Liometacen Uses

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Liometacen indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Oral

Pain and inflammation associated with musculoskeletal and joint disorders

Adult: Initially, 25 mg bid or tid, increased if necessary by 25-50 mg at wkly intervals to 150-200 mg daily.

Oral

Acute gout

Adult: 150-200 mg daily in divided doses until signs and symptoms subside.

Oral

Dysmenorrhoea

Adult: 75 mg daily.

Intravenous

Closure of patent ductus arteriosus

Child: Given as 3 IV doses at 12-24 hr intervals infused over 20-30 min. <48 hr old 0.2 mg/kg initially followed by 2 further doses of 0.1 mg/kg; 2-7 days old 3 doses of 0.2 mg/kg; >7 days old 0.2 mg/kg initially followed by 2 further doses of 0.25 mg/kg. 2nd course may be repeated if ductus remains open or re-opens 48 hr after the 1st course. Surgery may be required if neonate is unreponsive to 2 courses of treatment.

Reconstitution: Add 1 or 2 mL of sterile water for inj or NaCl 0.9% inj to Liometacen 1 mg to provide soln containing approx 1 or 0.5 mg/mL respectively. Further dilution of the reconstituted inj in IV infusions is not recommended.

Incompatibility: Y-site: Amino acid inj, Ca gluconate, cimetidine, dobutamine, dopamine, gentamicin, levofloxacin, pantoprazole, tobramycin.

Ophthalmic

Inhibition of intraoperative miosis

Adult: 4 drops 1 day pre-op and 4 drops 3 hr pre-op.

Ophthalmic

Prophylaxis and reduction of postoperative ocular inflammation

Adult: 1 drop 4-6 times daily.

Ophthalmic

Post-photorefractive keratectomy pain

Adult: 1 drop 4 times daily for a few days post-op.

Rectal

Pain and inflammation associated with musculoskeletal and joint disorders

Adult: As supp: 100 mg to be inserted at night and repeated in the morning if necessary.

Liometacen description

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A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Liometacen is considered an antioxidant.

Liometacen dosage

Oral

Pain and inflammation associated with musculoskeletal and joint disorders

Adult: Initially, 25 mg bid or tid, increased if necessary by 25-50 mg at wkly intervals to 150-200 mg daily.

Oral

Acute gout

Adult: 150-200 mg daily in divided doses until signs and symptoms subside.

Oral

Dysmenorrhoea

Adult: 75 mg daily.

Intravenous

Closure of patent ductus arteriosus

Child: Given as 3 IV doses at 12-24 hr intervals infused over 20-30 min. <48 hr old 0.2 mg/kg initially followed by 2 further doses of 0.1 mg/kg; 2-7 days old 3 doses of 0.2 mg/kg; >7 days old 0.2 mg/kg initially followed by 2 further doses of 0.25 mg/kg. 2nd course may be repeated if ductus remains open or re-opens 48 hr after the 1st course. Surgery may be required if neonate is unreponsive to 2 courses of treatment.

Reconstitution: Add 1 or 2 mL of sterile water for inj or NaCl 0.9% inj to Liometacen 1 mg to provide soln containing approx 1 or 0.5 mg/mL respectively. Further dilution of the reconstituted inj in IV infusions is not recommended.

Incompatibility: Y-site: Amino acid inj, Ca gluconate, cimetidine, dobutamine, dopamine, gentamicin, levofloxacin, pantoprazole, tobramycin.

Ophthalmic

Inhibition of intraoperative miosis

Adult: 4 drops 1 day pre-op and 4 drops 3 hr pre-op.

Ophthalmic

Prophylaxis and reduction of postoperative ocular inflammation

Adult: 1 drop 4-6 times daily.

Ophthalmic

Post-photorefractive keratectomy pain

Adult: 1 drop 4 times daily for a few days post-op.

Rectal

Pain and inflammation associated with musculoskeletal and joint disorders

Adult: As supp: 100 mg to be inserted at night and repeated in the morning if necessary.

Liometacen interactions

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May increase plasma levels of methotrexate. Increased risk of GI bleeding w/ warfarin. May reduce hypotensive effects of hydralazine, furosemide, β-blockers (e.g. atenolol, propranolol, oxprenolol), or thiazide diuretics. Increased risk of hyperkalaemia w/ K-sparing diuretics, ACE inhibitors, K supplements. May increase nephrotoxic effects of ciclosporin or triamterene. Increase plasma concentration w/ probenecid. May increase plasma levels of aminoglycoside (e.g. amikacin, gentamicin) in premature neonates. May enhance antipsychotic effect (e.g. severe drowsiness and confusion) of haloperidol. Al- or Mg-containing antacids may reduce GI disorders of Liometacen.

