The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
Miconazole Nitrate has a broad spectrum of antifungal activity against dermatophytes, yeasts and moulds. Miconazole Nitrate also possesses antimicrobial properties.
Dimethicone provides protection to the skin due to its water-repellant properties. It is non-irritating and has healing properties.
Phenethyl alcohol has antimicrobial properties.
Zinc oxide is protective and soothing and the menthol provides an immediate cooling sensation to help relieve itching skin.
Miconazole Nitrate tinea powder does not contain starch, which may support bacterial growth.
How should I take Miconazole Nitrate?
Keep Miconazole Nitrate away from the eyes.
Apply enough Miconazole Nitrate to cover the affected area, and rub in gently.
To use the aerosol powder form of Miconazole Nitrate:
Shake well before using.
From a distance of 6 to 10 inches, spray the powder on the affected areas. If it is used on the feet, spray it between the toes, on the feet, and in the socks and shoes.
Do not inhale the powder.
Do not use near heat, near open flame, or while smoking.
To use the aerosol solution form of Miconazole Nitrate:
Shake well before using.
From a distance of 4 to 6 inches, spray the solution on the affected areas. If it is used on the feet, spray it between the toes and on the feet.
Do not inhale the vapors from the spray.
Do not use near heat, near open flame, or while smoking.
To use the powder form of Miconazole Nitrate:
If the powder is used on the feet, sprinkle it between the toes, on the feet, and in the socks and shoes.
When Miconazole Nitrate is used to treat certain types of fungus infections of the skin, an occlusive dressing (airtight covering, such as kitchen plastic wrap) should not be applied over Miconazole Nitrate. To do so may cause irritation of the skin. Do not apply an occlusive dressing over Miconazole Nitrate unless you have been directed to do so by your doctor.
To help clear up your infection completely, keep using Miconazole Nitrate for the full time of treatment, even if your condition has improved. Do not miss any doses.
The dose of Miconazole Nitrate will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Miconazole Nitrate. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For aerosol powder, aerosol solution, cream, and powder dosage forms:
For fungus infections:
Adults and children—Apply to the affected area(s) of the skin two times a day, morning and evening.
For cream and lotion dosage forms:
For sun fungus:
Adults and children—Apply to the affected area(s) of the skin once a day.
If you miss a dose of Miconazole Nitrate, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Store the canister at room temperature, away from heat and direct light. Do not freeze. Do not keep Miconazole Nitrate inside a car where it could be exposed to extreme heat or cold. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Miconazole Nitrate administration
Administration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.
Use Miconazole Nitrate topical exactly as directed by your doctor or follow the directions that accompany the package. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
Wash your hands before and after using this medication.
Clean and dry the affected area. Apply the cream, lotion, spray, or powder once or twice daily as directed for 2 to 4 weeks.
Use this medication for the full amount of time prescribed by your doctor or as recommended in the package even if you begin to feel better. Your symptoms may improve before the infection is completely healed.
If the infection does not clear up in 2 weeks (or 4 weeks for athlete's foot), or if it appears to get worse, see your doctor.
Do not use bandages or dressings that do not allow air circulation over the affected area (occlusive dressings) unless otherwise directed by your doctor. A light cotton-gauze dressing may be used to protect clothing.
Avoid getting this medication in your eyes, nose, or mouth.
Store Miconazole Nitrate topical at room temperature away from moisture and heat.
Miconazole Nitrate pharmacology
Pharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.
Miconazole Nitrate interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Miconazole Nitrate may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
DailyMed. "MICONAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
NCIt. "Miconazole: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
EPA DSStox. "Miconazole: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
The results of a survey conducted on ndrugs.com for Miconazole Nitrate are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Miconazole Nitrate. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
1 consumer reported administration
When best can I take Miconazole Nitrate, on an empty stomach, before or after food? ndrugs.com website users have also released a report stating that Miconazole Nitrate should be taken After food. In any case, this may not be the right description on how you ought to take this Miconazole Nitrate. Kindly visit your doctor for more medical advice in this regard. Click here to see other users view on when best the Miconazole Nitrate can be taken.
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