Lv Ke Uses

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What is Lv Ke?

Albuterol is used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases. This medicine is also used to prevent wheezing caused by exercise (exercise-induced bronchospasm).

Albuterol belongs to the family of medicines known as adrenergic bronchodilators. Adrenergic bronchodilators are medicines that are breathed in through the mouth to open up the bronchial tubes (air passages) in the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

This medicine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, albuterol is used in certain patients with the following medical condition:

Lv Ke indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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As a bronchodilator in the treatment of bronchospasm associated with bronchial asthma, emphysema and chronic bronchitis and other conditions associated with reversible airways obstruction. Lv Ke also decreases uterine contractility and arrests premature labor.

Uses of Lv Ke in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Lv Ke is used to prevent reversible airways obstruction occurring during asthma, infections of airway passages (bronchitis), lung disorder in which the flow of air to the lungs is blocked (emphysema), and other lung diseases.

Lv Ke description

Each 200 mcg/dose powder for inhalation solution contains Salbutamol sulphate equivalent to Lv Ke 200 mcg per metered dose. The dose, which the patient gets through the mouthpiece of the device is Lv Ke 180 mcg.

It contains lactose monohydrate (milk protein) as excipient.

The Lv Ke multiple dose powder inhaler contains 200 doses of finely powdered Lv Ke sulphate mixed in a small quantity of lactose. The amount of drug received by the patient (180 mcg/dose) corresponds to that from Lv Ke inhalation aerosol. The dose to be inhaled is released from the container by pressing the device between the thumb and forefinger. This is followed by inhalation through the device. As a result, Lv Ke particles are transferred to their target, the lungs. Use of the Lv Ke does not require coordination of actuation of the dose and inhalation.

Lv Ke dosage

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Tablet: Adults: Usual Dose: 4 mg or 10 mL (2 tsp) of syrup. If adequate bronchodilation is not obtained, each single dose may be gradually increased to as much as 8 mg or 20 mL (4 tsp) of syrup.

To be taken every 6 or 8 hrs.

In some patients known to be unusually sensitive to β-adrenergic stimulant drugs who obtain adequate relief with 5 mL of syrup, it is advisable to initiate treatment with 5 mL (1 tsp) of syrup 3 or 4 times a day.

Children >12 years: 2-4 mg or 5-10 mL (1-2 tsp) of syrup; 6-12 years: 2 mg or 5 mL (1 tsp) of syrup; 2-6 years: 1-2 mg or 2.5-5 mL (½-1 tsp) of syrup.

Nebulizing Solution: Adults and Adolescents: Usual Dose: The usual initial dose of Lv Ke by wet inhalation is 2.5-5 mg. Treatment may be repeated up to 4 times daily. In adults, higher dosing up to 40 mg/day can be given under strict medical supervision in hospital for the treatment of severe airway obstruction.

Children up to 12 years: Dosage has not been established. Note: As there may be adverse effects associated with excessive dosing, the dosage or frequency of administration should only be increased on medical advice.

Administration: Lv Ke 1 mg/mL nebulizing solution for inhalation is given undiluted using a nebulizer, under the direction of a physician. However, if prolonged administration is desired (>10 min), the solution can be diluted with 0.9% sodium chloride solution.

Direction for Dilution/Prolonged Inhalation: Pipette 2.5-5 mL (equivalent to 2.5-5 mg Lv Ke, as sulfate) of Lv Ke nebulizing solution from the bottle by using a calibrated medicine dropper provided in the pack. Drop the solution into an electric nebulizer and dilute it with 2-4 mL normal saline solution and start inhalation. Any unused solution in the chamber of the nebulizer must be discarded. Repeat the same procedure every 8 hrs in a 24-hr period.

Lv Ke interactions

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The concomitant use of Lv Ke (albuterol sulfate syrup) and other oral sympathomimetic agents is not recommended since such combined use may lead to deleterious cardiovascular effects. This recommendation does not preclude the judicious use of an aerosol bronchodilator of the adrenergic stimulant type in patients receiving Lv Ke (albuterol sulfate syrup). Such concomitant use, however, should be individualized and not given on a routine basis. If regular coadministration is required, then alternative therapy should be considered.

Beta-Blockers

Beta-adrenergic receptor blocking agents not only block the pulmonary effect of beta-agonists, such as Lv Ke (albuterol sulfate syrup), but may produce severe bronchospasm in asthmatic patients. Therefore, patients with asthma should not normally be treated with beta-blockers. However, under certain circumstances, eg, as prophylaxis after myocardial infarction, there may be no acceptable alternatives to the use of beta-adrenergic blocking agents in patients with asthma. In this setting, cardioselective beta-blockers could be considered, although they should be administered with caution.

Diuretics

The ECG changes and/or hypokalemia that may result from the administration of nonpotassium-sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. Although the clinical significance of these effects is not known, caution is advised in the coadministration of beta-agonists with nonpotassium-sparing diuretics.

Digoxin

Mean decreases of 16% to 22% in serum digoxin levels were demonstrated after single dose intravenous and oral administration of albuterol, respectively, to normal volunteers who had received digoxin for 10 days. The clinical significance of these findings for patients with obstructive airway disease who are receiving albuterol and digoxin on a chronic basis is unclear. Nevertheless, it would be prudent to carefully evaluate the serum digoxin levels in patients who are currently receiving digoxin and albuterol.

