Narcozep Uses

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Narcozep indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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In the treatment of transient, situational and chronic insomnia.

In the case of situational transient insomnia, such as in shift workers, short-term treatment (3-7 days) with Zopiclone at the recommended dosage will be sufficient to re-establish normal sleep.

In insomnia secondary to psychiatric disorders including difficulty in falling asleep, nocturnal awakenings, and early wakening.

Insomnia caused by more persisting life stress or psychological distress can demand longer treatment with Zopiclone than for situational - transient insomnia. However patients need to be periodically assessed for their insomnia and treatment should not be prolonged if not necessary.

Narcozep description

A benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug. [PubChem]

Narcozep dosage

Oral

Short-term management of insomnia

Adult: 0.5-1 mg at night. Max: 2 mg daily.

Elderly: Initial dose: 0.5 mg at night; up to 1 mg, if necessary.

Oral

Premedication in surgery

Adult: 1-2 mg (15-30 mcg/kg) as a single dose. May also be given via IM inj.

Intravenous

Induction of anaesthesia

Adult: 1-2 mg (15-30 mcg/kg) via slow inj.

Narcozep interactions

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Narcozep potentiates medicine used in anaesthetics such as centrally acting analgesics, sedatives and neuroleptics.

Narcozep side effects

The side-effects most commonly encountered are drowsiness and oversedation. Less frequently occurring side-effects are depression of mood, disorientation or confusion, lethargy and ataxia. Other side-effects observed include dizziness, vertigo, light-headedness, headache, confusion, mental depression, slurred speech or dysarthria, changes in libido, ataxia, tremor, blurred vision, urinary retention or incontinence, gastro-intestinal disturbances, charges in salivation, jaundice and blood disorders. Narcozep can cause amnesia and may produce paradoxical excitation, respiratory depression and hypotension may occur with high dosage.

Narcozep may affect the central control of endocrine function by an action on the hypothalamus or anterior pituitary. Endocrine symptoms occurring in long-term users include menstrual irregularities, premenstrual tension, breast engorgement, gynaecomastia and galactorrhoea.

On being awakened from deep sleep, a patient may not recall some events which occur during the awakening period.

Narcozep contraindications

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Contra-indicated in children, pregnancy and lactation.

Patients with a known sensitivity to Narcozep or other benzodiazepines.

Pre-existing central nervous system depression or coma.

Psychotic patients, and those suffering from mental depression or suicidal tendencies, unless there is a marked component of anxiety in their illness.

Patients with acute closed-angle glaucoma and myasthenia.

Severe chronic hypercapnia.

Acute porphyria.

Active ingredient matches for Narcozep:

Flunitrazepam in France.


Unit description / dosage (Manufacturer)Price, USD
Injectable; Injection; Flunitrazepam 1 mg

List of Narcozep substitutes (brand and generic names):

Tablet; Oral; Flunitrazepam 1 mg (Alphapharm)
Tablet; Oral; Flunitrazepam 2 mg (Alphapharm)
Modipanol 1 mg x 100's
Modipanol 2 mg x 1000's
Modipanol 1 mg x 1000's
Injectable; Injection; Flunitrazepam 2 mg / ml (Roche)
Tablet, Film-Coated; Oral; Flunitrazepam 1 mg (Roche)
Rohypnol 1 mg x 30's (Roche)
Rohypnol 2 mg x 100's (Roche)
Rohypnol 2 mg x 5's (Roche)
Rohypnol 2 mg x 25's (Roche)
Sedex 100 ml Syrup (S.S. Pharmaceuticals (P) Ltd.)$ 0.03
Tablet; Oral; Flunitrazepam 1 mg
Sume 2 mg
Tablet; Oral; Flunitrazepam 1 mg

References

  1. PubChem. "flunitrazepam". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "flunitrazepam". http://www.drugbank.ca/drugs/DB01544 (accessed September 17, 2018).
  3. DTP/NCI. "NSC708829: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).

Reviews

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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