Metronidazole CCPC is used to treat bacterial infections in different areas of the body. The extended-release tablets are used to treat women with vaginal infections (bacterial vaginosis).
Metronidazole CCPC belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, Metronidazole CCPC will not work for colds, flu, or other virus infections.
Metronidazole CCPC is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Metronidazole CCPC is used in certain patients with the following medical conditions:
Clostridium difficile diarrhea or colitis (antibiotic-associated colitis).
Crohn's disease (inflammatory bowel disease).
Gastritis or stomach ulcers due to Helicobacter pylori.
Giardiasis (parasite infection in the intestines).
Metronidazole CCPC indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Symptomatic Trichomoniasis. Metronidazole CCPC Capsules USP 375 mg are indicated for the treatment of T. vaginalis infection in females and males when the presence of the trichomonad has been confirmed by appropriate laboratory procedures (wet smears and/or cultures).
Asymptomatic Trichomoniasis. Metronidazole CCPC Capsules USP 375 mg are indicated in the treatment of asymptomatic T. vaginalis infection in females when the organism is associated with endocervicitis, cervicitis, or cervical erosion. Since there is evidence that presence of the trichomonad can interfere with accurate assessment of abnormal cytological smears, additional smears should be performed after eradication of the parasite.
Treatment of Asymptomatic Sexual Partners. T. vaginalis infection is a venereal disease. Therefore, asymptomatic sexual partners of treated patients should be treated simultaneously if the organism has been found to be present, in order to prevent reinfection of the partner. The decision as to whether to treat an asymptomatic male partner who has a negative culture or one for whom no culture has been attempted is an individual one. In making this decision, it should be noted that there is evidence that a woman may become reinfected if her sexual partner is not treated. Also, since there can be considerable difficulty in isolating the organism from the asymptomatic male carrier, negative smears and cultures cannot be relied upon in this regard. In any event, the sexual partner should be treated with Metronidazole CCPC in cases of reinfection.
Amebiasis. Metronidazole CCPC Capsules USP 375 mg are indicated in the treatment of acute intestinal amebiasis (amebic dysentery) and amebic liver abscess.
In amebic liver abscess, Metronidazole CCPC Capsules USP 375 mg therapy does not obviate the need for aspiration or drainage of pus.
Anaerobic Bacterial Infections. Metronidazole CCPC Capsules USP 375 mg are indicated in the treatment of serious infections caused by susceptible anaerobic bacteria. Indicated surgical procedures should be performed in conjunction with Metronidazole CCPC therapy. In a mixed aerobic and anaerobic infection, antimicrobials appropriate for the treatment of the aerobic infection should be used in addition to Metronidazole CCPC Capsules USP 375 mg.
INTRA-ABDOMINAL INFECTIONS, including peritonitis, intra-abdominal abscess, and liver abscess, caused by Bacteroides species including the B. fragilis group (B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus), Clostridium species, Eubacterium species, Peptococcus species, or Peptostreptococcus species.
SKIN AND SKIN STRUCTURE INFECTIONS caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus species, Peptostreptococcus species, or Fusobacterium species.
GYNECOLOGIC INFECTIONS, including endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection, caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus species, Peptostreptococcus species, or Fusobacterium species.
BACTERIAL SEPTICEMIA caused by Bacteroides species including the B. fragilis group or Clostridium species.
BONE AND JOINT INFECTIONS (as adjunctive therapy) caused by Bacteroides species including the B. fragilis group.
CENTRAL NERVOUS SYSTEM (CNS) INFECTIONS, including meningitis and brain abscess, caused by Bacteroides species including the B. fragilis group.
LOWER RESPIRATORY TRACT INFECTIONS, including pneumonia, empyema, and lung abscess, caused by Bacteroides species including the B. fragilis group.
ENDOCARDITIS caused by Bacteroides species including the B. fragilis group.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Metronidazole CCPC Capsules USP 375 mg and other antibacterial drugs, Metronidazole CCPC Capsules USP 375 mg should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
How should I use Metronidazole CCPC?
Use Metronidazole CCPC cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Wash and completely dry the affected area. Be sure the area is completely dry before applying Metronidazole CCPC cream.
Apply a thin layer of Metronidazole CCPC cream to the affected area. Gently rub the medicine in until it is evenly distributed.
Wash your hands immediately after using Metronidazole CCPC cream.
You may apply cosmetics after you use Metronidazole CCPC cream. If you are using the lotion, wait 5 minutes after you use Metronidazole CCPC cream before you apply cosmetics so that the lotion has time to dry.
Use Metronidazole CCPC cream on a regular schedule to get the most benefit from it. Using it at the same time(s) each day will help you remember to use it.
Continue to use Metronidazole CCPC cream even if your condition improves, unless a doctor tells you otherwise. Do not miss any doses.
If you miss a dose of Metronidazole CCPC cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Metronidazole CCPC cream.
Uses of Metronidazole CCPC in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Metronidazole CCPC is an antibiotic that is used to treat a wide variety of infections. It works by stopping the growth of certain bacteria and parasites.
This antibiotic treats only certain bacterial and parasitic infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.
Metronidazole CCPC may also be used with other medications to treat certain stomach/intestinal ulcers caused by a bacteria (H. pylori).
How to use Metronidazole CCPC
Take this medication by mouth as directed by your doctor. To prevent stomach upset, take this medication with food or a full glass of water or milk. The dosage is based on your medical condition and response to treatment.
