Manialit Uses

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What is Manialit?

Manialit is used to treat mania that is part of bipolar disorder (manic-depressive illness). It is also used on a daily basis to reduce the frequency and severity of manic episodes. Manic-depressive patients experience severe mood changes, ranging from an excited or manic state (e.g., unusual anger or irritability or a false sense of well-being) to depression or sadness.

It is not known how Manialit works to stabilize a person's mood. However, it does act on the central nervous system. It helps you to have more control over your emotions and helps you cope better with the problems of living.

It is important that you and your family understand all the effects of Manialit. These effects depend on your individual condition and response and the amount of Manialit you use. You also must know when to contact your doctor if there are problems with using the medicine.

Manialit is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Manialit is used in certain patients with the following medical conditions:

Manialit indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Oral

Mania; Bipolar disorder; Recurrent unipolar depression

Adult: Dose depends on the preparation used. Doses should be adjusted to produce a serum-Manialit concentration of 0.4-1 mmol/l. Camcolit® tablets: Treatment: Initiate at 1-1.5 g daily; Prevention: Initiate at 300-400 mg daily. Priadel® tablets: Treatment and prevention: Initially, 400-1,200 mg daily in 1-2 divided doses. Priadel® syrup: Treatment and prevention: Initially, 1.04-3.12 g daily in 2 divided doses. Liskonum® tablets: Treatment: Initially, 450-675 mg bid; Prevention: Initially, 450 mg bid. Doses should be divided throughout the day during the initial period; once-daily dosing may be used when serum-Manialit concentrations have stabilised. Adjust initial dose 4-7 days after starting based on results of serum-Manialit concentrations. Monitor serum-Manialit concentrations once wkly until dosage has remained constant for 4 wk, after which monitoring may be reduced to once every 3 mth.

Child: ≥12 yr: Acute phase: Serum concentrations of 1-1.2 mEq/l. Max dose: 1.5 mEq/l. Initially, 1.8 g Manialit daily as conventional capsules/tablets in 3-4 divided doses, or 30 ml (approx 48 mEq) Manialit citrate oral solution daily in 3-4 divided doses. Alternatively, initially 1.8 g Manialit daily as extended-release tablets in 2-3 divided doses.

Maintenance: Not established.

Elderly: ≤900 mg Manialit daily. Titrate dose slowly to achieve therapeutic serum concentrations.

Maintenance: Maintain serum concentrations at the lower end of 0.6-1.2 mEq/l.

Renal impairment:

CrCl (ml/min)Dosage Recommendation
10-5050-75% of normal dose.
<1025-50% of normal dose.

How should I use Manialit?

Use Manialit as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Manialit.

Uses of Manialit in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Bipolar disorder:

Immediate release: Treatment of manic and mixed episodes and maintenance treatment in patients ≥7 years of age with a diagnosis of bipolar disorder.

Extended release: Treatment of manic episodes and maintenance treatment in patients ≥12 years of age with a diagnosis of bipolar disorder.

Off Label Uses

Bipolar disorder, hypomania

Data from a limited number of patients studied suggest that Manialit may be beneficial in the treatment of hypomania.

Manialit description

Manialit was used during the 19th century to treat gout. Manialit salts such as Manialit (Li2CO3), Manialit citrate, and Manialit orotate are mood stabilizers. They are used in the treatment of bipolar disorder, since unlike most other mood altering drugs, they counteract both mania and depression. Manialit can also be used to augment other antidepressant drugs. It is also sometimes prescribed as a preventive treatment for migraine disease and cluster headaches. The active principle in these salts is the Manialit ion Li+, which having a smaller diameter, can easily displace K+ and Na+ and even Ca+2, in spite of its greater charge, occupying their sites in several critical neuronal enzymes and neurotransmitter receptors.

Manialit dosage

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Acute Mania

Optimal patient response to Manialit usually can be established and maintained with 600 mg t.i.d. Optimal patient response to Manialit

Oral Solution usually can be established and maintained with 10 mL (2 full teaspoons) (16 mEq of Manialit) t.i.d. Such doses will normally produce an effective serum Manialit level ranging between 1.0 and 1.5 mEq/l. Dosage must be individualized according to serum levels and clinical response. Regular monitoring of the patient’s clinical state and of serum Manialit levels is necessary. Serum levels should be determined twice per week during the acute phase, and until the serum level and clinical condition of the patient have been stabilized.

