Medroxyprogesterone Uses

Did you have any side effects with this medicine?
sponsored

What is Medroxyprogesterone?

Medroxyprogesterone injection is used to prevent pregnancy. It is a birth control method that works by stopping a woman's egg from fully developing each month. The egg can no longer accept a sperm and fertilization is prevented.

No contraceptive method is 100 percent effective. Birth control methods such as having surgery to become sterile or not having sex are more effective than birth control pills. Discuss your options for birth control with your doctor.

Medroxyprogesterone does not prevent AIDS or other sexually transmitted diseases. It will not help as emergency contraception, such as after unprotected sexual contact.

Medroxyprogesterone injection is also used with other medicines to help relieve symptoms of inoperable, recurrent, and metastatic (cancer that has already spread) endometrial or kidney cancer.

Medroxyprogesterone is to be administered only by or under the immediate supervision of your doctor.

Medroxyprogesterone indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
sponsored

depo-subQ Medroxyprogesterone (Medroxyprogesterone) 104 is indicated for the prevention of pregnancy in women of child bearing potential.

depo-subQ Medroxyprogesterone (Medroxyprogesterone) 104 also is indicated for management of endometriosis-associated pain.

In considering use for either indication, the loss of bone mineral density (BMD) in women of all ages and the impact on peak bone mass in adolescents should be considered, along with the decrease in BMD that occurs during pregnancy and/or lactation, in the risk/benefit assessment for women who use depo-subQ Medroxyprogesterone 104 long-term.

Contraception Studies

In three clinical studies, no pregnancies were detected among 2,042 women using deposubQ Medroxyprogesterone 104 for up to 1 year. The Pearl Index pregnancy rate in women who were less than 36 years old at baseline, based on cycles in which they used no other contraceptive methods, was 0 pregnancies per 100 women-years of use (upper 95% confidence interval = 0.25).

Pregnancy rates for various contraceptive methods are typically reported for only the first year of use and are shown in Table 2.

Table 2 : Percentage of Women Experiencing an Unintended Pregnancy During the First Year of Typical Use and the First Year of Perfect Use of Contraception and the Percentage Continuing Use at the End of the First Year: United States

Favorable Response = reduction in severity of symptom or sign of ≥ 1 point on a scale of 0 to 3, as compared to baseline

Additionally, scores from each of the five categories were combined, with the total (composite score) considered a global measurement of overall disease improvement. For subjects with baseline scores for each of the 5 categories, a mean decrease of 4 points relative to baseline was considered a clinically meaningful improvement. Across both studies, for both treatment groups, the mean changes in the composite score met the protocol-defined criterion for improvement.

In the clinical trials, treatment with depo-subQ Medroxyprogesterone (Medroxyprogesterone) 104 was limited to six months. Data on the persistence of benefit with longer treatment are not available.

Subjects recorded daily the occurrence and severity of hot flushes. Of the depo-subQ Medroxyprogesterone (Medroxyprogesterone) 104 users, 28.6% reported experiencing moderate or severe hot flushes at baseline, 36.2% at month 3, and 26.7% at month 6. Of the leuprolide users, 32.8% reported experiencing moderate or severe hot flushes at baseline, 74.2% at month 3, and 68.5% at month 6.

How should I use Medroxyprogesterone?

Use Medroxyprogesterone injectable suspension (subcutaneous) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Medroxyprogesterone injectable suspension (subcutaneous).

Uses of Medroxyprogesterone in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
sponsored

Use: Labeled Indications

Abnormal uterine bleeding (tablet): Treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as fibroids or uterine cancer.

Amenorrhea, secondary (tablet): Treatment of secondary amenorrhea due to hormonal imbalance in the absence of organic pathology, such as fibroids or uterine cancer.

Contraception (104 mg per 0.65 mL and 150 mg/mL injection): Prevention of pregnancy in females of reproductive potential.

Endometrial hyperplasia prevention (tablet): Prevention of endometrial hyperplasia in nonhysterectomized postmenopausal persons receiving daily oral conjugated estrogens 0.625 mg. Note: Due to safety considerations, when a progesterone is needed, use of micronized progesterone is preferred over Medroxyprogesterone (AACE [Goodman 2011]; AACE/ACE [Cobin 2017])

Endometrial carcinoma (400 mg/mL injection) (100 mg tablet [Canadian product]): Adjunctive therapy and/or palliative treatment of inoperable, recurrent, and/or metastatic endometrial carcinoma.

