Linezolid Fresenius Kabi Pregnancy

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Pregnancy of Linezolid Fresenius Kabi in details

Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
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Information related to Linezolid Fresenius Kabi use during pregnancy is limited (Jaspard 2017; Mercieri 2010). Due to pregnancy-induced physiologic changes, some pharmacokinetic properties of Linezolid Fresenius Kabi may be altered (van Kampenhout 2017).

Linezolid Fresenius Kabi breastfeeding

When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!

Drug levels in breast milk are likely effective against staphylococcal strains found in mastitis. Based on limited data, the maximum dose an infant would receive via breast milk would be much less than the usual infant dose (maximum infant dose: 30 mg/kg/day). Milk samples were collected at 10 time points over 24 hours from a 32-year-old lactating woman after a single 600 mg oral dose. The peak breast milk drug level (12.4 mg/L) was reached 2 hours after dosing. Milk levels decreased with a half-life of 6.5 hours and were detectable up to 24 hours after dosing. Based on this data, an exclusively breastfed infant would receive about 2 mg/kg/day (estimated maximum) from the maximum recommended maternal dose. A woman was treated with 600 mg orally every 12 hours for methicillin-resistant Staphylococcus aureus mastitis. Milk was pumped from both breasts 8 times daily on the 1st and 14th day of therapy. Peak breast milk drug levels averaged 9.75 and 18.73 mg/L on day 1 and 14, respectively. According to author calculation, a fully breastfed infant would receive 7.85% and 15.61% of the weight-adjusted maternal dose on day 1 and 14, respectively. Based on the milk level on day 14, a fully breastfed infant would receive 1.84 mg/kg/day.

LactMed: Use of this drug is not a reason to discontinue breastfeeding if it is required by the mother; alternate therapy may be preferred, especially if the nursing infant is premature or younger than 1 month. -According to some authorities, breastfeeding is not recommended during use of this drug and should be discontinued before starting therapy. -According to other authorities, caution is recommended. Excreted into human milk: Yes Comments: -The effects in the nursing infant are unknown; according to some experts, the nursing infant should be monitored for possible effects on the gastrointestinal tract (e.g., diarrhea, vomiting, candidiasis [thrush, diaper rash]).

See references

References for pregnancy information

  1. Cerner Multum, Inc. "Australian Product Information." O 0
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. "Product Information. Zyvox (Linezolid Fresenius Kabi)" Pharmacia and Upjohn, Kalamazoo, MI.

References for breastfeeding information

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  2. "Product Information. Zyvox (Linezolid Fresenius Kabi)" Pharmacia and Upjohn, Kalamazoo, MI.
  3. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):
  4. Cerner Multum, Inc. "Australian Product Information." O 0


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References

  1. DailyMed. "LINEZOLID: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubMed Health. "Zyvox: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
  3. Human Metabolome Database (HMDB). "Linezolid: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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