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Mebeverine Hydrochloride Actions |
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Description: Mebeverine Hydrochloride is an antispasmodic agent which exerts direct action on the GI smooth muscle w/o affecting normal gut motility. The exact mechanism is unknown, but multiple mechanisms might contribute to its local effect in the GI tract, e.g. a decrease in ion channel permeabilities, blockade of norepinephrine reuptake, a local anaesth effect, changes in water absorption and weak anti-muscarinergic and phosphodiesterase inhibitory effect.
Pharmacokinetics:
Absorption: Rapidly absorbed from the GI tract. Time to peak plasma concentration: 1-3 hr.
Distribution: Plasma protein-binding: 75% to albumin.
Metabolism: Completely metabolised via hydrolysis to form veratric acid and Mebeverine Hydrochloride alcohol.
Excretion: Via urine (95% as metabolites).
The primary mechanism of action of hexachlorophene, based on studies with Bacillus megatherium, is to inhibit the membrane-bound part of the electron transport chain, respiratory D-lactate dehydrogenase. It induces leakage, causes protoplast lysis, and inhibits respiration.
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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