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What is Levofloxacin 1.5.% Takata?
Levofloxacin 1.5.% Takata is in a group of antibiotics called fluoroquinolones (flor-o-KWIN-o-lones). Levofloxacin 1.5.% Takata fights bacteria in the body.
Levofloxacin 1.5.% Takata is used to treat bacterial infections of the skin, sinuses, kidneys, bladder, or prostate. Levofloxacin 1.5.% Takata is also used to treat bacterial infections that cause bronchitis or pneumonia, and to treat people who have been exposed to anthrax or plague.
Levofloxacin 1.5.% Takata may also be used for purposes not listed in this medication guide.
Levofloxacin 1.5.% Takata indications
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Levofloxacin 1.5.% Takata and other antibacterial drugs, Levofloxacin 1.5.% Takata should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Treatment of adults (≥18 years) with mild, moderate and severe infections caused by susceptible strains of the designated microorganisms in the conditions listed as follows. Levofloxacin 1.5.% Takata is indicated when IV administration offers a route of administration advantageous to the patient (eg, patient cannot tolerate an oral dosage form).
Acute maxillary sinusitis due to Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis.
Acute bacterial exacerbation of chronic bronchitis due to Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae or Moraxella catarrhalis.
Nosocomial pneumonia due to methicillin-susceptible Staphylococcus aureus, Pseudomonas aeruginosa, Serratia marcescens, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae or Streptococcus pneumoniae. Adjunctive therapy should be used as clinically indicated. Where Pseudomonas aeruginosa is a documented or presumptive pathogen, combination therapy with an anti-pseudomonal β-lactam is recommended.
Community-acquired pneumonia due to Staphylococcus aureus, Streptococcus pneumoniae [including multi-drug resistant strains (MDRSP)*], Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Chlamydia pneumoniae, Legionella pneumophila or Mycoplasma pneumoniae.
Complicated skin and skin structure infections due to methicillin-susceptible Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes or Proteus mirabilis.
Uncomplicated skin and skin structure infections (mild to moderate) including abscesses, cellulitis, furuncles, impetigo, pyoderma, wound infections, due to Staphylococcus aureus or Streptococcus pyogenes.
Chronic bacterial prostatitis due to Escherichia coli, Enterococcus faecalis or Staphylococcus epidermidis.
Complicated urinary tract infections (mild to moderate) due to Enterococcus faecalis, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis or Pseudomonas aeruginosa.
Acute pyelonephritis (mild to moderate) caused by Escherichia coli.
Uncomplicated urinary tract infections (mild to moderate) due to Escherichia coli, Klebsiella pneumoniae or Staphylococcus saprophyticus.
How should I use Levofloxacin 1.5.% Takata?
Use Levofloxacin 1.5.% Takata tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Levofloxacin 1.5.% Takata tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Levofloxacin 1.5.% Takata tablets refilled.
- Take Levofloxacin 1.5.% Takata tablets by mouth with or without food.
- Drinking extra fluids while you are taking Levofloxacin 1.5.% Takata tablets is recommended. Check with your doctor for instructions.
- Do not take a product that has magnesium, aluminum, calcium, zinc, or iron in it within 2 hours before or 2 hours after you take Levofloxacin 1.5.% Takata tablets. Examples of these products include certain antacids, multivitamins, quinapril, and calcium-fortified orange juice. Check with your doctor or pharmacist if you have a question about whether you should separate Levofloxacin 1.5.% Takata tablets from a certain food or product.
- If you also take sucralfate or didanosine, do not take them within 2 hours before or 2 hours after taking Levofloxacin 1.5.% Takata tablets. Check with your doctor if you have questions.
- Levofloxacin 1.5.% Takata tablets works best if it is taken at the same time each day.
- To clear up your infection completely, take Levofloxacin 1.5.% Takata tablets for the full course of treatment. Keep taking it even if you feel better in a few days.
- Do not miss any doses of Levofloxacin 1.5.% Takata tablets. If you miss a dose of Levofloxacin 1.5.% Takata tablets, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once or more than 1 dose in 1 day.
Ask your health care provider any questions you may have about how to use Levofloxacin 1.5.% Takata tablets.
Uses of Levofloxacin 1.5.% Takata in details
Levofloxacin 1.5.% Takata is used to treat bacterial infections of the respiratory tract, urinary tract, ear, tooth and prostate gland. It is also used to treat skin and soft tissue infections, anthrax and plague.
Levofloxacin 1.5.% Takata description
Each tablet contains Levofloxacin 1.5.% Takata 250 mg as active ingredient corresponding to Levofloxacin 1.5.% Takata hemihydrate 256.23 mg.
Cravit IV also contains the following inactive ingredients: Sodium chloride; sodium hydroxide; hydrochloric acid (qs: pH 4.8) and water for injection for a volume of 100 mL (Na+ concentration: 154 mmol/L).
Levofloxacin 1.5.% Takata is a synthetic broad-spectrum antibacterial agent for oral and IV administration. Chemically, Levofloxacin 1.5.% Takata, a chiral fluorinated carboxyquinolone, is the pure (-)-(S)-enantiomer of the racemic drug substance ofloxacin. Levofloxacin 1.5.% Takata is (-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4 benzoxazine-6-carboxylic acid hemihydrate.
Its empirical formula is C18H20FN3O4·½H2O and its molecular weight is 370.38.
Levofloxacin 1.5.% Takata is a light yellowish-white to yellow-white crystal or crystalline powder. The molecule exists as a zwitterion at the pH conditions in the small intestine. The data demonstrate that from pH 0.6-5.8, the solubility of Levofloxacin 1.5.% Takata is essentially constant (approximately 100 mg/mL). Levofloxacin 1.5.% Takata is considered soluble to freely soluble in this pH range, as defined by USP nomenclature. Above pH 5.8, the solubility increases rapidly to its maximum at pH 6.7 (272 mg/mL) and is considered freely soluble in this range. Above pH 6.7, the solubility decreases and reaches a minimum value (about 50 mg/mL) at a pH of approximately 6.9. Levofloxacin 1.5.% Takata has the potential to form stable coordination compounds with many metal ions. This in vitro chelation potential has the following formation order: A1+3 > Cu+2 > Zn+2 > Mg+2 > Ca+2.
Active ingredient matches for Levofloxacin 1.5.% Takata:
Levofloxacin in Japan.
- DailyMed. "LEVOFLOXACIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailymed/se... (accessed September 18, 2017).
- Wikipedia. "levofloxacin anhydrous: Link to the compound information in Wikipedia.". https://en.wikipedia.org/wiki/Levofloxac... (accessed September 18, 2017).
- PubChem. "LEVOFLOXACIN". https://pubchem.ncbi.nlm.nih.gov/compoun... (accessed September 18, 2017).
- FDA Orange Book. "Patent:6806256: The publication, Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book), identifies drug products approved on the basis of safety and effectiveness by the Food and Drug Administration (FDA) under the Federal Food, Drug, and Cosmetic Act (the Act).". https://www.fda.gov/Drugs/InformationOnD... (accessed September 18, 2017).
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