Antibiotics work best when the amount of medicine in your body is kept at a constant level. Take this drug at evenly spaced intervals.
Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.
Tell your doctor if your condition lasts or gets worse.
Metronidazole CCPC description
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Each 100 mL contains Metronidazole USP 500 mg, sodium chloride USP 0.72% w/v, water for injection USP as needed.
Metronidazole CCPC injection, USP is a parenteral dosage form of the synthetic antibacterial agent 1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole. The empirical formula is C6H9N3O3 and the molecular weight is 171.15.
Metronidazole CCPC injection, USP in 100 mL is a sterile, nonpyrogenic, iso-osmotic, buffered solution of 500 mg Metronidazole CCPC, USP, 790 mg sodium chloride, USP, 47.6 mg dried dibasic sodium phosphate, USP and 22.9 mg anhydrous citric acid, USP. Metronidazole CCPC injection, USP has an osmolarity of 310 mOsmol/L (calc) and a pH of 5.5 (4.5 to 7).
Metronidazole CCPC dosage
Metronidazole CCPC ER Dosage
Generic name: Metronidazole CCPC 750mg
Dosage form: tablet, film coated, extended release
See also:
Metronidazole CCPC tablet, film coated
Metronidazole CCPC 375 Capsules capsule
Metronidazole CCPC Injection injection, solution
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Bacterial Vaginosis
750 mg once daily by mouth for seven consecutive days.
Metronidazole CCPC ER 750 mg tablets should be taken under fasting conditions, at least one hour before or two hours after meals. The optimum extended-release characteristics of Metronidazole CCPC ER 750 mg are obtained when the drug is taken under fasting conditions.
Metronidazole CCPC ER tablets should not be split, chewed, or crushed.
Dosage Adjustments
Patients Undergoing Hemodialysis
Hemodialysis removes significant amounts of Metronidazole CCPC and its metabolites from systemic circulation. The clearance of Metronidazole CCPC will depend on the type of dialysis membrane used, the duration of the dialysis session, and other factors. If the administration of Metronidazole CCPC cannot be separated from a hemodialysis session, supplementation of Metronidazole CCPC dosage following the hemodialysis session should be considered, depending on the patient's clinical situation.
More about Metronidazole CCPC ER (Metronidazole CCPC)
antacids that contain aluminum hydroxide, with kolestiraminom slightly decreases absorption of Metronidazole CCPC from the gastrointestinal tract;
Metronidazole CCPC potentiates the effect of indirect anticoagulants;
disulfiram may develop acute psychosis and impaired consciousness;
lansoprazole possible glossitis, stomatitis and / or the appearance of dark color language; with lithium carbonate - may increase the concentration of lithium in blood plasma and the development of symptoms of intoxication with prednisone - increased excretion of Metronidazole CCPC from the body by accelerating its metabolism in the liver under the influence of prednisone. It is possible a decrease the effectiveness of Zol.
rifampicin increased the clearance of Metronidazole CCPC from the body, with phenytoin - it is perhaps a slight increase in the concentration of phenytoin in blood plasma, described the case of toxic action;
phenobarbital significantly increased excretion of Metronidazole CCPC from the body, apparently due to acceleration of its metabolism in the liver under the influence of phenobarbital. It is possible a decrease the effectiveness of Zol;
fluorouracil enhanced the toxic effect but not the effectiveness of fluorouracil;
cimetidine may inhibit the metabolism of Metronidazole CCPC in the liver that can lead to slow its elimination and increase the concentration in blood plasma. It can not be excluded the increase in the concentration of carbamazepine in plasma and increased risk of toxicity with concomitant use of Zol. There was described a case of acute dystonia after a single dose of chloroquine in patients treated with Metronidazole CCPC.
In a controlled clinical trial, safety data from 141 patients who used Metronidazole CCPC Lotion
Topical Lotion (n=71), or the lotion vehicle (n=70), twice daily and experienced a local cutaneous adverse event which may or may not have been related to the treatments include: local allergic reaction, Metronidazole CCPC
Topical Lotion 0, lotion vehicle 1 (1%); and worsening of rosacea, Metronidazole CCPC Lotion
Topical Lotion 1 (1%), lotion vehicle 7 (10%).
The following additional adverse experiences have been reported with the topical use of Metronidazole CCPC: skin irritation, transient redness, metallic taste, tingling or numbness of extremities, and nausea.
Metronidazole CCPC Capsules 375 mg are contraindicated in patients with a prior history of hypersensitivity to Metronidazole CCPC or other nitroimidazole derivatives.
In patients with trichomoniasis, Metronidazole CCPC Capsules 375 mg are contraindicated during the first trimester of pregnancy.
Psychotic Reaction with Disulfiram
Use of oral Metronidazole CCPC is associated with psychotic reactions in alcoholic patients who were using disulfiram concurrently. Do not administer Metronidazole CCPC to patients who have taken disulfiram within the last two weeks.
Interaction with Alcohol
Use of oral Metronidazole CCPC is associated with a disulfiram-like reaction to alcohol, including abdominal cramps, nausea, vomiting, headaches, and flushing. Discontinue consumption of alcohol or products containing propylene glycol during and for at least three days after therapy with Metronidazole CCPC.
DailyMed. "BISMUTH SUBCITRATE POTASSIUM; METRONIDAZOLE; TETRACYCLINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
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