• Liothyronin indications
• Uses of Liothyronin in details
• Liothyronin description
• Liothyronin dosage
• Liothyronin interactions
• Liothyronin side effects
• Liothyronin contraindications

What is Liothyronin?

Liothyronin is a man-made form of a hormone that is normally produced by your thyroid gland to regulate the body's energy and metabolism. Liothyronin is given when the thyroid does not produce enough of this hormone on its own.

Liothyronin treats hypothyroidism (low thyroid hormone). Liothyronin is also used to treat or prevent goiter (enlarged thyroid gland), and is also given as part of a medical tests for thyroid disorders.

Liothyronin should not be used to treat obesity or weight problems.

Liothyronin may also be used for purposes not listed in this medication guide.

Liothyronin indications

Thyroid hormone drugs are indicated:

As replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. This category includes cretinism, myxedema and ordinary hypothyroidism in patients of any age (pediatric patients, adults, the elderly), or state (including pregnancy); primary hypothyroidism resulting from functional deficiency, primary atrophy, partial or total absence of thyroid gland, or the effects of surgery, radiation, or drugs, with or without the presence of goiter; and secondary (pituitary) or tertiary (hypothalamic) hypothyroidism.

As pituitary thyroid-stimulating hormone (TSH) suppressants, in the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute or chronic lymphocytic thyroiditis (Hashimoto's) and multinodular goiter.

As diagnostic agents in suppression tests to differentiate suspected mild hyperthyroidism or thyroid gland autonomy.

Liothyronin (Liothyronin sodium) Tablets can be used in patients allergic to desiccated thyroid or thyroid extract derived from pork or beef.

How should I use Liothyronin?

Use Liothyronin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Liothyronin is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Liothyronin at home, a health care provider will teach you how to use it. Be sure you understand how to use Liothyronin. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
• Do not use Liothyronin if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
• If you miss a dose of Liothyronin, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Liothyronin.

Uses of Liothyronin in details

Use: Labeled Indications

Thyroid disorders:

Oral: Replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism; adjunct to surgery and radioiodine therapy in the management of well-differentiated thyroid cancer; a diagnostic agent in suppression tests to differentiate suspected mild hyperthyroidism or thyroid gland autonomy.

Limitations of use: Not indicated for suppression of benign thyroid nodules and nontoxic diffuse goiter in iodine-sufficient patients; not indicated for treatment of hypothyroidism during the recovery phase of subacute thyroiditis.

Myxedema coma/precoma: IV: Treatment of myxedema coma/precoma

Note: May be used in patients allergic to desiccated thyroid or thyroid extract derived from pork or beef.

Off Label Uses

Antidepressant augmentation

Augmentation for treatment resistant depression: Data from a meta-analysis supports the use of Liothyronin in depression refractory to tricyclic antidepressants. Additional data may be necessary to further define the role of Liothyronin in this setting.

Liothyronin description

The L-triiodothyronine (T3, Liothyronin) thyroid hormone is normally synthesized and secreted by the thyroid gland in much smaller quantities than L-tetraiodothyronine (T4, levothyroxine, L-thyroxine). Most T3 is derived from peripheral monodeiodination of T4 at the 5 position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3. [PubChem]

Liothyronin dosage

Liothyronin Dosage

Generic name: Liothyronin sodium 10ug in 1mL

Dosage form: injection

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Adults

Myxedema coma is usually precipitated in the hypothyroid patient of long standing by intercurrent illness or drugs such as sedatives and anesthetics and should be considered a medical emergency. Therapy should be directed at the correction of electrolyte disturbances, possible infection, or other intercurrent illness in addition to the administration of intravenous Liothyronin (T3). Simultaneous glucocorticosteroids are required.

Liothyronin (Liothyronin sodium injection) (T3) is for intravenous administration only. It should not be given intramuscularly or subcutaneously.

• Prompt administration of an adequate dose of intravenous Liothyronin (T3) is important in determining clinical outcome.

• Initial and subsequent doses of Liothyronin should be based on continuous monitoring of the patient's clinical status and response to therapy.

• Liothyronin doses should normally be administered at least four hours–and not more than 12 hours–apart.

• Administration of at least 65 mcg/day of intravenous Liothyronin (T3) in the initial days of therapy was associated with lower mortality.

