Neomycin Topical Actions

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Actions of Neomycin Topical in details

The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
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Neomycin Topical belongs to the class of medications called as antibiotics. It prevents the bacterial growth by stopping the production of essential protein in the bacterial cells, thereby relieving the associated symptoms.

How should I take Neomycin Topical?

If you are using Neomycin Topical without a prescription, do not use it to treat deep wounds, puncture wounds, serious burns, or raw areas without first checking with your health care professional.

Do not use Neomycin Topical in the eyes.

Before applying Neomycin Topical, wash the affected area with soap and water, and dry thoroughly.

For patients using the cream form of Neomycin Topical:

For patients using the ointment form of Neomycin Topical:

After Neomycin Topical is applied, the treated area may be covered with a gauze dressing if desired.

To help clear up your infection completely, keep using Neomycin Topical for the full time of treatment, even if your symptoms have disappeared. Do not miss any doses.

Dosing

The dose of Neomycin Topical will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Neomycin Topical. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Missed Dose

If you miss a dose of Neomycin Topical, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Neomycin Topical administration

Administration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.
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Never take Neomycin Topical in larger amounts than recommended, or for longer than 2 weeks. High doses or long-term use of Neomycin Topical can cause serious kidney problems, or hearing loss that may not be reversible. The longer you take Neomycin Topical, the more likely you are to develop these serious side effects. Follow the directions on your prescription label.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Take this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Neomycin Topical will not treat a viral infection such as the common cold or flu.

To be sure this medication is not causing harmful effects, your kidney function, and your nerve and muscle function will need to be tested often. You may also need hearing tests. Neomycin Topical can have long lasting effects on your body. Do not miss any follow up visits to your doctor for blood or urine tests.

If you are taking Neomycin Topical for hepatic coma, your treatment may also include a special diet. It is very important to follow the diet plan created for you by your doctor. You should become very familiar with the list of foods you should avoid to help control your condition.

If you need surgery, tell the surgeon ahead of time that you are using Neomycin Topical. Neomycin Topical can interact with certain medicines that may be given during surgery.

Store at room temperature away from moisture and heat. Do not allow the liquid form of this medicine to freeze.

Neomycin Topical pharmacology

Pharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.
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Aminoglycosides like Neomycin Topical "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Neomycin Topical binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.

References

  1. DailyMed. "HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. NCIt. "Framycetin Sulfate: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
  3. EPA DSStox. "Neomycin B: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Neomycin Topical are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Neomycin Topical. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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