Endometriosis (104 mg/0.65 mL injection): Management of endometriosis-associated pain.

Off Label Uses

Abnormal uterine bleeding, acute

Data from a randomized, open-label clinical study support the use of oral Medroxyprogesterone in the treatment of acute uterine bleeding in nonpregnant, hemodynamically stable premenopausal women requiring emergent medical intervention. Additional data may be necessary to further define the role of Medroxyprogesterone in the management of this condition.

Medroxyprogesterone description

sponsored

Medroxyprogesterone contains Medroxyprogesterone, a derivative of progesterone, as its active ingredient. Medroxyprogesterone is active by the parenteral and oral routes of administration. It is a white to off-white, odorless crystalline powder that is stable in air and that melts between 200°C and 210°C. It is freely soluble in chloroform, soluble in acetone and dioxane, sparingly soluble in alcohol and methanol, slightly soluble in ether and insoluble in water.

Medroxyprogesterone is pregn-4-ene-3,20-dione,17-(acetyloxy)-6-methyl-,(6α).

Medroxyprogesterone dosage

Medroxyprogesterone Dosage

Generic name: Medroxyprogesterone 2.5mg

Dosage form: tablet

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Secondary Amenorrhea

Medroxyprogesterone tablets may be given in dosages of 5 or 10 mg daily for 5 to 10 days. A dose for inducing an optimum secretory transformation of an endometrium that has been adequately primed with either endogenous or exogenous estrogen is 10 mg of Medroxyprogesterone daily for 10 days. In cases of secondary amenorrhea, therapy may be started at any time. Progestin withdrawal bleeding usually occurs within three to seven days after discontinuing Medroxyprogesterone therapy.

Abnormal Uterine Bleeding Due to Hormonal Imbalance in the Absence of Organic Pathology

Beginning on the calculated 16th or 21st day of the menstrual cycle, 5 or 10 mg of Medroxyprogesterone may be given daily for 5 to 10 days. To produce an optimum secretory transformation of an endometrium that has been adequately primed with either endogenous or exogenous estrogen, 10 mg of Medroxyprogesterone daily for 10 days beginning on the 16th day of the cycle is suggested. Progestin withdrawal bleeding usually occurs within three to seven days after discontinuing therapy with Medroxyprogesterone. Patients with a past history of recurrent episodes of abnormal uterine bleeding may benefit from planned menstrual cycling with Medroxyprogesterone.

Reduction of Endometrial Hyperplasia in Postmenopausal Women Receiving Daily 0.625 mg Conjugated Estrogens

When estrogen is prescribed for a postmenopausal woman with a uterus, a progestin should also be initiated to reduce the risk of endometrial cancer. A woman without a uterus does not need progestin. Use of estrogen, alone or in combination with a progestin, should be with the lowest effective dose and for the shortest duration consistent with treatment goals and risks for the individual woman. Patients should be re-evaluated periodically as clinically appropriate (for example, 3 to 6 month intervals) to determine if treatment is still necessary. For women who have a uterus, adequate diagnostic measures, such as endometrial sampling, when indicated, should be undertaken to rule out malignancy in cases of undiagnosed persistent or recurring abnormal vaginal bleeding.

Medroxyprogesterone tablets may be given in dosages of 5 or 10 mg daily for 12 to 14 consecutive days per month, in postmenopausal women receiving daily 0.625 mg conjugated estrogens, either beginning on the 1st day of the cycle or the 16th day of the cycle.

Patients should be started at the lowest dose.

The lowest effective dose of Medroxyprogesterone has not been determined.

More about Medroxyprogesterone (Medroxyprogesterone)

Consumer resources

Professional resources

Other formulations

Related treatment guides

Medroxyprogesterone interactions

See also:
What other drugs will affect Medroxyprogesterone?

sponsored

Aminoglutethimide administered concomitantly with DEPO-Medroxyprogesterone Sterile Aqueous Suspension may significantly depress the serum concentrations of Medroxyprogesterone. DEPO-Medroxyprogesterone users should be warned of the possibility of decreased efficacy with the use of this or any related drugs.

In vitro

Medroxyprogesterone is metabolized primarily by hydroxylation via the CYP3A4. Though no formal drug interaction trials have been conducted, concomitant administration of strong CYP3A inhibitors is expected to increase concentrations of Medroxyprogesterone, whereas the concomitant administration of strong CYP3A inducers is expected to decrease Medroxyprogesterone concentrations. Therefore, coadministration with strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, atazanavir, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, voriconazole) or strong CYP3A inducers (e.g., phenytoin, carbamazepine, rifampin, rifabutin, rifapentin, phenobarbital, St. John's Wort) should be avoided.

