Lopra Actions

Rating: 1.25 - 4 review(s)
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Actions of Lopra in details

infoThe action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
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Synthetic antidiarrheal.

Pharmacology: Pharmacodynamics: Lopra binds to the opiate receptor in the gut wall. Consequently, it inhibits the release of acetylcholine and prostaglandins, thereby reducing propulsive peristalsis and increasing intestinal transit time.

Lopra increases the tone of the anal sphincter, thereby reducing incontinence and urgency.

Due to its high affinity to the gut wall and its high first-pass metabolism, Lopra hardly reaches the systemic circulation.

Pharmacokinetics: Lopra is easily absorbed from the gut, but it is almost completely extracted by the liver, where it is metabolized, conjugated and excreted via the bile.

The half-life of Lopra in man is about 11 hrs with a range of 9-14 hrs. Studies on distribution in rats show a high affinity for the gut wall with a preference for binding to receptors of the longitudinal muscle layer. Elimination mainly occurs by oxidative N-demethylation, which is the main metabolic pathway of Lopra. Excretion of the unchanged Lopra and the metabolites mainly occurs through the feces.

How should I take Lopra?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Take Lopra with a full glass of water. Drink extra water while you are taking this medication to keep from getting dehydrated.

Lopra is usually taken at the first sign of diarrhea, and again if diarrhea comes back. The first dose of Lopra is usually twice as much as the following doses. Do not take this medication more than 3 times in 24 hours without your doctor's advice.

The Lopra chewable tablet must be chewed before swallowing.

Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one.

Immodium A-D Liquid and New Immodium A-D Liquid contain two different strengths of Lopra. If you switch from using one brand to using the other, follow the dosing instructions carefully. Immodium A-D Liquid also contains a small amount of alcohol, but New Immodium A-D Liquid does not.

It may take up to 48 hours before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 10 days of treatment.

Store at room temperature away from moisture and heat. Do not freeze liquid Lopra.

Lopra administration

infoAdministration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.
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Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Take Lopra with a full glass of water. Drink extra water while you are taking this medication to keep from getting dehydrated.

Lopra is usually taken at the first sign of diarrhea, and again if diarrhea comes back. The first dose of Lopra is usually twice as much as the following doses. Do not take this medication more than 3 times in 24 hours without your doctor's advice.

The Lopra chewable tablet must be chewed before swallowing.

Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one.

Immodium A-D Liquid and New Immodium A-D Liquid contain two different strengths of Lopra. If you switch from using one brand to using the other, follow the dosing instructions carefully. Immodium A-D Liquid also contains a small amount of alcohol, but New Immodium A-D Liquid does not.

It may take up to 48 hours before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 10 days of treatment.

Store at room temperature away from moisture and heat. Do not freeze liquid Lopra.

Lopra pharmacology

infoPharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.
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In vitro and animal studies show that Lopra® (Lopra hydrochloride) acts by slowing intestinal motility and by affecting water and electrolyte movement through the bowel. Lopra binds to the opiate receptor in the gut wall. Consequently, it inhibits the release of acetylcholine and prostaglandins, thereby reducing peristalsis, and increasing intestinal transit time. Lopra increases the tone of the anal sphincter, thereby reducing incontinence and urgency.

In man, Lopra® (Lopra hcl) prolongs the transit time of the intestinal contents. It reduces the daily fecal volume, increases the viscosity and bulk density, and diminishes the loss of fluid and electrolytes. Tolerance to the antidiarrheal effect has not been observed. Clinical studies have indicated that the apparent elimination half-life of Lopra in man is 10.8 hours with a range of 9.1 - 14.4 hours. Plasma levels of unchanged drug remain below 2 nanograms per mL after the intake of a 2mg capsule of Lopra® (Lopra hcl). Plasma levels are highest approximately five hours after administration of the capsule and 2.5 hours after the liquid. The peak plasma levels of Lopra were similar for both formulations. Elimination of Lopra mainly occurs by oxidative N-demethylation. Cytochrome P450 (CYP450) isozymes, CYP2C8 and CYP3A4, are thought to play an important role in Lopra N-demethylation process since quercetin (CYP2C8 inhibitor) and ketoconazole (CYP3A4 inhibitor) significantly inhibited the N- demethylation process in vitro by 40% and 90%, respectively. In addition, CYP2B6 and CYP2D6 appear to play a minor role in Lopra N-demethylation. Excretion of the unchanged Lopra and its metabolites mainly occurs through the feces. In those patients in whom biochemical and hematological parameters were monitored during clinical trials, no trends toward abnormality during Lopra® (Lopra hcl) therapy were noted. Similarly, urinalyses, EKG and clinical ophthalmological examinations did not show trends toward abnormality.



References

  1. DailyMed. "OMEPRAZOLE MAGNESIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. NCIt. "Omeprazole Magnesium: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
  3. NCIt. "Loperamide: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Lopra are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Lopra. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

5 consumers reported administration

When best can I take Lopra, on an empty stomach, before or after food?
ndrugs.com website users have also released a report stating that Lopra should be taken After food. In any case, this may not be the right description on how you ought to take this Lopra. Kindly visit your doctor for more medical advice in this regard. Click here to see other users view on when best the Lopra can be taken.
Users%
After food4
80.0%
Before food1
20.0%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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