Monoamine Oxidase Inhibitors or Tricyclic Antidepressants

Albuterol should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, because the action of albuterol on the vascular system may be potentiated.

Lv Ke side effects

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What are the possible side effects of Lv Ke?

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The adverse reactions to albuterol are similar in nature to those of other sympathomimetic agents. In clinical trials, the most frequent adverse reactions to Lv Ke (albuterol sulfate syrup) in adults and older children were:

Percent Incidence of Adverse Reactions in Adults and Children (6-12 Years of Age)

Adverse Event

Percent Incidence

Central Nervous System

Tremor

10

Nervousness

9

Shakiness

9

Headache

4

Dizziness

3

Excitement

2

Hyperactivity

2

Sleeplessness

1

Disturbed sleep

<1

Irritable behavior

<1

Dilated pupils

<1

Weakness

1

Cardiovascular

Tachycardia

1

Palpitations

<1

Sweating

<1

Chest Pain

<1

Ear, Nose, and Throat

Epistaxis

1

Gastrointestinal

Increased appetite

3

Epigastric pain

<1

Stomachache

<1

Musculoskeletal

Muscle spasm

<1

Respiratory

Cough

<1

In clinical trials, the following adverse reactions to Lv Ke (albuterol sulfate syrup) were noted more frequently in young children 2 to 6 years of age than in adults and older children:

Percent Incidence of Adverse Reactions Noted More Frequently in Children 2 to 6 Years of Age Than in Older Children and Adults

Adverse Event

Percent Incidence

Central Nervous System

Excitement

20

Nervousness

15

Hypokinesia

4

Sleeplessness

2

Emotional lability

1

Fatigue

1

Cardiovascular

Tachycardia

2

Pallor

1

Gastrointestinal

Gastrointestinal symptoms

2

Loss of appetite

1

Ophthalmologic

Conjunctivitis

1

Cases of urticaria, angioedema, rash, bronchospasm, oropharyngeal edema, and arrhythmias (including atrial fibrillation, supraventricular tachycardia, and extrasystoles) have been reported after the use of Lv Ke (albuterol sulfate syrup).

In addition, albuterol, like other sympathomimetic agents, can cause adverse reactions such as angina, central nervous system stimulation, drying or irritation of the oropharynx, hypertension, nausea, unusual taste, vertigo, and vomiting.

The reactions are generally transient in nature, and it is usually not necessary to discontinue treatment with Lv Ke (albuterol sulfate syrup). In selected cases, however, dosage may be reduced temporarily; after the reaction has subsided, dosage should be increased in small increments to the optimal dosage.

Lv Ke contraindications

Hyperthyroidism and cardiac disease. Lv Ke may interact with monoamine oxidase inhibitors and should not be given to patients receiving such treatment or within 14 days after stopping treatment.

Use in pregnancy & lactation: Safety in pregnancy and lactating women has not been established.

Lv Ke is not indicated for the prevention of premature labor associated with toxemia of pregnancy or ante partum hemorrhage, nor should it be used for threatened abortion during the 1st and 2nd trimesters of pregnancy.

Active ingredient matches for Lv Ke:

Salbutamol in China.


List of Lv Ke substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Levolin Repules 1.25mg RESP / 2.5ml$ 0.08
Medolin 2 mg x 100 x 10's (Medochemie)
Medolin 4 mg x 100 x 10's (Medochemie)
Medolin 2 mg x 100 Tablet (Medochemie)
Medolin 2 mg x 500 Tablet (Medochemie)
Medolin 2 mg x 1000 Tablet (Medochemie)
Medolin 4 mg x 10 Blister x 10 Tablet (Medochemie)
Medolin 4 mg x 1 Bottle 500 Tablet (Medochemie)
Medolin 4 mg x 1 Bottle 1000 Tablet (Medochemie)
Tablets; Oral; Albuterol Sulfate 2 mg (Medochemie)
Tablets; Oral; Albuterol Sulfate 4 mg (Medochemie)
Medolin 10mg Tablet (Medochemie)$ 0.08
Mozal 4 mg x 100's
Mozal 4 mg x 500's
Mozal 4 mg x 1000's
Nefty S 1000+500 Injection (Neuron Pharma Pvt. Ltd.)$ 1.75
New Ventiphyline 2+157.23 Tablet (Yash Pharma International)$ 0.01
New Ventiphyline Forte 4+314.46 Tablet (Yash Pharma International)$ 0.01
Nioxol 100 ml Syrup (Woodrock Healthcare Pvt. Ltd.)$ 0.03
Nioxol S 100 ml Syrup (Woodrock Healthcare Pvt. Ltd.)$ 0.03
Nopant 6 mg/1 mL x 20 mL
Onimar PD 100 ml Syrup (Emcee Pharmaceuticals Pvt.Ltd.)$ 0.02
ONIMAR PD 50 MG/1 MG SYRUP 1 bottle / 100 ML syrup each (Emcee Pharmaceuticals Pvt.Ltd.)$ 0.51
Onimar PD 50 mg/1 mg Syrup (Emcee Pharmaceuticals Pvt.Ltd.)$ 0.51
Ophyl TR 300 mg Tablet (Octane Biotech Pvt. Ltd.)$ 0.31
Solution; Inhalation; Albuterol Sulfate

References

  1. DailyMed. "ALBUTEROL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "Salbutamol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "Salbutamol". http://www.drugbank.ca/drugs/DB01001 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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