Potentially Fatal: Diflunisal decreases renal clearance and increases plasma concentrations of Liometacen which leads to fatal GI haemorrhage.

Liometacen side effects

CHF, tachycardia, chest pain, arrhythmia, palpitations, HTN, pulmonary HTN, oedema; GI disturbances (e.g. nausea, vomiting, dyspepsia, indigestion, heartburn, epigastric pain); headache, frontal throbbing, apparent swelling of the temporal vessels, tinnitus, ataxia, tremor, dizziness, insomnia, vertigo, lightheadedness, confusion, psychiatric disturbances; haemolytic anaemia, bone marrow depression, agranulocytosis, leucopenia, thrombocytopenic purpura; corneal deposits and retinal disturbances, acute interstitial nephritis w/ haematuria, proteinuria, pruritus, urticaria, rash, macular and morbilliform eruptions, apnoea and exacerbation of pulmonary infection.

Potentially Fatal: Anaphylactic reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, aplastic anaemia, jaundice and fatal fulminant hepatitis, liver necrosis, hepatic failure, fulminant necrotising fasciitis, renal failure, MI, stroke, GI ulceration, perforation and haemorrhage.

Liometacen contraindications

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Known hypersensitivity to Liometacen, aspirin or other NSAIDs. Neonates w/ congenital heart disease when patency of the ductus arteriosus is needed for adequate pulmonary or systemic blood flow (e.g. neonates w/ pulmonary atresia, severe tetralogy of Fallot or severe coarctation of the aorta). Neonates w/ proven or suspected untreated infection, necrotising enterocolitis, impaired renal function, active bleeding (e.g. intraventricular haemorrhage or GI bleeding), thrombocytopenia or underlying coagulation defect. Patient w/ history of proctitis or recent rectal bleeding. History of asthma, urticaria, allergic-type reactions. Treatment of perioperative pain in the setting of CABG surgery. Concurrent use w/ diflunisal.

Active ingredient matches for Liometacen:

Indometacin in Cyprus, Egypt, Italy, Jordan, Kuwait, Lebanon, Saudi Arabia, Syria.

Indomethacin

Meglumine in Thailand.

Meglumine indometacin in Thailand.

Meglumine indomethacin in Thailand.


Unit description / dosage (Manufacturer)Price, USD
Liometacen 50 mg x 6's

List of Liometacen substitutes (brand and generic names):

Li Shin Ning 25 mg
1 mg x 1's (Alliance Overseas)
Lygacin 1mg VIAL / 1 (Alliance Overseas)$ 9.11
Lygacin 1mg VIAL / 1 (Alliance Overseas)$ 9.11
M-CIN 8 mg/1 mL x 50 mL (MacroPhar)
400 mg x 5's (MacroPhar)$ 5.24
M-Cin 400mg FC-TAB / 5 (MacroPhar)$ 5.27
M-CIN TABLET 1 strip / 5 tablets each (MacroPhar)$ 1.67
M-CIN topical spray 8 mg/mL 50 mL x 1's (MacroPhar)
M-CIN film-coated tab 400 mg x 5's (MacroPhar)$ 5.27
M-Cin 400mg FC-TAB / 5 (MacroPhar)$ 5.27
M-Cin 400mg Tablet (MacroPhar)$ 0.33
Capsule; Oral; Indometacin 25 mg (Silanes)
Capsules; Oral; Indometacin 25 mg (Silanes)
Capsule; Oral; Indometacin 50 mg
Capsules; Oral; Indometacin 50 mg
Meglumine 500 mg
Meglumine 500 mg
Meglumine 500 mg
Meko Indocin 25 25 mg x 1 Blister x 10 Tablet
Meko Indocin 25 25 mg x 1 Bottle x 100 Tablet
Mekoindocin 25 mg x 2 Blister x 10 Tablet
Methacid 25 mg x 1's
Methacid 25 mg
Methacin / Honten 25 mg x 1000's (Unicure)
Methacin / Purzer 1 % x 5 g (Unicure)

References

  1. DailyMed. "INDOMETHACIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "indomethacin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "indomethacin". http://www.drugbank.ca/drugs/DB00328 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Liometacen are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Liometacen. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


1 consumer reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by ndrugs.com website users about whether the Liometacen drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users%
Not expensive1
100.0%


1 consumer reported time for results

To what extent do I have to use Liometacen before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 2 days and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Liometacen. To get the time effectiveness of using Liometacen drug by other patients, please click here.
Users%
2 days1
100.0%


4 consumers reported age

Users%
46-602
50.0%
1-51
25.0%
30-451
25.0%


Consumer reviews


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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