Nidcyclin Uses

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What is Nidcyclin?

Nidcyclin is used to treat pimples and red bumps (non-nodular inflammatory lesions) that occur with moderate to severe acne vulgaris in patients 12 years of age and older.

Nidcyclin capsules are used to treat bacterial infections in many different parts of the body. It is also used to treat anthrax infection and other infections in patients who cannot receive penicillins.

Nidcyclin belongs to the class of medicines known as tetracycline antibiotics. It works by killing bacteria or preventing their growth. However, Nidcyclin will not work for colds, flu, or other virus infections.

Nidcyclin is available only with your doctor's prescription.

Nidcyclin indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Nidcyclin® Pellet-Filled Capsules are indicated in the treatment of the following infections due to susceptible strains of the designated microorganisms:

Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox and tick fevers caused by rickettsiae.

Respiratory tract infections caused by Mycoplasma pneumoniae.

Lymphogranuloma venereum caused by Chlamydia trachomatis.

Psittacosis (Ornithosis) due to Chlamydia psittaci.

Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated, as judged by immunofluorescence.

Inclusion conjunctivitis caused by Chlamydia trachomatis.

Nongonococcal urethritis, endocervical, or rectal infections in adults caused by Ureaplasma urealyticum or Chlamydia trachomatis.

Relapsing fever due to Borrelia recurrentis.

Chancroid caused by Haemophilus ducreyi.

Plague due to Yersinia pestis.

Tularemia due to Francisella tularensis.

Cholera caused by Vibrio cholerae.

Campylobacter fetus infections caused by Campylobacter fetus.

Brucellosis due to Brucella species (in conjunction with streptomycin).

Bartonellosis due to Bartonella bacilliformis.

Granuloma inguinale caused by Calymmatobacterium granulomatis.

Nidcyclin is indicated for the treatment of infections caused by the following gram-negative microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug:

Escherichia coli.

Enterobacter aerogenes.

Shigella species.

Acinetobacter species.

Respiratory tract infections caused by Haemophilus influenzae.

Respiratory tract and urinary tract infections caused by Klebsiella species.

Nidcyclin® Pellet-Filled Capsules are indicated for the treatment of infections caused by the following gram-positive microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug:

Upper respiratory tract infections caused by Streptococcus pneumoniae.

Skin and skin structure infections caused by Staphylococcus aureus. (Note: Nidcyclin is not the drug of choice in the treatment of any type of staphylococcal infection.)

When penicillin is contraindicated, Nidcyclin is an alternative drug in the treatment of the following infections:

Uncomplicated urethritis in men due to Neisseria gonorrhoeae and for the treatment of other gonococcal infections.

Infections in women caused by Neisseria gonorrhoeae.

Syphilis caused by Treponema pallidum subspecies pallidum.

Yaws caused by Treponema pallidum subspecies pertenue.

Listeriosis due to Listeria monocytogenes.

Anthrax due to Bacillus anthracis.

Vincent’s infection caused by Fusobacterium fusiforme.

Actinomycosis caused by Actinomyces israelii.

Infections caused by Clostridium species.

In acute intestinal amebiasis, Nidcyclin may be a useful adjunct to amebicides.

In severe acne, Nidcyclin may be useful adjunctive therapy.

Oral Nidcyclin is indicated in the treatment of asymptomatic carriers of Neisseria meningitidis to eliminate meningococci from the nasopharynx. In order to preserve the usefulness of Nidcyclin in the treatment of asymptomatic meningococcal carriers, diagnostic laboratory procedures, including serotyping and susceptibility testing, should be performed to establish the carrier state and the correct treatment. It is recommended that the prophylactic use of Nidcyclin be reserved for situations in which the risk of meningococcal meningitis is high.

Oral Nidcyclin is not indicated for the treatment of meningococcal infection.

Although no controlled clinical efficacy studies have been conducted, limited clinical data show that oral Nidcyclin hydrochloride has been used successfully in the treatment of infections caused by Mycobacterium marinum.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Nidcyclin® (Nidcyclin hydrochloride) Pellet-Filled Capsules and other antibacterial drugs, Nidcyclin® (Nidcyclin hydrochloride) Pellet-Filled Capsules should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

How should I use Nidcyclin?

