What happens if I overdose Lotense 5 mg Capsule?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.
Proper storage of Lotense 5 mg Capsule:
Store Lotense 5 mg Capsule at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Lotense 5 mg Capsule out of the reach of children and away from pets.
Overdose of Lotense 5 mg Capsule in details
Overdosage might be expected to cause excessive peripheral vasodilation with marked hypotension and possibly a reflex tachycardia. In humans, experience with intentional overdosage of Lotense 5 mg Capsule is limited.
Single oral doses of Lotense 5 mg Capsule maleate equivalent to 40 mg Lotense 5 mg Capsule/kg and 100 mg Lotense 5 mg Capsule/kg in mice and rats, respectively, caused deaths. Single oral Lotense 5 mg Capsule maleate doses equivalent to 4 or more mg Lotense 5 mg Capsule/kg or higher in dogs (11 or more times the maximum recommended human dose on a mg/m2 basis) caused a marked peripheral vasodilation and hypotension.
If massive overdose should occur, initiate active cardiac and respiratory monitoring. Frequent blood pressure measurements are essential. Should hypotension occur, provide cardiovascular support including elevation of the extremities and the judicious administration of fluids. If hypotension remains unresponsive to these conservative measures, consider administration of vasopressors (such as phenylephrine) with attention to circulating volume and urine output. As Lotense 5 mg Capsule is highly protein bound, hemodialysis is not likely to be of benefit.
What should I avoid while taking Lotense 5 mg Capsule?
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Drinking alcohol can further lower your blood pressure and may increase certain side effects of Lotense 5 mg Capsule.
Lotense 5 mg Capsule warnings
Hypotension
Symptomatic hypotension is possible, particularly in patients with severe aortic stenosis. Because of the gradual onset of action, acute hypotension is unlikely.
Increased Angina or Myocardial Infarction
Worsening angina and acute myocardial infarction can develop after starting or increasing the dose of Lotense 5 mg Capsule tablets, particularly in patients with severe obstructive coronary artery disease.
Patients with Hepatic Failure
Because Lotense 5 mg Capsule besyaate is extensively metabolized by the liver and the plasma elimination half-life (t1/2) is 56 hours in patients with impaired hepatic function, titrate slowly when administering Lotense 5 mg Capsule to patients with severe hepatic impairment.
What should I discuss with my healthcare provider before taking Lotense 5 mg Capsule?
Some medical conditions may interact with Lotense 5 mg Capsule. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have low blood pressure
- if you have a history of heart problems (eg, heart failure, aortic stenosis, coronary artery disease), or liver problems
Some MEDICINES MAY INTERACT with Lotense 5 mg Capsule. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Sildenafil because the risk of low blood pressure may be increased
- Azole antifungals (eg, itraconazole, ketoconazole), diltiazem, macrolide antibiotics (eg, clarithromycin), protease inhibitors (eg, ritonavir), or vasopressin receptor antagonists (eg, conivaptan) because they may increase the risk of Lotense 5 mg Capsule's side effects
- Cyclosporine, simvastatin, or tacrolimus because the risk of their side effects may be increased by Lotense 5 mg Capsule
This may not be a complete list of all interactions that may occur. Ask your health care provider if Lotense 5 mg Capsule may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Lotense 5 mg Capsule precautions
Concerns related to adverse effects:
• Angina/MI: Increased angina and/or MI have occurred with initiation or dosage titration of dihydropyridine calcium channel blockers. Reflex tachycardia may occur resulting in angina and/or MI in patients with obstructive coronary disease, especially in the absence of concurrent beta-blockade.
• Hypotension: Symptomatic hypotension can occur; acute hypotension upon initiation is unlikely due to the gradual onset of action. Blood pressure must be lowered at a rate appropriate for the patient's clinical condition.
• Peripheral edema: The most common side effect is peripheral edema; occurs within 2 to 3 weeks of starting therapy.
Disease-related concerns:
• Aortic stenosis: Use Lotense 5 mg Capsule with extreme caution in patients with severe aortic stenosis; may reduce coronary perfusion resulting in ischemia.
• Heart failure: With the exception of Lotense 5 mg Capsule, calcium channel blockers should be avoided whenever possible in patients with heart failure with reduced ejection fraction (HFrEF). Lotense 5 mg Capsule may be used for the treatment of hypertension or ischemic heart disease in patients with HFrEF, but has no effect on functional status or mortality (ACCF/AHA [Yancy 2013]).
• Hepatic impairment: Use with caution in patients with hepatic impairment; may require lower starting dose; titrate slowly in patients with severe hepatic impairment.
• Hypertrophic cardiomyopathy (HCM) with outflow tract obstruction: Use Lotense 5 mg Capsule with caution in patients with HCM and outflow tract obstruction since reduction in afterload may worsen symptoms associated with this condition (ACCF/AHA [Gersh 2011]).
Special populations:
•
Elderly: Initiate at a lower dose in the elderly.
Other warnings/precautions:
• Titration: Peak antihypertensive effect is delayed; dosage titration should occur after 7 to 14 days on a given dose.
What happens if I miss a dose of Lotense 5 mg Capsule?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
References
- DrugBank. "amlodipine". http://www.drugbank.ca/drugs/DB00381 (accessed September 17, 2018).
- MeSH. "Antihypertensive Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
- Safe Work Australia - HCIS. "88150-42-9: The Hazardous Chemical Information System (HCIS) at the Safe Work Australia is a database of chemical classifications and workplace exposure standards. It allows users to find information on chemicals that have been classified in accordance with the GHS or which have an Australian Workplace Exposure Standard.". http://hcis.safeworkaustralia.gov.au... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
