Lithium Carbonate Zensei Yakuhin Uses

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What is Lithium Carbonate Zensei Yakuhin?

Lithium Carbonate Zensei Yakuhin is used to treat mania that is part of bipolar disorder (manic-depressive illness). It is also used on a daily basis to reduce the frequency and severity of manic episodes. Manic-depressive patients experience severe mood changes, ranging from an excited or manic state (e.g., unusual anger or irritability or a false sense of well-being) to depression or sadness.

It is not known how Lithium Carbonate Zensei Yakuhin works to stabilize a person's mood. However, it does act on the central nervous system. It helps you to have more control over your emotions and helps you cope better with the problems of living.

It is important that you and your family understand all the effects of Lithium Carbonate Zensei Yakuhin. These effects depend on your individual condition and response and the amount of Lithium Carbonate Zensei Yakuhin you use. You also must know when to contact your doctor if there are problems with using the medicine.

Lithium Carbonate Zensei Yakuhin is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Lithium Carbonate Zensei Yakuhin is used in certain patients with the following medical conditions:

Lithium Carbonate Zensei Yakuhin indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Oral

Mania; Bipolar disorder; Recurrent unipolar depression

Adult: Dose depends on the preparation used. Doses should be adjusted to produce a serum-Lithium Carbonate Zensei Yakuhin concentration of 0.4-1 mmol/l. Lithium Carbonate Zensei Yakuhin® tablets: Treatment: Initiate at 1-1.5 g daily; Prevention: Initiate at 300-400 mg daily. Priadel® tablets: Treatment and prevention: Initially, 400-1,200 mg daily in 1-2 divided doses. Priadel® syrup: Treatment and prevention: Initially, 1.04-3.12 g daily in 2 divided doses. Liskonum® tablets: Treatment: Initially, 450-675 mg bid; Prevention: Initially, 450 mg bid. Doses should be divided throughout the day during the initial period; once-daily dosing may be used when serum-Lithium Carbonate Zensei Yakuhin concentrations have stabilised. Adjust initial dose 4-7 days after starting based on results of serum-Lithium Carbonate Zensei Yakuhin concentrations. Monitor serum-Lithium Carbonate Zensei Yakuhin concentrations once wkly until dosage has remained constant for 4 wk, after which monitoring may be reduced to once every 3 mth.

Child: ≥12 yr: Acute phase: Serum concentrations of 1-1.2 mEq/l. Max dose: 1.5 mEq/l. Initially, 1.8 g Lithium Carbonate Zensei Yakuhin carbonate daily as conventional capsules/tablets in 3-4 divided doses, or 30 ml (approx 48 mEq) Lithium Carbonate Zensei Yakuhin citrate oral solution daily in 3-4 divided doses. Alternatively, initially 1.8 g Lithium Carbonate Zensei Yakuhin carbonate daily as extended-release tablets in 2-3 divided doses.

Maintenance: Not established.

Elderly: ≤900 mg Lithium Carbonate Zensei Yakuhin carbonate daily. Titrate dose slowly to achieve therapeutic serum concentrations.

Maintenance: Maintain serum concentrations at the lower end of 0.6-1.2 mEq/l.

Renal impairment:

CrCl (ml/min)Dosage Recommendation
10-5050-75% of normal dose.
<1025-50% of normal dose.

How should I use Lithium Carbonate Zensei Yakuhin?

Use Lithium Carbonate Zensei Yakuhin controlled-release and extended-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Lithium Carbonate Zensei Yakuhin controlled-release and extended-release tablets.

Uses of Lithium Carbonate Zensei Yakuhin in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Bipolar disorder:

Immediate release: Treatment of manic and mixed episodes and maintenance treatment in patients ≥7 years of age with a diagnosis of bipolar disorder.

Extended release: Treatment of manic episodes and maintenance treatment in patients ≥12 years of age with a diagnosis of bipolar disorder.

Off Label Uses

Bipolar disorder, hypomania

Data from a limited number of patients studied suggest that Lithium Carbonate Zensei Yakuhin may be beneficial in the treatment of hypomania.

