An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Oral
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: Initially, 25 mg bid or tid, increased if necessary by 25-50 mg at wkly intervals to 150-200 mg daily.
Oral
Acute gout
Adult: 150-200 mg daily in divided doses until signs and symptoms subside.
Oral
Dysmenorrhoea
Adult: 75 mg daily.
Intravenous
Closure of patent ductus arteriosus
Child: Given as 3 IV doses at 12-24 hr intervals infused over 20-30 min. <48 hr old 0.2 mg/kg initially followed by 2 further doses of 0.1 mg/kg; 2-7 days old 3 doses of 0.2 mg/kg; >7 days old 0.2 mg/kg initially followed by 2 further doses of 0.25 mg/kg. 2nd course may be repeated if ductus remains open or re-opens 48 hr after the 1st course. Surgery may be required if neonate is unreponsive to 2 courses of treatment.
Reconstitution: Add 1 or 2 mL of sterile water for inj or NaCl 0.9% inj to Methacil 1 mg to provide soln containing approx 1 or 0.5 mg/mL respectively. Further dilution of the reconstituted inj in IV infusions is not recommended.
Adult: 4 drops 1 day pre-op and 4 drops 3 hr pre-op.
Ophthalmic
Prophylaxis and reduction of postoperative ocular inflammation
Adult: 1 drop 4-6 times daily.
Ophthalmic
Post-photorefractive keratectomy pain
Adult: 1 drop 4 times daily for a few days post-op.
Rectal
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: As supp: 100 mg to be inserted at night and repeated in the morning if necessary.
Methacil description
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A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Methacil is considered an antioxidant.
Methacil dosage
Oral
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: Initially, 25 mg bid or tid, increased if necessary by 25-50 mg at wkly intervals to 150-200 mg daily.
Oral
Acute gout
Adult: 150-200 mg daily in divided doses until signs and symptoms subside.
Oral
Dysmenorrhoea
Adult: 75 mg daily.
Intravenous
Closure of patent ductus arteriosus
Child: Given as 3 IV doses at 12-24 hr intervals infused over 20-30 min. <48 hr old 0.2 mg/kg initially followed by 2 further doses of 0.1 mg/kg; 2-7 days old 3 doses of 0.2 mg/kg; >7 days old 0.2 mg/kg initially followed by 2 further doses of 0.25 mg/kg. 2nd course may be repeated if ductus remains open or re-opens 48 hr after the 1st course. Surgery may be required if neonate is unreponsive to 2 courses of treatment.
Reconstitution: Add 1 or 2 mL of sterile water for inj or NaCl 0.9% inj to Methacil 1 mg to provide soln containing approx 1 or 0.5 mg/mL respectively. Further dilution of the reconstituted inj in IV infusions is not recommended.
Adult: 4 drops 1 day pre-op and 4 drops 3 hr pre-op.
Ophthalmic
Prophylaxis and reduction of postoperative ocular inflammation
Adult: 1 drop 4-6 times daily.
Ophthalmic
Post-photorefractive keratectomy pain
Adult: 1 drop 4 times daily for a few days post-op.
Rectal
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: As supp: 100 mg to be inserted at night and repeated in the morning if necessary.
Methacil interactions
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May increase plasma levels of methotrexate. Increased risk of GI bleeding w/ warfarin. May reduce hypotensive effects of hydralazine, furosemide, β-blockers (e.g. atenolol, propranolol, oxprenolol), or thiazide diuretics. Increased risk of hyperkalaemia w/ K-sparing diuretics, ACE inhibitors, K supplements. May increase nephrotoxic effects of ciclosporin or triamterene. Increase plasma concentration w/ probenecid. May increase plasma levels of aminoglycoside (e.g. amikacin, gentamicin) in premature neonates. May enhance antipsychotic effect (e.g. severe drowsiness and confusion) of haloperidol. Al- or Mg-containing antacids may reduce GI disorders of Methacil.
Potentially Fatal: Diflunisal decreases renal clearance and increases plasma concentrations of Methacil which leads to fatal GI haemorrhage.
Methacil side effects
CHF, tachycardia, chest pain, arrhythmia, palpitations, HTN, pulmonary HTN, oedema; GI disturbances (e.g. nausea, vomiting, dyspepsia, indigestion, heartburn, epigastric pain); headache, frontal throbbing, apparent swelling of the temporal vessels, tinnitus, ataxia, tremor, dizziness, insomnia, vertigo, lightheadedness, confusion, psychiatric disturbances; haemolytic anaemia, bone marrow depression, agranulocytosis, leucopenia, thrombocytopenic purpura; corneal deposits and retinal disturbances, acute interstitial nephritis w/ haematuria, proteinuria, pruritus, urticaria, rash, macular and morbilliform eruptions, apnoea and exacerbation of pulmonary infection.
Known hypersensitivity to Methacil, aspirin or other NSAIDs. Neonates w/ congenital heart disease when patency of the ductus arteriosus is needed for adequate pulmonary or systemic blood flow (e.g. neonates w/ pulmonary atresia, severe tetralogy of Fallot or severe coarctation of the aorta). Neonates w/ proven or suspected untreated infection, necrotising enterocolitis, impaired renal function, active bleeding (e.g. intraventricular haemorrhage or GI bleeding), thrombocytopenia or underlying coagulation defect. Patient w/ history of proctitis or recent rectal bleeding. History of asthma, urticaria, allergic-type reactions. Treatment of perioperative pain in the setting of CABG surgery. Concurrent use w/ diflunisal.
The results of a survey conducted on ndrugs.com for Methacil are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Methacil. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
User reports
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