Liorin Uses

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Liorin indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Oral

Agitation

Adult: 100-200 mg 4 times daily.

Elderly: Initially, 25 mg, may increase to 50 mg 4 times daily, if necessary.

Oral

Nausea and vomiting

Adult: 25-50 mg every 4-6 hr. May also be given via IM inj.

Parenteral

Agitation

Adult: 50 mg IM or slow IV inj (concentrations not >25 mg/ml), repeated if necessary after 6-8 hr.

Elderly: 25 mg administered IM.

Liorin description

A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. Liorin is not approved for use in the United States.

Liorin dosage

Liorin Dosage

Applies to the following strengths: 50 mg; 25 mg; 50 mg/mL; 25 mg/mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Agitated State

IM: 50-150 mg, depending on the degree of severity.

May give additional doses in 30 minutes up to a total of 300 mg. Once control is obtained, administer orally.

Oral or IM: 10-200 mg every 4-6 hours.

Usual Pediatric Dose for Psychosis

Child > 12 years:

Oral or IM: 10-25 mg every 4-6 hours.

Dose Adjustments

In less severe disturbances, adjust dose downward.

Dialysis

Liorin is not dialyzable.

Other Comments

The total daily dose should not exceed 1000 mg.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

More about Liorin

Related treatment guides

Liorin interactions

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The concomitant administration of this product with other medication such as central nervous system depressants (including alcohol and anaesthetics) or antihypertensives, anticholinergic or dopaminergic drugs may result in accentuation of their effects, while potentiation of action may also occur with monoamine oxidase inhibitors, antidepressants and analgesics. Liorin may impair the effects of anticonvulsants. Liorin may affect the control of diabetes. Undesirable anticholinergic effects can be enhanced by anti-parkinson or other anticholinergic drugs.

The concomitant administration of this product with myelosuppressive drugs (carbamazepine, co-trimoxazole, chloramphenicol, sulphonamides, pyralizone analgesics (e.g. azapropazone), penicillamine and cytotoxics) increases the risk of toxicity.

Lithium administration will result in an increased risk of extrapyramidal effects and the possibility of neurotoxicity.

Sotalol administration will result in an increased risk of ventricular arrhythmia.

Concomitant use of Liorin with drugs known to prolong the QT interval may increase the risk of ventricular arrhythmias, including torsade de pointes. Therefore concomitant use of these products is not recommended. Examples include certain antiarrhythmics, such as those of Class 1A (such as quinidine, disopyramide and procainamide) and Class III (such as amiodarone, sotalol and dofetilide), certain antimicrobials (sparfloxacin, moxifloxacin, erythromycin IV), tricyclic antidepressants (such as amitriptyline), certain tetracyclic antidepressants (such as maprotiline), other neuroleptics (e.g. phenothiazines, pimozide, sertindole and haloperidol), certain antihistamines (such as terfenadine), cisapride, bretylium and certain antimalarials such as quinine and mefloquine. This list is not comprehensive.

Concurrent use of drugs causing electrolyte imbalance is not recommended. Diuretics, in particular those causing hypokalemia, should be avoided but, if necessary, potassium-sparing diuretics are preferred.

Liorin side effects

See also:
What are the possible side effects of Liorin?

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Liorin is a member of the phenothiazine group of drugs and the side effects associated with that group have been noted. These include drowsiness, sedation, dry mouth, nasal stuffiness. Other possible anticholinergic side effects are blurred vision, tachycardia, constipation and urinary hesitancy or retention when due to enlarged prostate.

Confusional states or epileptic fits can occur. Extrapyramidal symptoms and hyperpyrexia have been reported. Neuroleptic malignant syndrome (hyperthermia, rigidity, autonomic dysfunction and altered consciousness) may occur with any neuroleptic.

Sexual function may be impaired. Agranulocytosis and transient leucopenia have rarely been reported. Allergic skin reactions and photosensitivity have also been reported.

Liorin rarely causes obstructive jaundice associated with stasis in biliary canaliculi. Liorin treatment should then be withdrawn and not given again. Transient abnormalities of liver function tests may occur without jaundice.

Some individuals may be susceptible to the drug in low dosage and show paradoxical effects of excitement, agitation or insomnia and other minor side effects. The elderly are particularly susceptible to side effects of Liorin, especially to the sedative, hypotensive and temperature regulation effects. These effects may be dose related.

Withdrawal symptoms, including nausea, vomiting, sweating, insomnia, recurrence of psychotic symptoms and involuntary movement disorders have been noted.

Phenothiazines can produce ECG changes with prolongation of QT interval and T-wave changes, ventricular arrhythmias (VF, VT (rare)), sudden unexplained death, cardiac arrest and Torsades de pointes have been reported

Cases of venous thromboembolism, including cases of pulmonary embolism and cases of deep vein thrombosis have been reported with antipsychotic drugs – Frequency unknown

Liorin contraindications

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Use in patients hypersensitive to the active ingredient or other phenothiazines.

Use in patients in coma

Use in patients with bone marrow depression

Use in patients with phaeochromocytoma

Use during lactation

Do not use during pregnancy, especially during the first three months, unless there are compelling reasons.

Active ingredient matches for Liorin:

Promazine in Croatia (Hrvatska).


List of Liorin substitutes (brand and generic names)

Sort by popularity
Unit description / dosage (Manufacturer)Price, USD
Dragee; Oral; Promazine Hydrochloride 25 mg (VHB)
Dragee; Oral; Promazine Hydrochloride 50 mg (VHB)
Dragee; Oral; Promazine Hydrochloride 100 mg (VHB)
PRAZINE Capsule/ Tablet / 600mg / 8 units (VHB)$ 5.40
Prazine 600mg TAB / 20 (VHB)$ 13.49
600 mg x 20's (VHB)$ 13.49
PRAZINE tab 600 mg x 5's (VHB)$ 3.37
Proma 100 mg x 100's$ 10.91
Proma 200 mg x 100's
Syrup; Oral; Promazine Hydrochloride 25 mg / 5 ml
Syrup; Oral; Promazine Hydrochloride 50 mg / 5 ml
Injectable; Injection; Promazine Hydrochloride 25 mg / ml
Injectable; Injection; Promazine Hydrochloride 50 mg / ml
Chlorpromazine 25 mg/ml amp$ 8.04
Chlorpromazine 200 mg tablet$ 1.05
Chlorpromazine Hcl 25 mg/ml$ 0.88
Chlorpromazine 100 mg tablet$ 0.39
Novo-Chlorpromazine 100 mg Tablet$ 0.35
Chlorpromazine 10 mg tablet$ 0.32
Chlorpromazine 50 mg tablet$ 0.30
Novo-Chlorpromazine 50 mg Tablet$ 0.21
Novo-Chlorpromazine 25 mg Tablet$ 0.18
Chlorpromazine 25 mg tablet$ 0.17
Promazine / amp 25 mg/1 mL x 2 mL x 10's

References

  1. PubChem. "promazine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "promazine". http://www.drugbank.ca/drugs/DB00420 (accessed September 17, 2018).
  3. DTP/NCI. "promazine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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