Actions of Lithiumchloride in details
The precise mechanism of action of Li+ as a mood-stabilizing agent is currently unknown. It is possible that Li+ produces its effects by interacting with the transport of monovalent or divalent cations in neurons. An increasing number of scientists have come to the conclusion that the excitatory neurotransmitter glutamate is the key factor in understanding how Lithiumchloride works. Lithiumchloride has been shown to change the inward and outward currents of glutamate receptors (especially GluR3), without a shift in reversal potential. Lithiumchloride has been found to exert a dual effect on glutamate receptors, acting to keep the amount of glutamate active between cells at a stable, healthy level, neither too much nor too little. It is postulated that too much glutamate in the space between neurons causes mania, and too little, depression. Another mechanism by which Lithiumchloride might help to regulate mood include the non-competitive inhibition of an enzyme called inositol monophosphatase. Alternately Lithiumchloride's action may be enhanced through the deactivation of the GSK-3B enzyme. The regulation of GSK-3B by Lithiumchloride may affect the circadian clock. GSK-3 is known for phosphorylating and thus inactivating glycogen synthase. GSK-3B has also been implicated in the control of cellular response to damaged DNA. GSK-3 normally phosphorylates beta catenin, which leads to beta catenin degratation. When GSK-3 is inhibited, beta catenin increases and transgenic mice with overexpression of beta catenin express similar behaviour to mice treated with Lithiumchloride. These results suggest that increase of beta catenin may be a possible pathway for the therapeutic action of Lithiumchloride.
How should I take Lithiumchloride?
Take Lithiumchloride exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Do not crush, chew, or break an extended-release Lithiumchloride tablet. Swallow the tablet whole.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
Taking Lithiumchloride can make it easier for you to become dehydrated, especially if you have any vomiting or diarrhea, if you are outdoors in the sun, or if you exercise vigorously or sweat more than usual. Dehydration can increase some of the side effects of Lithiumchloride.
Call your doctor if you have are sick with a fever and vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking Lithiumchloride, which may affect your dose needs. Do not change your dose or medication schedule without your doctor's advice.
Drink extra fluids each day to prevent dehydration.
It may take up to 3 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not begin to improve after 1 week of treatment.
If you need surgery, tell the surgeon ahead of time that you are using Lithiumchloride.
While using Lithiumchloride, you may need frequent blood tests.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Lithiumchloride administration
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results from this medication.
Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time.
Measure the liquid form of Lithiumchloride with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Taking Lithiumchloride can make it easier for you to become dehydrated, especially if you have any vomiting or diarrhea, if you are outdoors in the sun, or if you exercise vigorously or sweat more than usual. Dehydration can increase some of the side effects of Lithiumchloride.
Drink extra fluids each day to keep from getting dehydrated while you are taking Lithiumchloride. Tell your doctor if you have been sweating excessively, or if you are sick with fever, vomiting, or diarrhea for more than a few hours.
To be sure this medication is not causing harmful effects, your kidney function will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.
If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Lithiumchloride.
Store Lithiumchloride at room temperature away from moisture and heat.
Lithiumchloride pharmacology
The precise mechanism of action of Li+ as a mood-stabilizing agent is currently unknown. It is possible that Li+ produces its effects by interacting with the transport of monovalent or divalent cations in neurons. An increasing number of scientists have come to the conclusion that the excitatory neurotransmitter glutamate is the key factor in understanding how Lithiumchloride works. Lithiumchloride has been shown to change the inward and outward currents of glutamate receptors (especially GluR3), without a shift in reversal potential. Lithiumchloride has been found to exert a dual effect on glutamate receptors, acting to keep the amount of glutamate active between cells at a stable, healthy level, neither too much nor too little. It is postulated that too much glutamate in the space between neurons causes mania, and too little, depression. Another mechanism by which Lithiumchloride might help to regulate mood include the non-competitive inhibition of an enzyme called inositol monophosphatase. Alternately Lithiumchloride's action may be enhanced through the deactivation of the GSK-3B enzyme. The regulation of GSK-3B by Lithiumchloride may affect the circadian clock. GSK-3 is known for phosphorylating and thus inactivating glycogen synthase. GSK-3B has also been implicated in the control of cellular response to damaged DNA.
Reviews
The results of a survey conducted on ndrugs.com for Lithiumchloride are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Lithiumchloride. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported administration
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Information checked by Dr. Sachin Kumar, MD Pharmacology
