Moxifloxacin Side effects

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What are the possible side effects of Moxifloxacin?

Get emergency medical help if you have signs of an allergic reaction to Avelox: hives, or the first sign of a skin rash; fast heartbeat, difficult breathing; swelling of your face, lips, tongue, or throat.

Moxifloxacin may cause swelling or tearing of (rupture) a tendon. Moxifloxacin can also have serious effects on your nerves, and may cause permanent nerve damage.

Stop using Moxifloxacin and call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

  • muscle pain or weakness;

  • a seizure (convulsions);

  • sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, easy bruising or bleeding;

  • signs of tendon rupture - sudden pain, swelling, bruising, tenderness, stiffness, movement problems, or a snapping or popping sound in any of your joints (rest the joint until you receive medical care or instructions);

  • nerve symptoms - numbness, weakness, tingling, burning, pain, or being more sensitive to temperature, light touch, or the sense of your body position;

  • changes in mood or behavior - depression, confusion, hallucinations, paranoia, tremors, feeling restless or anxious, unusual thoughts or behavior, insomnia, nightmares;

  • liver problems - upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • increased pressure inside the skull - severe headaches, ringing in your ears, vision problems, pain behind your eyes; or

  • severe skin reaction - skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common Moxifloxacin side effects may include:

  • nausea, constipation, diarrhea;

  • dizziness; or

  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Moxifloxacin in details

infoA side effect of any drug can be defined as the unwanted or undesired effect produced by the drug. The side effect can be major or in few medications minor that can be ignored. Side effects not only vary from drug to drug, but it also depends on the dose of the drug, the individual sensitivity of the person, brand or company which manufactures it. If side effects overweigh the actual effect of the medicine, it may be difficult to convince the patient to take the drug. Few patients get specific side effects to specific drugs; in that case, a doctor replaces the drug with another. If you feel any side effect and it troubles you, do not forget to share with your healthcare practitioner.

Applies to moxifloxacin ophthalmic: ophthalmic solution

In addition to its needed effects, some unwanted effects may be caused by moxifloxacin ophthalmic. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking moxifloxacin ophthalmic:

Incidence not known:

  • Fainting or loss of consciousness
  • fast or irregular breathing
  • itching
  • skin rash
  • swelling of the eyes or eyelids
  • tightness in the chest or wheezing
  • trouble with breathing

Minor Side Effects

Some of the side effects that can occur with moxifloxacin ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

  • Burning, dry, or itching eyes
  • change in vision
  • decreased vision
  • dry eye
  • excessive tearing
  • eye discharge
  • itching of the eye
  • pain in the eye
  • red, sore eyes
  • redness of the eye
  • swelling of the eye, eyelid, or inner lining of the eyelid
  • tearing
Less common:
  • Body aches or pain
  • congestion
  • cough or hoarseness
  • decreased hearing
  • dryness or soreness of the throat
  • fever or chills
  • general body discomfort
  • lower back or side pain
  • painful or difficult urination
  • rash
  • rubbing or pulling of the ears (in children)
  • runny nose
  • sore throat
  • tender, swollen glands in the neck
  • trouble with swallowing
  • voice changes
  • vomiting and diarrhea (in infants)

What is the most important information I should know about Moxifloxacin?

  • Moxifloxacin may cause dizziness, drowsiness, light-headedness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Moxifloxacin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Be sure to use Moxifloxacin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Moxifloxacin may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Moxifloxacin. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
  • Nerve problems in the arms, hands, legs, or feet can happen in people taking Moxifloxacin. These nerve problems can happen soon after Moxifloxacin is started and may be permanent. Call your doctor right away if you have symptoms or nerve problems (eg, not able to handle heat or cold; decreased sensation of touch; unusual burning, numbness, tingling, pain, or weakness of the arms, hands, legs, or feet).
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
  • Severe and sometimes fatal effects have rarely happened with Moxifloxacin. These have included muscle or joint, kidney, liver, blood, and other problems. Talk with your doctor if you have questions.
  • Moxifloxacin only works against bacteria; it does not treat viral infections (eg, the common cold).
  • Do not receive certain live vaccines (oral typhoid vaccine, bacille Calmette-Guérin [BCG] vaccine) while you are taking Moxifloxacin. Talk with your doctor before you receive any vaccine.
  • Long-term or repeated use of Moxifloxacin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Moxifloxacin has infrequently caused tendon problems, including tendon rupture. If you experience any unusual pain or swelling in your joints (eg, shoulder, elbow, hand, hip, knee, ankle, foot), contact your doctor immediately. Rest and avoid exercise or other physically stressful activity until your doctor tells you otherwise.
  • Diabetes patients - Moxifloxacin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Use Moxifloxacin with caution in the ELDERLY; they may be more sensitive to its effects (eg, tendon problems), especially if they take corticosteroids (eg, prednisone). They may also be more sensitive to other effects (eg, irregular heartbeat).
  • PREGNANCY and BREAST-FEEDING: It is not known if Moxifloxacin can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Moxifloxacin while you are pregnant. It is not known if Moxifloxacin is found in breast milk. Do not breast-feed while using Moxifloxacin.

Moxifloxacin contraindications

infoContraindication can be described as a special circumstance or a disease or a condition wherein you are not supposed to use the drug or undergo particular treatment as it can harm the patient; at times, it can be dangerous and life threatening as well. When a procedure should not be combined with other procedure or when a medicine cannot be taken with another medicine, it is called Relative contraindication. Contraindications should be taken seriously as they are based on the relative clinical experience of health care providers or from proven research findings.

Hypersensitivity to other quinolones, moxifloxacin or any of the excipients of Moxifloxacin.

Use in pregnancy: The safe use of moxifloxacin in human pregnancy has not been established. Reversible joint injuries are described in children receiving some quinolones. However, this effect has not been reported as occurring on exposed foetuses. Animal studies have shown reproductive toxicity. The potential risk for humans is unknown.

Consequently, the use of moxifloxacin during pregnancy is contraindicated.

Use in lactation: As with other quinolones, moxifloxacin has been shown to cause lesions in the cartilage of the weight bearing joints of immature animals. Preclinical evidence indicates that small amounts of moxifloxacin may be secreted in human milk. There is no data available in lactating or nursing women. Therefore, the use of moxifloxacin in nursing mothers is contraindicated.

Use in children: Safety and efficacy of moxifloxacin in children and adolescents have not been established.



  1. European Chemicals Agency - ECHA. "1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". (accessed September 18, 2017).
  2. HSDB. "Moxifloxacin". (accessed September 18, 2017).


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