Laboratory Test Interactions

The pathologist should be advised of progestin therapy when relevant specimens are submitted. The following laboratory tests may be affected by progestins including DEPOPROVERA Sterile Aqueous Suspension:

  1. Plasma and urinary steroid levels are decreased (e.g. progesterone, estradiol, pregnanediol, testosterone, cortisol).
  2. Gonadotropin levels are decreased.
  3. Sex-hormone binding globulin concentrations are decreased.
  4. Protein bound iodine and butanol extractable protein bound iodine may increase. T3 uptake values may decrease.
  5. Coagulation test values for prothrombin (Factor II), and Factors VII, VIII, IX, and X may increase.
  6. Sulfobromophthalein and other liver function test values may be increased.
  7. The effects of Medroxyprogesterone on lipid metabolism are inconsistent. Both increases and decreases in total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol have been observed in studies.

Medroxyprogesterone side effects

See also:
What are the possible side effects of Medroxyprogesterone?

Applies to Medroxyprogesterone: oral tablet

Other dosage forms:

As well as its needed effects, Medroxyprogesterone (the active ingredient contained in Medroxyprogesterone) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking Medroxyprogesterone, check with your doctor immediately:

Incidence not known:

Minor Side Effects

Some Medroxyprogesterone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:

Medroxyprogesterone contraindications

See also:
What is the most important information I should know about Medroxyprogesterone?

Known hypersensitivity to Medroxyprogesterone or to any other ingredients of Medroxyprogesterone.

Undiagnosed vaginal bleeding; known, suspected or history of breast carcinoma; previous idiopathic or current venous thromboembolism (deep vein thrombosis, pulmonary embolism); active or recent (within the past year) arterial thromboembolic disease (eg, angian, myocardial infarction); known liver dysfunction or disease; missed abortion; known or suspected pregnancy.

Thrombophlebitis, thromboembolic disorders and where there is a high risk of developing such manifestations (presence or history of arterial fibrillation, valvular disorders, endocarditis, heart failure, thromboembolic ishcaemic attack, cerebral infarction; atherosclerosis; immediate post-surgery period); hypercalcaemia in patients with osseous metastases, metrorrhagia.

Progestogens are known to be porphyrogenic. Patients with history of attacks or aged <30 are at greatest risk of an acute attack while on progesterone treatment. A careful assessment of potential benefit should be made where this risk is present.

Use in pregnancy: Medroxyprogesterone is contraindicated in women who are pregnant. If Medroxyprogesterone is used during pregnancy, or if the patient becomes pregnant while using Medroxyprogesterone, the patient should be apprised of the potential hazard to the fetus.

Some reports suggest an association between intrauterine exposure to progestational drugs in the 1st trimester of pregnancy and genital abnormalities in male and female fetuses.

Infants from unintentional pregnancies that occur 1-2 months after injection of Medroxyprogesterone injectable suspension may be at an increased risk of low birth weight, which, in turn, is associated with an increased risk of neonatal death. The attributable risk is low because pregnancies while on Medroxyprogesterone are uncommon.

Use in lactation: Medroxyprogesterone and/or its metabolites are secreted in breast milk. Therefore, the use of Medroxyprogesterone whilst breastfeeding is not recommended.



Active ingredient matches for Medroxyprogesterone:

