Overdose of Nimesulide in details
In case of overdose, call your local poison control center or emergency services.
Symptoms of overdose may include: dizziness; fast eye movements that you cannot control; slow breathing or short periods of time without breathing; blue color around the lips, mouth, and nose.
Nimesulide warnings
General: Blurred and/or diminished vision, Fluid retention and edema,.
Liver effects: borderline elevations of one or more liver function tests may occur in up to 15% of patients. Severe hepatic reactions, including jaundice and cases of fatal hepatitis, have been reported.
Hemoglobin levels: in cross-study comparisons with doses ranging from 1200 mg to 3200 mg daily for several weeks, a slight dose-response decrease in hemoglobin/hematocrit was noted.
Aseptic meningitis: aseptic meningitis with fever and coma has been observed on rare occasions.
Renal effects: there have been reports of acute interstitial nephritis with hematuria, proteinuria, and occasionally nephrotic syndrome.
Since Ibuprofen is eliminated primarily by the kidneys, patients with significantly impaired renal function should be closely monitored; and a reduction in dosage should be anticipated to avoid drug accumulation.
Nimesulide precautions
Gel: If local irritation develops, discontinue using the gel and appropriate therapy should be instituted as necessary. The gel should not be applied over eyes, mucosal surface or to any sites affected by open skin lesions, dermatosis or infections or open wounds. Burning and stinging may occur while rubbing Nimesulide gel. This usually stops after using the gel for a few days. Sensitive areas should not be touched while Nimesulide gel is on the hands. Nimesulide gel should be used with caution in patients at increased risk of developing salicylate-related adverse events.
Use in pregnancy & lactation: Safety and efficacy of Nimesulide in pregnant and lactating women has not been established. Therefore, Nimesulide is not indicated for use in pregnant and lactating women.
Use in children: Dosage recommendations and indications for use in children have not been established.
Use in the
Elderly: The pharmacokinetics of oral Nimesulide are similar in elderly patients <80 years, with normal renal function, when compared to young healthy volunteers. However, caution should be used when prescribing Nimesulide in elderly patients with compromised renal function.
Oral Nimesulide has been reported to cause hepatic adverse events, ranging from transient increase in liver enzyme values to severe liver injuries including fatal hepatic failure in a few cases. Most of these patients were elderly women. It is reported that the adverse event appears to be idiosyncratic or immunologic in nature.
References
- DrugBank. "nimesulide". http://www.drugbank.ca/drugs/DB04743 (accessed September 17, 2018).
- MeSH. "Anti-Inflammatory Agents, Non-Steroidal". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
