Nalitik Dosage

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Dosage of Nalitik in details

The dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.
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Nalitik AS A MUCOLYTIC AGENT

General

Nalitik Solution, USP (n-acetyl-l-cysteine) is available in rubber stoppered glass vials containing 10 mL or 30 mL. The 20% solution may be diluted to a lesser concentration with either Sodium Chloride Injection, Sodium Chloride for Inhalation, Sterile Water for Injection, or Sterile Water for Inhalation. The 10% solution may be used undiluted.

Nalitik does not contain an antimicrobial agent, and care must be taken to minimize contamination of the sterile solution. If only a portion of the solution in a vial is used, store the remainder in a refrigerator and use for inhalation only within 96 hours.

Nebulization - Face Mask, Mouthpiece, Tracheostomy: When nebulized into a face mask, mouthpiece, or tracheostomy, 1 to 10 mL of the 20% solution or 2 to 20 mL of the 10% solution may be given every 2 to 6 hours; the recommended dose for most patients is 3 to 5 mL of the 20% solution or 6 to 10 mL of the 10% solution three to four times a day.

Nebulization - Tent, Croupette: In special circumstances it may be necessary to nebulize into a tent or Croupette, and this method of use must be individualized to take into account the available equipment and the patient's particular needs. This form of administration requires very large volumes of the solution, occasionally as much as 300 mL during a single treatment period.

If a tent or Croupette must be used, the recommended dose is the volume of Nalitik (using 10 or 20%) that will maintain a very heavy mist in the tent or Croupette for the desired period. Administration for intermittent or continuous prolonged periods, including overnight, may be desirable.

Direct Instillation: When used by direct instillation, 1 to 2 mL of a 10% to 20% solution may be given as often as every hour.

When used for the routine nursing care of patients with tracheostomy, 1 to 2 mL of a 10% to 20% solution may be given every 1 to 4 hours by instillation into the tracheostomy.

Nalitik may be introduced directly into a particular segment of the bronchopulmonary tree by inserting (under local anesthesia and direct vision) a small plastic catheter into the trachea. Two to 5 mL of the 20% solution may then be instilled by means of a syringe connected to the catheter.

Nalitik may also be given through a percutaneous intratracheal catheter. One to 2 mL of the 20% or 2 to 4 mL of the 10% solution every 1 to 4 hours may then be given by a syringe attached to the catheter.

Diagnostic Bronchograms: For diagnostic bronchial studies, 2 or 3 administrations of 1 to 2 mL of the 20% solution or 2 to 4 mL of the 10% solution should be given by nebulization or by instillation intratracheally, prior to the procedure.

Administration of Aerosol

Materials: Nalitik solution (n-acetyl-l-cysteine) may be administered using conventional nebulizers made of plastic or glass. Certain materials used in nebulization equipment react with Nalitik. The most reactive of these are certain metals (notably iron and copper) and rubber. Where materials may come into contact with Nalitik solution (n-acetyl-l-cysteine), parts made of the following acceptable materials should be used: glass, plastic, aluminum, anodized aluminum, chromed metal, tantalum, sterling silver, or stainless steel. Silver may become tarnished after exposure, but this is not harmful to the drug action or to the patient.

Nebulizing Gases: Compressed tank gas (air) or an air compressor should be used to provide pressure for nebulizing the solution. Oxygen may also be used but should be used with usual precautions in patients with severe respiratory disease and CO if prothrombin time ratio exceeds 1.5 or fresh frozen plasma if the prothrombin time ratio exceeds 3.0.

  • Diuretics and forced diuresis should be avoided.
  • Dosage Guide and Preparation

    Doses in relation to body weight are:

    Loading Dose of Nalitik* Solution

    Hours Post-Ingestion

    Adapted from Rumack and Mathews, Pediatrics 1975; 55:871-876.

    How supplied

    Nalitik Solution, USP (n-acetyl-l-cysteine), is available in rubber stopped glass vials containing 10 or 30 mL. The 20% solution may be diluted to a lesser concentration with either Sodium Chloride for Injection, Sodium Chloride for Inhalation, Sterile Water for Injection, or Sterile Water for Inhalation. The 10% solution may be used undiluted.

    Acetycysteine is sterile, not for injection and can be used for inhalation (mucolytic agent) or oral administration (acetaminophen antidote). It is available as follows:

    10% Nalitik Solution, USP (n-acetyl-l-cysteine) (100 mg Nalitik per mL).

    NDC 0054-3027-02....................................10 mL vials; carton of 3

    NDC 0054-3025-02....................................30 mL vials; carton of 3

    20% Nalitik Solution, USP (n-acetyl-l-cysteine) (200 mg Nalitik per mL).

