Monobenzone Uses

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Monobenzone indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Monobenzone Cream 20% is indicated for final depigmentation in extensive Vitiligo.

Monobenzone Cream 20% is applied topically to permanently depigment normal skin surrounding vitiliginous lesions in patients with disseminated (greater than 50 percent of body surface area) idiopathic vitiligo.

Monobenzone Cream 20% is not recommended in freckling; hyperpigmentation caused by photosensitization following the use of certain perfumes (berlock dermatitis); melasma (chloasma) of pregnancy; or hyperpigmentation resulting from inflammation of the skin. Monobenzone Cream 20% is not effective for the treatment of cafe-au-lait spots, pigmented nevi, malignant melanoma or pigmentation resulting from pigments other than melanin (e.g.: bile, silver, or artificial pigments).

Monobenzone description

Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. The topical application of Monobenzone in animals increases the excretion of melanin from the melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans. Monobenzone may cause destruction of melanocytes and permanent depigmentation.

Monobenzone dosage


Monobenzone Dosage

Generic name: Monobenzone

Dosage form: cream, USP

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

A thin layer of Monobenzone Cream 20% should be applied and rubbed into the pigmented area two or three times daily, or as directed by physician. Prolonged exposure to sunlight should be avoided during treatment with Monobenzone Cream 20%, or a sunscreen should be used.

Depigmentation is usually accomplished after one to four months of Monobenzone Cream 20% treatment. If satisfactory results are not obtained after four months of Monobenzone Cream 20% treatment, the drug should be discontinued. When the desired degree of depigmentation is obtained, Monobenzone Cream 20% should be applied only as often as needed to maintain depigmentation (usually only two times weekly).

More about Monobenzone (Monobenzone topical)

Professional resources

Monobenzone interactions


Possible food and drug interactions when taking Balsalazide disodium

While drug interactions with Balsalazide disodium have not yet been studied, it is possible that oral antibiotics could interfere with the release of Balsalazide disodium in the colon.

Monobenzone side effects

Mild, transient skin irritation and sensitization, including erythematous and eczematous reactions have occurred following topical application of Monobenzone Cream 20%. Although those reactions are usually transient, treatment with Monobenzone Cream 20% should be discontinued if irritation, a burning sensation, or dermatitis occur. Areas of normal skin distant to the site of Monobenzone Cream 20% application frequently have become depigmented, and irregular, excessive, unsightly, and frequently permanent depigmentation has occurred.

Monobenzone contraindications

Monobenzone Cream 20% contains a potent depigmenting agent and is not a cosmetic skin bleach. Use of Monobenzone Cream 20% is contraindicated in any conditions other than disseminated vitiligo. Monobenzone Cream 20% frequently produces irreversible depigmentation, and it must not be used as a substitute for hydroquinone.

Monobenzone Cream 20% is also contraindicated in individuals with a history of sensitivity or allergic reactions to this product, or any of its ingredients.

Active ingredient matches for Monobenzone:


Unit description / dosage (Manufacturer)Price, USD
Hydroquinone mono benzyl ether$ 5.28

List of Monobenzone substitutes (brand and generic names):

Albaquine 20% CRM / 20g (Puneet Lab)$ 4.37
ALBAQUINE cream 20 % x 20g (Puneet Lab)$ 4.37
Cream; Topical; Monobenzone 20% (Mac Laboratories Limited)
35.4 gram in 1 tube (Mac Laboratories Limited)
Benoquin Skin 20 gm Ointment (Mac Laboratories Limited)$ 0.51
Benoquin 20% OINT / 20g (Mac Laboratories Limited)$ 0.51
20 % x 20g (Mac)$ 0.51
Benoquin Oint 20% OINT / 20g (Mac)$ 0.51
BENOQUIN OINT oint 20 % x 20g (Mac)$ 0.51
Benoquin Oint 20% OINT / 20g (Mac)$ 0.51
BENOQUIN OINT. Cream/ Gel/ Ointment / 0.2 / 20gm units (Mac Laboratories)$ 0.48


The results of a survey conducted on for Monobenzone are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Monobenzone. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

2 consumers reported useful

Was the Monobenzone drug useful in terms of decreasing the symptom or the disease?
According to the reports released by website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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