Use Nidcyclin extended-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Nidcyclin extended-release tablets.

Uses of Nidcyclin in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Acute intestinal amebiasis: Adjunctive therapy to amebicides in the treatment of acute intestinal amebiasis

Acne:

Oral (immediate release) and IV:

Adjunctive therapy for the treatment of severe acne

Oral (extended-release):

Treatment of only inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 12 years and older

Actinomycosis: Treatment of actinomycosis caused by Actinomyces israelii when penicillin is contraindicated

Anthrax: Treatment of anthrax caused by Bacillus anthracis when penicillin is contraindicated

Asymptomatic carriers of Neisseria meningitidis:

Oral (immediate-release):

To eliminate the meningococci from the nasopharynx of asymptomatic carriers of N. meningitidis

Campylobacter: Treatment of infections caused by Campylobacter fetus

Cholera: Treatment of cholera caused by Vibrio cholerae

Clostridium: Treatment of infections caused by Clostridium spp when penicillin is contraindicated

Gram-negative infections: Treatment of infections caused by Acinetobacter spp, Escherichia coli, Enterobacter aerogenes, Shigella spp

Listeriosis: Treatment of listeriosis due to Listeria monocytogenes when penicillin is contraindicated

Meningitis: Treatment of meningitis due to Neisseria meningitidis when penicillin is contraindicated

Ophthalmic infections:

Treatment of inclusion conjunctivitis or trachoma caused by Chlamydia trachomatis

Relapsing fever: Treatment of relapsing fever caused by Borrelia recurrentis

Respiratory tract infections: Treatment of respiratory tract infections caused by Haemophilus influenzae, Klebsiella spp, or Mycoplasma pneumonia. For the treatment of upper respiratory tract infections caused by Streptococcus pneumoniae.

Rickettsial infections: Treatment of Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae

Sexually transmitted infections: Treatment of lymphogranuloma venereum caused by C. trachomatis; nongonococcal urethritis, endocervical, or rectal infections in adults caused by Ureaplasma urealyticum or C. trachomatis; donovanosis (granuloma inguinale) caused by Klebsiella granulomatis; syphilis caused by Treponema pallidum subspecies pallidum, when penicillin is contraindicated

Skin and skin structure infections: Treatment of skin and skin structure infections caused by Staphylococcus aureus (not considered a first-line agent for any staphylococcal infection)

Urinary tract infections: Treatment of urinary tract infections caused by Klebsiella species

Vincent infection: Treatment of Vincent infection caused by Fusobacterium fusiforme when penicillin is contraindicated

Yaws: Treatment of yaws caused by T. pallidum subspecies pertenue when penicillin is contraindicated

Zoonotic infections: Treatment of psittacosis (ornithosis) due to Chlamydia psittaci; plague due to Yersinia pestis; tularemia due to Francisella tularensis; brucellosis due to Brucella spp (in conjunction with streptomycin); bartonellosis due to Bartonella bacilliformis

Off Label Uses

Cellulitis (purulent) due to community-acquired MRSA

Based on the Infectious Diseases Society of America (IDSA) Clinical Practice Guidelines for the Treatment of Methicillin-Resistant Staphylococcus Aureus Infections in Adults and Children, Nidcyclin is effective and recommended in the outpatient management of purulent cellulitis due to community-acquired methicillin-resistant S. aureus (MRSA).

Leprosy

Based on the National Hansen's Disease Program (NHDP) treatment recommendations, Nidcyclin, in combination with other agents, is an effective and recommended alternative agent for treatment of lepromatous (multibacillary) and tuberculoid (paucibacillary) leprosy.

