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Losolvan Uses |
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For use Max Pidek Pharmaceuticals as monotherapy and in combination with clavulanic acid: an infectious-inflammatory diseases caused by susceptible microorganisms, including bronchitis, pneumonia, tonsillitis, pyelonephritis, urethritis, infections of the gastrointestinal tract, gynecological infections, infections of the skin and soft tissue, listeria, leptospirosis, gonorrhea.
For use Max Pidek Pharmaceuticals in combination with metronidazole: chronic gastritis in acute, peptic ulcer and duodenal ulcer in acute, associated with Helicobacter Pylori.
Losolvan is used to treat certain diseases of the respiratory tract and to relieve cough associated with thickened mucous.
Each retard capsule contains Ambroxol hydrochloride 75 mg.
Each tablet contains Ambroxol hydrochloride 30 mg.
Each 5 mL of syrup contains Ambroxol hydrochloride 15 or 30 mg.
Each mL of syrup (infant drops) contains Ambroxol hydrochloride 6 mg.
Losolvan hydrochloride is trans-4-[(2-amino-3,5-dibromo-benzyl)amino] cyclohexanol hydrochloride.
It also contains the following excipients: Retard Capsules: Crospovidone collidon CL, carnauba wax, stearyl alcohol, magnesium stearate.
Tablets: Lactose, maize starch, colloidal silica, magnesium stearate.
Syrup: Purified water, sorbitol liquid, glycerol 85%, woodberry aroma (15 mg only), strawberry aroma (30 mg only), hydroxyethylcellulose, benzoic acid, acesulfame potassium, vanilla aroma.
Infant Drops: Hydroxyethylcellulose, sorbitol solution, glycerol 85%, sodium saccharin, pharma flavors, menthol, benzoic acid, propylene glycol.
Sustained-Release Capsule: Adults and Children >12 years: 1 cap once daily after meal with plenty of liquid (sufficient supply of liquid supports the expectorant effect of Losolvan).
Losolvan SR capsule is not suitable for children <12 years.
Tablet: Adults and Children >12 years: 1 tab thrice daily for the first 2-3 days and then 1 tab twice daily or ½ tab thrice daily. Children 6-12 years: ½ tab 2-3 times a day.
Syrup: Adults and Children >12 years: 10 mL thrice daily during the first 2-3 days, them 10 mL twice daily or 5 mL thrice daily. Children 6-12 years: 5 mL 2-3 times a day; 2-5 years: 2.5 mL 3 times a day; <2 years: 2.5 mL 2 times a day.
DS Syrup: Adults and Children >12 years: 5 mL thrice daily for 2-3 days then 5 mL twice daily for 2.5 mL thrice daily. Children 6-12 years: 2.5 mL 2-3 times a day.
Infant Drops: Children 13-24 months: 1.25 mL twice a day; 7-12 months: 1 mL twice a day; ≤6 months: 0.5 mL twice a day.
Amoxicillin may decrease the effectiveness of contraceptives for oral administration.
With the simultaneous use of Max Pidek Pharmaceuticals with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) appears synergies; with bacteriostatic antibiotic (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulphonamide) - antagonism.
Amoxicillin increases the effects of indirect anticoagulants inhibiting intestinal microflora, reduces the synthesis of vitamin K and prothrombin index.
Amoxicillin reduces the effect of drugs, in the process of metabolism that produce PABA.
Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs decrease the tubular secretion of amoxicillin, which can be accompanied by an increase in its concentration in blood plasma.
Antacids, glucosamine, laxatives, aminoglycosides, slow down and reduce, and ascorbic acid increases the absorption of amoxicillin.
With the combined use of amoxicillin and clavulanic acid pharmacokinetics of both components unchanged.
Allergic reactions: urticaria, erythema, edema Quincke, rhinitis, conjunctivitis, rarely - fever, joint pain, eosinophilia, in rare cases - anaphylactic shock.
Side effects associated with chemotherapy effect: possible development of super-infection (particularly in patients with chronic diseases or low resistance of the organism).
With prolonged use at high doses: dizziness, ataxia, confusion, depression, peripheral neuropathy, seizures.
Mostly when Max Pidek Pharmaceuticals used in combination with metronidazole: nausea, vomiting, anorexia, diarrhea, constipation, epigastric pain, glossitis, stomatitis; rarely - hepatitis, pseudomembranous colitis, allergic reactions (urticaria, angioedema), interstitial nephritis, a violation of hematopoiesis.
Mostly when Max Pidek Pharmaceuticals used in combination with clavulanic acid: cholestatic jaundice, hepatitis, rarely - erythema multiforme, toxic epidermal necrolysis, exfoliative dermatitis.
