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Magnesium Chloride Actions |
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Description: Magnesium is essential to many enzymatic reactions in the body, acting as a cofactor in protein synthesis and carbohydrate metabolism. 8.36 g of Magnesium Chloride (hexahydrate) is equivalent to about 1 g of magnesium. Each g of Magnesium Chloride (hexahydrate) represents about 4.9 mmol of magnesium and 9.8 mmol of chloride.
Pharmacokinetics:
Absorption:
Oral: About one-third is absorbed from the small intestine. The fraction of magnesium absorbed is inversely proportional to amount ingested.
Distribution: Plasma protein binding: About 25-30%. Magnesium crosses the placenta.
Excretion:
Your doctor may check your kidney function before you start using Magnesium Chloride.
Magnesium Chloride is given as an infusion into a vein. A healthcare provider will give you this injection.
You may be given other medications to help prevent serious side effects or allergic reaction.
Your breathing and blood pressure will be watched closely during and after each injection.
You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective.
Oral: Bariatric surgery: Tablet, delayed release: Some institutions may have specific protocols that conflict with these recommendations; refer to institutional protocols as appropriate. ER tablets should be swallowed whole. Do not cut, chew, or crush. IR tablet and injectable formulations are available.
If safety and efficacy can be effectively monitored, no change in formulation or administration is required after bariatric surgery; however, clinicians should be aware that bariatric vitamin supplementation is recommended lifelong and may include magnesium. Consider integrating part or all of magnesium supplementation requirements into the postsurgery bariatric vitamin regimen.
Magnesium is important as a cofactor in many enzymatic reactions in the body involving protein synthesis and carbohydrate metabolism (at least 300 enzymatic reactions require magnesium). Actions on lipoprotein lipase have been found to be important in reducing serum cholesterol and on sodium/potassium ATPase in promoting polarization (eg, neuromuscular functioning).
Oral: Inversely proportional to amount ingested; 40% to 60% under controlled dietary conditions; 15% to 36% at higher doses
Bone (50% to 60%); extracellular fluid (1% to 2%)
Urine (as magnesium)
30%, to albumin
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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