What is Multifungin-H?
Reducing swelling, itching, and discomfort associated with certain rectal conditions, including hemorrhoids.
Multifungin-H suppositories is a topical corticosteroid. It works by depressing the formation, release, and activity of different cells and chemicals that cause swelling, redness, and itching.
(Systemic use):Endocrine disordes ( primary or secondary adrenocortical insufficiency ).
shock unresponsive to conVentional therapy if adrenocortical insufficiency exists or is suspected, Rheumati
c disorders ( post – traumatic osteoarthritis, synovitis of osteoarthritis, Rheumatoid arthritis, Acute and subacute bursitis.
Epicondylitis, Acute nonspecific tenosynovitis, Acute gouty arthritis, Psoriatic arthritis
Collagen diseases ( systemic lupus erythematosus, Acute rheumatic Carditis, systemic dermatomysitis ), Dermatologic disease ( Pemphigus, Severe erythma multiforme, Exfoliative dermatitis, Severe psoriasis ) ophthalmic diseases, ( in allergic and inflammatory processes involving the eye, such as : Herpes Zoster ophthalmicus, Iritis, iridocy clitis, chorioretinitis, Keratitis ), Gastrointestinal diseases ( ulcerative colitis systemic theropy ) Respiratory diseases ( symptomatic sarcoidosis, Berylliosis ) Hematologic disorders ( Acquired [ autoimmune ] hemolytic anemia ) Neoplastic disease. (Topical use):variety of skin conditions (e.g., insect bites, poison oak/ivy, eczema, dermatitis, allergies, rash, itching of the outer female genitals, anal itching). Multifungin-H reduces the swelling, itching, and redness that can occur in these types of conditions. This medication is a mild corticosteroid.
How should I use Multifungin-H?
Use Multifungin-H suppositories as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Avoid excessive handling of the suppository. It is designed to melt at body temperature.
- Wash your hands before and after using Multifungin-H suppositories. If the suppository is too soft to use, put it in the refrigerator for about 15 minutes. You may also run cold water over it. Remove the wrapper. Moisten the suppository with cool water. Lie down on your side. Insert the pointed end of the suppository into the rectum. Use your finger to push it in completely.
- If you miss a dose of Multifungin-H suppositories and you are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Ask your health care provider any questions you may have about how to use Multifungin-H suppositories.
Uses of Multifungin-H in details
This medication is used to treat minor pain, itching, swelling, and discomfort caused by hemorrhoids and other problems of the anal area (e.g., anal fissures, itching). Multifungin-H is a corticosteroid that reduces redness, itching, and swelling.
How to use Multifungin-H rectal
Before use, clean the affected area with mild soap and water, rinse well, and pat dry.
To apply this product inside the anus, use the applicator tip/cap/nozzle, following all instructions in the product package, or use as directed by your doctor. Fill the applicator with medication from the container as directed. Gently insert the applicator tip just 1/2 to 1 inch (1.5 to 2.5 centimeters) inside the anus and apply in and around the anal opening as directed. Do not insert your finger or any part of the container into the anus, and do not insert the applicator tip/nozzle more than 1/2 to 1 inch (1.5 to 2.5 centimeters) inside the anus. Do not use your finger to apply this medication inside the anus. If you are using a single-use tube and applicator, discard after one use.
To apply the product to the outside of the anus only, use your finger to apply a small amount of cream or ointment to the affected area and rub in gently.
Do not cover the area with plastic or waterproof bandages unless directed to do so by your doctor. Covering the treated area may increase the absorption of the medication through the skin. This may improve how well the drug works, but it may also increase the risk of side effects.
Wash hands immediately after use. Avoid getting the product in your eyes, nose, ears or mouth. If the medication gets in these areas, rinse the area immediately with clean water.
This product is usually used 2 to 4 times daily, or after each bowel movement, or as directed by your doctor. Dosage is based on your medical condition and response to therapy. Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day.
Do not use more of this product, use it more often, or keep using it longer than prescribed by your doctor. If you have been using this medication for a long time or in high doses, do not suddenly stop using it without your doctor's approval. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.
Inform your doctor if your condition does not improve or if it worsens after 1 to 2 weeks.
Multifungin-H 100 mg contains hydrocortisone acetate sodium succinate equivalent to Multifungin-H 100 mg, monobasic sodium phosphate 1 mg, dibasic sodium 9 mg and sodium hydroxide 10%.
Multifungin-H 100 mg/2 mL contains hydrocortisone acetate sodium succinate equivalent to Multifungin-H 100 mg/2 mL, monobasic sodium phosphate 1 mg, dibasic sodium 10 mg and sodium hydroxide 10%.
Multifungin-H 250 mg/2 mL contains hydrocortisone acetate sodium succinate equivalent to Multifungin-H 250 mg/2 mL, monobasic sodium phosphate 2 mg, dibasic sodium phosphate 25 mg and sodium hydroxide 10%.
Multifungin-H 500 mg/4 mL contains hydrocortisone acetate sodium succinate equivalent to Multifungin-H 500 mg/4 mL, monobasic sodium phosphate 5 mg, dibasic sodium phosphate 52 mg and sodium hydroxide 10%.