• There is limited clinical experience with intravenous Liothyronin (T3) at total daily doses exceeding 100 mcg/day.

No controlled clinical studies have been done with Liothyronin. The following dosing guidelines have been derived from data analysis of myxedema coma/precoma case reports collected by SmithKline Beecham Pharmaceuticals since 1963 and from scientific literature since 1956.

An initial intravenous Liothyronin dose ranging from 25 mcg to 50 mcg is recommended in the emergency treatment of myxedema coma/precoma in adults. In patients with known or suspected cardiovascular disease, an initial dose of 10 mcg to 20 mcg is suggested. However, both the initial dose and subsequent doses should be determined on the basis of continuous monitoring of the patient's clinical condition and response to Liothyronin therapy. Normally at least four hours should be allowed between doses to adequately assess therapeutic response and no more than 12 hours should elapse between doses to avoid fluctuations in hormone levels. Caution should be exercised in adjusting the dose due to the potential of large changes to precipitate adverse cardiovascular events. Review of the myxedema case reports indicates decreased mortality in patients receiving at least 65 mcg/day in the initial days of treatment. However, there is limited clinical experience at total daily doses above 100 mcg. See PRECAUTIONS–Drug Interactions for potential interactions between thyroid hormones and digitalis and vasopressors.

Pediatric Use

There is limited experience with Liothyronin in the pediatric population. Safety and effectiveness in pediatric patients have not been established.

Switching to

Oral Therapy

Oral therapy should be resumed as soon as the clinical situation has been stabilized and the patient is able to take oral medication. When switching a patient to Liothyronin sodium tablets from Liothyronin, discontinue Liothyronin, initiate oral therapy at a low dosage, and increase gradually according to the patient's response.

If L-thyroxine rather than Liothyronin sodium is used in initiating oral therapy, the physician should bear in mind that there is a delay of several days in the onset of L-thyroxine activity and that intravenous therapy should be discontinued gradually.

More about Liothyronin (Liothyronin)

• Side Effects
• During Pregnancy or Breastfeeding
• Dosage Information
• Drug Interactions
• Support Group
• 0 Reviews - Add your own review/rating
• Generic Availability

Consumer resources

• Liothyronin
• Liothyronin (Advanced Reading)

• Other brands: Liothyronin

Professional resources

• Liothyronin (FDA)
• Liothyronin Sodium (AHFS Monograph)

Related treatment guides

• Hypothyroidism, After Thyroid Removal
• Myxedema
• Myxedema Coma
• Thyroid Suppression Test
• TSH Suppression
• More (1) »

Liothyronin interactions

See also:
What other drugs will affect Liothyronin?

Reduced absorption with iron, colestyramine, colestipol, aluminium- and magnesium-containing antacids, calcium carbonate, simethicone, sucralfate. May alter requirements of antidiabetic drugs. Reduced efficacy of thyroid replacement therapy with imatinib. Reduced serum levels with amiodarone, carbamazepine, phenytoin, phenobarbital, rifampicin, oestrogens.

Potentially Fatal: Increased therapeutic and toxic effects of Liothyronin and TCAs. May change hypoprothrombinaemic response to warfarin and other oral anticoagulants (markedly increased response during replacement). Increased risk of significant hypertension and tachycardia with ketamine.

Liothyronin side effects

See also:
What are the possible side effects of Liothyronin?

Applies to Liothyronin: oral tablet

Other dosage forms:

• intravenous injectable, intravenous solution

In addition to its needed effects, some unwanted effects may be caused by Liothyronin (the active ingredient contained in Liothyronin). In the event that any of these side effects do occur, they may require medical attention.

If any of the following symptoms of overdose occur while taking Liothyronin, get emergency help immediately:

• Arm, back or jaw pain
• changes in appetite
• changes in menstrual periods
• chest pain or discomfort
• chest tightness or heaviness
• cold clammy skin
• confusion
• decreased urine output
• diarrhea
• dilated neck veins
• dizziness
• extreme fatigue
• fainting
• fast, slow, pounding, or irregular heartbeat or pulse
• fever
• hand tremors
• headache
• increased bowel movements
• irregular breathing
• irritability
• leg cramps
• lightheadedness
• menstrual changes
• nausea
• nervousness
• sensitivity to heat
• shortness of breath
• sweating
• swelling of face, fingers, feet, or lower legs
• troubled breathing
• trouble sleeping
• vomiting
• weak pulse
• weight gain
• weight loss
• wheezing

Liothyronin contraindications

See also:
What is the most important information I should know about Liothyronin?

