Overdose of Meliane Difarmed in details
Symptoms: Overdosage in adults and children may include nausea, vomiting, breast tenderness, dizziness, abdominal pain, drowsiness/fatigue; withdrawal bleeding may occur in females.
Treatment: There is no specific antidote, and further treatment of overdose, if necessary, is directed to the symptoms.
Meliane Difarmed warnings
Use with caution in patients with impaired renal function and liver.
During the period of treatment required to conduct monitoring of blood glucose. Long-term therapy is necessary to periodically monitor the kidney function, liver and peripheral blood picture.
When using Meliane Difarmed it should be ensure adequate hydration of the body, the patient should be subjected to ultraviolet irradiation.
In experimental studies the mutagenic potential was not been identified. Long-term studies to determine the carcinogenicity of ofloxacin were not conducted.
Safety and efficacy in children and adolescents under the age of 18 is not defined.
Use with caution in patients whose activities are connected with the necessity of high concentration of attention and quickness of psychomotor reactions.
Meliane Difarmed precautions
Regular consultation with a physician is recommended while taking Meliane Difarmed. The physician should be informed if the patient is suffering from the following conditions: Gallbladder disease, sickle-cell disease, conditions influenced by fluid retention, clinical depression, varicose veins, risk factor for cardiovascular disease eg, diabetes mellitus, smoking, obesity, hypertension and history of cardiovascular disease, undergoing laboratory tests ie, liver, thyroid, adrenal and renal function test, plasma concentrations of binding proteins and lipid/lipoprotein fractions, fibrinolysis and coagulation factors, inflammatory bowel disease.
Meliane Difarmed should not be used after the recent evacuation of a hydatidiform mole until urine and plasma gonadotropin concentrations have returned to normal.
References
- DrugBank. "GESTODENE". http://www.drugbank.ca/drugs/DB06730 (accessed September 17, 2018).
- MeSH. "Contraceptives, Oral, Synthetic". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
