Medroxyprogesterone Acetate Uses

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What is Medroxyprogesterone Acetate?

Medroxyprogesterone Acetate is used to prevent pregnancy. It is a birth control method that works by stopping a woman's egg from fully developing each month. The egg can no longer accept a sperm and fertilization is prevented.

No contraceptive method is 100 percent effective. Birth control methods such as having surgery to become sterile or not having sex are more effective than birth control pills. Discuss your options for birth control with your doctor.

Medroxyprogesterone Acetate does not prevent AIDS or other sexually transmitted diseases. It will not help as emergency contraception, such as after unprotected sexual contact.

Medroxyprogesterone Acetate is also used with other medicines to help relieve symptoms of inoperable, recurrent, and metastatic (cancer that has already spread) endometrial or kidney cancer.

Medroxyprogesterone Acetate is to be administered only by or under the immediate supervision of your doctor.

Medroxyprogesterone Acetate indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Medroxyprogesterone Acetate (MPA) Injectable Suspension, USP is indicated only for the prevention of pregnancy. The loss of bone mineral density (BMD) in women of all ages and the impact on peak bone mass in adolescents should be considered, along with the decrease in BMD that occurs during pregnancy and/or lactation, in the risk/benefit assessment for women who use MPA Injectable Suspension, USP long-term.

How should I use Medroxyprogesterone Acetate?

Use Medroxyprogesterone Acetate (subcutaneous) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Medroxyprogesterone Acetate (subcutaneous).

Uses of Medroxyprogesterone Acetate in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Use: Labeled Indications

Abnormal uterine bleeding (tablet): Treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as fibroids or uterine cancer.

Amenorrhea, secondary (tablet): Treatment of secondary amenorrhea due to hormonal imbalance in the absence of organic pathology, such as fibroids or uterine cancer.

Contraception (104 mg per 0.65 mL and 150 mg/mL injection): Prevention of pregnancy in females of reproductive potential.

Endometrial hyperplasia prevention (tablet): Prevention of endometrial hyperplasia in nonhysterectomized postmenopausal persons receiving daily oral conjugated estrogens 0.625 mg. Note: Due to safety considerations, when a progesterone is needed, use of micronized progesterone is preferred over Medroxyprogesterone Acetate (AACE [Goodman 2011]; AACE/ACE [Cobin 2017])

Endometrial carcinoma (400 mg/mL injection) (100 mg tablet [Canadian product]): Adjunctive therapy and/or palliative treatment of inoperable, recurrent, and/or metastatic endometrial carcinoma.

Endometriosis (104 mg/0.65 mL injection): Management of endometriosis-associated pain.

Off Label Uses

Abnormal uterine bleeding, acute

Data from a randomized, open-label clinical study support the use of oral Medroxyprogesterone Acetate in the treatment of acute uterine bleeding in nonpregnant, hemodynamically stable premenopausal women requiring emergent medical intervention. Additional data may be necessary to further define the role of Medroxyprogesterone Acetate in the management of this condition.

Medroxyprogesterone Acetate description


Each mL of suspension (vial) contains Medroxyprogesterone Acetate 150 mg, polyethylene glycol 3350 28.9 mg, polysorbate 80 2.41 mg, sodium chloride 8.68 mg, methylparaben 1.37 mg, propylparaben 0.15 mg and water for injection.

Each mL of suspension (prefilled syringe) contains Medroxyprogesterone Acetate 150 mg, polyethylene glycol 3350 28.5 mg, polysorbate 80 2.37 mg, sodium chloride 8.56 mg, methylparaben 1.35 mg, propylparaben 0.147 mg and water for injection.

When necessary, pH is adjusted with sodium hydroxide or hydrochloric acid, or both.

Medroxyprogesterone Acetate is pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-,(6α).

Medroxyprogesterone Acetate contraceptive injection contains Medroxyprogesterone Acetate, a derivative of progesterone, as its active ingredient. Medroxyprogesterone Acetate is active by the parenteral and oral routes of administration. It is a white to off-white, odorless crystalline powder that is stable in air and that melts between 200°C and 210°C. It is freely soluble in chloroform, soluble in acetone and dioxane, sparingly soluble in alcohol and methanol, slightly soluble in ether, and insoluble in water.

Medroxyprogesterone Acetate dosage


Prevention of Pregnancy: The recommended dose is 150 mg of Medroxyprogesterone Acetate contraceptive injection every 3 months (13 weeks) administered by deep IM injection in the gluteal or deltoid muscle. Medroxyprogesterone Acetate should not be used as a long-term birth control method (ie, >2 years) unless other birth control methods are considered inadequate. Dosage does not need to be adjusted for body weight.