Since thyroid hormone occurs naturally in the body, almost anyone can take Liothyronin. However, you may not be able to use this medication if you have a thyroid disorder called thyrotoxicosis, or an adrenal gland problem that is not controlled by treatment.

Before taking Liothyronin, tell your doctor if you have heart disease, angina (chest pain), coronary artery disease, congestive heart failure, diabetes, or problems with your pituitary or adrenal glands.

Tell your doctor if you are pregnant or breast-feeding.

To be sure this medication is helping your condition, your blood may need to be tested often. Visit your doctor regularly.

Keep using this medicine as directed, even if you feel well. You may need to take thyroid medication for the rest of your life.

Call your doctor if you notice any signs of thyroid toxicity, such as chest pain, fast or pounding heartbeats, feeling hot or nervous, or sweating more than usual.

Active ingredient matches for Liothyronin:

Liothyronine in Norway, Sweden.

List of Liothyronin substitutes (brand and generic names)	Sort by popularity
Unit description / dosage (Manufacturer)	Price, USD
Dispon (Italy)
Liothyronine (Costa Rica, Dominican Republic, El Salvador, Guatemala, Honduras, Mexico, Panama)
Tablet; Oral; Liothyronine Sodium 0.025 mg
Tablet; Oral; Liothyronine Sodium 0.05 mg
Tablet; Oral; Liothyronine Sodium 0.005 mg
Triostat 10 mcg/ml vial	$ 627.90
Cytomel 50 mcg tablet	$ 1.89
Liothyronine Sodium 50 mcg tablet	$ 1.69
Liothyronine sod 50 mcg tablet	$ 1.62
Cytomel 25 mcg tablet	$ 1.20
Cytomel 5 mcg Tablet	$ 0.89
Liothyronine Sodium 25 mcg tablet	$ 1.09
Liothyronine sod 25 mcg tablet	$ 1.06
Liothyronine Sodium 5 mcg tablet	$ 0.84
Liothyronine sod 5 mcg tablet	$ 0.81
Liothyronine Amdipharm (United Kingdom)
Liothyronine natrium Global Farma (Netherlands)
Liothyronine Sodium Amdipharm (United Kingdom)
Liothyronine Sodium Central Procurement (Malta)
Liothyronine Sodium Coastal (United States)
Liothyronine Sodium Goldshield (Malta)
Liothyronine Sodium Mercury (Malta)
Liothyronine Sodium Mylan (United States)
Liothyronine Sodium X-Gen (United States)
Liothyroninenatrium ERC (Netherlands)
Liotir (Italy)
Liotironina Dispert (Uruguay)
Liotironina Sodica L.CH. (Chile)
Neo-Tiroimade (Portugal)
QG (Mexico)
T3 (Greece)
Tertroxin (Australia, Czech Republic, South Africa, United Kingdom)
Tablet; Oral; Liothyronine Sodium 20 mcg (Aspen Pharmacare)
Tetroxin (Australia)
Thybon 100 Henning (Germany)
Thybon 20 Henning (Germany)
Thybon Henning (Germany)
Thyreotom (Czech Republic)
Tablet; Oral; Levothyroxine 0.04 mg; Liothyronine 0.01 mg (Berlin-chemie)
Thyronamin (Japan)
Thyrotardin (Germany)
Injectable; Injection; Liothyronine Sodium 0.1 mg
Thyrotardin N (Germany)
Ti-Tre (Italy)
Tiromel (Turkey)
Titre (Italy)
See 67 substitutes for Liothyronin

References

1. PubChem. "liothyronine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
2. DrugBank. "liothyronine". http://www.drugbank.ca/drugs/DB00279 (accessed September 17, 2018).
3. MeSH. "MeSH Tree: MeSH (Medical Subject Headings) is the NLM controlled vocabulary thesaurus used for indexing articles for PubMed.". http://www.nlm.nih.gov/mesh/meshhome... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Liothyronin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Liothyronin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology