Loxoprofen - Shin Poong Pharm Actions

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Actions of Loxoprofen - Shin Poong Pharm in details

The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.


Pharmacology: Sodium Loxoprofen - Shin Poong Pharm, synthesized and developed by Sankyo Co. Ltd., is a new nonsteroidal analgesic and anti-inflammatory drug in the phenylpropionic acid group. It is rapidly absorbed from the gastrointestinal tract and shows excellent analgesic and anti-inflammatory effects, while this drug is characterized by its relatively lower toxicity to the gastrointestinal tract than other nonsteroidal analgesic and anti-inflammatory drugs because it is a prodrug showing effects after conversion to active compounds in the body.

Loxoprofen - Shin Poong Pharm has excellent analgesic and anti-inflammatory effects, and its analgesic effect is specifically powerful. Loxoprofen - Shin Poong Pharm has pharmacological characteristics eg, a relatively lower toxicity to the gastrointestinal tract than other nonsteroidal analgesic and anti-inflammatory drugs because it is the prodrug showing the effect after absorption from the gastrointestinal tract and conversion to active metabolites. The mode of action of Loxoprofen - Shin Poong Pharm is prostaglandin biosynthesis inhibition and its site of action is cyclooxygenase.

Pharmacokinetics: After oral administration, Loxoprofen - Shin Poong Pharm is rapidly absorbed from the digestive tract in the unchanged form causing weak irritation to the stomach mucosa, and then rapidly converted to an active metabolite, the trans-alcohol form (in SRS configuration) which potently inhibits prostaglandin biosynthesis.

Urinary excretion of Loxoprofen - Shin Poong Pharm is rapid, and most amount of the drug administered is excreted in the unchanged form or in the glucuronic acid conjugated trans-OH form. About 50% of the dose is excreted in the urine within 8 hrs after administration.

Loxoprofen - Shin Poong Pharm administration

Administration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.

Should be taken with food. Take w/ or immediately after meals.

Loxoprofen - Shin Poong Pharm pharmacology

Pharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.

The exact mechanisms of action of Loxoprofen - Shin Poong Pharm is unknown. Its antiinflammatory effects are believed to be due to inhibition of both cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2) which leads to the inhibition of prostaglandin synthesis, and results in the inhibition of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.


  1. EPA DSStox. "Loxoprofen: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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