Lithium Carbonate Zensei Yakuhin description

Lithium Carbonate Zensei Yakuhin was used during the 19th century to treat gout. Lithium Carbonate Zensei Yakuhin salts such as Lithium Carbonate Zensei Yakuhin carbonate (Li2CO3), Lithium Carbonate Zensei Yakuhin citrate, and Lithium Carbonate Zensei Yakuhin orotate are mood stabilizers. They are used in the treatment of bipolar disorder, since unlike most other mood altering drugs, they counteract both mania and depression. Lithium Carbonate Zensei Yakuhin can also be used to augment other antidepressant drugs. It is also sometimes prescribed as a preventive treatment for migraine disease and cluster headaches. The active principle in these salts is the Lithium Carbonate Zensei Yakuhin ion Li+, which having a smaller diameter, can easily displace K+ and Na+ and even Ca+2, in spite of its greater charge, occupying their sites in several critical neuronal enzymes and neurotransmitter receptors.

Lithium Carbonate Zensei Yakuhin dosage

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Immediate-release capsules are usually given t.i.d. or q.i.d. Doses of controlled-release tablets are usually given b.i.d. (approximately 12-hour intervals). When initiating therapy with immediate-release or controlled-release Lithium Carbonate Zensei Yakuhin, dosage must be individualized according to serum levels and clinical response.

When switching a patient from immediate-release capsules to Lithium Carbonate Zensei Yakuhin (Lithium Carbonate Zensei Yakuhin carbonate) CR Controlled-Release Tablets, give the same total daily dose when possible. Most patients on maintenance therapy are stabilized on 900 mg daily, e.g., Lithium Carbonate Zensei Yakuhin (Lithium Carbonate Zensei Yakuhin carbonate) CR 450 mg b.i.d. When the previous dosage of immediate-release Lithium Carbonate Zensei Yakuhin is not a multiple of 450 mg, e.g., 1,500 mg, initiate Lithium Carbonate Zensei Yakuhin (Lithium Carbonate Zensei Yakuhin carbonate) CR at the multiple of 450 mg nearest to, but below, the original daily dose, i.e., 1,350 mg. When the 2 doses are unequal, give the larger dose in the evening. In the above example, with a total daily dose of 1,350 mg, generally 450 mg of Lithium Carbonate Zensei Yakuhin (Lithium Carbonate Zensei Yakuhin carbonate) CR should be given in the morning and 900 mg of Lithium Carbonate Zensei Yakuhin (Lithium Carbonate Zensei Yakuhin carbonate) CR in the evening. If desired, the total daily dose of 1,350 mg can be given in 3 equal 450-mg doses of Lithium Carbonate Zensei Yakuhin (Lithium Carbonate Zensei Yakuhin carbonate) CR. These patients should be monitored at 1- to 2-week intervals, and dosage adjusted if necessary, until stable and satisfactory serum levels and clinical state are achieved.

When patients require closer titration than that available with doses of Lithium Carbonate Zensei Yakuhin (Lithium Carbonate Zensei Yakuhin carbonate) CR in increments of 450 mg, immediate-release capsules should be used.

Acute Mania: Optimal patient response to Lithium Carbonate Zensei Yakuhin (Lithium Carbonate Zensei Yakuhin carbonate) can usually be established and maintained with 1,800 mg per day in divided doses. Such doses will normally produce the desired serum Lithium Carbonate Zensei Yakuhin level ranging between 1.0 and 1.5 mEq/L.

Dosage must be individualized according to serum levels and clinical response. Regular monitoring of the patient's clinical state and serum Lithium Carbonate Zensei Yakuhin levels is necessary. Serum levels should be determined twice per week during the acute phase, and until the serum level and clinical condition of the patient have been stabilized.

Long-Term Control: The desirable serum Lithium Carbonate Zensei Yakuhin levels are 0.6 to 1.2 mEq/L. Dosage will vary from one individual to another, but usually 900 mg to 1,200 mg per day in divided doses will maintain this level. Serum Lithium Carbonate Zensei Yakuhin levels in uncomplicated cases receiving maintenance therapy during remission should be monitored at least every two months.

Patients unusually sensitive to Lithium Carbonate Zensei Yakuhin may exhibit toxic signs at serum levels below 1.0 mEq/L.

