Lindynette 20 Actions

Rating: 3.55 - 7 review(s)
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Actions of Lindynette 20 in details

The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.

Pharmacology: The hormonal components of Lindynette 20 inhibit ovulation by suppressing gonadotropin release. Secondary mechanisms which may contribute to the effectiveness of Lindynette 20 as a contraceptive include changes in the cervical mucus (which increase the difficulty of sperm penetration) and in the endometrium (which reduce the likelihood of implantation).

Pharmacokinetics: Ethinyl estradiol and Gestodene (Lindynette 20) are rapidly and almost completely absorbed from the gastrointestinal tract.

Peak plasma levels of each drug are reached within 1-2 hours. Post maximum concentration curves show 2 phases with half-lives of 1 and 15 hours in the case of Gestodene (Lindynette 20) and 1-3 and approximately 24 hours in the case of ethinyl estradiol.

After oral administration, Gestodene (Lindynette 20), unlike ethinyl estradiol is not subject to first-pass metabolism. Following oral administration, Gestodene (Lindynette 20) is completely bioavailable, ethinyl estradiol about 40%.

Gestodene (Lindynette 20) is extensively plasma protein bound to sex hormone binding globulin (SHBG). Ethinyl estradiol is bound in plasma to albumin and enhances the binding capacity of SHBG.

The elimination half-life of ethinyl is approximately 25 hours. It is primarily metabolized by aromatic hydroxylation but a wide variety of hydroxylated and methylated metabolites are formed, and these are present both free and as conjugates with glucuronide and sulfate. Conjugated ethinyl estradiol is excreted in bile and subject to enterohepatic recirculation. About 40% of the drug is excreted in the urine and 60% is eliminated in the feces.

The elimination half-life of Gestodene (Lindynette 20) is approximately 16-18 hours after multiple oral doses. The drug is primarily metabolized by reduction of the A ring followed by glucuronidation. About 50% of Gestodene (Lindynette 20) is excreted in the urine and 33% is eliminated in the feces.

Cycle Control in Clinical Trials: In clinical trials with Lindynette 20 including 14,281 cycles of treatment, the overall incidence of spotting was 5% and breakthrough bleeding was 0.7%.

Amenorrhea (absence of expected withdrawal bleeding), occurred in 68 of 14,281 treatment cycles, an incidence of 0.5%.

Influence of Missed Tablets: Table 2 shows that the rate of intermenstrual bleeding is increased by intake errors, ie when one or more tablets are omitted.

Lindynette 20 pharmacology

Pharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.

Lindynette 20 is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. Lindynette 20 (through catecholamine elevation) may also indirectly affect leptin levels in the brain. It is theorized that diethylpropion can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as neuropeptide Y. This peptide initiates eating, decreases energy expenditure, and increases fat storage.


  1. DailyMed. "ETHINYL ESTRADIOL; NORETHINDRONE ACETATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. NCIt. "Ethinyl Estradiol: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". (accessed September 17, 2018).
  3. EPA DSStox. "Gestodene: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". (accessed September 17, 2018).


The results of a survey conducted on for Lindynette 20 are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Lindynette 20. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

6 consumers reported administration

When best can I take Lindynette 20, on an empty stomach, before or after food? website users have also released a report stating that Lindynette 20 should be taken After food. In any case, this may not be the right description on how you ought to take this Lindynette 20. Kindly visit your doctor for more medical advice in this regard. Click here to see other users view on when best the Lindynette 20 can be taken.
After food4
Empty stomach1
With a meal1

Consumer reviews

Teri23 Sep 2017 09:39
I have recently started this b/c pill however it is causing my period to last longer than normal....I'm not liking it

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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