Lidocaine 2% Epinephrine Normon Dosage

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Dosage of Lidocaine 2% Epinephrine Normon in details

The dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.
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The dosage of 2% Lidocaine 2% Epinephrine Normon solutions (Lidocaine (Lidocaine 2% Epinephrine Normon) HCl and Epinephrine (Lidocaine (Lidocaine 2% Epinephrine Normon) 2% Epinephrine Normon)) depends on the physical status of the patient, the area of the oral cavity to be anesthetized, the vascularity of the oral tissues, and the technique of anesthesia used. The least volume of solution that results in effective local anesthesia should be administered; time should be allowed between injections to observe the patient for manifestations of an adverse reaction. For specific techniques and procedures of a local anesthesia in the oral cavity, refer to standard textbooks.

For most routine dental procedures, 2% Lidocaine 2% Epinephrine Normon with Epinephrine (Lidocaine (Lidocaine 2% Epinephrine Normon) 2% Epinephrine Normon) 1:100,000 (Lidocaine (Lidocaine 2% Epinephrine Normon) HCl 2% with a 1:100,000 Epinephrine (Lidocaine (Lidocaine 2% Epinephrine Normon) 2% Epinephrine Normon) concentration) is preferred. However, when greater depth and a more pronounced hemostasis are required, 2% Lidocaine 2% Epinephrine Normon with Epinephrine (Lidocaine (Lidocaine 2% Epinephrine Normon) 2% Epinephrine Normon) 1:50,000 (Lidocaine (Lidocaine 2% Epinephrine Normon) HCl 2 % with 1:50,000 Epinephrine (Lidocaine (Lidocaine 2% Epinephrine Normon) 2% Epinephrine Normon) concentration) should be used.

Dosage requirements should be determined on an individual basis. In oral infiltration and / or mandibular block, initial dosages of 1.0 - 5.0 mL (1/2 to 21⁄2 cartridges) of 2% Lidocaine 2% Epinephrine Normon (Lidocaine (Lidocaine 2% Epinephrine Normon) HCl 2% solutions with a 1:50,000 or a 1:100,000 Epinephrine (Lidocaine (Lidocaine 2% Epinephrine Normon) 2% Epinephrine Normon) concentration) are usually effective.

In children under 10 years of age, it is rarely necessary to administer more than one-half cartridge (0.9-1.0 mL or 18-20 mg of Lidocaine (Lidocaine 2% Epinephrine Normon)) per procedure to achieve local anesthesia for a procedure involving a single tooth. In maxillary infiltration, this amount will often suffice to the treatment of two or even three teeth. In the mandibular block, however, satisfactory anesthesia achieved with this amount of drug, will allow treatment of the teeth of an entire quadrant. Aspiration is recommended since it reduces the possibility of intravascular injection, thereby keeping the incidence of side effects and anesthetic failures to a minimum. Moreover, injection should always be made slowly.

Maximum recommended dosages for 2% Lidocaine 2% Epinephrine Normon (Lidocaine (Lidocaine 2% Epinephrine Normon) HCl 2% solutions with a 1:50,000 or a 1:100,000 Epinephrine (Lidocaine (Lidocaine 2% Epinephrine Normon) 2% Epinephrine Normon) concentration).

Adult

For normal healthy adults, the amount of Lidocaine (Lidocaine 2% Epinephrine Normon) HCl administered should be kept below 500 mg, and in any case, should not exceed 7 mg/kg (3.2 mg/lb) of body weight.

Pediatric

Pediatric patients : It is difficult to recommend a maximum dose of any drug for pediatric patients since this varies as a function of age and weight. For pediatric patients of less than ten years who have a normal lean body mass and normal body development, the maximum dose may be determined by the application of one of the standard pediatric drug formulas (e.g., Clark's rule). For example, in pediatric patients of five years weighing 50 Ibs, the dose of Lidocaine (Lidocaine 2% Epinephrine Normon) hydrochloride should not exceed 75-100mg when calculated according to Clark's rule. In any case, the maximum dose of Lidocaine (Lidocaine 2% Epinephrine Normon) hydrochloride should not exceed 7 mg/kg (3.2 mg/lb) of body weight.

NOTE :

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever the solution and container permit. Solutions that are discolored and or contain particulate matter should not be used and any unused portion of a cartridge of 2% Lidocaine 2% Epinephrine Normon should be discarded.

Lidocaine 2% Epinephrine Normon interactions

Interactions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Lidocaine 2% Epinephrine Normon, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.
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Lidocaine 2% Epinephrine Normon should be used cautiously in patients with hyperthyroidism, hypertension and cardiac arrhythmias. All vasopressors should be used cautiously in patients taking monoamine oxidase (MAO) inhibitors.

Lidocaine 2% Epinephrine Normon should not be administered concomitantly with other sympathomimetic drugs (such as isoproterenol) because of possible additive effects and increased toxicity.

Combined effects may induce serious cardiac arrhythmias. They may be administered alternately when the preceding effect of other such drug has subsided.

Administration of Epinephrine (Lidocaine (Lidocaine 2% Epinephrine Normon) 2% Epinephrine Normon) to patients receiving cyclopropane or halogenated hydrocarbon general anesthetics such as halothane which sensitize the myocardium, may induce cardiac arrhythmia.. When encountered, such arrhythmias may respond to administration of a beta-adrenergic blocking drug. Lidocaine 2% Epinephrine Normon also should be used cautiously with other drugs (e.g., digitalis, glycosides) that sensitize the myocardium to the actions of sympathomimetic drugs.

Diuretic agents may decrease vascular response to pressor drugs such as Epinephrine (Lidocaine (Lidocaine 2% Epinephrine Normon) 2% Epinephrine Normon).

Lidocaine 2% Epinephrine Normon may antagonize the neuron blockade produced by guanethidine resulting in decreased antihypertensive effect and requiring increased dosage of the latter.


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References

  1. DailyMed. "LIDOCAINE; TETRACAINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "EPINEPHRINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. FDA/SPL Indexing Data. "YKH834O4BH: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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