Long-Term Control

The desirable serum Manialit levels are 0.6 to 1.2 mEq/l. Dosage will vary from one individual to another, but usually 300 mg of Manialit t.i.d. or q.i.d., or 5 mL (1 full teaspoon) (8 mEq of Manialit) of Manialit

Oral Solution t.i.d. or q.i.d. will maintain this level. Serum Manialit levels in uncomplicated cases receiving maintenance therapy during remission should be monitored at least every two months.

Patients abnormally sensitive to Manialit may exhibit toxic signs at serum levels of 1.0 to 1.5 mEq/l. Elderly patients often respond to reduced dosage, and may exhibit signs of toxicity at serum levels ordinarily tolerated by other patients.

N.B.

Blood samples for serum Manialit determination should be drawn immediately prior to the next dose when Manialit concentrations are relatively stable (i.e., 8-12 hours after the previous dose). Total reliance must not be placed on serum levels alone. Accurate patient evaluation requires both clinical and laboratory analysis.

Manialit interactions

See also:
What other drugs will affect Manialit?

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Almotriptan: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Alosetron: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Amphetamines: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Angiotensin II Receptor Blockers: May increase the serum concentration of Manialit. Management: Manialit dosage reductions will likely be needed following the addition of an angiotensin II receptor antagonist. Consider therapy modification

Angiotensin-Converting Enzyme Inhibitors: May increase the serum concentration of Manialit. Management: Manialit dosage reductions will likely be needed following the addition of an ACE inhibitor. Monitor patient response to Manialit closely following addition or discontinuation of concurrent ACE inhibitor treatment. Consider therapy modification

Antiemetics (5HT3 Antagonists): May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Exceptions: Alosetron; Ondansetron; Ramosetron. Monitor therapy

Antipsychotic Agents: Manialit may enhance the neurotoxic effect of Antipsychotic Agents. Manialit may decrease the serum concentration of Antipsychotic Agents. Specifically noted with chlorpromazine. Monitor therapy

BusPIRone: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Caffeine and Caffeine Containing Products: May decrease the serum concentration of Manialit. Monitor therapy

Calcitonin: May decrease the serum concentration of Manialit. Monitor therapy

Calcium Channel Blockers (Nondihydropyridine): May enhance the neurotoxic effect of Manialit. Calcium Channel Blockers (Nondihydropyridine) may increase the serum concentration of Manialit. Decreased or unaltered Manialit concentrations have also been reported with this combination. Exceptions: Bepridil. Monitor therapy

Calcium Polystyrene Sulfonate: May decrease the serum concentration of Manialit. Management: Consider separating administration of Manialit from administration of oral calcium polystyrene sulfonate by at least 6 hours. Consider therapy modification

CarBAMazepine: May enhance the adverse/toxic effect of Manialit. Monitor therapy

Carbonic Anhydrase Inhibitors: May decrease the serum concentration of Manialit. Exceptions: Brinzolamide; Dorzolamide. Monitor therapy

Cyclobenzaprine: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Dapoxetine: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Do not use serotonergic agents (high risk) with dapoxetine or within 7 days of serotonergic agent discontinuation. Do not use dapoxetine within 14 days of monoamine oxidase inhibitor use. Dapoxetine labeling lists this combination as contraindicated. Avoid combination

Desmopressin: Manialit may diminish the therapeutic effect of Desmopressin. Desmopressin may increase the serum concentration of Manialit. Monitor therapy

Dexmethylphenidate-Methylphenidate: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Dextromethorphan: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Eletriptan: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Eplerenone: May increase the serum concentration of Manialit. Monitor therapy

Ergot Derivatives: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Exceptions: Nicergoline. Monitor therapy

Fexinidazole [INT]: Manialit may enhance the QTc-prolonging effect of Fexinidazole [INT]. Avoid combination

Fosphenytoin: May enhance the adverse/toxic effect of Manialit. Monitor therapy

Haloperidol: QT-prolonging Agents (Indeterminate Risk - Caution) may enhance the QTc-prolonging effect of Haloperidol. Monitor therapy

