Lozol Uses

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What is Lozol?

Lozol belongs to the group of medicines known as diuretics. It is commonly used to treat high blood pressure (hypertension).

High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Lozol is also used to help reduce the amount of water in the body by increasing the flow of urine.

Lozol is available only with your doctor's prescription.

Lozol indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Lozol (Lozol) is indicated for the treatment of hypertension, alone or in combination with other antihypertensive drugs.

Lozol (Lozol) is also indicated for the treatment of salt and fluid retention associated with congestive heart failure.

Usage in Pregnancy

The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard.

Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia.

Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy. Lozol is indicated in pregnancy when edema is due to pathologic causes, just as it is in the absence of pregnancy (however, see PRECAUTIONS below). Dependent edema in pregnancy, resulting from restriction of venous return by the expanded uterus, is properly treated through elevation of the lower extremities and use of support hose; use of diuretics to lower intravascular volume in this case is illogical and unnecessary. There is hypervolemia during normal pregnancy which is not harmful to either the fetus or the mother (in the absence of cardiovascular disease), but which is associated with edema, including generalized edema in the majority of pregnant women. If this edema produces discomfort, increased recumbency will often provide relief. In rare instances, this edema may cause extreme discomfort which is not relieved by rest. In these cases, a short course of diuretics may provide relief and may be appropriate.

How should I use Lozol?

Use Lozol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Lozol.

Uses of Lozol in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Use: Labeled Indications

Heart failure: Treatment of edema in heart failure

Hypertension: Management of mild to moderate hypertension

Guideline recommendations: The 2017 Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults recommends if monotherapy is warranted, in the absence of comorbidities (eg, cerebrovascular disease, chronic kidney disease, diabetes, heart failure, ischemic heart disease, etc), that thiazide-like diuretics or dihydropyridine calcium channel blockers may be preferred options due to improved cardiovascular endpoints (eg, prevention of heart failure and stroke). ACE inhibitors and ARBs are also acceptable for monotherapy. Combination therapy may be required to achieve blood pressure goals and is initially preferred in patients at high risk (stage 2 hypertension or atherosclerotic cardiovascular disease [ASCVD] risk ≥10%) (ACC/AHA [Whelton 2017]).

Off Label Uses

Calcium nephrolithiasis

Data from a prospective, randomized, study supports the use of Lozol for the prevention of recurrent calcium nephrolithiasis. Additional trials may be necessary to further define the role of Lozol in the treatment of this condition.

Based on the American Urologic Association (AUA) guidelines for the medical management of kidney stones, Lozol is effective and recommended for the prevention of recurrent calcium stones in patients with high or relatively high urine calcium concentrations.

Lozol description


Lozol also contains the following excipients: Tablet: Lactose monohydrate 124.5 mg, anhydrous colloidal silica, hypromellose, magnesium stearate, povidone. Film-coating: Glycerol, hypromellose, macrogol 6000, magnesium stearate, titanium dioxide.

Lozol dosage

Lozol Dosage

Generic name: Lozol

Dosage form: Tablets

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.


The adult starting Lozol dose for hypertension is 1.25 mg as a single daily dose taken in the morning. If the response to 1.25 mg is not satisfactory after four weeks, the daily dose may be increased to 2.5 mg taken once daily. If the response to 2.5 mg is not satisfactory after four weeks, the daily dose may be increased to 5.0 mg taken once daily, but adding another antihypertensive should be considered.

Edema of Congestive Heart Failure

The adult starting Lozol dose for edema of congestive heart failure is 2.5 mg as a single daily dose taken in the morning. If the response to 2.5 mg is not satisfactory after one week, the daily dose may be increased to 5.0 mg taken once daily.

If the antihypertensive response to Lozol is insufficient, Lozol may be combined with other antihypertensive drugs, with careful monitoring of blood pressure. It is recommended that the usual dose of other agents be reduced by 50% during initial combination therapy. As the blood pressure response becomes evident, further dosage adjustments may be necessary.

In general, doses of 5.0 mg and larger have not appeared to provide additional effects on blood pressure or heart failure, but are associated with a greater degree of hypokalemia. There is minimal clinical trial experience in patients with doses greater than 5.0 mg once a day.

More about Lozol (Lozol)

Consumer resources

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Lozol interactions

See also:
What other drugs will affect Lozol?


Other Antihypertensives

Lozol (Lozol) may add to or potentiate the action of other antihypertensive drugs. In limited controlled trials that compared the effect of Lozol combined with other antihypertensive drugs with the effect of the other drugs administered alone, there was no notable change in the nature or frequency of adverse reactions associated with the combined therapy.

