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Linezolid Pregnancy |
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Information related to Linezolid use during pregnancy is limited (Jaspard 2017; Mercieri 2010). Due to pregnancy-induced physiologic changes, some pharmacokinetic properties of Linezolid may be altered (van Kampenhout 2017).
Drug levels in breast milk are likely effective against staphylococcal strains found in mastitis. Based on limited data, the maximum dose an infant would receive via breast milk would be much less than the usual infant dose (maximum infant dose: 30 mg/kg/day). Milk samples were collected at 10 time points over 24 hours from a 32-year-old lactating woman after a single 600 mg oral dose. The peak breast milk drug level (12.4 mg/L) was reached 2 hours after dosing. Milk levels decreased with a half-life of 6.5 hours and were detectable up to 24 hours after dosing. Based on this data, an exclusively breastfed infant would receive about 2 mg/kg/day (estimated maximum) from the maximum recommended maternal dose. A woman was treated with 600 mg orally every 12 hours for methicillin-resistant Staphylococcus aureus mastitis. Milk was pumped from both breasts 8 times daily on the 1st and 14th day of therapy. Peak breast milk drug levels averaged 9.75 and 18.73 mg/L on day 1 and 14, respectively. According to author calculation, a fully breastfed infant would receive 7.85% and 15.61% of the weight-adjusted maternal dose on day 1 and 14, respectively. Based on the milk level on day 14, a fully breastfed infant would receive 1.84 mg/kg/day.
LactMed: Use of this drug is not a reason to discontinue breastfeeding if it is required by the mother; alternate therapy may be preferred, especially if the nursing infant is premature or younger than 1 month. -According to some authorities, breastfeeding is not recommended during use of this drug and should be discontinued before starting therapy. -According to other authorities, caution is recommended. Excreted into human milk: Yes Comments: -The effects in the nursing infant are unknown; according to some experts, the nursing infant should be monitored for possible effects on the gastrointestinal tract (e.g., diarrhea, vomiting, candidiasis [thrush, diaper rash]).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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