To ensure the patient is not pregnant at the time of the 1st injection, the 1st injection should be given only during the first 5 days of a normal menstrual period; only within the first 5-days postpartum if not breastfeeding; and if exclusively breastfeeding, only at the 6th postpartum week. If the time interval between injections is >13 weeks, the physician should determine that the patient is not pregnant before administering the drug. The efficacy of Medroxyprogesterone Acetate contraceptive injection depends on adherence to the dosage schedule of administration.

Switching from Other Methods of Contraception: When switching from other contraceptive methods, Medroxyprogesterone Acetate should be given in a manner that ensures continuous contraceptive coverage based upon the mechanism of action of both methods (eg, patients switching from oral contraceptives should have their 1st injection of Medroxyprogesterone Acetate on the day after the last active tablet or at the latest, on the day following the final inactive tablet).

Administration: Medroxyprogesterone Acetate contraceptive injection should be shaken just before use to ensure that the dose being administered represents a uniform suspension.

Medroxyprogesterone Acetate interactions

See also:
What other drugs will affect Medroxyprogesterone Acetate?

Changes in Contraceptive Effectiveness Associated with Co-Administration of Other Products: If a woman on hormonal contraceptives takes a drug or herbal product that induces enzymes, including CYP3A4, that metabolize contraceptive hormones, counsel her to use additional contraception or a different method of contraception. Drugs or herbal products that induce such enzymes may decrease the plasma concentrations of contraceptive hormones, and may decrease the effectiveness of hormonal contraceptives.

Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include barbiturates, bosentan, carbamazepine, felbamate, griseofulvin, oxcarbazepine, phenytoin, rifampin, St. John’s wort, and topiramate.

HIV-Protease Inhibitors and Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs): Significant changes (increase or decrease) in the plasma levels of progestin have been noted in some cases of co-administration of HIV-protease inhibitors. Significant changes (increase or decrease) in the plasma levels of the progestin have been noted in some cases of co-administration with NNRTIs.

Antibiotics: There have been reports of pregnancy while taking hormonal contraceptives and antibiotics, but clinical pharmacokinetic studies have not shown consistent effects of antibiotics on plasma concentrations of synthetic steroids.

Consult the labeling of all concurrently-used drugs to obtain further information about interactions with hormonal contraceptives or the potential for enzyme alterations.

Laboratory Test Interactions: The pathologist should be advised of progestin therapy when relevant specimens are submitted.

The following laboratory tests may be affected by progestins including Medroxyprogesterone Acetate contraceptive injection:

Plasma and urinary steroid levels are decreased (eg, progesterone, estradiol, pregnanediol, testosterone, cortisol).

Gonadotropin levels are decreased.

Sex-hormone binding globulin concentrations are decreased.

Protein-bound iodine and butanol extractable protein-bound iodine may increase. T3-uptake values may decrease.

Coagulation test values for prothrombin (Factor II) and Factors VII, VIII, IX and X may increase.

Sulfobromophthalein and other liver function test values may be increased.

The effects of Medroxyprogesterone Acetate on lipid metabolism are inconsistent. Both increases and decreases in total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol have been observed in studies.

Medroxyprogesterone Acetate side effects

See also:
What are the possible side effects of Medroxyprogesterone Acetate?

Clinical Trials Experience: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

In the 2 clinical trials with Medroxyprogesterone Acetate, over 3900 women, who were treated for up to 7 years, reported the following adverse reactions, which may or may not be related to the use of Medroxyprogesterone Acetate. The population studied ranges in from 15-51 years, of which 46% were White, 50% non-White and 4.9% Unknown race. The patients received Medroxyprogesterone Acetate mg every 3-months (90 days). The median study duration was 13 months with a range of 1-84 months. Fifty eight percent (58%) of patients remained in the study after 13 months and 34% after 24 months.

Adverse reactions that were reported by >5% of subjects are: Body as a Whole*: Headache (16.5%), abdominal pain/discomfort (11.2%).

Metabolic/Nutritional*: Increased weight >10 lbs at 24 months (37.7%).

Nervous*: Nervousness (10.8%), dizziness (5.6%), decreased libido (5.5%).

Urogenital*: Menstrual irregularities [bleeding (57.3% at 12 months, 32.1% at 24 months), amenorrhea (55% at 12 months, 68% at 24 months)].