N.B.: Blood samples for serum Lithium Carbonate Zensei Yakuhin determinations should be drawn immediately prior to the next dose when Lithium Carbonate Zensei Yakuhin concentrations are relatively stable (i.e., 8 to 12 hours after the previous dose). Total reliance must not be placed on serum levels alone. Accurate patient evaluation requires both clinical and laboratory analysis.

Elderly patients often respond to reduced dosage, and may exhibit signs of toxicity at serum levels ordinarily tolerated by younger patients.

How supplied

Lithium Carbonate Zensei Yakuhin (Lithium Carbonate Zensei Yakuhin carbonate) Capsules 300 mg are gray and yellow capsules imprinted with "Lithium Carbonate Zensei Yakuhin (Lithium Carbonate Zensei Yakuhin carbonate) " and "SB" on one side of each half of the capsule, in bottles of 100 (NDC 0007-4007-20).

Lithium Carbonate Zensei Yakuhin (Lithium Carbonate Zensei Yakuhin carbonate) CR Tablets 450 mg are round, yellow, biconvex, controlled-release tablets, debossed with "SKF" and "J10" on one side and scored on the other side, in bottles of 100 (NDC 0007-4010-20).

STORAGE CONDITIONS: Store at 25°C (77°F), excursions permitted to 15-30°C (59-86°F).

Manufactured by: Cardinal Health., Winchester, KY 40391 for GlaxoSmithKline., Research Triangle Park, NC 27709. September 2003

FDA rev date: 03/11/2004

Lithium Carbonate Zensei Yakuhin interactions

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What other drugs will affect Lithium Carbonate Zensei Yakuhin?

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Caution should be used when Lithium Carbonate Zensei Yakuhin and diuretics are used concomitantly because diuretic-induced sodium loss may reduce the renal clearance of Lithium Carbonate Zensei Yakuhin and increase serum Lithium Carbonate Zensei Yakuhin levels with risk of Lithium Carbonate Zensei Yakuhin toxicity. Patients receiving such combined therapy should have serum Lithium Carbonate Zensei Yakuhin levels monitored closely and the Lithium Carbonate Zensei Yakuhin dosage adjusted if necessary.

Lithium Carbonate Zensei Yakuhin levels should be closely monitored when patients initiate or discontinue NSAID use. In some cases, Lithium Carbonate Zensei Yakuhin toxicity has resulted from interactions between an NSAID and Lithium Carbonate Zensei Yakuhin. Indomethacin and piroxicam have been reported to increase significantly steady-state plasma Lithium Carbonate Zensei Yakuhin concentrations. There is also evidence that other nonsteroidal anti-inflammatory agents, including the selective cyclooxygenase-2 (COX-2) inhibitors, have the same effect. In a study conducted in healthy subjects, mean steady-state Lithium Carbonate Zensei Yakuhin plasma levels increased approximately 17% in subjects receiving Lithium Carbonate Zensei Yakuhin 450 mg b.i.d. with celecoxib 200 mg b.i.d. as compared to subjects receiving Lithium Carbonate Zensei Yakuhin alone.

Concurrent use of metronidazole with Lithium Carbonate Zensei Yakuhin may provoke Lithium Carbonate Zensei Yakuhin toxicity due to reduced renal clearance. Patients receiving such combined therapy should be monitored closely.

There is evidence that angiotensin-converting enzyme inhibitors, such as enalapril and captopril, and angiotension II receptor antagonists, such as losartan, may substantially increase steady-state plasma Lithium Carbonate Zensei Yakuhin levels, sometimes resulting in Lithium Carbonate Zensei Yakuhin toxicity. When such combinations are used, Lithium Carbonate Zensei Yakuhin dosage may need to be decreased, and plasma Lithium Carbonate Zensei Yakuhin levels should be measured more often.

Concurrent use of calcium channel blocking agents with Lithium Carbonate Zensei Yakuhin may increase the risk of neurotoxicity in the form of ataxia, tremors, nausea, vomiting, diarrhea, and/or tinnitus. Caution is recommended.

The concomitant administration of Lithium Carbonate Zensei Yakuhin with selective serotonin reuptake inhibitors should be undertaken with caution as this combination has been reported to result in symptoms such as diarrhea, confusion, tremor, dizziness, and agitation.

