Levofloxacin 1.5.% Amel.

Geriatric

There are no significant differences in Levofloxacin 1.5.% Amel pharmacokinetics between young and elderly subjects when the subjects' differences in creatinine clearance are taken into consideration. Following a 500 mg oral dose of Levofloxacin 1.5.% Amel to healthy elderly subjects (66 – 80 years of age), the mean terminal plasma elimination half-life of Levofloxacin 1.5.% Amel was about 7.6 hours, as compared to approximately 6 hours in younger adults. The difference was attributable to the variation in renal function status of the subjects and was not believed to be clinically significant. Drug absorption appears to be unaffected by age. Levofloxacin 1.5.% Amel dose adjustment based on age alone is not necessary.

Pediatrics

The pharmacokinetics of Levofloxacin 1.5.% Amel following a single 7 mg/kg intravenous dose were investigated in pediatric patients ranging in age from 6 months to 16 years. Pediatric patients cleared Levofloxacin 1.5.% Amel faster than adult patients, resulting in lower plasma exposures than adults for a given mg/kg dose. Subsequent pharmacokinetic analyses predicted that a dosage regimen of 8 mg/kg every 12 hours (not to exceed 250 mg per dose) for pediatric patients 6 months to 17 years of age would achieve comparable steady state plasma exposures (AUC0-24 and Cmax) to those observed in adult patients administered 500 mg of Levofloxacin 1.5.% Amel once every 24 hours.

Gender

There are no significant differences in Levofloxacin 1.5.% Amel pharmacokinetics between male and female subjects when subjects' differences in creatinine clearance are taken into consideration. Following a 500 mg oral dose of Levofloxacin 1.5.% Amel to healthy male subjects, the mean terminal plasma elimination half-life of Levofloxacin 1.5.% Amel was about 7.5 hours, as compared to approximately 6.1 hours in female subjects. This difference was attributable to the variation in renal function status of the male and female subjects and was not believed to be clinically significant. Drug absorption appears to be unaffected by the gender of the subjects. Dose adjustment based on gender alone is not necessary.

Race

The effect of race on Levofloxacin 1.5.% Amel pharmacokinetics was examined through a covariate analysis performed on data from 72 subjects: 48 white and 24 non-white. The apparent total body clearance and apparent volume of distribution were not affected by the race of the subjects.

Renal Impairment

Clearance of Levofloxacin 1.5.% Amel is substantially reduced and plasma elimination half-life is substantially prolonged in adult patients with impaired renal function (creatinine clearance < 50 mL/min), requiring dosage adjustment in such patients to avoid accumulation. Neither hemodialysis nor continuous ambulatory peritoneal dialysis (CAPD) is effective in removal of Levofloxacin 1.5.% Amel from the body, indicating that supplemental doses of Levofloxacin 1.5.% Amel are not required following hemodialysis or CAPD.

Hepatic Impairment

Pharmacokinetic studies in hepatically impaired patients have not been conducted. Due to the limited extent of Levofloxacin 1.5.% Amel metabolism, the pharmacokinetics of Levofloxacin 1.5.% Amel are not expected to be affected by hepatic impairment.

Bacterial Infection

The pharmacokinetics of Levofloxacin 1.5.% Amel in patients with serious community-acquired bacterial infections are comparable to those observed in healthy subjects.

Drug-Drug Interactions

The potential for pharmacokinetic drug interactions between Levofloxacin 1.5.% Amel and antacids warfarin, theophylline, cyclosporine, digoxin, probenecid, and cimetidine has been evaluated.

Microbiology

Mechanism of Action

Levofloxacin 1.5.% Amel is the L-isomer of the racemate, ofloxacin, a quinolone antimicrobial agent. The antibacterial activity of ofloxacin resides primarily in the L-isomer. The mechanism of action of Levofloxacin 1.5.% Amel and other fluoroquinolone antimicrobials involves inhibition of bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for DNA replication, transcription, repair and recombination.

Mechanism of Resistance

Fluoroquinolone resistance can arise through mutations in defined regions of DNA gyrase or topoisomerase IV, termed the Quinolone-Resistance Determining Regions (QRDRs), or through altered efflux.

Fluoroquinolones, including Levofloxacin 1.5.% Amel, differ in chemical structure and mode of action from aminoglycosides, macrolides and ß-lactam antibiotics, including penicillins. Fluoroquinolones may, therefore, be active against bacteria resistant to these antimicrobials.

Resistance to Levofloxacin 1.5.% Amel due to spontaneous mutation in vitro is a rare occurrence (range: 10-9 to 10-10). Cross-resistance has been observed between Levofloxacin 1.5.% Amel and some other fluoroquinolones, some microorganisms resistant to other fluoroquinolones may be susceptible to Levofloxacin 1.5.% Amel.

Activity in vitro and in vivo

Levofloxacin 1.5.% Amel has in vitro activity against Gram-negative and Gram-positive bacteria.