Post-Sympathectomy Patient

The antihypertensive effect of the drug may be enhanced in the post-sympathectomized patient.


Lozol, like the thiazides, may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use.

Lozol side effects

See also:
What are the possible side effects of Lozol?

Most adverse effects have been mild and transient.

The Clinical Adverse Reactions listed in Table 1 represent data from Phase II/III placebo-controlled studies (306 patients given Lozol 1.25 mg). The Clinical Adverse Reactions listed in Table 2 represent data from Phase II placebo-controlled studies and long-term controlled clinical trials (426 patients given Lozol (Lozol) 2.5 mg or 5.0 mg). The reactions are arranged into two groups: 1) a cumulative incidence equal to or greater than 5%; 2) a cumulative incidence less than 5%. Reactions are counted regardless of relation to drug.

TABLE 1: Adverse Reactions from Studies of 1.25 mg

Incidence ≥ 5% Incidence < 5%*
Headache Asthenia
Infection Flu Syndrome
Pain Abdominal Pain
Back Pain Chest Pain
Dizziness Hypertonia
Rhinitis Pharyngitis
SPECIAL SENSES Conjunctivitis

All other clinical adverse reactions occurred at an incidence of < 1%.

Approximately 4% of patients given Lozol 1.25 mg compared to 5% of the patients given placebo discontinued treatment in the trials of up to eight weeks because of adverse reactions. In controlled clinical trials of six to eight weeks in duration, 20% of patients receiving Lozol 1.25 mg, 61% of patients receiving Lozol 5.0 mg, and 80% of patients receiving Lozol 10.0 mg had at least one potassium value below 3.4 mEq/L. In the Lozol 1.25 mg group, about 40% of those patients who reported hypokalemia as a laboratory adverse event returned to normal serum potassium values without intervention. Hypokalemia with concomitant clinical signs or symptoms occurred in 2% of patients receiving Lozol 1.25 mg.

TABLE 2: Adverse Reactions from Studies of 2.5 mg and 5.0 mg

table 2
Incidence ≥ 5% Incidence < 5%
Headache Lightheadedness
Dizziness Drowsiness
Fatigue, weakness, loss of energy, lethargy, tiredness, or malaise Vertigo
Muscle cramps or spasm, or numbness of the extremities Depression
Blurred Vision
Nervousness, tension, anxiety, irritability, or agitation
Gastric irritation
Abdominal pain or cramps
CARDIOVASCULAR SYSTEM Orthostatic hypotension
Premature ventricular contractions
Irregular heart beat
GENITOURINARY SYSTEM Frequency of urination
OTHER Impotence or reduced libido
Increase in serum urea nitrogen
(BUN) or creatinine
Weight loss
Dry mouth
Tingling of extremities

Because most of these data are from long-term studies (up to 40 weeks of treatment), it is probable that many of the adverse experiences reported are due to causes other than the drug. Approximately 10% of patients given Lozol discontinued treatment in long-term trials because of reactions either related or unrelated to the drug.

Hypokalemia with concomitant clinical signs or symptoms occurred in 3% of patients receiving Lozol 2.5 mg q.d. and 7% of patients receiving Lozol 5 mg q.d. In long-term controlled clinical trials comparing the hypokalemic effects of daily doses of Lozol and hydrochlorothiazide, however, 47% of patients receiving Lozol 2.5 mg, 72% of patients receiving Lozol 5 mg, and 44% of patients receiving hydrochlorothiazide 50 mg had at least one potassium value (out of a total of 11 taken during the study) below 3.5 mEq/L. In the Lozol 2.5 mg group, over 50% of those patients returned to normal serum potassium values without intervention.

In clinical trials of six to eight weeks, the mean changes in selected values were as shown in the tables below.

Mean Changes from Baseline after 8 Weeks of Treatment – 1.25 mg
Serum Electrolytes (mEq/L) Potassium Sodium Chloride Serum Uric Acid (mg/dL) BUN (mg/dL)
1.25 mg (n=255-257) – 0.28 – 0.63 – 2.60 0.69 1.46
(n=263-266) 0.00 – 0.11 – 0.21 0.06 0.06

No patients receiving Lozol 1.25 mg experienced hyponatremia considered possibly clinically significant ( < 125 mEq/L). Lozol had no adverse effects on lipids.