Adverse reactions that were reported between 1% and 5% of subjects are: Body as a Whole*: Asthenia/fatigue (4.2%), backache (2.2%), dysmenorrhea (1.7%), hot flashes (1%).

Digestive*: Nausea (3.3%), bloating (2.3%).

Metabolic/Nutritional*: Edema (2.2%).

Musculoskeletal*: Leg cramps (3.7%), arthralgia (1%).

Nervous*: Depression (1.5%), insomnia (1%).

Skin and Appendages*: Acne (1.2%), no hair growth/alopecia (1.1%), rash (1.1%).

Urogenital*: Leukorrhea (2.9%), breast pain (2.8%), vaginitis (1.2%).

*Body system represented from COSTART medical dictionary.

Adverse reactions leading to study discontinuation in ≥2% subjects are bleeding (8.2%), amenorrhea (2.1%), weight gain (2%).

Post-Marketing Experience: The following adverse reactions have been identified during post approval use of Medroxyprogesterone Acetate.

Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

There have been cases of osteoporosis including osteoporotic fractures reported post-marketing in patients taking Medroxyprogesterone Acetate.

Adverse reactions reported during post-marketing experience are: Body as Whole*: Chest pain, Allergic reactions, fever, injection site pain, chills, axillary swelling.

Cardiovascular*: Syncope, tachycardia, thrombophlebitis, deep vein thrombosis, pulmonary embolus, varicose veins.

Digestive*: Appetite changes, gastrointestinal disturbances, jaundice, excessive thirst, rectal bleeding.

Hematologic and Lymphatic*: Anemia, blood dyscrasia.

Musculoskeletal*: Osteoporosis.

Nervous*: Paralysis, facial palsy, paresthesia, drowsiness.

Respiratory*: Dyspnea and asthma, hoarseness.

Skin and Appendages*: Hirsutism, excessive sweating and body odor, dry skin, scleroderma.

Urogenital*: Cervical and breast cancer, lack of return to fertility, unexpected pregnancy, prevention of lactation, changes in breast size, breast lumps or nipple bleeding, galactorrhea, melasma, chloasma, increased libido, uterine hyperplasia, genitourinary infections, vaginal cysts, dyspareunia.

Medroxyprogesterone Acetate contraindications

See also:
What is the most important information I should know about Medroxyprogesterone Acetate?

Known hypersensitivity to Medroxyprogesterone Acetate or any other ingredients of Medroxyprogesterone Acetate.

Known or suspected pregnancy or as a diagnostic test for pregnancy. Active thrombophlebitis, or current or past history of thromboembolic disorders, or cerebral vascular disease. Known or suspected malignancy of breast. Significant liver disease. Undiagnosed vaginal bleeding.

Medroxyprogesterone Acetate should not be used as a long-term birth control method (ie, >2 years) unless other birth control methods are considered inadequate.

Use in pregnancy: Medroxyprogesterone Acetate should not be administered during pregnancy.

Active ingredient matches for Medroxyprogesterone Acetate:

Medroxyprogesterone Acetate

Unit description / dosage (Manufacturer)Price, USD
100 tablet in 1 bottle
1000 tablet in 1 bottle
30 tablet in 1 bottle
50 tablet in 1 bottle
500 tablet in 1 bottle
90 tablet in 1 bottle
Medroxyprogesterone Acetate tablet 2.5 mg/1 (Pd Rx Pharmaceuticals, Inc. (US))
Medroxyprogesterone Acetate tablet 5 mg/1 (Physicians Total Care, Inc. (US))
Medroxyprogesterone Acetate injection, suspension 150 mg/mL (Greenstone LLC (US))
Medroxyprogesterone Acetate tablet 10 mg/1 (Physicians Total Care, Inc. (US))
Depo-Provera 400 mg/ml Suspension 2.5ml Vial$ 201.13
Depo-subq provera 104 syringe$ 108.17
Depo-provera 400 mg/ml vial$ 96.70
Depo-Provera 150 mg/ml Suspension 1ml Syringe$ 94.58
MedroxyPROGESTERone Acetate 150 mg/ml Suspension 1ml Syringe$ 60.56
MedroxyPROGESTERone Acetate 150 mg/ml Suspension 1ml Vial$ 55.17
Depo-Provera 150 mg/ml$ 31.02
Medroxyprogesterone Acetate 150 mg/ml$ 23.05
Medroxyprogesterone ace powder$ 18.97
Depo-Provera 50 mg/ml$ 6.01
Provera 10 mg tablet$ 0.73
Provera 5 mg tablet$ 0.36
Provera 100 mg Tablet$ 1.41
Provera 2.5 mg tablet$ 0.18
Apo-Medroxy 100 mg Tablet$ 0.96
MedroxyPROGESTERone Acetate 10 mg tablet$ 0.51
MedroxyPROGESTERone Acetate 5 mg tablet$ 0.48
MedroxyPROGESTERone Acetate 2.5 mg tablet$ 0.43
Medroxyprogesterone 10 mg tablet$ 0.40
Medroxyprogesterone 5 mg tablet$ 0.33
Apo-Medroxy 10 mg Tablet$ 0.33
Novo-Medrone 10 mg Tablet$ 0.33
Medroxyprogesterone 2.5 mg tablet$ 0.32
Apo-Medroxy 5 mg Tablet$ 0.16
Novo-Medrone 5 mg Tablet$ 0.16
Apo-Medroxy 2.5 mg Tablet$ 0.08
Novo-Medrone 2.5 mg Tablet$ 0.08