Levofloxacin 1.5.% Amel has been shown to be active against most isolates of the following bacteria both in vitro and in clinical infections as described in :

Gram-Positive Bacteria

Enterococcus faecalis

Staphylococcus aureus (methicillin-susceptible isolates)

Staphylococcus epidermidis (methicillin-susceptible isolates)

Staphylococcus saprophyticus

Streptococcus pneumoniae (including multi-drug resistant isolates [MDRSP])1

Streptococcus pyogenes

_________________________________________

1 MDRSP (Multi-drug resistant Streptococcus pneumoniae) isolates are isolates resistant to two or more of the following antibiotics: penicillin (MIC ≥ 2 mcg/mL), 2nd generation cephalosporins, e.g., cefuroxime; macrolides, tetracyclines and trimethoprim/sulfamethoxazole.

Gram-Negative Bacteria

Enterobacter cloacae

Escherichia coli

Haemophilus influenzae

Haemophilus parainfluenzae

Klebsiella pneumoniae

Legionella pneumophila

Moraxella catarrhalis

Proteus mirabilis

Pseudomonas aeruginosa

Serratia marcescens

Other Bacteria

Chlamydophila pneumoniae

Mycoplasma pneumoniae

The following in vitro data are available, but their clinical significance is unknown: Levofloxacin 1.5.% Amel exhibits in vitro minimum inhibitory concentrations (MIC values) of 2 mcg/mL or less against most (≥ 90%) isolates of the following microorganisms; however, the safety and effectiveness of Levofloxacin 1.5.% Amel in treating clinical infections due to these bacteria have not been established in adequate and well-controlled clinical trials.

Gram-Positive Bacteria

Staphylococcus haemolyticus

ß-hemolytic Streptococcus (Group C/F)

ß-hemolytic Streptococcus (Group G)

Streptococcus agalactiae

Streptococcus milleri

Viridans group streptococci

Bacillus anthracis

Gram-Negative Bacteria

Acinetobacter baumannii

Acinetobacter lwoffii

Bordetella pertussis

Citrobacter koseri

Citrobacter freundii

Enterobacter aerogenes

Enterobacter sakazakii

Klebsiella oxytoca

Morganella morganii

Pantoea agglomerans

Proteus vulgaris

Providencia rettgeri

Providencia stuartii

Pseudomonas fluorescens

Yersinia pestis

Anaerobic Gram-Positive Bacteria

Clostridium perfringens

Susceptibility Tests

When available, the clinical microbiology laboratory should provide the results of in vitro susceptibility test results for antimicrobial drug products used in the resident hospitals to the physician as periodic reports that describe the susceptibility profile of nosocomial and community-acquired pathogens. These reports should aid the physician in selecting an antibacterial drug product for treatment.

Dilution techniques:

Quantitative methods are used to determine antimicrobial minimal inhibitory concentrations (MICs). These MICs provide estimates of the susceptibility of bacteria to antimicrobial compounds. The MIC values should be determined using a standardized procedure. Standardized procedures are based on a dilution method1, 2, 4 (broth or agar) or equivalent with standardized inoculum concentrations and standardized concentrations of Levofloxacin 1.5.% Amel powder. The MIC values should be interpreted according to the criteria outlined in Table 9.

Diffusion techniques:

Quantitative methods that require measurement of zone diameters also provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. One such standardized procedure2, 3 requires the use of standardized inoculum concentrations. This procedure uses paper disks impregnated with 5 mcg Levofloxacin 1.5.% Amel to test the susceptibility of bacteria to Levofloxacin 1.5.% Amel.

Reports from the laboratory providing results of the standard single-disk susceptibility test with a 5 mcg Levofloxacin 1.5.% Amel disk should be interpreted according to the criteria outlined in Table 9.

A report of Susceptible indicates that the pathogen is likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable. A report of Intermediate indicates that the result should be considered equivocal, and, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where a high dosage of drug can be used. This category also provides a buffer zone which prevents small uncontrolled technical factors from causing major discrepancies in interpretation. A report of Resistant indicates that the pathogen is not likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable; other therapy should be selected.

Quality Control:

Standardized susceptibility test procedures require the use of laboratory controls to monitor and ensure the accuracy and precision of supplies and reagents used in the assay, and the techniques of the individuals performing the test.1,2,3,4 Standard Levofloxacin 1.5.% Amel powder should provide the range of MIC values noted in Table 10. For the diffusion technique using the 5 mcg disk, the criteria in Table 10 should be achieved.


sponsored

References

  1. DailyMed. "LEVOFLOXACIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. NCIt. "Levofloxacin: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
  3. EPA DSStox. "Levofloxacin: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Levofloxacin 1.5.% Amel are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Levofloxacin 1.5.% Amel. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported administration

No survey data has been collected yet


Consumer reviews


There are no reviews yet. Be the first to write one!


Your name: 
Email: 
Spam protection:  < Type 28 here

Information checked by Dr. Sachin Kumar, MD Pharmacology

| Privacy Policy
This site does not supply any medicines. It contains prices for information purposes only.
© 2003 - 2024 ndrugs.com All Rights Reserved