Meglumine antimonate Uses

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Meglumine antimonate indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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This medication is used before an X-ray or similar tests (e.g., tomography) to help your doctor view on film, your throat (esophagus), stomach, and intestines more effectively. It may be used with other injectable products (IV contrast) as determined by your doctor.

Meglumine antimonate interactions

Hypersensitivity reactions can be aggravated in patients on beta-blockers, particularly in people with bronchial asthma. Moreover, it should be considered that patients on beta-blockers may be refractory to standard treatment of hypersensitivity reactions with beta-agonists.

The prevalence of delayed reactions (eg fever, rash, flu-like symptoms, joint pain and pruritus) to contrast media is higher in patients who have received interleukin.

The presence of renal damage in diabetic patients is one of the factors predisposing to renal impairment following contrast media administration. This may precipitate lactic acidosis in patients who are taking biguanides. As a precaution, biguanides should be stopped 48 hours prior to the contrast agent examination and reinstated only after control of renal function has been regained.

Interference with diagnostic tests

Following the administration of iodinated contrast media, the capacity of the thyroid tissue to take up radioisotopes for diagnosing disorders of the thyroid is reduced for up to two weeks, and even longer in individual cases.

Pregnancy and lactation

Reproduction-toxicological studies with meglumine- or sodium amidotrizoate gave no indication of a teratogenic or other embryotoxic potential following an inadvertent administration of Urografin during pregnancy.

It has not been sufficiently demonstrated that contrast media are safe for use in pregnant patients. Since, wherever possible, radiation exposure should be avoided during pregnancy, the benefits of any X-ray examination, with or without contrast media, should be carefully weighed against the possible risk.

Renally eliminated contrast media like Urografin enter the breast milk in only very small amounts.

Limited data suggest that the risk to the suckling infant of administering salts of diatrizoic acid to its mother is low. Breastfeeding is probably safe.

Meglumine antimonate side effects

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Intravascular use

Side effects in association with the use of iodinated contrast media are usually mild to moderate and transient in nature. However, severe and life-threatening reactions as well as deaths have been reported. The prevalence of adverse drug reactions in patients receiving ionic contrast media is reported to be over 12% compared to over 3% for non-ionics.

Nausea, vomiting, a sensation of pain and a general feeling of warmth are the most frequently recorded reactions.

Anaphylactoid reactions/hypersensitivity

Angioedema, conjunctivitis, coughing, pruritus, rhinitis, sneezing and urticaria have been reported commonly. These reactions which can occur irrespective of the amount administered and the mode of administration, may be the first signs of an incipient state of shock. Administration of the contrast medium must be discontinued immediately and –if necessary –specific therapy instituted via a venous access.

Severe reactions requiring emergency treatment can occur in the form of a circulatory reaction accompanied by peripheral vasodilatation and subsequent hypotension, reflex tachycardia, dyspnoea, agitation, confusion and cyanosis possibly leading to unconsciousness.

Hypotension, bronchospasm and laryngeal spasm or oedema occur uncommonly.

Delayed contrast medium reactions are rare.

Body as a whole

Heat sensations and headache have been reported as being common. Malaise, chills or sweating and vasovagal reactions are uncommon.

In rare cases alterations in body temperature and swelling of salivary glands are possible.

Respiratory

Transient disturbance in respiratory rate, dyspnoea and respiratory distress and coughing are common.

Respiratory arrest and pulmonary oedema are rare reactions.

Cardiovascular

Clinically relevant transient disturbance in heart rate, blood pressure, disturbance in cardiac rhythm or function and cardiac arrest are uncommon.

Severe reactions requiring emergency treatment can occur in the form of a circulatory reaction accompanied by peripheral vasodilatation and subsequent hypotension, reflex tachycardia, dyspnoea, agitation, confusion and cyanosis possibly leading to unconsciousness.

Serious thromboembolic events causing myocardial infarction have been reported in rare cases.

Gastrointestinal

Nausea and vomiting are common reactions. Abdominal pain has been reported as being uncommon.

Cerebrovascular

Cerebral angiography and other procedures in which the contrast medium reaches the brain in high concentrations with the arterial blood can be accompanied by transient neurological complications such as: dizziness, headache, agitation or confusion, amnesia, disturbed speech, vision, hearing, convulsions, tremor, paresis/paralysis, photophobia, temporary blindness, coma, and somnolence are uncommon.

Serious, in isolated cases fatal, thromboembolic events causing stroke have been reported on rare occasions.

Renal

In rare cases renal impairment or failure have been reported.

Skin

Mild angioedema, flush reaction with vasodilatation, urticaria, pruritus and erythema have been commonly observed.

Toxic skin reactions such as the mucocutaneous syndrome (eg Stevens-Johnson

Meglumine antimonate contraindications

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Hypersensitivity to iodinated contrast media, thyrotoxicosis, decompensated cardiac insufficiency.

Active ingredient matches for Meglumine antimonate:

Meglumine antimonate


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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