Lasmiditan: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Linezolid: May enhance the serotonergic effect of Manialit. This could result in serotonin syndrome. Management: Consider alternatives to this drug combination. If combined, monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes). Consider therapy modification

Loop Diuretics: May decrease the serum concentration of Manialit. Loop Diuretics may increase the serum concentration of Manialit. Monitor therapy

Lorcaserin (Withdrawn From US Market): May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Metaxalone: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Methyldopa: May enhance the adverse/toxic effect of Manialit. This may occur without notable changes in serum Manialit concentrations. Monitor therapy

Methylene Blue: May enhance the serotonergic effect of Manialit. This could result in serotonin syndrome. Management: Consider alternatives to this drug combination. If combined, monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes). Consider therapy modification

MetroNIDAZOLE (Systemic): May enhance the adverse/toxic effect of Manialit. MetroNIDAZOLE (Systemic) may increase the serum concentration of Manialit. Monitor therapy

Monoamine Oxidase Inhibitors (Antidepressant): May enhance the serotonergic effect of Manialit. This could result in serotonin syndrome. Management: Consider alternatives to this drug combination. If combined, monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes). Consider therapy modification

Monoamine Oxidase Inhibitors (Type B): May enhance the serotonergic effect of Serotonergic Agents (High Risk, Miscellaneous). This could result in serotonin syndrome. Avoid combination

Nefazodone: May enhance the serotonergic effect of Serotonergic Agents (High Risk, Miscellaneous). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Neuromuscular-Blocking Agents: Manialit may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. Monitor therapy

Nonsteroidal Anti-Inflammatory Agents: May increase the serum concentration of Manialit. Management: Consider reducing the Manialit dose when initiating a NSAID. Monitor for increased Manialit therapeutic/toxic effects if a NSAID is initiated/dose increased, or decreased effects if a NSAID is discontinued/dose decreased. Exceptions: Sulindac. Consider therapy modification

Ondansetron: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Opioid Agonists: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Exceptions: FentaNYL; Meperidine; TraMADol. Monitor therapy

Oxitriptan: Serotonergic Agents (High Risk) may enhance the serotonergic effect of Oxitriptan. This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Ozanimod: May enhance the adverse/toxic effect of Serotonergic Agents (High Risk). Management: Concomitant use of ozanimod with serotonergic agents is not recommended. If combined, monitor patients closely for the development of hypertension, including hypertensive crises. Consider therapy modification

Phenytoin: May enhance the adverse/toxic effect of Manialit. Monitor therapy

Potassium Iodate: Manialit may enhance the hypothyroid effect of Potassium Iodate. Monitor therapy

Potassium Iodide: May enhance the hypothyroid effect of Manialit. Monitor therapy

QT-prolonging Agents (Highest Risk): QT-prolonging Agents (Indeterminate Risk - Caution) may enhance the QTc-prolonging effect of QT-prolonging Agents (Highest Risk). Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Monitor therapy

Ramosetron: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Sargramostim: May enhance the adverse/toxic effect of Manialit. Specifically, the myeloproliferative effects may be increased. Monitor therapy

Selective Serotonin Reuptake Inhibitors: Serotonergic Agents (High Risk, Miscellaneous) may enhance the serotonergic effect of Selective Serotonin Reuptake Inhibitors. This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Exceptions: Dapoxetine. Monitor therapy

Serotonergic Non-Opioid CNS Depressants: Serotonergic Agents (High Risk, Miscellaneous) may enhance the serotonergic effect of Serotonergic Non-Opioid CNS Depressants. This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Serotonergic Opioids (High Risk): May enhance the serotonergic effect of Serotonergic Agents (High Risk, Miscellaneous). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) if these agents are combined. Monitor therapy

Serotonin 5-HT1D Receptor Agonists (Triptans): May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Exceptions: Almotriptan; Eletriptan. Monitor therapy

Serotonin/Norepinephrine Reuptake Inhibitors: May enhance the serotonergic effect of Serotonergic Agents (High Risk, Miscellaneous). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Sodium Bicarbonate: May increase the excretion of Manialit. Monitor therapy