The following drugs can lower serum Lithium Carbonate Zensei Yakuhin concentrations by increasing urinary Lithium Carbonate Zensei Yakuhin excretion: acetazolamide, urea, xanthine preparations, and alkalinizing agents such as sodium bicarbonate.

The following have also been shown to interact with Lithium Carbonate Zensei Yakuhin: methyldopa, phenytoin, and carbamazepine.

Lithium Carbonate Zensei Yakuhin side effects

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What are the possible side effects of Lithium Carbonate Zensei Yakuhin?

Lithium Carbonate Zensei Yakuhin Toxicity

The likelihood of toxicity increases with increasing serum Lithium Carbonate Zensei Yakuhin levels. Serum Lithium Carbonate Zensei Yakuhin levels greater than 1.5 mEq/L carry a greater risk than lower levels. However, patients sensitive to Lithium Carbonate Zensei Yakuhin may exhibit toxic signs at serum levels below 1.5 mEq/L.

Diarrhea, vomiting, drowsiness, muscular weakness and lack of coordination may be early signs of Lithium Carbonate Zensei Yakuhin toxicity, and can occur at Lithium Carbonate Zensei Yakuhin levels below 2.0 mEq/L. At higher levels, giddiness, ataxia, blurred vision, tinnitus and a large output of dilute urine may be seen. Serum Lithium Carbonate Zensei Yakuhin levels above 3.0 mEq/L may produce a complex clinical picture involving multiple organs and organ systems. Serum Lithium Carbonate Zensei Yakuhin levels should not be permitted to exceed 2.0 mEq/L during the acute treatment phase.

Fine hand tremor, polyuria and mild thirst may occur during initial therapy for the acute manic phase, and may persist throughout treatment. Transient and mild nausea and general discomfort may also appear during the first few days of Lithium Carbonate Zensei Yakuhin administration.

These side effects are an inconvenience rather than a disabling condition, and usually subside with continued treatment or a temporary reduction or cessation of dosage. If persistent, a cessation of dosage is indicated.

The following adverse reactions have been reported and do not appear to be directly related to serum Lithium Carbonate Zensei Yakuhin levels.

Neuromuscular: Tremor, muscle hyperirritability (fasciculations, twitching, clonic movements of whole limbs), ataxia, choreoathetotic movements, hyperactive deep tendon reflexes.

Central Nervous System: Blackout spells, epileptiform seizures, slurred speech, dizziness, vertigo, incontinence of urine or feces, somnolence, psychomotor retardation, restlessness, confusion, stupor, coma, acute dystonia, downbeat nystagmus.

Cardiovascular: Cardiac arrhythmia, hypotension, peripheral circulatory collapse, sinus node dysfunction with severe bradycardia (which may result in syncope).

Neurological: Cases of pseudotumor cerebri (increased intracranial pressure and papilledema) have been reported with Lithium Carbonate Zensei Yakuhin use. If undetected, this condition may result in enlargement of the blind spot, constriction of visual fields and eventual blindness due to optic atrophy. Lithium Carbonate Zensei Yakuhin should be discontinued, if clinically possible, if this syndrome occurs.

Gastrointestinal: Anorexia, nausea, vomiting, diarrhea.

Genitourinary: Albuminuria, oliguria, polyuria, glycosuria.

Dermatologic: Drying and thinning of hair, anesthesia of skin, chronic folliculitis, xerosis cutis, alopecia and exacerbation of psoriasis.

Autonomic Nervous System: Blurred vision, dry mouth.

Thyroid Abnormalities: Euthyroid goiter and/or hypothyroidism (including myxedema) accompanied by lower T3 and T4. Iodine 131 uptake may be elevated.. Paradoxically, rare cases of hyperthyroidism have been reported.

EEG Changes: Diffuse slowing, widening of frequency spectrum, potentiation and disorganization of background rhythm.

EKG Changes: Reversible flattening, isoelectricity or inversion of T-waves.

Miscellaneous: Fatigue, lethargy, transient scotomata, dehydration, weight loss, tendency to sleep.

Miscellaneous reactions unrelated to dosage are: Transient electroencephalographic and electrocardiographic changes, leukocytosis, headache, diffuse nontoxic goiter with or without hypothyroidism, transient hyperglycemia, generalized pruritis with or without rash, cutaneous ulcers, albuminuria, worsening of or-ganic brain syndromes, excessive weight gain, edematous swelling of ankles or wrists, and thirst or polyuria, sometimes resembling diabetes insipidus, and metallic taste.