    NDC 0054-3028-02.....................................10 mL vials; carton of 3

    NDC 0054-3026-02.....................................30 mL vials; carton of 3

    Store unopened vials at controlled room temperature, 15° to 30°C (59° to 86°F).

    Nalitik Solution, USP (n-acetyl-l-cysteine) does not contain an antimicrobial agent, and care must be taken to minimize contamination of the sterile solution. Dilutions of Nalitik should be used freshly prepared and utilized within one hour. If only a portion of the solution in a vial is used, store the remaining undiluted portion in a refrigerator and use within 96 hours.

    REFERENCES

    1. Bonanomi L, Gazzaniga A. Toxicological pharmacokinetic and metabolic studies on Nalitik. Eur J Respir Dis 1981 61 (Suppl III):45-51.

    2. Amer Rev Resp Dis 1960 82:627-639.

    Mfd. by Ben Venue Laboratories, Inc., Bedford, Ohio 44146. Revised March 2007. Mfd. for Boehringer Ingelheim Roxane Laboratories. FDA Rev date: 8/28/2000

    What other drugs will affect Nalitik?

    Other drugs may affect Nalitik, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

    Nalitik drug interactions (in more detail)

    Nalitik interactions

    Interactions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Nalitik, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.
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    With simultaneous use of antacids containing magnesium and / or aluminum hydroxide, slow down and reduce the absorption of acetylsalicylic acid.

    With simultaneous use of calcium channel blockers, means limiting intake of calcium or increasing the excretion of calcium from the body, increases the risk of bleeding.

    With simultaneous use with acetylsalicylic acid enhances the action of heparin and indirect anticoagulants, hypoglycemic funds derived sulfonylureas, insulin, methotrexate, phenytoin, valproic acid.

    With simultaneous use of Nalitik Industrias Quimico Farmaceuticas Americanas with SCS increases the risk of ulcerogenic effect and occurrence of gastrointestinal bleeding.

    With simultaneous use of decreasing the effectiveness of diuretics (spironolactone, furosemide).

    With simultaneous use of other NSAIDs increases the risk of side effects. Acetylsalicylic acid may reduce plasma concentrations indomethacin, piroxicam.

    With simultaneous use of gold drugs acetylsalicylic acid can induce liver damage.

    With simultaneous use decreases effectiveness of uricosuric medications (including probenecid, sulfinpirazon, benzbromarone).

    With simultaneous use of acetylsalicylic acid and alendronate sodium may develop severe esophagitis.

    With simultaneous use of griseofulvin may be in breach Absorption of acetylsalicylic acid.

    There is one case of spontaneous hemorrhage in the iris while taking Ginkgo Biloba extract on the background of prolonged use of aspirin in a dose of 325 mg / day. It is believed that this may be due to additive inhibitory effect on platelet aggregation.

    With simultaneous use of dipyridamole may increase Cmax of salicylate in plasma and AUC.

    When applied simultaneously with acetylsalicylic acid increased concentration of digoxin, barbiturates and lithium salts in the blood plasma.

    With simultaneous use of salicylates in high doses with carbonic anhydrase inhibitors can intoxication salicylates.

    Acetylsalicylic acid in doses of less than 300 mg have little effect on the effectiveness of captopril and enalapril. When aspirin (acetylsalicylic acid) is admistered in high doses may decrease the effectiveness of captopril and enalapril.

    With simultaneous application of caffeine increases the rate of absorption, plasma concentrations and bioavailability of acetylsalicylic acid.

    With simultaneous use of Nalitik Industrias Quimico Farmaceuticas Americanas with metoprolol may increase Cmax of salicylate in blood plasma.

    In the application of pentazocine on the background of long-term use of aspirin in high doses there is a risk of severe adverse reactions in the kidneys.

    With simultaneous application phenylbutazone reduces uricosuria caused by acetylsalicylic acid.

    With simultaneous application of ethanol may exacerbate the effects of acetylsalicylic acid on the gastrointestinal tract.


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    Reviews

    The results of a survey conducted on ndrugs.com for Nalitik are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Nalitik. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

    User reports

    1 consumer reported frequency of use

    How frequently do I need to take Nalitik?
    It was reported by ndrugs.com website users that Nalitik should ideally be taken 3 times in a day as the most common frequency of the Nalitik. You should you adhere strictly to the instructions and guidelines provided by your doctor on how frequently this Nalitik should be taken. Get another patient's view on how frequent the capsule should be used by clicking here.
    Users%
    3 times in a day1
    100.0%


    1 consumer reported doses

    What doses of Nalitik drug you have used?
    The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Nalitik drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
    Users%
    201-500mg1
    100.0%


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    Information checked by Dr. Sachin Kumar, MD Pharmacology

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