Medroxyprogesterone


Unit description / dosage (Manufacturer)Price, USD
Tablet; Oral; Medroxyprogesterone Acetate 10 mg
Injectable; Injection; Medroxyprogesterone Acetate 150 mg / ml
Tablet; Oral; Medroxyprogesterone Acetate 2.5 mg
Tablet; Oral; Medroxyprogesterone Acetate 5 mg
Depo-Provera 400 mg/ml Suspension 2.5ml Vial$ 201.13
Depo-subq provera 104 syringe$ 108.17
Depo-provera 400 mg/ml vial$ 96.70
Depo-Provera 150 mg/ml Suspension 1ml Syringe$ 94.58
MedroxyPROGESTERone Acetate 150 mg/ml Suspension 1ml Syringe$ 60.56
MedroxyPROGESTERone Acetate 150 mg/ml Suspension 1ml Vial$ 55.17
Depo-Provera 150 mg/ml$ 31.02
Medroxyprogesterone Acetate 150 mg/ml$ 23.05
Medroxyprogesterone ace powder$ 18.97
Depo-Provera 50 mg/ml$ 6.01
Provera 10 mg tablet$ 0.73
Provera 5 mg tablet$ 0.36
Provera 100 mg Tablet$ 1.41
Provera 2.5 mg tablet$ 0.18
Apo-Medroxy 100 mg Tablet$ 0.96
MedroxyPROGESTERone Acetate 10 mg tablet$ 0.51
MedroxyPROGESTERone Acetate 5 mg tablet$ 0.48
MedroxyPROGESTERone Acetate 2.5 mg tablet$ 0.43
Medroxyprogesterone 10 mg tablet$ 0.40
Medroxyprogesterone 5 mg tablet$ 0.33
Apo-Medroxy 10 mg Tablet$ 0.33
Novo-Medrone 10 mg Tablet$ 0.33
Medroxyprogesterone 2.5 mg tablet$ 0.32
Apo-Medroxy 5 mg Tablet$ 0.16
Novo-Medrone 5 mg Tablet$ 0.16
Apo-Medroxy 2.5 mg Tablet$ 0.08
Novo-Medrone 2.5 mg Tablet$ 0.08

List of Medroxyprogesterone substitutes (brand and generic names):

100 tablet in 1 bottle
1000 tablet in 1 bottle
30 tablet in 1 bottle
50 tablet in 1 bottle
500 tablet in 1 bottle
90 tablet in 1 bottle
Medroxyprogesterone Acetate tablet 2.5 mg/1 (Pd Rx Pharmaceuticals, Inc. (US))
Medroxyprogesterone Acetate tablet 5 mg/1 (Physicians Total Care, Inc. (US))
Medroxyprogesterone Acetate injection, suspension 150 mg/mL (Greenstone LLC (US))
Medroxyprogesterone Acetate tablet 10 mg/1 (Physicians Total Care, Inc. (US))
Depo-Provera 400 mg/ml Suspension 2.5ml Vial$ 201.13
Depo-subq provera 104 syringe$ 108.17
Depo-provera 400 mg/ml vial$ 96.70
Depo-Provera 150 mg/ml Suspension 1ml Syringe$ 94.58
MedroxyPROGESTERone Acetate 150 mg/ml Suspension 1ml Syringe$ 60.56
MedroxyPROGESTERone Acetate 150 mg/ml Suspension 1ml Vial$ 55.17
Depo-Provera 150 mg/ml$ 31.02
Medroxyprogesterone Acetate 150 mg/ml$ 23.05
Medroxyprogesterone ace powder$ 18.97
Depo-Provera 50 mg/ml$ 6.01
Provera 10 mg tablet$ 0.73
Provera 5 mg tablet$ 0.36
Provera 100 mg Tablet$ 1.41
Provera 2.5 mg tablet$ 0.18
Apo-Medroxy 100 mg Tablet$ 0.96
MedroxyPROGESTERone Acetate 10 mg tablet$ 0.51
MedroxyPROGESTERone Acetate 5 mg tablet$ 0.48
MedroxyPROGESTERone Acetate 2.5 mg tablet$ 0.43
Medroxyprogesterone 10 mg tablet$ 0.40
Medroxyprogesterone 5 mg tablet$ 0.33
Apo-Medroxy 10 mg Tablet$ 0.33
Novo-Medrone 10 mg Tablet$ 0.33
Medroxyprogesterone 2.5 mg tablet$ 0.32
Apo-Medroxy 5 mg Tablet$ 0.16
Novo-Medrone 5 mg Tablet$ 0.16
Apo-Medroxy 2.5 mg Tablet$ 0.08
Novo-Medrone 2.5 mg Tablet$ 0.08

References

  1. DailyMed. "MEDROXYPROGESTERONE ACETATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "Medroxyprogesterone acetate". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "Medroxyprogesterone acetate". http://www.drugbank.ca/drugs/DB00603 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Medroxyprogesterone are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Medroxyprogesterone. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


Consumer reported price estimates

No survey data has been collected yet


Consumer reported time for results

No survey data has been collected yet


1 consumer reported age

Users%
30-451
100.0%


Consumer reviews


There are no reviews yet. Be the first to write one!


Your name: 
Email: 
Spam protection:  < Type 25 here

Information checked by Dr. Sachin Kumar, MD Pharmacology

| Privacy Policy
This site does not supply any medicines. It contains prices for information purposes only.
© 2003 - 2022 ndrugs.com All Rights Reserved