A single report has been received of the development of painful discoloration of fingers and toes and coldness of the extremities within one day of the starting of treatment of Lithium Carbonate Zensei Yakuhin. The mechanism through which these symptoms (resembling Raynaud's Syndrome) developed is not known. Recovery followed discontinuance.

Lithium Carbonate Zensei Yakuhin contraindications

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What is the most important information I should know about Lithium Carbonate Zensei Yakuhin?

Do not use this medication without telling your doctor if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Call your doctor at once if you have any early signs of Lithium Carbonate Zensei Yakuhin toxicity, such as nausea, vomiting, diarrhea, drowsiness, muscle weakness, tremor, lack of coordination, blurred vision, or ringing in your ears.

Do not crush, chew, or break an extended-release tablet. Swallow the pill whole.

Drink extra fluids to keep from getting dehydrated while you are taking Lithium Carbonate Zensei Yakuhin. Tell your doctor if you have been sweating excessively, or if you are sick with fever, vomiting, or diarrhea.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Lithium Carbonate Zensei Yakuhin can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.



Active ingredient matches for Lithium Carbonate Zensei Yakuhin:

Lithium in Japan.


List of Lithium Carbonate Zensei Yakuhin substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Lithmax tablet / extended-release 300 mg (Aa Pharma Inc (Canada))
Tablet, Extended Release; Oral; Lithium Carbonate 300 mg (Solvay)
Tablets, Extended Release; Oral; Lithium Carbonate 300 mg (Solvay)
Lithobid tablet, film coated, extended release 300 mg/1 (Solvay)
Lithocap 150mg CAP / 10 (Intas)$ 0.08
Lithocap 300mg CAP / 10 (Intas)$ 0.12
150 mg x 10's (Intas)$ 0.08
300 mg x 10's (Intas)$ 0.12
LITHOCAP cap 150 mg x 10's (Intas)$ 0.08
LITHOCAP cap 300 mg x 10's (Intas)$ 0.12
LITHOCAP 300MG CAPSULE 1 strip / 10 capsules each (Intas Pharmaceuticals Ltd)$ 0.11
Lithocent 300mg TAB / 10 (Crescent)$ 0.32
300 mg x 10's (Crescent)$ 0.32
LITHOCENT 300MG TABLET 1 strip / 10 tablets each (Crescent)$ 0.33
LITHOCENT CR 400MG TABLET 1 strip / 10 tablets each (Crescent)$ 0.54
LITHOCENT tab 300 mg x 10's (Crescent)$ 0.32
Lithocent 300mg Tablet (Crescent)$ 0.03
Lithocent 400mg Tablet CR (Crescent)$ 0.05
Lithocent-CR 450mg TAB / 10 (Crescent)$ 0.38
450 mg x 10's (Crescent)$ 0.38
LITHOCENT-CR tab 450 mg x 10's (Crescent)$ 0.38
LITHOCHIK 300MG TABLET 1 strip / 10 tablets each (Chicky Pharma Pvt Ltd)$ 0.23
LITHOLENT 300MG TABLET 1 strip / 10 tablets each (Talent Healthcare)$ 0.25
LITHOLENT 400MG TABLET SR 1 strip / 10 tablet srs each (Talent Healthcare)$ 0.49
Litholent 400mg Tablet SR (Talent India )$ 0.06
LITHOLITE 300MG TABLET 1 strip / 10 tablets each (Digmedi Pvt Ltd)$ 0.18
LITHON 300MG TABLET 1 strip / 10 tablets each (RKG Pharma)$ 0.16
LITHON SR 450MG TABLET 1 strip / 10 tablets each (RKG Pharma)$ 0.37
Lithon 450mg Tablet SR (RKG Pharma)$ 0.04
LITHONEX 300MG TABLET 1 strip / 10 tablets each (Theo Pharma Pvt Ltd)$ 0.23
LITHONEX SR TABLET 1 strip / 10 tablets each (Theo Pharma Pvt Ltd)$ 0.31
LITHONEX XL 450MG TABLET 1 strip / 10 tablets each (Theo Pharma Pvt Ltd)$ 0.57

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