List of Medroxyprogesterone Acetate substitutes (brand and generic names):

Deviry 100mg TAB / 100 (Elder Pharmaceuticals Pvt Ltd)$ 4.44
Deviry 2.5 mg Tablet (Elder Pharmaceuticals Pvt Ltd)$ 0.02
Deviry 100 mg Tablet (Elder Pharmaceuticals Pvt Ltd)$ 0.44
Deviry 10 mg Tablet (Elder Pharmaceuticals Pvt Ltd)$ 0.09
DEVIRY 10 MG TABLET 1 strip / 30 tablets each (Elder Pharmaceuticals Pvt Ltd)$ 2.65
DEVIRY 10 MG TABLET 1 strip / 10 tablets each (Elder Pharmaceuticals Pvt Ltd)$ 0.94
DEVIRY 100 MG TABLET 1 strip / 10 tablets each (Elder Pharmaceuticals Pvt Ltd)$ 0.96
DEVIRY 2.5 MG TABLET 1 strip / 10 tablets each (Elder Pharmaceuticals Pvt Ltd)$ 0.22
DEVIRY tab 10 mg x 10's (Elder Pharmaceuticals Pvt Ltd)$ 0.87
DEVIRY tab 100 mg x 10's (Elder Pharmaceuticals Pvt Ltd)$ 4.44
Deviry 10mg TAB / 10 (Elder Pharmaceuticals Pvt Ltd)$ 0.79
Deviry 100mg TAB / 100 (Elder Pharmaceuticals Pvt Ltd)$ 4.44
Deviry 10mg Tablet (Elder Pharmaceuticals Pvt Ltd)$ 0.09
Deviry 2.5mg Tablet (Elder Pharmaceuticals Pvt Ltd)$ 0.02
EXPROG-M tab 10 mg x 10's (Biocin)$ 0.87
Meterone 100/Meterone 500 100 mg
Meterone 100/Meterone 500 500 mg
Meterone 2.5/Meterone 5/Meterone 10 2.5 mg x 3 x 10's
Meterone 2.5/Meterone 5/Meterone 10 5 mg x 3 x 10's
Meterone 2.5/Meterone 5/Meterone 10 10 mg x 3 x 10's
Provera 5/Provera 10 5 mg x 100's
Provera 5/Provera 10 10 mg x 100's
10 mg x 100's (East African)$ 5.95
Rivgest-M 10mg TAB / 100 (East African)$ 5.95
RIVGEST-M tab 10 mg x 10's (East African)$ 0.60
Rivgest-M 10mg TAB / 100 (East African)$ 5.95
10 mg x 100's (Siesta Pharmaceuticals)$ 6.98
Tab Litmus 10 mg Tablet (Siesta Pharmaceuticals)$ 0.07
Tab Litmus 10mg TAB / 100 (Siesta Pharmaceuticals)$ 6.98
TAB LITMUS tab 10 mg x 10's (Siesta Pharmaceuticals)$ 0.70
Tab Litmus 10mg TAB / 100 (Siesta Pharmaceuticals)$ 6.98
Veraplex 500 100's$ 415.40


  1. DailyMed. "MEDROXYPROGESTERONE ACETATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. PubChem. "Medroxyprogesterone acetate". (accessed September 17, 2018).
  3. DrugBank. "Medroxyprogesterone acetate". (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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