Mefoxin Pregnancy

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Pregnancy of Mefoxin in details

Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
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There are no reports of adverse side effects due to Mefoxin during human pregnancy. Data from its use immediately prior to abortion reveal that it crosses the placenta. In one case, a woman who was given Mefoxin 1 gram intravenously produced maternal and fetal serum levels of zero and 35.7 mcg per mL 4.25 hours after administration; in another case these levels were 10.5 mcg per mL and zero at 0.9 hours after administration. Data from the use of Mefoxin at term after doses of 1 or 2 gram intravenously or intramuscularly reveal umbilical cord levels up to 22 mcg per mL (11% to 90% of the maternal serum levels).

Mefoxin has been assigned to pregnancy category B by the FDA. Animal studies failed to reveal evidence of teratogenicity. There are no controlled data in human pregnancy. Mefoxin should only be given during pregnancy when need has been clearly established.

See references

Mefoxin breastfeeding

When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!

Mefoxin is excreted into human milk in small amounts. Adverse effects in the nursing infant are unlikely. Mefoxin is considered compatible with breast-feeding by the American Academy of Pediatrics. The manufacturer recommends that caution be used when administering Mefoxin to nursing women.

Approximately 25 hours after a single, prophylactic dose of Mefoxin 2 to 4 grams intravenously was given to 18 women, only one sample in one patient at 19 hours post-dosing revealed detectable Mefoxin levels in milk (0.9 mcg per mL). This represents a miniscule dose to the nursing infant. Some experts, however, warn of the possibility of modification of neonatal gut flora, unknown direct side effects on the nursing infant, and interference with the interpretation of culture results in the evaluation of a suspected infection.

See references

References for pregnancy information

  1. Brogden RN, Heel RC, Speight TM, Avery GS "Mefoxin: a review of its antibacterial activity, pharmacological properties and therapeutic use." Drugs 17 (1979): 1-2,5-6,17-20,28-37
  2. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
  3. "Product Information. Mefoxin (Mefoxin)." Merck & Co, Inc, West Point, PA.

References for breastfeeding information

  1. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
  2. Dubois M, Delapierre D, Chanteux L, et al "A study of the transplacental transfer and the mammary excretion of Mefoxin in humans." J Clin Pharmacol 21 (1981): 477-83
  3. Dresse A, Lambotte R, Dubois M, et al "Transmammary passage of Mefoxin: additional results." J Clin Pharmacol 23 (1983): 438-40
  4. Roberts RJ, Blumer JL, Gorman RL, et al "American Academy of Pediatrics Committee on Drugs: Transfer of drugs and other chemicals into human milk." Pediatrics 84 (1989): 924-36
  5. "Product Information. Mefoxin (Mefoxin)." Merck & Co, Inc, West Point, PA.
  6. Roex AJ, van Loenen AC, Puyenbroek JI, Arts NF "Secretion of Mefoxin in breast milk following short-term prophylactic administration in caesarean section." Eur J Obstet Gynecol Reprod Biol 25 (1987): 299-302


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References

  1. PubMed Health. "Zinacef: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
  2. PubMed Health. "Cefoxitin (By injection): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
  3. Human Metabolome Database (HMDB). "Cefoxitin: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).

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