Nocardiosis

Data from a limited number of patients studied suggest that Nidcyclin, with or without other concomitant antimicrobials, may be beneficial for the treatment of nocardiosis

Prosthetic Joint Infection

Based on the Infectious Diseases Society of America (IDSA) Diagnosis and Management of Prosthetic Joint Infection: Clinical Practice Guideline, Nidcyclin (based on in vitro susceptibility) given for indefinite chronic oral antimicrobial suppression of prosthetic joint infections is an effective and recommended treatment option. Nidcyclin is one of the preferred agents for Staphylococci (oxacillin-resistant) infections and is an alternative treatment for infections caused by Cutibacterium spp.

Rheumatoid arthritis

Data from older controlled studies and a meta-analysis have demonstrated a beneficial effect on laboratory parameters and modest clinical benefit in patients with rheumatoid arthritis (RA). Some data suggest that Nidcyclin may be effective in patients with recent-onset disease to reduce the total steroid dose needed.

The American College of Rheumatology (ACR) updated guideline for the treatment of RA did not include Nidcyclin due to its infrequent use in RA and lack of new data since prior publication.

Nidcyclin description

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Nidcyclin hydrochloride is a yellow, crystalline powder; sparingly soluble or soluble in water, slightly soluble in alcohol, practically insoluble in chloroform and in ether, dissolves in solutions of alkali hydroxides and carbonates.

Nidcyclin hydrochloride is 4-7, bis (dimethylamino)-1, 4, 4a, 5, 5a, 6, 11, 12a-octahydro-3,10,12, 12a-tetrahydroxy- 1,11-dioxo-2-naphthacenecarboxamide monohydrochloride.

It has a molecular formula of C23H27N3O7 HCl. Molecular weight is 493.94.

Nidcyclin dosage

Nidcyclin Dosage

Generic name: Nidcyclin hydrochloride 45mg

Dosage form: tablet, film coated, extended release

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

The recommended dosage of Nidcyclin® is approximately 1 mg/kg daily for 12 weeks. Higher doses have not shown to be of additional benefit in the treatment of inflammatory lesions of acne, and may be associated with more acute vestibular side effects.

The following table shows tablet strength and body weight to achieve approximately 1 mg/kg.

Table 3: Dosing Table for Nidcyclin®
Patient's Weight (lbs.) Patient's Weight (kg) Tablet Strength (mg) Actual mg/kg Dose
99 – 120 45 – 54 45 1 – 0.83
121 – 170 55 – 77 65 1.18 – 0.84
171 – 225 78 – 102 90 1.15 – 0.88
226 – 276 103 – 125 115 1.12 – 0.92
277 – 300 126 – 136 135 1.07 – 0.99

Nidcyclin® Tablets may be taken with or without food. Ingestion of food along with Nidcyclin® may help reduce the risk of esophageal irritation and ulceration.

In patients with renal impairment, the total dosage should be decreased by either reducing the recommended individual doses and/or by extending the time intervals between doses.

More about Nidcyclin (Nidcyclin)

Consumer resources

Professional resources

Related treatment guides

Nidcyclin interactions

See also:
What other drugs will affect Nidcyclin?

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Anticoagulants

Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.

Penicillin

Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin.

Methoxyflurane

The concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity.

Antacids and Iron Preparations

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium and iron-containing preparations.

Low Dose

Oral Contraceptives

In a multi-center study to evaluate the effect of Nidcyclin on low dose oral contraceptives, hormone levels over one menstrual cycle with and without Nidcyclin 1 mg/kg once-daily were measured. Based on the results of this trial, Nidcyclin-related changes in estradiol, progestinic hormone, FSH and LH plasma levels, of breakthrough bleeding, or of contraceptive failure, cannot be ruled out. To avoid contraceptive failure, female patients are advised to use a second form of contraceptive during treatment with Nidcyclin.

Drug/Laboratory Test Interactions

False elevations of urinary catecholamine levels may occur due to interference with the fluorescence test.

Nidcyclin side effects

See also:
What are the possible side effects of Nidcyclin?

Applies to Nidcyclin: oral capsule, oral capsule extended release, oral suspension, oral tablet, oral tablet extended release

Other dosage forms:

As well as its needed effects, Nidcyclin (the active ingredient contained in Nidcyclin) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking Nidcyclin, check with your doctor immediately:

Incidence not known:

Minor Side Effects

Some Nidcyclin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:

Incidence not known:

Nidcyclin contraindications

See also:
What is the most important information I should know about Nidcyclin?