Sodium Chloride: May increase the excretion of Manialit. Monitor therapy

Sodium Polystyrene Sulfonate: May decrease the serum concentration of Manialit. Management: Consider separating administration of Manialit from administration of oral sodium polystyrene sulfonate by at least 6 hours. Consider therapy modification

St John's Wort: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. St John's Wort may decrease the serum concentration of Serotonergic Agents (High Risk). Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Syrian Rue: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Tetracyclines: May increase the serum concentration of Manialit. Monitor therapy

Theophylline Derivatives: May decrease the serum concentration of Manialit. Monitor therapy

Thiazide and Thiazide-Like Diuretics: May decrease the excretion of Manialit. Management: Condsider reducing the Manialit dose by 50% upon initiation of a thiazide diuretic. Monitor for increased Manialit therapeutic/toxic effects if a thiazide is initiated/dose increased, or decreased effects if a thiazide is discontinued/dose decreased. Consider therapy modification

Topiramate: May increase the serum concentration of Manialit. Monitor therapy

Tricyclic Antidepressants: May enhance the serotonergic effect of Serotonergic Agents (High Risk, Miscellaneous). This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Tryptophan: Manialit may enhance the serotonergic effect of Tryptophan. This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy

Manialit side effects

See also:
What are the possible side effects of Manialit?

Manialit Toxicity

The likelihood of toxicity increases with increasing serum Manialit levels. Serum Manialit levels greater than 1.5 mEq/L carry a greater risk than lower levels. However, patients sensitive to Manialit may exhibit toxic signs at serum levels below 1.5 mEq/L.

Diarrhea, vomiting, drowsiness, muscular weakness and lack of coordination may be early signs of Manialit toxicity, and can occur at Manialit levels below 2.0 mEq/L. At higher levels, giddiness, ataxia, blurred vision, tinnitus and a large output of dilute urine may be seen. Serum Manialit levels above 3.0 mEq/L may produce a complex clinical picture involving multiple organs and organ systems. Serum Manialit levels should not be permitted to exceed 2.0 mEq/L during the acute treatment phase.

Fine hand tremor, polyuria and mild thirst may occur during initial therapy for the acute manic phase, and may persist throughout treatment. Transient and mild nausea and general discomfort may also appear during the first few days of Manialit administration.

These side effects are an inconvenience rather than a disabling condition, and usually subside with continued treatment or a temporary reduction or cessation of dosage. If persistent, a cessation of dosage is indicated.

The following adverse reactions have been reported and do not appear to be directly related to serum Manialit levels.

Neuromuscular: Tremor, muscle hyperirritability (fasciculations, twitching, clonic movements of whole limbs), ataxia, choreoathetotic movements, hyperactive deep tendon reflexes.

Central Nervous System: Blackout spells, epileptiform seizures, slurred speech, dizziness, vertigo, incontinence of urine or feces, somnolence, psychomotor retardation, restlessness, confusion, stupor, coma, acute dystonia, downbeat nystagmus.

Cardiovascular: Cardiac arrhythmia, hypotension, peripheral circulatory collapse, sinus node dysfunction with severe bradycardia (which may result in syncope).

Neurological: Cases of pseudotumor cerebri (increased intracranial pressure and papilledema) have been reported with Manialit use. If undetected, this condition may result in enlargement of the blind spot, constriction of visual fields and eventual blindness due to optic atrophy. Manialit should be discontinued, if clinically possible, if this syndrome occurs.

Gastrointestinal: Anorexia, nausea, vomiting, diarrhea.

Genitourinary: Albuminuria, oliguria, polyuria, glycosuria.

Dermatologic: Drying and thinning of hair, anesthesia of skin, chronic folliculitis, xerosis cutis, alopecia and exacerbation of psoriasis.

Autonomic Nervous System: Blurred vision, dry mouth.

Thyroid Abnormalities: Euthyroid goiter and/or hypothyroidism (including myxedema) accompanied by lower T3 and T4. Iodine 131 uptake may be elevated.. Paradoxically, rare cases of hyperthyroidism have been reported.

EEG Changes: Diffuse slowing, widening of frequency spectrum, potentiation and disorganization of background rhythm.

