Nicotinic Acid Pregnancy

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Pregnancy of Nicotinic Acid in details

Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
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Nicotinic Acid has been assigned to pregnancy category C by the FDA when given in doses above the recommended daily allowance (RDA). There are no data from animal reproductive studies or controlled human pregnancy studies. The manufacturers of timed-release Nicotinic Acid do not recommend the use of this form of the drug for pregnant women. The manufacturer recommends that Nicotinic Acid be discontinued in women receiving the drug for primary hypercholesterolemia. If used for hypertriglyceridemia, Nicotinic Acid should be given during pregnancy when there are no alternatives and benefit outweighs risk.

Nicotinic Acid is converted to niacinamide in vivo. Niacinamide is actively transported across the human placenta such that fetal blood levels of niacinamide are greater than corresponding maternal blood levels. There are no reports of adverse effects of Nicotinic Acid or niacinamide on the human fetus.

See references

Nicotinic Acid breastfeeding

When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!

In one study of lactating women who were taking 2 to 60 mg of Nicotinic Acid per day, the average milk concentration ranged from 1.17 to 2.75 mcg/mL, and was directly proportional to dietary intake. The recommended daily allowance (RDA) for niacinamide during lactation is 18 to 20 mg. Dietary supplementation is only necessary in cases of poor nutritional intake.

It is not known whether or not Nicotinic Acid is excreted into human milk. Some studies indicate that it may be excreted into milk in small amounts. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
  2. Kaminetzky HA, Baker H, Frank O, Langer A "The effects of intravenously administered water-soluble vitamins during labor in normovitaminemic and hypovitaminemic gravidas on maternal and neonatal blood vitamin levels at delivery." Am J Obstet Gynecol 120 (1974): 697-703
  3. Figge HL, Figge J, Souney PF, Mutnick AH, Sacks F "Nicotinic acid: a review of its clinical use in the treatment of lipid disorders." Pharmacotherapy 8 (1988): 287-94
  4. Hill EP, Longo LD "Dynamics of maternal-fetal nutrient transfer." Fed Proc 39 (1980): 239-44
  5. "Product Information. Nicobid (Nicotinic Acid)." Rhone-Poulenc Rorer, Collegeville, PA.
  6. "Product Information. Slo-Nicotinic Acid." Upsher-Smith Laboratories Inc, Minneapolis, MN.

References for breastfeeding information

  1. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
  2. Ford JE, Zechalko A, Murphy J, Brooke OG "Comparison of the B vitamin composition of milk from mothers of preterm and term babies." Arch Dis Child 58 (1983): 367-72


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References

  1. DailyMed. "NIACIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubMed Health. "Slo-Niacin: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
  3. Human Metabolome Database (HMDB). "Nicotinic acid: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).

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