Do not use this medicine if you are pregnant. It could harm the unborn baby or cause permanent tooth discoloration later in life.

Nidcyclin can make birth control pills less effective. Ask your doctor about using a non hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using Nidcyclin.

Nidcyclin passes into breast milk and may affect bone and tooth development in a nursing baby. Do not take this medication without telling your doctor if you are breast-feeding a baby.

Children should not take Nidcyclin. Nidcyclin can cause permanent yellowing or graying of the teeth in children younger than 8 years old.

Avoid exposure to sunlight or tanning beds. Nidcyclin can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Do not take iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2 hours before or after taking Nidcyclin. These products can make Nidcyclin less effective.

Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.

Throw away any unused medicine after the expiration date on the label has passed. Using expired Nidcyclin can cause damage to your kidneys.



Active ingredient matches for Nidcyclin:

Minocycline in India.


Unit description / dosage (Manufacturer)Price, USD
50 mg x 10's$ 2.30
Nidcyclin 50mg TAB / 10$ 2.30
Nidcyclin 50 mg Tablet$ 0.23
NIDCYCLIN tab 50 mg x 10's (Nidus)$ 2.86
Nidcyclin 50mg TAB / 10$ 2.30

List of Nidcyclin substitutes (brand and generic names):

Nimolin 50 mg Tablet (Ochoa Laboratories (P) Ltd.)$ 0.21
Nimolin 100 mg Tablet (Ochoa Laboratories (P) Ltd.)$ 0.40
Nocigen 100 mg
Nomika 50 mg x 10 x 10's (Ikapharmindo)$ 57.04
Nomika 100 mg x 10 x 10's (Ikapharmindo)$ 96.72
Capsule; Oral; Minocycline Hydrochloride 100 mg
Capsule; Oral; Minocycline Hydrochloride 50 mg
Capsules; Oral; Minocycline Hydrochloride 100 mg
Capsules; Oral; Minocycline Hydrochloride 50 mg
Gel; Dental; Minocycline Hydrochloride 2% (Csp)
Capsule; Oral; Minocycline Hydrochloride 100 mg
Capsule; Oral; Minocycline Hydrochloride 50 mg
Capsules; Oral; Minocycline Hydrochloride 100 mg
Capsules; Oral; Minocycline Hydrochloride 50 mg
PHL-minocycline capsule 100 mg (Pharmel Inc (Canada))
PHL-minocycline capsule 50 mg (Pharmel Inc (Canada))
Capsule; Oral; Minocycline Hydrochloride 100 mg
Capsule; Oral; Minocycline Hydrochloride 50 mg
Capsules; Oral; Minocycline Hydrochloride 100 mg
Capsules; Oral; Minocycline Hydrochloride 50 mg
PMS-minocycline capsule 50 mg (Pharmascience Inc (Canada))
PMS-minocycline capsule 100 mg (Pharmascience Inc (Canada))
Capsule; Oral; Minocycline 100 mg (Grunenthal)
Capsule; Oral; Minocycline 50 mg (Grunenthal)
Capsules; Oral; Minocycline 100 mg (Grunenthal)
Capsules; Oral; Minocycline 50 mg (Grunenthal)
Capsule; Oral; Minocycline Hydrochloride 100 mg
Capsule; Oral; Minocycline Hydrochloride 50 mg
Capsules; Oral; Minocycline Hydrochloride 100 mg
Capsules; Oral; Minocycline Hydrochloride 50 mg
Ratio-minocycline capsule 100 mg (Ratiopharm Inc Division Of Teva Canada Limited (Canada))
Ratio-minocycline capsule 50 mg (Ratiopharm Inc Division Of Teva Canada Limited (Canada))

References

  1. PubChem. "minocycline". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "minocycline". http://www.drugbank.ca/drugs/DB01017 (accessed September 17, 2018).
  3. MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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