EKG Changes: Reversible flattening, isoelectricity or inversion of T-waves.

Miscellaneous: Fatigue, lethargy, transient scotomata, dehydration, weight loss, tendency to sleep.

Miscellaneous reactions unrelated to dosage are: Transient electroencephalographic and electrocardiographic changes, leukocytosis, headache, diffuse nontoxic goiter with or without hypothyroidism, transient hyperglycemia, generalized pruritis with or without rash, cutaneous ulcers, albuminuria, worsening of or-ganic brain syndromes, excessive weight gain, edematous swelling of ankles or wrists, and thirst or polyuria, sometimes resembling diabetes insipidus, and metallic taste.

A single report has been received of the development of painful discoloration of fingers and toes and coldness of the extremities within one day of the starting of treatment of Manialit. The mechanism through which these symptoms (resembling Raynaud's Syndrome) developed is not known. Recovery followed discontinuance.

Manialit contraindications

See also:
What is the most important information I should know about Manialit?

Manialit should generally not be given to patients with significant renal or cardiovascular disease, severe debilitation or dehydration, or sodium depletion, and to patients receiving diuretics, since the risk of Manialit toxicity is very high in such patients. If the psychiatric indication is life-threatening, and if such a patient fails to respond to other measures, Manialit treatment may be undertaken with extreme caution, including daily serum Manialit determinations and adjustment to the usually low doses ordinarily tolerated by these individuals. In such instances, hospitalization is a necessity.

Active ingredient matches for Manialit:

Lithium Carbonate in Italy.


List of Manialit substitutes (brand and generic names)

Sort by popularity
Unit description / dosage (Manufacturer)Price, USD
Microlit tab 300 mg 50's (Micro Labs)
Solution; Oral; Lithium Gluconate 200 mg / ml (Cristalia)
Capsule; Oral; Lithium Carbonate 150 mg
Capsule; Oral; Lithium Carbonate 300 mg
Capsule; Oral; Lithium Carbonate 600 mg
Capsules; Oral; Lithium Carbonate 150 mg
Capsules; Oral; Lithium Carbonate 300 mg
Capsules; Oral; Lithium Carbonate 600 mg
Pal-lithium Carbonate capsule 300 mg (Paladin Labs Inc (Canada))
Pal-lithium Carbonate capsule 600 mg (Paladin Labs Inc (Canada))
Pal-lithium Carbonate capsule 150 mg (Paladin Labs Inc (Canada))
Capsule; Oral; Lithium Carbonate 150 mg
Capsule; Oral; Lithium Carbonate 300 mg
Capsule; Oral; Lithium Carbonate 600 mg
Capsules; Oral; Lithium Carbonate 150 mg
Capsules; Oral; Lithium Carbonate 300 mg
Capsules; Oral; Lithium Carbonate 600 mg
PHL-lithium Carbonate capsule 300 mg (Pharmel Inc (Canada))
PHL-lithium Carbonate capsule 600 mg (Pharmel Inc (Canada))
PHL-lithium Carbonate capsule 150 mg (Pharmel Inc (Canada))
450 mg x 100's (Solitaire (Psychotop))$ 7.78
Psycolith 450mg CR-TAB / 100 (Solitaire (Psychotop))$ 7.78
PSYCOLITH CR tab 450 mg x 10's (Solitaire (Psychotop))$ 0.78
Psycolith 450mg CR-TAB / 100 (Solitaire (Psychotop))$ 7.78
Salith SR 400 mg Tablet (Orchid Chemicals & Pharmaceuticals Ltd.)$ 0.03
Tablet, Film-Coated; Oral; Lithium Carbonate 300 mg
Tablets, Film-Coated; Oral; Lithium Carbonate 300 mg
300 mg x 10's (Stadmed Pvt Ltd)$ 0.12
Staleth 300mg TAB / 10 (Stadmed Pvt Ltd)$ 0.12
Staleth 300 mg Tablet (Stadmed Pvt Ltd)$ 0.01
STALETH tab 300 mg x 10's (Stadmed Pvt Ltd)$ 0.12
Staleth 300mg TAB / 10 (Stadmed Pvt Ltd)$ 0.12

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