Mean Changes from Baseline after 40 Weeks of Treatment – 2.5 mg and 5.0 mg
Serum Electrolytes (mEq/L) Potassium Sodium Chloride Serum Uric Acid (mg/dL) BUN (mg/dL)
Lozol 2.5 mg (n=76) – 0.4 – 0.6 – 3.6 0.7 – 0.1
Lozol 5.0 mg (n=81) – 0.6 – 0.7 – 5.1 1.1 1.4

The following reactions have been reported with clinical usage of Lozol (Lozol) : jaundice (intrahepatic cholestatic jaundice), hepatitis, pancreatitis and abnormal liver function tests. These reactions were reversible with discontinuance of the drug.

Also reported are erythema multiforme, Stevens-Johnson Syndrome, bullous eruptions, purpura, photosensitivity, fever, pneumonitis, anaphylactic reactions, agranulocytosis, leukopenia, thrombocytopenia and aplastic anemia. Other adverse reactions reported with antihypertensive/diuretics are necrotizing angiitis, respiratory distress, sialadenitis, xanthopsia.

Lozol contraindications

See also:
What is the most important information I should know about Lozol?

Hypersensitivity to Lozol or any component of the formulation or sulfonamide-derived drugs; anuria

Note: Although the FDA approved product labeling states this medication is contraindicated with other sulfonamide-containing drug classes, the scientific basis of this statement has been challenged. See “Warnings/Precautions” for more detail.

Canadian labeling: Additional contraindications (not in US labeling): Severe renal failure (CrCl <30 mL/minute); hepatic encephalopathy; severe hepatic impairment; hypokalemia; concomitant use with antiarrhythmic agents causing torsade de pointes; pregnancy; breast-feeding; hereditary problems of galactose intolerance, glucose-galactose malabsorption, or Lapp lactase deficiency

Active ingredient matches for Lozol:


Unit description / dosage (Manufacturer)Price, USD
Tablet; Oral; Indapamide 1.25 mg
Tablet; Oral; Indapamide 2.5 mg
100 tablet in 1 bottle
1000 tablet in 1 bottle

List of Lozol substitutes (brand and generic names):

Lozide tablet 2.5 mg (Servier)
Milisher 1.25 mg
Milisher 30 mg
Milisher 100 mg
Milix 2.5 mg x 500's
Milix 2.5 mg x 1000's
Milix 1.25 mg x 500's
Milix 1.25 mg x 1000's
Milix 1.5 mg x 500's
Millibar 2.5 mg x 50's (Lisapharma)
Tablet; Oral; Indapamide 1.25 mg
Tablet; Oral; Indapamide 2.5 mg
Mylan-indapamide tablet 2.5 mg (Mylan Pharmaceuticals Ulc (Canada))
Mylan-indapamide tablet 1.25 mg (Mylan Pharmaceuticals Ulc (Canada))
Nakamide 1.25 mg x 1000's
Nakamide 2.5 mg x 1000's
Nakamide 1.5 mg x 1000's
Tablet; Oral; Indapamide Hemihydrate 2.5 mg (Douglas)
Napamide 2.5 mg x 30's (Douglas)
Napamide 2.5 mg x 90's (Douglas)
Napamide 2.5 mg x 100's (Douglas)
Napamide 2.5 mg (Douglas)
Napamide tab 2.5 mg 90's (Douglas)
Narix 1.5 mg (Cimed)
NATRIDAC SR 1.5 MG TABLET 1 strip / 10 tablets each (Zydus Cadila)$ 0.78
Tablet, Film-Coated; Oral; Indapamide Hemihydrate 2.5 mg (Serdia Pharmaceuticals (India) Ltd.)
Natrilix 1.5mg SR-TAB / 10 (Serdia Pharmaceuticals (India) Ltd.)$ 1.25
Natrilix 2.5mg TAB / 10 (Serdia Pharmaceuticals (India) Ltd.)$ 1.24
Natrilix 2.5 mg x 30's (Serdia Pharmaceuticals (India) Ltd.)
Natrilix SR 1.5 mg x 30's (Serdia Pharmaceuticals (India) Ltd.)


  1. DailyMed. "INDAPAMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "indapamide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "indapamide". http://www.drugbank.ca/drugs/DB00808 (accessed September 17, 2018).


The results of a survey conducted on ndrugs.com for Lozol are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Lozol. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

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Consumer reported price estimates

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1 consumer reported time for results

To what extent do I have to use Lozol before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 3 days and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Lozol. To get the time effectiveness of using Lozol drug by other patients, please click here.
3 days1

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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