Multifungin-H sodium succinate or pregn-4-ene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy; monosodium salt,(11β) is an anti-inflammatory adrenocortical steroid. This highly water-soluble sodium succinate ester of Multifungin-H permits the immediate IV administration of high doses of Multifungin-H in a small volume of diluent and is particularly useful where high blood levels of Multifungin-H are required rapidly.
When necessary, the pH of Multifungin-H was adjusted with sodium hydroxide so that the pH of the reconstituted solution is within the USP specified range of 7-8.
Apply to the affected area as a thin film from two to four times daily depending on the severity of the condition.
Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions.
If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted.
(Systemic use):Combinations containing any of the following medications, depending on the amount present, also may interact with this medication:
Acetaminophen-Alcohol-Anti-inflammatory drugs, nonsteroidal (NSAIDs)- Aminoglutethimide
Amphotericin B,Carbonic anhydrase inhibitors,Anabolic steroids,Androgens,Antacids,Anticholinergics, especially atropine and related compounds
Anticoagulants, coumarin- or indanedione-
Heparin orStreptokinase orUrokinase
Antidiabetic agents, oral - Insulin -Antithyroid agents-Thyroid hormones-Contraceptives, oral, estrogen-containing.(Topical use): No specific interactions
Multifungin-H side effects
(Systemic use):Mineralocorticoid adverse effects ( retention of sodium and water, with oedema and hypertension ), increased excretion of potassium with the possibility of hypokalaemic alkalosis, cardiac failure, disturbances of electrolyte balance, osteoporosis, spontaneous fractures, muscle wasting and nitrogen depletion, hyperglycaemia, menstrual irregularities. Immunosuppression, cushingoid symptoms ( with moon-face, hirsutism, buffalo hump, flushing, CHF, psychic disturbances, sudden blindness, Adrenal suppression, avascular necrosis, cataracts, cutaneous or subcutaneous tissue atrophy, growth suppression ( in children ), impaired wound healing, pancreatitis, peptic ulceration or intestinal perforation, tendon rupture and thin, fragile skin.(Topical use):Stinging, burning, irritation, dryness, or redness at the application site may occur. Acne, unusual hair growth, "hair bumps" (folliculitis), skin thinning/discoloration, or stretch marks may also occur.
(Systemic use) Prior Arthroplasty of joint, Blood Clotting disorders, intra – articular fracture, infection ( periaticular, current or history of ), osteoporosis, unstable joint.(Topical use): variety of skin conditions (e.g., insect bites, poison oak/ivy, eczema, dermatitis, allergies, rash, itching of the outer female genitals, anal itching). Multifungin-H reduces the swelling, itching, and redness that can occur in these types of conditions. This medication is a mild corticosteroid.
Active ingredient matches for Multifungin-H:
Hydrocortisone acetate in India.
5-bromosalicyl-4-chloroanilide/bamipine in India.
|Unit description / dosage (Manufacturer)||Price, USD|
|Multifungin-H 10g CRM|
|MULTIFUNGIN-H cream 10g (AHPL)|
|Multifungin-H 10g CRM|
List of Multifungin-H substitutes (brand and generic names):
|Monistat Smoothing Care (United States)|
|Muni 20 g|
|Muni HC (Germany)|
|Ointment, Fatty; Topical; Hydrocortisone|
|Ointment; Topical; Hydrocortisone|
|Mycort 100mg VIAL / 1 (Novogen Captab)||$ 0.95|
|Mylocort (South Africa)|
|Cream; Topical; Hydrocortisone Acetate 2%|
|Neopolygramin H Skin 3 gm Ointment (Sunways India Pvt. Ltd.)||$ 0.08|
|Neuroderm Akut (Germany)|
|Neutrogena T / Scalp|
|Niscort - VIAL / 1 (Neiss)||$ 0.67|
|1's (Neiss)||$ 0.67|
|NITICORT 100MG INJECTION 1 vial / 2 ML injection each (Nitin Lifesciences Ltd)||$ 0.67|
|Nitten HC Solone (Japan)|
|No More Itchies (United States)|
|Noble Formula HC (United States)|
|Injectable; Injection; Hydrocortisone Sodium Succinate 100 mg / ml (Cryopharma)|
|Injectable; Injection; Hydrocortisone Sodium Succinate 50 mg / ml (Cryopharma)|
|Nupercainal Hydrocortisone Anti-Itch Cream|
|Obagi Nu-Derm Tolereen (Singapore)|
|Oftalmolosa Cusi Hidrocortisona (Spain)|
|Oncotose A L'Hydrocortisone (Belgium)|
|Ophthalmo-Hydrocortison Leciva (Czech Republic, Slovakia)|
|Oralsone (Argentina, Spain)|
- DailyMed. "CIPROFLOXACIN HYDROCHLORIDE; HYDROCORTISONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "hydrocortisone". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "hydrocortisone". http://www.drugbank.ca/drugs/DB00741 (accessed September 17, 2018).
- DTP/NCI. "hydrocortisone: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
- Wikipedia. "cortisol: Link to the compound information in Wikipedia.". https://en.wikipedia.org/wiki/Cortis... (accessed September 17, 2018).
ReviewsThe results of a survey conducted on ndrugs.com for Multifungin-H are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Multifungin-H. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
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Information checked by Dr. Sachin Kumar, MD Pharmacology