Hypersensitivity to Losolvan hydrochloride or to any other excipients of Losolvan.
In case of rare hereditary conditions that may be incompatible with an excipient of Losolvan, the use of Losolvan is contraindicated.
Ambroxol in China, Taiwan.
Unit description / dosage (Manufacturer) | Price, USD |
Losolvan 3 mg/1 mL x 1 mL | |
Losolvan 3 mg/1 mL x 60 mL | |
Losolvan 3 mg/1 mL x 100 mL | |
Losolvan 3 mg/1 mL x 120 mL | |
Losolvan 3 mg/1 mL x 3.8 L | |
List of Losolvan substitutes (brand and generic names): | |
Lorfast-AM Syr (India) | |
LORFAST-AM SYR syr 60ml (Cadila (Le Sante)) | $ 0.57 |
Loxibrin (Mexico) | |
Loxol (Taiwan) | |
Loxol 75 mg x 1000's | |
Luzenup (India) | |
Luzenup Ambroxol 15 mg, terbutaline1.25 mg, guaiphenesin 50 mg/5mL. O-LQD / 100ml (Rytus) | $ 0.79 |
LUZENUP oral liqd 100ml (Rytus) | $ 0.79 |
Luzer-A (India) | |
Luzer-A Levocetirizine hydrochloride 5mg, Ambroxol hydrochloride 60mg. TAB / 100 (Pharmacon) | $ 6.35 |
100's (Pharmacon) | $ 6.35 |
LUZER-A tab 10's (Pharmacon) | $ 0.63 |
Lv Plus (India) | |
Lv Plus Levocetirizine hydrochloride2.5 mg, phenylephrine 5 mg, ambroxol hydrochloride 60 mg, paracetamol 500 mg. TAB / 10 (Iscon) | $ 0.71 |
LV PLUS tab 10's (Iscon) | $ 0.71 |
Lysopadol (France) | |
Lysopadol Menthe sans sucre | |
Pastilles; Oral; Ambroxol Hydrochloride 20 mg | |
Lysopain dol Ambroxol (Switzerland) | |
Tablet; Oral; Ambroxol Hydrochloride 20 mg | |
Lysopaïne Ambroxol Maux de Gorge (France) | |
Lysopaïne Maux de Gorge Ambroxol (France) | |
Lytex (Bangladesh) | |
Lytex SR (Bangladesh) | |
Mags (India) | |
Mags Terbutaline sulphate 1.25 mg, Guaiphenesin 50 mg, Ambroxolhydrochloride 15 mg, Menthol2.5 mg. SYR / 100ml (Plus India) | $ 0.51 |
100ml (Plus India) | $ 0.51 |
MAGS syr 100ml (Plus India) | $ 0.51 |
Marbroxol (Hong Kong) | |
Mavixan (Greece) | |
Max (Hong Kong, Myanmar, Singapore) | |
Max 30 mg x 50 x 10's (Pidek) | |
Max 30 mg x 1, 000's (Pidek) | |
500 mg x 10's (Pidek) | $ 1.03 |
Max 30 mg x 500's (Pidek) | |
MAX cap 500 mg x 10's (Pidek) | $ 1.03 |
Mbroxol (Bangladesh) | |
Meclocelin (Japan) | |
Medibron (Philippines) | |
Medibron 30 mg/5 mL x 60 mL (Medi-Rx) | $ 2.44 |
Medibron 30 mg/5 mL x 120 mL (Medi-Rx) | $ 3.81 |
Medibron 6 mg/1 mL x 15 mL (Medi-Rx) | $ 2.03 |
Medibron oral drops 6 mg/mL 15 mL x 1's (Medi-Rx) | $ 2.03 |
Medibron syr 30 mg/5 mL 60 mL x 1's (Medi-Rx) | $ 2.44 |
Medibron syr 30 mg/5 mL 120 mL x 1's (Medi-Rx) | $ 3.81 |
Medirox-A (India) | |
Medirox-A Roxithromycin 150 mg, Ambroxolhydrochloride 30 mg. TAB / 10 | $ 1.03 |
10's | $ 1.03 |
Medovent (Malta) | |
Medovent 30 (Vietnam) | |
Medox (Georgia, Poland, Russian Federation) | |
Syrup; Oral; Ambroxol Hydrochloride 15 mg / 5 ml | |
Tablet; Oral; Ambroxol Hydrochloride 30 mg | |
Medox 7.5 mg x 1 Blister x 10 Tablet | |
See 3101 substitutes for Losolvan |
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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